A unique role for 6-O sulfation modification in zebrafish vascular development.

abstract：:We describe the characterization and a functional analysis in Xenopus development of RalB, a small G protein. RalB RNA and protein are detectable during oogenesis and early development, but the gene is expressed only weakly in adult tissues. The RalB transcripts are processed by poly(A) extension during oocyte maturat...

journal_title：Developmental biology

authors： Moreau J,Lebreton S,Iouzalen N,Mechali M

更新日期：1999-05-15 00:00:00

abstract：:We have investigated the regulation of DNA synthesis in the heterokaryons of HL60 human myelomonocytic leukemia cells and NIH3T3 mouse fibroblasts to examine if the differentiated leukemia cells contained a replication inhibiting activity. Cell fusions were performed either by exposing a suspension of mixed cells to a...

journal_title：Developmental biology

authors： Prudovsky IA,Tsong TY

更新日期：1991-04-01 00:00:00

abstract：:Little is known about the biochemical changes underlying the morphological differentiation of the sea urchin egg during oogenesis. Because of this and the essential role of gamete recognition in fertilization, we studied the developmental expression of the recently identified egg surface receptor for sperm during ooge...

journal_title：Developmental biology

authors： Ohlendieck K,Partin JS,Stears RL,Lennarz WJ

更新日期：1994-09-01 00:00:00

abstract：:Murine ovarian folliculogenesis commences after birth involving oocyte growth, somatic cell differentiation and structural remodeling of follicle stromal boundaries. The extracellular metalloproteinase ADAMTS-1 has activity against proteoglycans and collagen and is produced by the granulosa cells of ovarian follicles....

journal_title：Developmental biology

authors： Brown HM,Dunning KR,Robker RL,Pritchard M,Russell DL

更新日期：2006-12-15 00:00:00

abstract：:The earliest muscle in zebrafish arises from iterated sets of two to six cells in each somite, the muscle pioneers (MP). MP develop synchronously in young trunk myotomes adjacent to the notochord, precisely where the horizontal myoseptum will form. They elongate without cell fusion and differentiate hours earlier than...

journal_title：Developmental biology

authors： Felsenfeld AL,Curry M,Kimmel CB

更新日期：1991-11-01 00:00:00

abstract：:Caudal homeobox genes are found across animals, typically linked to two other homeobox genes in what has been called the ParaHox cluster. These genes have been proposed to pattern the anterior-posterior axis of the endoderm ancestrally, but the expression of Caudal in extant groups is varied and often occurs in other ...

journal_title：Developmental biology

authors： Johnson AB,Lambert JD

更新日期：2021-02-01 00:00:00

abstract：:The Drosophila abnormal wing discs (awd) gene encodes the subunit of a protein that has nucleoside diphosphate kinase (NDP kinase) activity. Null mutations of the awd gene cause lethality after puparium formation. Larvae homozygous for such mutations have small imaginal discs, lymph glands, and brain lobes. Neither th...

journal_title：Developmental biology

authors： Xu J,Liu LZ,Deng XF,Timmons L,Hersperger E,Steeg PS,Veron M,Shearn A

更新日期：1996-08-01 00:00:00

abstract：:Retinoic acid (RA) is a potent inducer of cell differentiation and plays an essential role in sex-specific germ cell development in the mammalian gonad. RA is essential for male gametogenesis and hence fertility. However, RA can also disrupt sexual cell fate in somatic cells of the testis, promoting transdifferentiati...

journal_title：Developmental biology

authors： Minkina A,Lindeman RE,Gearhart MD,Chassot AA,Chaboissier MC,Ghyselinck NB,Bardwell VJ,Zarkower D

更新日期：2017-04-15 00:00:00

abstract：:We have used an in vitro model to investigate the relationship between cell proliferation, cell maturation, and intercellular junctional changes that are seen during normal liver development. Chick liver fragments of embryonic stages 21, 28, and 39 were grown in organ culture in Medium 199 with 10% bovine serum albumi...

journal_title：Developmental biology

authors： Meyer RA,Overton J

更新日期：1983-09-01 00:00:00

abstract：:The scalloped and vestigial genes are both required for the formation of the Drosophila wing, and recent studies have indicated that they can function as a heterodimeric complex to regulate the expression of downstream target genes. We have analyzed the consequences of complete loss of scalloped function, ectopic expr...

