当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells.

Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells.

Abstract：

:Branching morphogenesis, the process by which cells or tissues generate tree-like networks that function to increase surface area or in contacting multiple targets, is a common developmental motif in multicellular organisms. We use Drosophila tracheal terminal cells, a component of the insect respiratory system, to investigate branching morphogenesis that occurs at the single cell level. Here, we show that the exocyst, a conserved protein complex that facilitates docking and tethering of vesicles at the plasma membrane, is required for terminal cell branch outgrowth. We find that exocyst-deficient terminal cells have highly truncated branches and show an accumulation of vesicles within their cytoplasm and are also defective in subcellular lumen formation. We also show that vesicle trafficking pathways mediated by the Rab GTPases Rab10 and Rab11 are redundantly required for branch outgrowth. In terminal cells, the PAR-polarity complex is required for branching, and we find that the PAR complex is required for proper membrane localization of the exocyst, thus identifying a molecular link between the branching and outgrowth programs. Together, our results suggest a model where exocyst mediated vesicle trafficking facilitates branch outgrowth, while de novo branching requires cooperation between the PAR and exocyst complexes.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Jones TA,Nikolova LS,Schjelderup A,Metzstein MM

doi

10.1016/j.ydbio.2014.02.021

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

41-50

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(14)00113-4

journal_volume

390

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • Analysis of early human neural crest development.

    abstract：:The outstanding migration and differentiation capacities of neural crest cells (NCCs) have fascinated scientists since Wilhelm His described this cell population in 1868. Today, after intense research using vertebrate model organisms, we have gained considerable knowledge regarding the origin, migration and differenti...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.05.012

    authors： Betters E,Liu Y,Kjaeldgaard A,Sundström E,García-Castro MI

    更新日期：2010-08-15 00:00:00

  • Keratin 9 is a component of the perinuclear ring of the manchette of rat spermatids.

    abstract：:Previous work in our laboratory has shown that a 62- to 64-kDa protein was a major component of the perinuclear ring of manchettes fractionated from rat spermatids. Mass spectrometry analysis of this protein indicated the presence of a glycine-rich domain homologous to human keratin 9 (K9). Several antibodies to K9, r...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9911

    authors： Mochida K,Rivkin E,Gil M,Kierszenbaum AL

    更新日期：2000-11-15 00:00:00

  • The Jonah genes: a new multigene family in Drosophila melanogaster.

    abstract：:The Jonah gene family consists of approximately 20 genes, distributed in small clusters at eight or more widely dispersed chromosomal sites. Gene clusters differ in the number of genes per cluster, ranging up to four, and in the arrangement of genes within clusters, which include direct repeats, inverted repeats, and ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(85)90038-7

    authors： Carlson JR,Hogness DS

    更新日期：1985-04-01 00:00:00

  • Protein kinase D regulates metabolism and growth by controlling secretion of insulin like peptide.

    abstract：:Mechanisms coupling growth and metabolism are conserved in Drosophila and mammals. In metazoans, such coupling is achieved across tissue scales through the regulated secretion of chemical messengers such as insulin that control the metabolism and growth of cells. Although the regulated secretion of Insulin like peptid...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2017.12.008

    authors： Ashe S,Malhotra V,Raghu P

    更新日期：2018-02-01 00:00:00

  • BMP receptor-activated Smads confer diverse functions during the development of the dorsal spinal cord.

    abstract：:Bone Morphogenetic Proteins (BMPs) have multiple activities in the developing spinal cord: they specify the identity of the dorsal-most neuronal populations and then direct the trajectories of dorsal interneuron (dI) 1 commissural axons. How are these activities decoded by dorsal neurons to result in different cellula...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.05.014

    authors： Hazen VM,Andrews MG,Umans L,Crenshaw EB 3rd,Zwijsen A,Butler SJ

    更新日期：2012-07-15 00:00:00

  • Accumulation kinetics of cotton late embryogenesis-abundant mRNAs and storage protein mRNAs: coordinate regulation during embryogenesis and the role of abscisic acid.

    abstract：:The accumulation of total RNA transcripts of 18 late embryo-abundant (Lea) gene families, each encoding two closely related Lea mRNAs, was measured in cotyledon total RNA during embryogenesis and germination of Gossypium hirsutum L. by RNA dot hybridization. Transcript abundance of the three storage protein families w...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90442-8

    authors： Galau GA,Bijaisoradat N,Hughes DW

    更新日期：1987-09-01 00:00:00

  • SpGCF1, a sea urchin embryo DNA-binding protein, exists as five nested variants encoded by a single mRNA.

