Abstract:
:The aim of this study was to evaluate the role segmentation plays in the determination of neuronal identity in the hindbrain. We focused on two specific sets of hindbrain neurons, namely, the vestibulospinal and vestibulo-ocular neurons, which comprise distinct groups that can be identified and distinguished by virtue of their axonal projection pathways. The relationship between rhombomeres and the vestibular neuron groups was assessed by a combination of quail-chicken chimeric grafting and selective retrograde axonal tracing. Individual quail hemirhombomeres were transplanted homotopically and isochronically into a chicken embryo host. Subsequently, vestibulospinal and vestibulo-ocular neurons with specific axon trajectories were labeled retrogradely with biotin-conjugated dextran-amines. The relationship between the spatial domains of the vestibular neuron groups and rhombomere-derived domains had the following features: (1) some groups were derived from single rhombomeres; (2) some groups were derived from multiple contiguous rhombomeres; (3) two groups occupied domains that could not be defined in terms of whole rhombomere lengths; (4) some groups spanning multiple rhombomeres exhibited an internal cytoarchitectonic organization that related to individual rhombomeres; and (5) some groups exhibited limited boundary violation. These results support the notion that positional information within defined domains of the neural tube provides a groundplan for the regional determination of neuronal identity and axon pathfinding, and that hindbrain segmentation contributes to this process. But they also indicate that segmentation is not the only mechanism that defines the rostrocaudal domains of neuron types. Moreover, they emphasize that the relationship between rhombomeres and neuronal determination cannot be couched simply in terms of segmental iteration or of bimeric (paired rule) specification.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Díaz C,Puelles L,Marín F,Glover JCdoi
10.1006/dbio.1998.8986subject
Has Abstractpub_date
1998-10-01 00:00:00pages
14-28issue
1eissn
0012-1606issn
1095-564Xpii
S0012-1606(98)98986-2journal_volume
202pub_type
杂志文章abstract::How organisms control organ size is not fully understood. We found that Syd/JIP3 is required for proper wing size in Drosophila. JIP3 mutations are associated with organ size defects in mammals. The underlying mechanisms are not well understood. We discovered that Syd/JIP3 inhibition results in a downregulation of the...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2020.09.017
更新日期:2021-01-01 00:00:00
abstract::The mammary gland (MG) is a unique organ responsible for milk synthesis, secretion, and involution to prepare the gland for subsequent lactation. The mammary epithelial cells (MECs), which are the milk synthesizing units of the MG, proliferate, differentiate, undergo apoptosis and regenerate following a cyclic pathway...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2018.11.002
更新日期:2019-01-15 00:00:00
abstract::Multipotent, self-renewing neural stem cells reside in the embryonic mouse telencephalic germinal zone. Using an in vitro neurosphere assay for neural stem cell proliferation, we demonstrate that FGF-responsive neural stem cells are present as early as E8.5 in the anterior neural plate, but EGF-responsive neural stem ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1998.9192
更新日期:1999-04-01 00:00:00
abstract::Type 1 protein phosphatases (PP1) are involved in diverse cellular activities, ranging from glycogen metabolism to chromatin structure modification, mitosis, and meiosis. The holoenzymes are composed of two or more subunits, including a catalytic subunit (PP1c) and one or more regulatory subunits. Many eukaryotes poss...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1998.9100
更新日期:1999-01-01 00:00:00
abstract::The cranial base is a component of the neurocranium and has a central role in the structural integration of the face, brain and vertebral column. Consequently, alteration in the shape of the human cranial base has been intimately linked with primate evolution and defective development is associated with numerous human...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2015.12.024
更新日期:2016-07-15 00:00:00
abstract::It has long been appreciated that the localization of cytoplasmic determinants in the egg can provide the foundation for patterning in the embryo. Differences in cell fate among the early blastomeres are thus a consequence of asymmetric distributions of informational molecules prior to fertilization. The frog egg has ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1997.8773
更新日期:1997-12-15 00:00:00
