Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1.

abstract：:Pulses of ecdysteroids induce dramatic changes in gene expression that direct the early stages of Drosophila metamorphosis. This gene activity is reflected by the appearance of early and late puffs in the salivary gland polytene chromosomes. Curiously, the early puff genes that have been studied to date are induced by...

journal_title：Developmental biology

authors： Baehrecke EH,Thummel CS

更新日期：1995-09-01 00:00:00

abstract：:We have identified a cellular efflux pump, RhT, with the properties of an MDR transporter-a type of ATP-binding cassette transporter whose substrates include small hydrophobic molecules. RhT transports rhodamine 123 (Rh123) and is inhibited by low temperature, energy poisons, and several MDR transport inhibitors, such...

journal_title：Developmental biology

authors： Good JR,Kuspa A

更新日期：2000-04-01 00:00:00

abstract：:Primary mesenchyme cell migration in the sea urchin embryo is inhibited by sulfate deprivation and exposure to exogenous beta-D-xylosides, two treatments known to disrupt proteoglycan synthesis. We show that in the developing sea urchin, exogenous xyloside affects the synthesis by the primary mesenchyme cells of a ver...

journal_title：Developmental biology

authors： Lane MC,Solursh M

更新日期：1991-02-01 00:00:00

abstract：:Choroideremia (CHM) is a hereditary eye disease caused by mutations in the X-linked CHM gene. Disruption of the Chm gene in mice resulted in prenatal death of Chm-/Y males and Chm-/Chm+ females that had inherited the mutation from their mothers. Male chimeras and Chm+/Chm- females with paternal transmission of the mut...

journal_title：Developmental biology

authors： Shi W,van den Hurk JA,Alamo-Bethencourt V,Mayer W,Winkens HJ,Ropers HH,Cremers FP,Fundele R

更新日期：2004-08-01 00:00:00

abstract：:The differentiation of three anterior pituitary cell types is regulated by the tissue-specific POU domain factor Pit-1, which is initially expressed on Embryonic Day 13.5-14 in mice. The Pit-1 gene remains continuously, highly expressed in the somatotrope, thyrotrope, and lactotrope cells of the adult. Using the Pit-1...

journal_title：Developmental biology

authors： DiMattia GE,Rhodes SJ,Krones A,Carrière C,O'Connell S,Kalla K,Arias C,Sawchenko P,Rosenfeld MG

更新日期：1997-02-01 00:00:00

abstract：:Gnathostomes (jawed vertebrates) possess skeletal muscles with unique functional and developmental features that are absent from cyclostomes-i.e., lamprey and hagfish. These gnathostome-specific traits include the epaxial and hypaxial division of myotomes, paired fin/limb muscles, shoulder girdle muscles, and the musc...

journal_title：Developmental biology

authors： Kusakabe R,Kuraku S,Kuratani S

更新日期：2011-02-01 00:00:00

abstract：:Primordial germ cells (PGCs) are the embryonic precursors of the adult gametes. Although restricted in developmental potency, PGCs express many of the same molecular markers as pluripotent embryonic stem (ES) cells and can give rise to embryonal carcinoma (EC) cells, the stem cells of testicular tumors, in vivo. Likew...

journal_title：Developmental biology

authors： Elliott AM,de Miguel MP,Rebel VI,Donovan PJ

更新日期：2007-11-15 00:00:00

abstract：:Nicastrin is a recently identified member of high-molecular weight complexes containing presenilin. The Caenorhabditis elegans homolog of nicastrin, aph-2, was shown to be required for GLP-1/Notch signaling in the early embryo. In addition to the maternal-effect embryonic lethal phenotype, aph-2 mutant animals also di...

journal_title：Developmental biology

authors： Levitan D,Yu G,St George Hyslop P,Goutte C

更新日期：2001-12-15 00:00:00

abstract：:We have reported previously that sequence-specific adenylations and deadenylations accompany changes in the translation of maternal mRNA following fertilization of Spisula oocytes (E.T. Rosenthal, T.R. Tansey, and J.V. Ruderman, 1983, J. Mol. Biol. 166, 309-327). The data presented here confirm and extend those observ...

journal_title：Developmental biology

authors： Rosenthal ET,Ruderman JV

更新日期：1987-05-01 00:00:00

abstract：:In the retinotectal projection, the Eph receptor tyrosine kinase ligands ephrinA2 and ephrinA5 are differentially expressed not only in the tectum, but also in a high-nasal-to-low-temporal pattern in the retina. Recently, we have shown that retrovirally driven overexpression of ephrinA2 on retinal axons leads to topog...