    abstract：:Several Strongylocentrotus purpuratus gene cis-regulatory regions contain asymmetric C4 sequences which are core elements of target sites for a specific DNA-protein interaction. Blastula stage nuclear extract contains five proteins which specifically bind to these target sites, resulting in a characteristic pattern of...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.1181

    authors： Zeller RW,Coffman JA,Harrington MG,Britten RJ,Davidson EH

    更新日期：1995-06-01 00:00:00

  • Manipulation of medium conditions and differentiation in the rat myogenic cell line L6.

    abstract：:Myoblasts of the L6 rat cell line were grown in Ham's F12 nutrient medium containing 10% fetal calf serum (F12 + FCS). Although the cells were confluent by 6 days in culture, fusion was not observed even if cultures were maintained for 10-14 days. At least 80% of the cells in such confluent unfused cultures were in th...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(84)90192-1

    authors： Pinset C,Whalen RG

    更新日期：1984-04-01 00:00:00

  • Insect Tc-six4 marks a unit with similarity to vertebrate placodes.

    abstract：:Cranial placodes are specialized ectodermal regions in the developing vertebrate head that give rise to both neural and non-neural cell types of the neuroendocrine system and the sense organs of the visual, olfactory and acoustic systems. The cranial placodes develop from a panplacodal region which is specifically mar...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.10.024

    authors： Posnien N,Koniszewski N,Bucher G

    更新日期：2011-02-01 00:00:00

  • The responses of pollen to applied electrical fields.

    abstract：:The growing pollen tubes of tomato and tobacco were exposed to electrical fields and the effect on the direction of growth was measured. They responded by turning toward the positive electrode (anode) and gave a detectable response in fields as small as 0.1 mV/tube diameter. The sites of germination of tobacco pollen ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(89)90266-2

    authors： Wang C,Rathore KS,Robinson KR

    更新日期：1989-12-01 00:00:00

  • A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes.

    abstract：:Drosophila Polycomb Repressive Complex 2 (PRC2) is a lysine methyltransferase that trimethylates histone H3 lysine 27 (H3K27me3), a modification essential for Polycomb silencing. Mutations in its catalytic subunit, E(Z), that abolish its methyltransferase activity disrupt Polycomb silencing, causing derepression of Po...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.12.007

    authors： Stepanik VA,Harte PJ

    更新日期：2012-04-15 00:00:00

  • FGF-10 plays an essential role in the growth of the fetal prostate.

    abstract：:Induction and branching morphogenesis of the prostate are dependent on androgens, which act via the mesenchyme to induce prostatic epithelial development. One mechanism by which the mesenchyme may regulate the epithelium is through secreted growth factors such as FGF-10. We have examined the male reproductive tract of...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(03)00250-1

    authors： Donjacour AA,Thomson AA,Cunha GR

    更新日期：2003-09-01 00:00:00

  • Assembly of myotendinous junctions in the chick embryo: deposition of P68 is an early event in myotendinous junction formation.

    abstract：:Myotendinous junctions (MTJs) are specialized sites at the surface of muscle fibers where force is transmitted between muscle and tendon. Morphogenesis of MTJs in the latter half of embryonic chick development is characterized by formation of basement membrane, appearance of subsarcolemmal densities, association of my...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1994.1161

    authors： Tidball JG

    更新日期：1994-06-01 00:00:00

  • Translation of maternal histone mRNAs in sea urchin embryos: a test of control by 5' cap methylation.

    abstract：:Recent results have demonstrated the occurrence of mRNA cap methylation in the sea urchin embryo following fertilization. It has been suggested that this methylation event is responsible for the translational activation of maternal histone mRNAs in these embryos. We have used aphidicolin, an effective inhibitor of bot...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90161-8

    authors： Showman RM,Leaf DS,Anstrom JA,Raff RA

    更新日期：1987-05-01 00:00:00

  • Neuronal determination during embryonic development of the grasshopper nervous system.