abstract::Metazoan replication-dependent histone mRNAs accumulate to high levels during S phase as a result of an increase in the rate of histone gene transcription, pre-mRNA processing, and mRNA stability at the G1-S transition. However, relatively little is known about the contribution of these processes to histone expression...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.06.019
更新日期:2004-10-01 00:00:00
abstract::Arthropods, vertebrates, and annelids all have a segmented body. Our recent discovery of involvement of Notch-signalling in spider segmentation revived the discussion on the origin of segmented body plans and suggests the sharing of a common genetic program in a common ancestor. Here, we analysed the spider homologues...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2005.01.024
更新日期:2005-04-01 00:00:00
abstract::We have used in situ hybridization and RNA blotting analysis to compare the timing of accumulation of poly(A) and alpha-subtype histone mRNA during oogenesis in the sea urchin Strongylocentrotus purpuratus. In situ hybridization with 3H-poly(U) shows that the content of poly(A) in the developing oocyte increases four-...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(84)90161-1
更新日期:1984-02-01 00:00:00
abstract::The sensory neurons of the Drosophila wing differentiate during the initial stages of metamorphosis, appearing in the imaginal wing disc as it everts and flattens. These identifiable neurons arise in a stereotyped sequence, and lay down a specific pattern of axon bundles which travel proximally to the CNS. In several ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(85)90044-2
更新日期:1985-04-01 00:00:00
abstract::During the last stages of fetal life, the immature epithelial cells of the rat lung alveolus develop the properties of mature type 2 cells. Adult type 2 cells rapidly lose these same properties when isolated and maintained in cell culture. We have examined the synthesis of cytokeratin proteins by adult type 2 cells as...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(88)90396-x
更新日期:1988-10-01 00:00:00
abstract::Eph receptors play important roles in axon guidance at the midline. In the auditory system, growth of axons across the midline is an important determinant of auditory function. The avian cochlear nucleus, n. magnocellularis (NM), makes bilateral projections to its target, n. laminaris (NL). We examined the time course...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.03.010
更新日期:2006-07-01 00:00:00
abstract::The embryonic dorsal vessel in Drosophila possesses anteroposterior polarity and is subdivided into two chamber-like portions, the aorta in the anterior and the heart in the posterior. The heart portion features a wider bore as compared with the aorta and develops inflow valves (ostia) that allow the pumping of hemoly...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2002.0839
更新日期:2002-11-15 00:00:00
abstract::C. elegans ahr-1 is orthologous to the mammalian aryl hydrocarbon receptor, and it functions as a transcription factor to regulate the development of certain neurons. Here, we describe the role of ahr-1 in a specific behavior: the aggregation of C. elegans on lawns of bacterial food. This behavior is modulated by nutr...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.07.017
更新日期:2006-10-15 00:00:00
abstract::We examined the effects of ciliary neurotrophic factor (CNTF) and depolarization, two environmental signals that influence noradrenergic and cholinergic function, on neuropeptide expression by cultured sympathetic neurons. Sciatic nerve extract, a rich source of CNTF, increased levels of vasoactive intestinal peptide ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90242-9
更新日期:1992-04-01 00:00:00
abstract::Macronuclei of Tetrahymena thermophila contain a typical H1 which has been shown to be missing from micronuclei. Instead, micronuclei contain three unique polypeptides, alpha, beta, and gamma, which are associated with linker regions of micronuclear chromatin. In this report polyclonal antibodies raised against macron...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(85)90339-2
更新日期:1985-05-01 00:00:00
abstract::We have examined the response of bovine oocytes matured in vitro for 24 hr to parthenogenic activation using compounds that increase intracellular calcium (ionomycin) or inhibit protein phosphorylation (6-dimethylaminopurine, DMAP). Treatment with ionomycin alone caused resumption of meiosis (57.8 +/- 7.8%) but not pr...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1994.1351
更新日期:1994-12-01 00:00:00
abstract::These studies examined the potential for reorganization and differentiation of dissociated 18-day fetal rat intestine. Cultures of trypsin-dissociated fetal intestine were maintained in vitro for 1 week on a three-dimensional matrix, then transplanted into syngeneic hosts. When harvested after 4 weeks, these transplan...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(83)90209-9