journal_title：Developmental biology

authors： Dütting D,Handwerker C,Drescher U

更新日期：1999-12-01 00:00:00

abstract：:Vertebrate heart development requires specification of cardiac precursor cells, migration of cardiac progenitors as well as coordinated cell movements during looping and septation. DM-GRASP/ALCAM/CD166 is a member of the neuronal immunoglobulin domain superfamily of cell adhesion molecules and was recently suggested t...

journal_title：Developmental biology

authors： Gessert S,Maurus D,Brade T,Walther P,Pandur P,Kühl M

更新日期：2008-09-01 00:00:00

abstract：:Notch signaling is involved in a large range of developmental processes, and has been functionally implicated in body plan segmentation in two of the three diverse segmented taxa, the vertebrates and arthropods. Here we investigate expression of Notch, Delta, and hes gene homologues during larval and juvenile developm...

journal_title：Developmental biology

authors： Thamm K,Seaver EC

更新日期：2008-08-01 00:00:00

abstract：:Chick sensory neurons grow to their correct targets in the hindlimb from the outset during normal development and following various experimental manipulations. This may result not because sensory neurons respond to specific limb-derived cues, but because they interact in some way with motoneurons which are responsive ...

journal_title：Developmental biology

authors： Landmesser L,Honig MG

更新日期：1986-12-01 00:00:00

abstract：:Skeletal muscle fibers express members of the myosin heavy chain (MyHC) gene family in a fiber-type-specific manner. In avian skeletal muscle it is the expression of the slow MyHC isoforms that most clearly distinguishes slow- from fast-contracting fiber types. Two hypotheses have been proposed to explain fiber-type-s...

journal_title：Developmental biology

authors： DiMario JX,Stockdale FE

更新日期：1997-08-01 00:00:00

abstract：:Sonic hedgehog is a secreted factor regulating patterning of the anterior-posterior axis in the developing limb. The signaling pathway mediating the transduction of the signal is still poorly understood. In Drosophila several genes are known to act downstream of hedgehog, the fly homolog of Sonic hedgehog. An importan...

journal_title：Developmental biology

authors： Marigo V,Johnson RL,Vortkamp A,Tabin CJ

更新日期：1996-11-25 00:00:00

abstract：:To understand cell interactions during induction of skin appendages, we studied the roles of adhesion molecules N-CAM, tenascin, integrin, and fibronectin during feather development. Tenascin appeared in a periodic pattern on epithelia and was so far the earliest molecule detected in placodes. Three placode domains we...

journal_title：Developmental biology

authors： Jiang TX,Chuong CM

更新日期：1992-03-01 00:00:00

abstract：:Spore germination is a defined developmental process that marks a critical point in the life cycle of Dictyostelium discoideum. Upon germination the environmental conditions must be conducive to cell growth to ensure survival of emerged amoebae. However, the signal transduction pathways controlling the various aspects...

journal_title：Developmental biology

authors： Zinda MJ,Singleton CK

更新日期：1998-04-15 00:00:00

abstract：:The homebox gene Hlxb9, encoding Hb9, exhibits a dual expression profile during pancreatic development. The early expression in the dorsal and ventral pancreatic epithelium is transient and spans from embryonic day (e) 8 to e9-e10, whereas the later expression is confined to differentiating beta-cells as they appear. ...

journal_title：Developmental biology

authors： Li H,Edlund H

更新日期：2001-12-01 00:00:00

abstract：:Octopamine is an important neuroactive substance that modulates several physiological functions and behaviors of invertebrate species. Its biosynthesis involves two steps, one of which is catalyzed by Tyramine beta-hydroxylase enzyme (TBH). The Tbetah gene has been previously cloned from Drosophila melanogaster, and n...

journal_title：Developmental biology

authors： Monastirioti M

更新日期：2003-12-01 00:00:00

abstract：:The zebrafish fin is an excellent system to study the mechanisms of dermal bone patterning. Fin rays are segmented structures that form successive bifurcations both during ontogenesis and regeneration. Previous studies showed that sonic hedgehog (shha) may regulate regenerative bone patterning based on its expression ...