    abstract：:We have examined the roles of cell lineage and interactions in the determination of individual identified neurons in the grasshopper embryo by selective ablations of individual cells and/or their neighbors at successive stages following their birth. The neurons in the grasshopper central nervous system (CNS) are produ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(85)90069-7

    authors： Kuwada JY,Goodman CS

    更新日期：1985-07-01 00:00:00

  • An oocyte-specific astacin family protease, alveolin, is released from cortical granules to trigger egg envelope hardening during fertilization in medaka (Oryzias latipes).

    abstract：:It has long been hypothesized that in fishes the contents of cortical granules are involved in the hardening of egg envelope following fertilization. We previously purified the egg envelope hardening initiation factor from the exudates released from activated medaka (Oryzias latipes) eggs and tentatively termed this p...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.09.016

    authors： Shibata Y,Iwamatsu T,Suzuki N,Young G,Naruse K,Nagahama Y,Yoshikuni M

    更新日期：2012-12-15 00:00:00

  • The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis.

    abstract：:We have characterized a phosphoprotein protein with a death effector domain that has a novel bifunctional role in programmed cell death. The 15-kDa phosphoprotein enriched in astrocytes (PEA-15) inhibits Fas-mediated apoptosis and increases tumor necrosis factor receptor-1 (TNF-R1)-mediated apoptosis in the same cell ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9510

    authors： Estellés A,Charlton CA,Blau HM

    更新日期：1999-12-01 00:00:00

  • Multi-organ transcriptomic landscape of Ambystoma velasci metamorphosis.

    abstract：:Metamorphosis is a postembryonic developmental process that involves morphophysiological and behavioral changes, allowing organisms to adapt into a novel environment. In some amphibians, aquatic organisms undergo metamorphosis to adapt in a terrestrial environment. In this process, these organisms experience major cha...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2020.08.002

    authors： Palacios-Martinez J,Caballero-Perez J,Espinal-Centeno A,Marquez-Chavoya G,Lomeli H,Salas-Vidal E,Schnabel D,Chimal-Monroy J,Cruz-Ramirez A

    更新日期：2020-10-01 00:00:00

  • TGF-beta 1 prevents hypertrophy of epiphyseal chondrocytes: regulation of gene expression for cartilage matrix proteins and metalloproteases.

    abstract：:Using an in vitro model of rat epiphyseal chondrocyte differentiation in which cells are maintained in a three-dimensional cell pellet, we show that exogenous TGF-beta 1 reversibly prevents terminal differentiation of epiphyseal chondrocytes into hypertrophic cells. Through maintenance of gene expression for the carti...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1993.1200

    authors： Ballock RT,Heydemann A,Wakefield LM,Flanders KC,Roberts AB,Sporn MB

    更新日期：1993-08-01 00:00:00

  • The mouse 14-3-3 epsilon isoform, a kinase regulator whose expression pattern is modulated in mesenchyme and neuronal differentiation.

    abstract：:Kidney development is a complex, little understood process based on inductive interactions and intricate epithelial and mesenchymal morphogenesis. Here, we report the use of subtractive hybridization to clone cDNAs expressed in early nephrogenesis. cDNA made from E14.5 mouse kidney was hybridized with adult mouse live...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.1139

    authors： McConnell JE,Armstrong JF,Hodges PE,Bard JB

    更新日期：1995-05-01 00:00:00

  • Gradients of differentiation in wild-type and bithorax mutants of Drosophila.

    abstract：:We present evidence to show that differentiation in wing cells to produce hairs is synchronous over the distal 90% of the wing surface (approximately 28,000 cells). In spite of this synchrony within such a large area a temporal gradient exists between zones (in general anterior to posterior) on the animal surface with...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(83)90047-7

    authors： Mitchell HK,Petersen NS

    更新日期：1983-02-01 00:00:00

  • Multiple Shh signaling centers participate in fungiform papilla and taste bud formation and maintenance.

    abstract：:The adult fungiform taste papilla is a complex of specialized cell types residing in the stratified squamous tongue epithelium. This unique sensory organ includes taste buds, papilla epithelium and lateral walls that extend into underlying connective tissue to surround a core of lamina propria cells. Fungiform papilla...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2013.07.022

    authors： Liu HX,Ermilov A,Grachtchouk M,Li L,Gumucio DL,Dlugosz AA,Mistretta CM

    更新日期：2013-10-01 00:00:00

  • Wnt6 signaling regulates heart muscle development during organogenesis.

