Identification of a novel isoform of poly(A) polymerase, TPAP, specifically present in the cytoplasm of spermatogenic cells.

abstract：:These studies examined the potential for reorganization and differentiation of dissociated 18-day fetal rat intestine. Cultures of trypsin-dissociated fetal intestine were maintained in vitro for 1 week on a three-dimensional matrix, then transplanted into syngeneic hosts. When harvested after 4 weeks, these transplan...

journal_title：Developmental biology

authors： Montgomery RK,Zinman HM,Smith BT

更新日期：1983-11-01 00:00:00

abstract：:Early (alpha) histone genes are one of several histone gene families in the sea urchin genome. They are expressed at high levels in blastula-stage embryos and are inactivated by the early gastrula stage. By microinjecting mutant early H2B genes into sea urchin zygotes and monitoring their transcriptional activity in b...

journal_title：Developmental biology

authors： Bell J,Char BR,Maxson R

更新日期：1992-04-01 00:00:00

abstract：:Previous work in our laboratory has shown that a 62- to 64-kDa protein was a major component of the perinuclear ring of manchettes fractionated from rat spermatids. Mass spectrometry analysis of this protein indicated the presence of a glycine-rich domain homologous to human keratin 9 (K9). Several antibodies to K9, r...

journal_title：Developmental biology

authors： Mochida K,Rivkin E,Gil M,Kierszenbaum AL

更新日期：2000-11-15 00:00:00

abstract：:A genetically complex mutant, two-faced (tfd), which causes the production of extra eye and antennal tissue on the dorsal head cuticle, has been analyzed for connectivity to and projection patterns in the central brain of nerves derived from these extra structures. It has been found that the extra antennal nerves freq...

journal_title：Developmental biology

authors： Lipshitz HD,Kankel DR

更新日期：1985-01-01 00:00:00

abstract：:Recent data suggest that dental cells utilize the evolutonarily conserved Notch-mediated intercellular signaling pathway to regulate their fates. Here we report on the expression and regulation of Delta1, a transmembrane ligand of the Notch receptors, during mouse odontogenesis. Delta1 is weakly expressed in dental ep...

journal_title：Developmental biology

authors： Mitsiadis TA,Hirsinger E,Lendahl U,Goridis C

更新日期：1998-12-15 00:00:00

abstract：:The aim of this study was to evaluate the role segmentation plays in the determination of neuronal identity in the hindbrain. We focused on two specific sets of hindbrain neurons, namely, the vestibulospinal and vestibulo-ocular neurons, which comprise distinct groups that can be identified and distinguished by virtue...

journal_title：Developmental biology

authors： Díaz C,Puelles L,Marín F,Glover JC

更新日期：1998-10-01 00:00:00

abstract：:Thoracic sensory neurons in bullfrog tadpoles can be induced to form connections typical of brachial sensory neurons by transplanting thoracic ganglia to the branchial level at stages when some thoracic sensory neurons already have formed connections. In order to find out how many postmitotic sensory neurons survive t...

journal_title：Developmental biology

authors： Smith CL

更新日期：1990-12-01 00:00:00

abstract：:Polychaete annelids and arthropods are both segmented protostome invertebrates. To investigate whether the segmented body plan of these two phyla share a common molecular ground pattern, we report the developmental expression of orthologues of the arthropod segment polarity genes engrailed (en), hedgehog (hh), and win...

journal_title：Developmental biology

authors： Seaver EC,Kaneshige LM

更新日期：2006-01-01 00:00:00

abstract：:In the developing retina, as in other regions of the CNS, neural progenitors give rise to individual cell types during discrete temporal windows. Pax6 is expressed in retinal progenitor cells (RPCs) throughout the course of retinogenesis, and has been shown to be required during early retinogenesis for generation of m...

journal_title：Developmental biology

authors： Remez LA,Onishi A,Menuchin-Lasowski Y,Biran A,Blackshaw S,Wahlin KJ,Zack DJ,Ashery-Padan R

更新日期：2017-12-01 00:00:00

abstract：:The ability of adult vertebrates to repair tissue damage is widespread and impressive; however, the ability to regenerate structurally complex organs such as the limb is limited largely to the salamanders. The fact that most of the tissues of the limb can regenerate has led investigators to question and identify the b...