更新日期:1983-11-01 00:00:00
abstract::Mesenchymal-epithelial interactions are an important source of information for pattern formation during organogenesis. In the developing excretory system, one of the secreted mesenchymal factors thought to play a critical role in patterning the growth and branching of the epithelial ureteric bud is GDNF. We have teste...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2005.04.008
更新日期:2005-07-01 00:00:00
abstract::In this report we describe the development of a sensitive assay for gene expression in zebrafish embryos using beta-lactamase as a reporter gene. We show that injection of a green fluorescent substrate for beta-lactamase allows the detection of reporter gene expression in live embryos. The beta-lactamase enzyme cataly...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1998.8999
更新日期:1998-11-15 00:00:00
abstract::Artificial extracellular matrices composed of collagen, glycosaminoglycans (GAG), proteoglycans (PG), plasma fibronectin (FN), and a hyaluronate-binding protein (HABP) have been prepared that morphologically resemble embryonic extracellular matrices in vivo at the light and electron microscope level. The effect of eac...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/0012-1606(85)90461-0
更新日期:1985-06-01 00:00:00
abstract::A series of chimeras was generated by injecting single normal, parthenogenetic, or androgenetic blastomeres carrying transgenic markers under the zona pellucida of nontransgenic eight-cell embryos. These chimeras were cultured to the blastocyst stage and sectioned, and the transgenic component was detected by in situ ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(89)80028-4
更新日期:1989-02-01 00:00:00
abstract::Germ cells provide maternal mRNAs that are stored in the oocyte, and later translated at a specific time of development. In this context, gene regulation depends mainly on post-transcriptional mechanisms that contribute to keep maternal transcripts in a stable and translationally silent state. In recent years, small n...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2016.06.007
更新日期:2016-08-01 00:00:00
abstract::Somatic embryogenesis is one of the best examples of the remarkable developmental plasticity of plants, in which committed somatic cells can dedifferentiate and acquire the ability to form an embryo and regenerate an entire plant. In Arabidopsis thaliana, the shoot apices of young seedlings have been reported as an al...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2018.04.023
更新日期:2018-10-01 00:00:00
abstract::Previous experiments in which vitamin A has been administered to developing or regenerating limbs have shown that different limb axes are affected. In regenerating axolotl limbs, serial reduplications in the proximodistal axis are produced. In the developing chick limb bud, mirror-imaged reduplications in the anteropo...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(83)90370-6
更新日期:1983-08-01 00:00:00
abstract::Copyright ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1998.8954
更新日期:1998-07-15 00:00:00
abstract::The midbrain-hindbrain boundary (MHB) acts as a local organizer in the development of the CNS in vertebrates. Previously, we identified an MHB-specific bHLH-WRPW transcriptional repressor gene, Xenopus Hes-related 1 (XHR1), which is initially expressed in the presumptive MHB (pre-MHB) region at the early gastrula stag...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2005.04.020
更新日期:2005-07-01 00:00:00
abstract::Nerve and muscle development was studied in paralysé mutant mice. The mutant phenotype is first recognizable 6-7 days after birth (PN 6-PN 7) as cessation of muscle growth and weakness and incoordination of movement. Mutant animals die between 2 and 3 weeks of age. Muscle fibers from paralysé mutants had a unimodal di...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(89)90213-3
更新日期:1989-03-01 00:00:00
abstract::Chick embryonic heart cell isolates and monolayer cultures were prepared from atria and ventricles at selected stages of cardiac development. The cardiac myocytes were assayed for myosin heavy chain (MHC) content using monoclonal antibodies (McAbs) specific in the heart for atrial (B-1), ventricular (ALD-19), or condu...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90241-1
更新日期:1986-05-01 00:00:00
abstract::Named for its assembly near exon-exon junctions during pre-mRNA splicing, the exon junction complex (EJC) regulates multiple aspects of RNA biochemistry, including export of spliced mRNAs from the nucleus and translation. Transcriptome analyses have revealed broad EJC occupancy of spliced metazoan transcripts, yet inh...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2019.09.010
更新日期:2020-01-01 00:00:00