journal_title：Developmental biology

authors： Zhang J,Jeradi S,Strähle U,Akimenko MA

更新日期：2012-05-15 00:00:00

abstract：:This work has identified the enzymes involved in the activation and conjugation of the ubiquitin-like protein NED-8 in Caenorhabditis elegans. A C. elegans conjugating enzyme, UBC-12, is highly specific in its ability to utilize NED-8 as a substrate. Immunostaining shows that NED-8 is conjugated in vivo to a major tar...

journal_title：Developmental biology

authors： Jones D,Candido EP

更新日期：2000-10-01 00:00:00

abstract：:A complex regulatory cascade is required for normal cardiac development, and many aspects of this network are conserved from Drosophila to mammals. In Drosophila, the seven-up (svp) gene, an ortholog of the vertebrate chick ovalbumin upstream promoter transcription factors (COUP-TFI and II), is initially activated in ...

journal_title：Developmental biology

authors： Ryan KM,Hendren JD,Helander LA,Cripps RM

更新日期：2007-02-15 00:00:00

abstract：:Artificial extracellular matrices composed of collagen, glycosaminoglycans (GAG), proteoglycans (PG), plasma fibronectin (FN), and a hyaluronate-binding protein (HABP) have been prepared that morphologically resemble embryonic extracellular matrices in vivo at the light and electron microscope level. The effect of eac...

journal_title：Developmental biology

authors： Turley EA,Erickson CA,Tucker RP

更新日期：1985-06-01 00:00:00

abstract：:We have investigated the function of the neurogenic gene Notch (N) during development of the adult sensilla of Drosophila. Heat pulses were applied to flies carrying the temperature-sensitive Notch allele Nts1 at different larval and pupal stages. We can show that the reduction of Notch+ function during a short interv...

journal_title：Developmental biology

authors： Hartenstein V,Posakony JW

更新日期：1990-11-01 00:00:00

abstract：:Cleft palate is one of the most common craniofacial congenital defects in humans. It is associated with multiple genetic and environmental risk factors, including mutations in the genes encoding signaling molecules in the sonic hedgehog (Shh) pathway, which are risk factors for cleft palate in both humans and mice. Ho...

journal_title：Developmental biology

authors： Li J,Yuan Y,He J,Feng J,Han X,Jing J,Ho TV,Xu J,Chai Y

更新日期：2018-09-01 00:00:00

abstract：:Developmentally regulated gene expression has been analyzed in the wild-type D. discoideum strain NC-4 and a series of temporally deranged mutants. The mutants include representatives from each class of rapid development mutation, Fr17(rdeA-) and HT506(rdeC-), and strain HIfm-1, which appears to be defective in the ti...

journal_title：Developmental biology

authors： Saxe CL 3rd,Firtel RA

更新日期：1986-06-01 00:00:00

abstract：:The Drosophila brain is generated by a complex series of morphogenetic movements. To better understand brain development and to provide a guide for experimental manipulation of brain progenitors, we created a fate map using photoactivated gene expression to mark cells originating within specific mitotic domains and ti...

journal_title：Developmental biology

authors： Robertson K,Mergliano J,Minden JS

更新日期：2003-08-01 00:00:00

abstract：:We examined the effects of ciliary neurotrophic factor (CNTF) and depolarization, two environmental signals that influence noradrenergic and cholinergic function, on neuropeptide expression by cultured sympathetic neurons. Sciatic nerve extract, a rich source of CNTF, increased levels of vasoactive intestinal peptide ...

journal_title：Developmental biology

authors： Rao MS,Tyrrell S,Landis SC,Patterson PH

更新日期：1992-04-01 00:00:00

abstract：:In most ascidians, metamorphosis of tadpole-like swimming larvae is accompanied by dynamic changes in their shape to form sessile adults. The mechanisms underlying ascidian metamorphosis have been debated for a long time. Although recent molecular studies have revealed the presence of various molecules involving in th...

journal_title：Developmental biology

authors： Nakayama-Ishimura A,Chambon JP,Horie T,Satoh N,Sasakura Y

更新日期：2009-02-15 00:00:00

abstract：:Thrombospondin type 1 repeat (TSR) superfamily members regulate diverse biological activities ranging from cell motility to inhibition of angiogenesis. In this study, we verified that mouse protein O-fucosyltransferase-2 (POFUT2) specifically adds O-fucose to TSRs. Using two Pofut2 gene-trap lines, we demonstrated tha...

journal_title：Developmental biology

authors： Du J,Takeuchi H,Leonhard-Melief C,Shroyer KR,Dlugosz M,Haltiwanger RS,Holdener BC

更新日期：2010-10-01 00:00:00