journal_title：Developmental biology

authors： Satoh A,Bryant SV,Gardiner DM

更新日期：2012-06-15 00:00:00

abstract：:Two 80- to 100-kb chromosomal replicons containing clustered chorion genes amplify in the ovarian follicle cells during the final 22 hr of Drosophila oogenesis. We have studied the relationship between amplification and transcription within one of these domains, located at 7E10-7F3,4 on the X chromosome. A tandem clus...

journal_title：Developmental biology

authors： Parks S,Wakimoto B,Spradling A

更新日期：1986-09-01 00:00:00

abstract：:During the process of gastrulation in the sea urchin embryo, the vegetal plate invaginates to form the archenteron, a long narrow tube that extends across the blastocoel. Rearrangement of cells within the archenteron is thought to be a key component of the process of archenteron elongation. While these cell rearrangem...

journal_title：Developmental biology

authors： Ingersoll EP,Ettensohn CA

更新日期：1994-06-01 00:00:00

abstract：:Pigment cells of the zebrafish, Danio rerio, offer an exceptionally tractable system for studying the genetic and cellular bases of cell fate decisions. In the zebrafish, neural crest cells generate three types of pigment cells during embryogenesis: yellow xanthophores, iridescent iridophores and black melanophores. I...

journal_title：Developmental biology

authors： Curran K,Lister JA,Kunkel GR,Prendergast A,Parichy DM,Raible DW

更新日期：2010-08-01 00:00:00

abstract：:In vertebrates, hematopoietic and vascular progenitors develop from ventral mesoderm. The first primitive wave of hematopoiesis yields embryonic red blood cells, whereas progenitor cells of subsequent definitive waves form all hematopoietic cell lineages. In this report we examine the development of hematopoietic and ...

journal_title：Developmental biology

authors： Thompson MA,Ransom DG,Pratt SJ,MacLennan H,Kieran MW,Detrich HW 3rd,Vail B,Huber TL,Paw B,Brownlie AJ,Oates AC,Fritz A,Gates MA,Amores A,Bahary N,Talbot WS,Her H,Beier DR,Postlethwait JH,Zon LI

更新日期：1998-05-15 00:00:00

abstract：:The Drosophila brain is generated by a complex series of morphogenetic movements. To better understand brain development and to provide a guide for experimental manipulation of brain progenitors, we created a fate map using photoactivated gene expression to mark cells originating within specific mitotic domains and ti...

journal_title：Developmental biology

authors： Robertson K,Mergliano J,Minden JS

更新日期：2003-08-01 00:00:00

abstract：:During organogenesis, Sonic hedgehog (Shh) possesses dual functions: Shh emanating from midline structures regulates the positioning of bilateral structures at early stages, whereas organ-specific Shh locally regulates organ morphogenesis at later stages. The mesonephros is a transient embryonic kidney in amniote, whe...

journal_title：Developmental biology

authors： Murashima A,Akita H,Okazawa M,Kishigami S,Nakagata N,Nishinakamura R,Yamada G

更新日期：2014-02-01 00:00:00

abstract：:During endochondral ossification, the differentiation of proliferating into hypertrophic chondrocytes is a key step determining the pace of bone formation and the future length of the skeletal elements. A variety of transcription factors are expressed at the onset of hypertrophy coordinating the expression of differen...

journal_title：Developmental biology

authors： Wuelling M,Schneider S,Schröther VA,Waterkamp C,Hoffmann D,Vortkamp A

更新日期：2020-01-01 00:00:00

abstract：:CHARGE syndrome is caused by spontaneous loss-of-function mutations to the ATP-dependant chromatin remodeller chromodomain-helicase-DNA-binding protein 7 (CHD7). It is characterised by a distinct pattern of congenital anomalies, including cardiovascular malformations. Disruption to the neural crest lineage has previou...

journal_title：Developmental biology

authors： Payne S,Burney MJ,McCue K,Popal N,Davidson SM,Anderson RH,Scambler PJ

更新日期：2015-09-01 00:00:00

abstract：:The members of the transforming growth factor-beta (TGF-beta) superfamily are secreted proteins that interact with cell-surface receptors to elicit signals that regulate a variety of biological processes during vertebrate embryogenesis. Alk2, also known as ActRIA, Tsk7L, and SKR1, encodes a type I TGF-beta family rece...

journal_title：Developmental biology

authors： Mishina Y,Crombie R,Bradley A,Behringer RR

更新日期：1999-09-15 00:00:00

abstract：:The distribution of microtubules and microtubule organizing centers in the events leading up to the establishment of the first asymmetric cleavage furrow in nematode embryos was followed using indirect immunofluorescence of antibodies to tubulin. Oocytes arrest in meiotic prophase then undergo two meiotic reduction di...

