The 5' UTR and 3' UTR of the sperm mitochondria-associated cysteine-rich protein mRNA regulate translation in spermatids by multiple mechanisms in transgenic mice.

abstract：:The correct assembly of junction components, such as E-cadherin and beta-catenin, into the zonula adherens is fundamental for the function of epithelia, both in flies and in vertebrates. In C. elegans, however, the cadherin-catenin system is not essential for general adhesion, raising the question as to the genetic ba...

journal_title：Developmental biology

authors： Bossinger O,Klebes A,Segbert C,Theres C,Knust E

更新日期：2001-02-01 00:00:00

abstract：:Chondrocytes were isolated from the auricular cartilage of rabbits, aged 1 week to 30 months, and grown in short-term cell culture. The cells from the 1-week animals were small, polygonal, and mononucleated, while the chondrocytes from the older animals were larger, rounded, and frequently binucleated. The synthesis o...

journal_title：Developmental biology

authors： Madsen K,Moskalewski S,von der Mark K,Friberg U

更新日期：1983-03-01 00:00:00

abstract：:Larvae homozygous for the recessive lethal allele without children(rgl) (woc(rgl)) fail to pupariate. Application of exogenous 20-hydroxyecdysone elicits puparium formation and pupation. Ecdysteroid titer measurements on mutant larvae show an endocrine deficiency in the brain-ring gland complex, which normally synthes...

journal_title：Developmental biology

authors： Wismar J,Habtemichael N,Warren JT,Dai JD,Gilbert LI,Gateff E

更新日期：2000-10-01 00:00:00

abstract：:The msh/Msx family is a subclass of homeobox-containing genes suggested to perform a conserved function in the patterning of the early embryo. We had already isolated a member of this gene family (Ci-msxb) in Ciona intestinalis, which has a very complex expression pattern during embryogenesis. To identify the regulato...

journal_title：Developmental biology

authors： Russo MT,Donizetti A,Locascio A,D'Aniello S,Amoroso A,Aniello F,Fucci L,Branno M

更新日期：2004-03-15 00:00:00

abstract：:The development of asymmetric patterns along biologically relevant axes is a hallmark of many vertebrate organs or structures. One example is the sensory epithelium of the mammalian auditory system. Two distinct types of mechanosensory hair cells (inner and outer) and at least six types of associated supporting cells ...

journal_title：Developmental biology

authors： Ellis K,Driver EC,Okano T,Lemons A,Kelley MW

更新日期：2019-09-15 00:00:00

abstract：:Pulses of ecdysteroids induce dramatic changes in gene expression that direct the early stages of Drosophila metamorphosis. This gene activity is reflected by the appearance of early and late puffs in the salivary gland polytene chromosomes. Curiously, the early puff genes that have been studied to date are induced by...

journal_title：Developmental biology

authors： Baehrecke EH,Thummel CS

更新日期：1995-09-01 00:00:00

abstract：:To investigate the lineage relationships of neurons and astroglial cells early in central nervous system development, we have analyzed the progeny of neural plate cells in an amphibian embryo (Pleurodeles waltl). A fluorescent tracer, lysinated rhodamine-dextran, was iontophoretically injected into individual precurso...

journal_title：Developmental biology

authors： Soula C,Foulquier F,Duprat AM,Cochard P

更新日期：1993-09-01 00:00:00

abstract：:In medusae of the hydrozoan Cytaeis uchidae, oocyte meiotic maturation and spawning occur as a consequence of dark-light transition. In this study, we investigated the mechanism underlying the initiation of meiotic maturation using in vitro (isolated oocytes from ovaries) and in vivo (ovarian oocytes in medusae) syste...

journal_title：Developmental biology

authors： Takeda N,Kyozuka K,Deguchi R

更新日期：2006-10-01 00:00:00

abstract：:Rho GTPases control signal transduction pathways that link cell surface receptors to a variety of intracellular responses. They are best known as regulators of the actin cytoskeleton, but in addition they control cell polarity, gene expression, microtubule dynamics and vesicular trafficking. Through these diverse func...

journal_title：Developmental biology

authors： Raftopoulou M,Hall A

更新日期：2004-01-01 00:00:00

abstract：:Retinal stem cells (RSCs) exist as rare pigmented ciliary epithelial cells in adult mammalian eyes. We hypothesized that RSCs are at the top of the retinal cell lineage. Thus, genes expressed early in embryonic development to establish the retinal field in forebrain neuroectoderm may play important roles in RSCs. Pax6...