    abstract：:Mesodermal tissue with heart forming potential (cardiogenic mesoderm) is induced during gastrulation. This cardiogenic mesoderm later differentiates into heart muscle tissue (myocardium) and non-muscular heart tissue. Inhibition of Wnt/beta-catenin signaling is known to be required early for induction of cardiogenic m...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.08.032

    authors： Lavery DL,Martin J,Turnbull YD,Hoppler S

    更新日期：2008-11-15 00:00:00

  • Prolactin controls mammary gland development via direct and indirect mechanisms.

    abstract：:The inactivation of the prolactin receptor gene by homologous recombination has made it possible to investigate the role of prolactin signaling in mammary gland development without resort to ablative surgery of the endocrine glands. In knockout mice lacking the prolactin receptor, mammary development is normal up to p...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9271

    authors： Brisken C,Kaur S,Chavarria TE,Binart N,Sutherland RL,Weinberg RA,Kelly PA,Ormandy CJ

    更新日期：1999-06-01 00:00:00

  • Slowing of synapse elimination by alpha-bungarotoxin superfusion of the neonatal rabbit soleus muscle.

    abstract：:To examine the role of postsynaptic activity in regulating the rate of neuromuscular synapse elimination, contractile activity of neonatal rabbit soleus muscles was decreased by chronic superfusion of alpha-bungarotoxin (alpha-BGT) over their surfaces. Superfusion was begun at 6 days postnatal and continued for a vari...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(89)80009-0

    authors： Callaway EM,Van Essen DC

    更新日期：1989-02-01 00:00:00

  • Complementary striped expression patterns of NK homeobox genes during segment formation in the annelid Platynereis.

    abstract：:NK genes are related pan-metazoan homeobox genes. In the fruitfly, NK genes are clustered and involved in patterning various mesodermal derivatives during embryogenesis. It was therefore suggested that the NK cluster emerged in evolution as an ancestral mesodermal patterning cluster. To test this hypothesis, we cloned...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.02.013

    authors： Saudemont A,Dray N,Hudry B,Le Gouar M,Vervoort M,Balavoine G

    更新日期：2008-05-15 00:00:00

  • Cholecalcin (28-kDa calcium-binding protein) in the rat hippocampus: development in normal animals and in altered thyroid states. An immunocytochemical study.

    abstract：:An immunocytochemical study of cholecalcin (28-kDa calcium-binding protein, CaBP, calbindin) was carried out during the development of the rat hippocampus. In normal animals, the protein appeared from Postnatal Day 3 in the granule cells of the dentate gyrus and from Day 5 in the CA1-CA2 pyramidal cells of Ammon's hor...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90474-x

    authors： Rami A,Bréhier A,Thomasset M,Rabié A

    更新日期：1987-11-01 00:00:00

  • Modulation of AP and DV signaling pathways by the homeotic gene Ultrabithorax during haltere development in Drosophila.

    abstract：:Suppression of wing fate and specification of haltere fate in Drosophila by the homeotic gene Ultrabithorax is a classical example of Hox regulation of serial homology (Lewis, E.B. 1978. Nature 276, 565-570) and has served as a paradigm for understanding homeotic gene function. We have used DNA microarray analyses to ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.12.022

    authors： Mohit P,Makhijani K,Madhavi MB,Bharathi V,Lal A,Sirdesai G,Reddy VR,Ramesh P,Kannan R,Dhawan J,Shashidhara LS

    更新日期：2006-03-15 00:00:00

  • Fertilization of rabbit ova and the role of ovum investments in the block to polyspermy.

    abstract：:The rabbit ovum seldom becomes polyspermic despite the presence of supernumerary sperm with easy access to the ovum plasma membrane. The purpose of this study was to characterize the role of ovum investments in blocking polyspermy. Ova were inseminated with capacitated sperm in vitro and were fertilized. Early stages ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90241-7

    authors： McCulloh DH,Wall RJ,Levitan H

    更新日期：1987-04-01 00:00:00

  • Specification of the mouse cardiac conduction system in the absence of Endothelin signaling.

    abstract：:Coordinated contraction of the heart is essential for survival and is regulated by the cardiac conduction system. Contraction of ventricular myocytes is controlled by the terminal part of the conduction system known as the Purkinje fiber network. Lineage analyses in chickens and mice have established that the Purkinje...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2014.07.008

    authors： Hua LL,Vedantham V,Barnes RM,Hu J,Robinson AS,Bressan M,Srivastava D,Black BL

    更新日期：2014-09-15 00:00:00