journal_title：Developmental biology

authors： Albertson DG

更新日期：1984-01-01 00:00:00

abstract：:To examine whether the 200-kDa neurofilament protein (200K NFP) is involved in mechanically stabilizing axons, we studied the developmental appearance of immunoreactivity to nonphosphorylated and phosphorylated 200K NFP at the neuromuscular junction. Polyinnervated rat muscle fibers become singly innervated during the...

journal_title：Developmental biology

authors： Donahue SP,Wood JG,English AW

更新日期：1988-11-01 00:00:00

abstract：:The patterns of myosin heavy chain (MyHC) isoform expression in the embryo and in the adult mouse are reasonably well characterized and quite distinct. However, little is known about the transition between these two states, which involves major decreases and increases in the expression of several MyHC genes. In the pr...

journal_title：Developmental biology

authors： Allen DL,Leinwand LA

更新日期：2001-01-15 00:00:00

abstract：:Retinoic acid (RA) plays a critical role in neural patterning and organogenesis in the vertebrate embryo. Here we characterize a mutant of the zebrafish named giraffe (gir) in which the gene for the RA-degrading enzyme Cyp26a1 is mutated. The gir mutant displayed patterning defects in multiple organs including the com...

journal_title：Developmental biology

authors： Emoto Y,Wada H,Okamoto H,Kudo A,Imai Y

更新日期：2005-02-15 00:00:00

abstract：:Dictyostelium discoideum is a simple eukaryote that lives as an amoeba until starvation triggers aggregation. The aggregate forms a slug which then develops into a fruiting body with two main cell types, stalk and spore cells. Two mechanisms have been proposed to explain cell-type differentiation. Studies using expres...

journal_title：Developmental biology

authors： Clay JL,Ammann RR,Gomer RH

更新日期：1995-12-01 00:00:00

abstract：:Interleukin-6 is a member of a class of hormone-like molecules termed cytokines. The actions of IL-6 are highly pleiotropic. In adults IL-6 functions as a major mediator of inflammatory responses as well as inducing the synthesis of acute phase proteins by the liver following infection or injury. Based on in vitro and...

journal_title：Developmental biology

authors： Lee FD

更新日期：1992-06-01 00:00:00

abstract：:The chicken retina is capable of limited regeneration. In response to injury, some Müller glia proliferate and de-differentiate into progenitor cells. However, most of these progenitors fail to differentiate into neurons. The Notch pathway is upregulated during retinal regeneration in both fish and amphibians. Since t...

journal_title：Developmental biology

authors： Hayes S,Nelson BR,Buckingham B,Reh TA

更新日期：2007-12-01 00:00:00

abstract：:The embryonic vertebrate heart consists of two epithelia: the myocardium and endothelium, separated by the myocardial basement membrane (MBM). The myocardium has been shown to induce endothelial transformation into prevalvular mesenchyme in a temporally and site restricted manner. Previously, we hypothesized that the ...

journal_title：Developmental biology

authors： Mjaatvedt CH,Markwald RR

更新日期：1989-11-01 00:00:00

abstract：:Maintaining tissue homeostasis is a critical process during infection and inflammation. Tissues with a high intrinsic turnover, such as the intestinal epithelium, must launch a rapid response to infections while simultaneously coordinating cell proliferation and differentiation decisions. In this study, we searched fo...

journal_title：Developmental biology

authors： Zhou J,Florescu S,Boettcher AL,Luo L,Dutta D,Kerr G,Cai Y,Edgar BA,Boutros M

更新日期：2015-03-15 00:00:00

abstract：:Polycomb group (PcG) proteins are best known for their role in maintaining stable, mitotically heritable silencing of the homeotic (HOX) genes during development. In addition to loss of homeotic gene silencing, some PcG mutants also have small imaginal discs. These include mutations in E(z), Su(z)12, esc and escl, whi...

journal_title：Developmental biology

authors： Mason-Suares H,Tie F,Yan CM,Harte PJ

更新日期：2013-08-01 00:00:00

abstract：:Branching morphogenesis, the process by which cells or tissues generate tree-like networks that function to increase surface area or in contacting multiple targets, is a common developmental motif in multicellular organisms. We use Drosophila tracheal terminal cells, a component of the insect respiratory system, to in...

journal_title：Developmental biology

authors： Jones TA,Nikolova LS,Schjelderup A,Metzstein MM

更新日期：2014-06-01 00:00:00