journal_title：Developmental biology

authors： Xu S,Sunderland ME,Coles BL,Kam A,Holowacz T,Ashery-Padan R,Marquardt T,McInnes RR,van der Kooy D

更新日期：2007-04-15 00:00:00

abstract：:Coordinated locomotion of Drosophila larvae depends on accurate patterning and stable attachment to the cuticle of both muscles and proprioceptors (chordotonal organs). Unlike muscle spindles in mammals, the fly chordotonal organs are not embedded in the body-wall muscles. Yet, the contractile system (muscles and tend...

journal_title：Developmental biology

authors： Klein Y,Halachmi N,Egoz-Matia N,Toder M,Salzberg A

更新日期：2010-01-15 00:00:00

abstract：:Malfunctions of motile cilia cause a variety of developmental defects and diseases in humans and animal model organisms. Defects include impaired mucociliary clearance of the airways, sperm immotility, hydrocephalus and organ laterality. Here, we characterize the evolutionary conserved Cfap43 gene by loss-of-function ...

journal_title：Developmental biology

authors： Rachev E,Schuster-Gossler K,Fuhl F,Ott T,Tveriakhina L,Beckers A,Hegermann J,Boldt K,Mai M,Kremmer E,Ueffing M,Blum M,Gossler A

更新日期：2020-03-15 00:00:00

abstract：:Cleft palate is one of the most common craniofacial congenital defects in humans. It is associated with multiple genetic and environmental risk factors, including mutations in the genes encoding signaling molecules in the sonic hedgehog (Shh) pathway, which are risk factors for cleft palate in both humans and mice. Ho...

journal_title：Developmental biology

authors： Li J,Yuan Y,He J,Feng J,Han X,Jing J,Ho TV,Xu J,Chai Y

更新日期：2018-09-01 00:00:00

abstract：:Single cells from 512-cell Xenopus embryos, totally labeled with intracellular horseradish peroxidase, were transplanted orthotopically (from either dorsal or lateral marginal zone) or heterotopically (between these two marginal zones) to unlabeled host embryos at the 512-cell stage. At tailbud stage 23 the locations,...

journal_title：Developmental biology

authors： Jacobson M,Xu WL

更新日期：1989-01-01 00:00:00

abstract：:Developmental patterning and growth of the vertebrate digestive and respiratory tracts requires interactions between the epithelial endoderm and adjacent mesoderm. The esophagus is a specialized structure that connects the digestive and respiratory systems and its normal development is critical for both. Shh signaling...

journal_title：Developmental biology

authors： Korzh S,Winata CL,Zheng W,Yang S,Yin A,Ingham P,Korzh V,Gong Z

更新日期：2011-11-15 00:00:00

abstract：:Thoracic sensory neurons in bullfrog tadpoles can be induced to form connections typical of brachial sensory neurons by transplanting thoracic ganglia to the branchial level at stages when some thoracic sensory neurons already have formed connections. In order to find out how many postmitotic sensory neurons survive t...

journal_title：Developmental biology

authors： Smith CL

更新日期：1990-12-01 00:00:00

abstract：:Tbx18 has been shown to be essential for ureteral development. However, it remains unclear whether it plays a direct role in kidney development. Here we addressed this by focusing on examining the pattern and contribution of Tbx18+ cells in the kidney and its role in kidney vascular development. Expression studies and...

journal_title：Developmental biology

authors： Xu J,Nie X,Cai X,Cai CL,Xu PX

更新日期：2014-07-01 00:00:00

abstract：:A small number of signaling pathways are used repeatedly during organogenesis, and they can have drastically different effects on the same population of cells depending on the embryonic stage. How cellular competence changes over developmental time is not well understood. Here we used Xenopus, mouse, and human pluripo...

journal_title：Developmental biology

authors： Rankin SA,McCracken KW,Luedeke DM,Han L,Wells JM,Shannon JM,Zorn AM

更新日期：2018-02-01 00:00:00

abstract：:We have been studying oligodendrocyte generation in vitro to obtain insights into how the timely generation of these cells might be regulated. Our studies suggest the existence of timing mechanisms quite different from those of existing models, wherein it is proposed that timely oligodendrocyte generation is associate...

journal_title：Developmental biology

authors： Ibarrola N,Mayer-Pröschel M,Rodriguez-Peña A,Noble M

更新日期：1996-11-25 00:00:00

abstract：:A fundamental issue during nervous system development is how individual cells are formed from the undefined precursors. Differentiated neurons and glia, two major cell types mediating neuronal function, are acquired from immature precursors via a series of explicit controls exerted by transcription factors such as pro...

