Multi-organ transcriptomic landscape of Ambystoma velasci metamorphosis.

abstract：:Thyroid hormone deficiency is known to deeply affect cerebellum post-natal development. We present here a detailed analysis of the phenotype of a recently generated mouse model, expressing a dominant-negative TRα1 mutation. Although hormonal level is not affected, the cerebellum of these mice displays profound alterat...

journal_title：Developmental biology

authors： Fauquier T,Romero E,Picou F,Chatonnet F,Nguyen XN,Quignodon L,Flamant F

更新日期：2011-08-15 00:00:00

abstract：:The chick spinal cord can regenerate following injury until advanced developmental stages. It is conceivable that changes in stem/progenitor cell plasticity contribute to the loss of this capacity, which occurs around E13. We investigated the contribution of proliferation, phenotypic changes in radial glia progenitors...

journal_title：Developmental biology

authors： Whalley K,Gögel S,Lange S,Ferretti P

更新日期：2009-08-15 00:00:00

abstract：:Bone morphogenetic protein (BMP) signalling is key to many developmental processes, including early regionalisation of the ectoderm. The neural crest is induced here by a combination of BMP and Wnt signals from nearby tissues with many secreted factors contributing to its initial specification at the neural plate bord...

journal_title：Developmental biology

authors： Pegge J,Tatsinkam AJ,Rider CC,Bell E

更新日期：2020-04-15 00:00:00

abstract：:Trophoblast cells are characterized by an invasive behavior into the surrounding uterine tissue. In rodents, an early peri-/endovascular type of invasion exerted by trophoblast giant cells can be distinguished from a late interstitial type carried out by glycogen trophoblast cells. Analysis of the molecular mechanisms...

journal_title：Developmental biology

authors： Hemberger M,Hughes M,Cross JC

更新日期：2004-07-15 00:00:00

abstract：:Expression of cardiac troponin I (TnIcardiac) and slow skeletal troponin I (TnIslow) genes was analyzed at the mRNA and protein level in the developing rat heart. TnIslow mRNA was detectable by in situ hybridization in the embryonic cardiac tube as early as the 13-somite stage (Embryonic Day 10). In contrast, TnIcardi...

journal_title：Developmental biology

authors： Gorza L,Ausoni S,Merciai N,Hastings KE,Schiaffino S

更新日期：1993-03-01 00:00:00

abstract：:The level of early histone mRNA in Strongylocentrotus purpuratus changes abruptly at 6 hr of development, increasing an average of 10-fold by 9-10.5 hr and then decreasing over 2-fold by 13.5-15 hr. These changes occur when the late embryonic mRNA is still a very minor component of histone gene transcription. The exac...

journal_title：Developmental biology

authors： Weinberg ES,Hendricks MB,Hemminki K,Kuwabara PE,Farrelly LA

更新日期：1983-07-01 00:00:00

abstract：:Oligodendrocyte precursor cells (OPCs) can be differentiated in culture into either oligodendrocytes or type-2 astrocytes (2As), depending on the culture conditions. Whereas oligodendrocyte development can occur in the absence of inducing signals, 2A development apparently cannot. Fetal calf serum (FCS) and bone morph...

journal_title：Developmental biology

authors： Kondo T,Raff MC

更新日期：2004-03-01 00:00:00

abstract：:The protein tyrosine phosphatase PTP1, which mediates reversible phosphorylation on tyrosine, has been shown to play an important regulatory role during Dictyostelium development. Mutants lacking PTP1 develop more rapidly than normal, while strains that overexpress PTP1 display aberrant morphology. However, the signal...

journal_title：Developmental biology

authors： Early A,Gamper M,Moniakis J,Kim E,Hunter T,Williams JG,Firtel RA

更新日期：2001-04-01 00:00:00

abstract：:The GATA family of transcription factors are known to play multiple critical roles in vertebrate developmental processes, including erythropoiesis, endoderm formation and cardiogenesis. There have been no previous demonstrations of a functional role for any GATA family member being associated with musculoskeletal deve...

journal_title：Developmental biology

authors： Alexandrovich A,Qureishi A,Coudert AE,Zhang L,Grigoriadis AE,Shah AM,Brewer AC,Pizzey JA

更新日期：2008-02-15 00:00:00

abstract：:Activin is a potent inducer of axial mesoderm in vitro and may have a similar role in vivo. Xenopus laevis eggs contain significant amounts of activin or activin-like factors, but maternal activin transcripts have not been detected in Xenopus eggs. The maternal activin protein might be translated from activin beta A o...