journal_title：Developmental biology

authors： Liu X,Grammont M,Irvine KD

更新日期：2000-12-15 00:00:00

abstract：:In the development of mammalian organs, a rapid and robust expansion of the parenchymal compartment must occur following allocation of organ primordia. This expansion must be regulated so that sufficient tissue mass is generated for further organization into functional tissues. The discovery that mosaic patches in the...

journal_title：Developmental biology

authors： Khokha MK,Landini G,Iannaccone PM

更新日期：1994-10-01 00:00:00

abstract：:Voltage-gated Na(+) and K(+) channels are localized to distinct subcellular domains in mammalian myelinated nerve fibers. Specifically, Na(+) channels are clustered in high densities at nodes of Ranvier, while K(+) channels are found in juxtaparanodal zones just beyond regions of axoglial contact where sequential laye...

journal_title：Developmental biology

authors： Rasband MN,Trimmer JS

更新日期：2001-08-01 00:00:00

abstract：:We have characterized a phosphoprotein protein with a death effector domain that has a novel bifunctional role in programmed cell death. The 15-kDa phosphoprotein enriched in astrocytes (PEA-15) inhibits Fas-mediated apoptosis and increases tumor necrosis factor receptor-1 (TNF-R1)-mediated apoptosis in the same cell ...

journal_title：Developmental biology

authors： Estellés A,Charlton CA,Blau HM

更新日期：1999-12-01 00:00:00

abstract：:We have cloned a member of the fork head/HNF-3 family of transcription factors from the nematode Caenorhabditis elegans. Within the predicted DNA binding domain, this gene, called Ce-fkh-1, is 75-78% identical to the Drosophila fork head and rat liver HNF-3 alpha, beta, and gamma genes. Ce-fkh-1 mRNA is highly enriche...

journal_title：Developmental biology

authors： Azzaria M,Goszczynski B,Chung MA,Kalb JM,McGhee JD

更新日期：1996-09-15 00:00:00

abstract：:Intercellular communication mediated by gap junctions is important for tissue homeostasis in the avascular lens, and extensive areas of gap junctions form between fiber cells during fiber cell differentiation and lens development. We examined the role of the calcium-dependent cell adhesion molecule, N-cadherin, in the...

journal_title：Developmental biology

authors： Frenzel EM,Johnson RG

更新日期：1996-10-10 00:00:00

abstract：:Nontransformed cultures of vascular smooth muscle cells proliferate until they form a confluent sheet of cells. Subsequently, the cells become reorganized to form multicellular nodules that are loosely attached to the substrate. The formation of nodules is facilitated by the addition of medium conditioned by nodular c...

journal_title：Developmental biology

authors： Brennan MJ,Millis AJ,Mann D,Fritz KE

更新日期：1983-06-01 00:00:00

abstract：:The eyes absent (eya) gene plays an essential role in the events that lead to formation of the Drosophila eye; without expression of eya in retinal progenitor cells, they undergo programmed cell death just prior to the morphogenetic furrow, leading to an eyeless or reduced eye phenotype. The eya gene has recently been...

journal_title：Developmental biology

authors： Bonini NM,Leiserson WM,Benzer S

更新日期：1998-04-01 00:00:00

abstract：:Although a large superfamily of G-protein-coupled receptors serves multiple functions, little is known about their functional activation during ontogeny. To examine the functional activation of the mu-opioid receptor (MOR) and the delta-opioid receptor (DOR) during development, sections of mouse embryos and fetuses fr...

journal_title：Developmental biology

authors： Nitsche JF,Pintar JE

更新日期：2003-01-01 00:00:00

abstract：:Bone morphogenetic protein-4 (BMP-4) induces epidermis and represses neural fate in Xenopus ectoderm. Our previous findings implicate p42 Erk MAP kinase (MAPK) in the response to neural induction. We have examined the effects of BMP-4 on MAPK activity in gastrula ectoderm. Expression of a dominant negative BMP-4 recep...

journal_title：Developmental biology

authors： Goswami M,Uzgare AR,Sater AK

更新日期：2001-08-15 00:00:00

abstract：:Two populations of blastomeres become positionally distinct during fourth cleavage in the mouse embryo; the inner cells become enclosed within the embryo and the outer cells form the enclosing layer. The segregation of these two cell populations is important for later development, because it represents the initial ste...

