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Distinct octopamine cell population residing in the CNS abdominal ganglion controls ovulation in Drosophila melanogaster.

Abstract：

:Octopamine is an important neuroactive substance that modulates several physiological functions and behaviors of invertebrate species. Its biosynthesis involves two steps, one of which is catalyzed by Tyramine beta-hydroxylase enzyme (TBH). The Tbetah gene has been previously cloned from Drosophila melanogaster, and null mutations have been generated resulting in octopamine-less flies that show profound female sterility. Here, I show that ovulation process is defective in the mutant females resulting in blockage of mature oocytes within the ovaries. The phenotype is conditionally rescued by expressing a Tbetah cDNA under the control of a hsp70 promoter in adult females. Fertility of the mutant females is also restored when TBH is expressed, via the GAL4-UAS system, in cells of the CNS abdominal ganglion that express TBH and produce octopamine. This neuronal population differs from the dopamine- and serotonin-expressing cells indicating distinct patterns of expression and function of the three substances in the region. Finally, I demonstrate that these TBH-expressing cells project to the periphery where they innervate the ovaries and the oviducts of the reproductive system. The above results point to a neuronal focus that can synthesize and release octopamine in specific sites of the female reproductive system where the amine is required to trigger ovulation.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Monastirioti M

doi

10.1016/j.ydbio.2003.07.019

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

38-49

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012160603004597

journal_volume

264

pub_type

杂志文章

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