journal_title：Developmental biology

authors： Rebagliati MR,Dawid IB

更新日期：1993-10-01 00:00:00

abstract：:The members of the transforming growth factor-beta (TGF-beta) superfamily are secreted proteins that interact with cell-surface receptors to elicit signals that regulate a variety of biological processes during vertebrate embryogenesis. Alk2, also known as ActRIA, Tsk7L, and SKR1, encodes a type I TGF-beta family rece...

journal_title：Developmental biology

authors： Mishina Y,Crombie R,Bradley A,Behringer RR

更新日期：1999-09-15 00:00:00

abstract：:We have identified cDNA clones encoding a testis-specific poly(A) polymerase, termed TPAP, a candidate molecule responsible for cytoplasmic polyadenylation of preexisting mRNAs in male haploid germ cells. The TPAP gene was most abundantly expressed coincident with the additional elongation of mRNA poly(A) tails in rou...

journal_title：Developmental biology

authors： Kashiwabara S,Zhuang T,Yamagata K,Noguchi J,Fukamizu A,Baba T

更新日期：2000-12-01 00:00:00

abstract：:Temporal and spatial aspects of floral determination in seedling terminal buds of the qualitative short-day plant Pharbitis nil were examined using a grafting assay. Floral determination in the terminal buds of 6-day-old P. nil seedlings is rapid; by 9 hr after the end of a 14-hr inductive dark period more than 50% of...

journal_title：Developmental biology

authors： Larkin JC,Felsheim R,Das A

更新日期：1990-02-01 00:00:00

abstract：:Development and plasticity of synapses are brought about by a complex interplay between various signaling pathways. Typically, either changing the number of synapses or strengthening an existing synapse can lead to changes during synaptic plasticity. Altering the machinery that governs the exocytosis of synaptic vesic...

journal_title：Developmental biology

authors： Wairkar YP,Trivedi D,Natarajan R,Barnes K,Dolores L,Cho P

更新日期：2013-12-01 00:00:00

abstract：:Zygotic Wnt signaling has been shown to be involved in dorsoventral mesodermal patterning in Xenopus embryos, but how it regulates different myogenic gene expression in the lateral mesodermal domains is not clear. Here, we use transient exposure of embryos or explants to lithium, which mimics Wnt/beta-catenin signalin...

journal_title：Developmental biology

authors： Shi DL,Bourdelas A,Umbhauer M,Boucaut JC

更新日期：2002-05-01 00:00:00

abstract：:Members of the fibroblast growth factor (FGF) family of peptide growth factors are widely expressed in the germ layer derivatives during gastrulation and early organogenesis of the mouse. We have investigated the effect of administering recombinant FGF-4 in the late-primitive streak stage embryo to test if the pattern...

journal_title：Developmental biology

authors： Davidson BP,Cheng L,Kinder SJ,Tam PP

更新日期：2000-05-01 00:00:00

abstract：:Mutations at the Drosophila melanogaster locus female sterile (1) homeotic (fs(1)h) result in segmental abnormalities including missing organs and homeotic transformations in the progeny of mutant mothers. Homeotic transformations are enhanced when the zygotes carry one of several third chromosome mutations, specifica...

journal_title：Developmental biology

authors： Digan ME,Haynes SR,Mozer BA,Dawid IB,Forquignon F,Gans M

更新日期：1986-03-01 00:00:00

abstract：:Heparan sulfate proteoglycans are important modulators of growth factor signaling in a variety of patterning processes. Secreted growth factors that play critical roles in angiogenesis bind to heparan sulfate, and this association is affected by 6-O-sulfation of the heparan sulfate chains. Addition of 6-O-sulfate is c...

journal_title：Developmental biology

authors： Chen E,Stringer SE,Rusch MA,Selleck SB,Ekker SC

更新日期：2005-08-15 00:00:00

abstract：:Changes in gene regulatory networks are a major engine for creating developmental novelty during evolution. Conversely, regulatory linkages that survive for very long evolutionary periods might be characteristic of ancient and abstract functions of fundamental utility to all metazoans. The proneural genes, which encod...

journal_title：Developmental biology

authors： Rebeiz M,Stone T,Posakony JW

更新日期：2005-05-15 00:00:00

abstract：:NK genes are related pan-metazoan homeobox genes. In the fruitfly, NK genes are clustered and involved in patterning various mesodermal derivatives during embryogenesis. It was therefore suggested that the NK cluster emerged in evolution as an ancestral mesodermal patterning cluster. To test this hypothesis, we cloned...