journal_title：Developmental biology

authors： Sutherland AE,Speed TP,Calarco PG

更新日期：1990-01-01 00:00:00

abstract：:Spermatogenesis is a complex process that requires coordinated proliferation and differentiation of male germ cells. The molecular events that dictate this process are largely unknown, but are likely to involve highly regulated transcriptional control. In this study, we investigate the contribution of chromatin associ...

journal_title：Developmental biology

authors： Pellegrino J,Castrillon DH,David G

更新日期：2012-09-15 00:00:00

abstract：:Primary mesenchyme cell migration in the sea urchin embryo is inhibited by sulfate deprivation and exposure to exogenous beta-D-xylosides, two treatments known to disrupt proteoglycan synthesis. We show that in the developing sea urchin, exogenous xyloside affects the synthesis by the primary mesenchyme cells of a ver...

journal_title：Developmental biology

authors： Lane MC,Solursh M

更新日期：1991-02-01 00:00:00

abstract：:Using gene-specific probes derived from four mouse gamma-crystallin cDNAs, we have examined the regulation of different members of the mouse gamma-crystallin gene family during lens development. Our analysis revealed that, while the different gamma-crystallin genes appear to be coordinately activated during embryogene...

journal_title：Developmental biology

authors： Murer-Orlando M,Paterson RC,Lok S,Tsui LC,Breitman ML

更新日期：1987-01-01 00:00:00

abstract：:This study tested the proposition that Na/K-ATPase activity could be involved in the morphogenetic aspects of mouse blastocyst formation by facilitating the localization of certain organelles to apposed borders, the production of nascent blastocoele fluid, and cavitation. It was assumed that such Na/K-ATPase activity ...

journal_title：Developmental biology

authors： Wiley LM

更新日期：1984-10-01 00:00:00

abstract：:Drosophila Polycomb Repressive Complex 2 (PRC2) is a lysine methyltransferase that trimethylates histone H3 lysine 27 (H3K27me3), a modification essential for Polycomb silencing. Mutations in its catalytic subunit, E(Z), that abolish its methyltransferase activity disrupt Polycomb silencing, causing derepression of Po...

journal_title：Developmental biology

authors： Stepanik VA,Harte PJ

更新日期：2012-04-15 00:00:00

abstract：:During vesicular transport between the endoplasmic reticulum and the Golgi, members of the TMED/p24 protein family form hetero-oligomeric complexes that facilitate protein-cargo recognition as well as vesicle budding. In addition, they regulate each other's level of expression. Despite analyses of TMED/p24 protein dis...

journal_title：Developmental biology

authors： Jerome-Majewska LA,Achkar T,Luo L,Lupu F,Lacy E

更新日期：2010-05-01 00:00:00

abstract：:GATA4, a transcription factor expressed in the proximal small intestine but not in the distal ileum, maintains proximal-distal distinctions by multiple processes involving gene repression, gene activation, and cell fate determination. Friend of GATA (FOG) is an evolutionarily conserved family of cofactors whose member...

journal_title：Developmental biology

authors： Beuling E,Bosse T,aan de Kerk DJ,Piaseckyj CM,Fujiwara Y,Katz SG,Orkin SH,Grand RJ,Krasinski SD

更新日期：2008-10-01 00:00:00

abstract：:Several Strongylocentrotus purpuratus gene cis-regulatory regions contain asymmetric C4 sequences which are core elements of target sites for a specific DNA-protein interaction. Blastula stage nuclear extract contains five proteins which specifically bind to these target sites, resulting in a characteristic pattern of...

journal_title：Developmental biology

authors： Zeller RW,Coffman JA,Harrington MG,Britten RJ,Davidson EH

更新日期：1995-06-01 00:00:00

abstract：:The development of the Drosophila leg is a good model to study processes of pattern formation, cell death and segmentation. Such processes require the coordinate activity of different genes and signaling pathways that progressively subdivide the leg territory into smaller domains. One of the main pathways needed for l...

journal_title：Developmental biology

authors： Guarner A,Manjón C,Edwards K,Steller H,Suzanne M,Sánchez-Herrero E

更新日期：2014-01-15 00:00:00

abstract：:We have investigated oocyte development in Hydra vulgaris, a member of one of the oldest metazoan phyla. We show that oocyte determination involves a mechanism that establishes a subset of precursor interstitial cells competent to differentiate into oocytes. The oocyte is singled out from this subset and the competenc...

journal_title：Developmental biology

authors： Miller MA,Technau U,Smith KM,Steele RE

更新日期：2000-08-15 00:00:00