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Structural alterations in fibronectin correlated with morphological changes in smooth muscle cells.

Abstract：

:Nontransformed cultures of vascular smooth muscle cells proliferate until they form a confluent sheet of cells. Subsequently, the cells become reorganized to form multicellular nodules that are loosely attached to the substrate. The formation of nodules is facilitated by the addition of medium conditioned by nodular cultures. Nodulation is inhibited by the addition of fibronectin. Fibronectins derived from monolayer culture conditioned medium or from plasma are maximally effective while fibronectin isolated from nodular cell conditioned medium is inactive. Analysis by NaDodSO4-polyacrylamide gel electrophoresis reveals that the nodular cell fibronectin has a molecular weight that is about 20-30 kd less than that of monolayer cell fibronectin. Further, nodular cell conditioned medium contains an activity that can convert both plasma fibronectin and monolayer cell fibronectin to the lower molecular weight correlated with the loss of biological activity.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Brennan MJ,Millis AJ,Mann D,Fritz KE

doi

10.1016/0012-1606(83)90095-7

subject

Has Abstract

pub_date

1983-06-01 00:00:00

pages

391-7

issue

2

eissn

0012-1606

issn

1095-564X

pii

0012-1606(83)90095-7

journal_volume

97

pub_type

杂志文章

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