journal_title：Developmental biology

authors： Saudemont A,Dray N,Hudry B,Le Gouar M,Vervoort M,Balavoine G

更新日期：2008-05-15 00:00:00

abstract：:The adult fungiform taste papilla is a complex of specialized cell types residing in the stratified squamous tongue epithelium. This unique sensory organ includes taste buds, papilla epithelium and lateral walls that extend into underlying connective tissue to surround a core of lamina propria cells. Fungiform papilla...

journal_title：Developmental biology

authors： Liu HX,Ermilov A,Grachtchouk M,Li L,Gumucio DL,Dlugosz AA,Mistretta CM

更新日期：2013-10-01 00:00:00

abstract：:Angiogenesis relies on specialized endothelial tip cells to extend toward guidance cues in order to direct growing blood vessels. Although many of the signaling pathways that control this directional endothelial sprouting are well known, the specific cellular mechanisms that mediate this process remain to be fully elu...

journal_title：Developmental biology

authors： Yang H,Fang L,Zhan R,Hegarty JM,Ren J,Hsiai TK,Gleeson JG,Miller YI,Trejo J,Chi NC

更新日期：2015-08-15 00:00:00

abstract：:The molting cycle in insects is regulated by the fluctuating levels of ecdysteroids. Twenty-four hours prior to the pupal molt in Manduca sexta steroid titers are relatively high and they fall to very low levels at 4 hr before the molt. Several physiological events accompanying molts have been shown to require the ris...

journal_title：Developmental biology

authors： Mészáros M,Morton DB

更新日期：1994-04-01 00:00:00

abstract：:The murine cpk mouse develops a rapid-onset polycystic kidney disease (PKD) with many similarities to human PKD. During kidney development, the transcription factor Pax2 is required for the specification and differentiation of the renal epithelium. In humans, Pax2 is also expressed in juvenile cystic kidneys where it ...

journal_title：Developmental biology

authors： Ostrom L,Tang MJ,Gruss P,Dressler GR

更新日期：2000-03-15 00:00:00

abstract：:Growth factors and the extracellular matrix have been shown to fulfill vital developmental roles in many embryonic systems. Our hypothesis is that a developmental role played by the extracellular matrix in sea urchins may be the binding of a PDGF-like growth factor to promote signaling activity. We report here that an...

journal_title：Developmental biology

authors： Govindarajan V,Ramachandran RK,George JM,Shakes DC,Tomlinson CR

更新日期：1995-12-01 00:00:00

abstract：:This study evaluated Na/K-ATPase alpha 1- and alpha 3-subunit isoform polypeptide expression and localization during bovine preattachment development. Na/K-ATPase cation transport activity from the one-cell to blastocyst stage was also determined by measuring ouabain-sensitive 86Rb+ uptake. Both alpha1- and alpha 3-su...

journal_title：Developmental biology

authors： Betts DH,Barcroft LC,Watson AJ

更新日期：1998-05-01 00:00:00

abstract：:The genetic and developmental bases for trait expression and variation in adults are largely unknown. One system in which genes and cell behaviors underlying adult traits can be elucidated is the larval-to-adult transformation of zebrafish, Danio rerio. Metamorphosis in this and many other teleost fishes resembles amp...

journal_title：Developmental biology

authors： Parichy DM,Turner JM

更新日期：2003-04-15 00:00:00

abstract：:We have reported previously that sequence-specific adenylations and deadenylations accompany changes in the translation of maternal mRNA following fertilization of Spisula oocytes (E.T. Rosenthal, T.R. Tansey, and J.V. Ruderman, 1983, J. Mol. Biol. 166, 309-327). The data presented here confirm and extend those observ...

journal_title：Developmental biology

authors： Rosenthal ET,Ruderman JV

更新日期：1987-05-01 00:00:00

abstract：:CD9 is a membrane protein belonging to the tetraspanin family. Despite CD9's broad tissue distribution, the only abnormality observed in CD9-deficient mice was infertility of females, which was responsible for a defect in the sperm-egg fusion process. However, the function of CD9 in sperm-egg fusion is not clear at al...

journal_title：Developmental biology

authors： Kaji K,Oda S,Miyazaki S,Kudo A

更新日期：2002-07-15 00:00:00

abstract：:The growing pollen tubes of tomato and tobacco were exposed to electrical fields and the effect on the direction of growth was measured. They responded by turning toward the positive electrode (anode) and gave a detectable response in fields as small as 0.1 mV/tube diameter. The sites of germination of tobacco pollen ...

journal_title：Developmental biology

authors： Wang C,Rathore KS,Robinson KR

更新日期：1989-12-01 00:00:00