journal_title：Developmental biology

authors： Mao H,Lv Z,Ho MS

更新日期：2012-10-01 00:00:00

abstract：:The murine allantois will become the umbilical artery and vein of the chorioallantoic placenta. In previous studies, growth and differentiation of the allantois had been elucidated in whole embryos. In this study, the extent to which explanted allantoises grow and differentiate outside of the conceptus was investigate...

journal_title：Developmental biology

authors： Downs KM,Temkin R,Gifford S,McHugh J

更新日期：2001-05-15 00:00:00

abstract：:The mechanism by which pluripotent progenitors give rise to distinct classes of mature neurons in vertebrates is not well understood. To address this issue we undertook a genetic screen for mutations which affect the commitment and differentiation of catecholaminergic (CA) [dopaminergic (DA), noradrenergic (NA), and a...

journal_title：Developmental biology

authors： Guo S,Wilson SW,Cooke S,Chitnis AB,Driever W,Rosenthal A

更新日期：1999-04-15 00:00:00

abstract：:In the nematode Caenorhabditis elegans, the BMP-related growth factor DBL-1 regulates body size and male tail morphogenesis via a conserved receptor/Smad signaling pathway. Smads are transcription factors, but rely on transcription cofactors for appropriate regulation of target genes in response to TGF-beta- and BMP-r...

journal_title：Developmental biology

authors： Liang J,Yu L,Yin J,Savage-Dunn C

更新日期：2007-05-15 00:00:00

abstract：:Axon outgrowth between the spinal cord and the hindlimb of the chick embryo is constrained by three tissues that border axon pathways. Growth cones turn to avoid the posterior sclerotome, perinotochordal mesenchyme, and pelvic girdle precursor during normal development and after experimental manipulation. We wanted to...

journal_title：Developmental biology

authors： Oakley RA,Tosney KW

更新日期：1991-09-01 00:00:00

abstract：:Expression of the c-abl proto-oncogene in the mouse testis is characterized by the production of a unique 4.7-kb transcript present in germ cells that have entered the haploid phase of spermatogenesis. A similar developmental stage specificity of expression is observed for a member of the 70-kDa heat-shock protein (hs...

journal_title：Developmental biology

authors： Zakeri ZF,Ponzetto C,Wolgemuth DJ

更新日期：1988-02-01 00:00:00

abstract：:We present evidence to show that differentiation in wing cells to produce hairs is synchronous over the distal 90% of the wing surface (approximately 28,000 cells). In spite of this synchrony within such a large area a temporal gradient exists between zones (in general anterior to posterior) on the animal surface with...

journal_title：Developmental biology

authors： Mitchell HK,Petersen NS

更新日期：1983-02-01 00:00:00

abstract：:Branching morphogenesis, the process by which cells or tissues generate tree-like networks that function to increase surface area or in contacting multiple targets, is a common developmental motif in multicellular organisms. We use Drosophila tracheal terminal cells, a component of the insect respiratory system, to in...

journal_title：Developmental biology

authors： Jones TA,Nikolova LS,Schjelderup A,Metzstein MM

更新日期：2014-06-01 00:00:00

abstract：:During endochondral ossification, the differentiation of proliferating into hypertrophic chondrocytes is a key step determining the pace of bone formation and the future length of the skeletal elements. A variety of transcription factors are expressed at the onset of hypertrophy coordinating the expression of differen...

journal_title：Developmental biology

authors： Wuelling M,Schneider S,Schröther VA,Waterkamp C,Hoffmann D,Vortkamp A

更新日期：2020-01-01 00:00:00

abstract：:Brain 4 (Brn4/Pou3f4) and Pax6 are POU-homeodomain and paired-homeodomain transcription factors, respectively, that are expressed in the brain and the glucagon-expressing cells in the pancreas. Brn4 expression begins at embryonic day 10 in the pancreas, just before pax6 and both appear in the glucagon immunoreactive c...

journal_title：Developmental biology

authors： Heller RS,Stoffers DA,Liu A,Schedl A,Crenshaw EB 3rd,Madsen OD,Serup P

更新日期：2004-04-01 00:00:00

abstract：:Germ line transformation has been used to map the cis regulatory DNA elements responsible for the precise and evolutionarily stable developmental expression of the s18 chorion gene. Constructs containing chimeric combinations of Drosophila melanogaster and D. grimshawi DNA regions, as well as D. grimshawi sequences al...

journal_title：Developmental biology

authors： Swimmer C,Kashevsky H,Mao G,Kafatos FC

更新日期：1992-07-01 00:00:00