The union of somatic gonad precursors and primordial germ cells during Caenorhabditis elegans embryogenesis.

abstract：:To understand mechanisms of sex determination, it is important to know the lineage relationships of cells comprising the gonads. For example, in mice, the Y-linked gene Sry triggers differentiation of Sertoli cells from a cell population originating in the coelomic epithelium overlying the nascent gonad that also give...

journal_title：Developmental biology

authors： Sekido R,Lovell-Badge R

更新日期：2007-02-01 00:00:00

abstract：:Spermatogenesis is initiated by the interaction of germ cells and somatic cells in seminiferous tubules. We used cDNA microarrays and representational difference analysis to identify genes that are expressed in the testis of the jsd/jsd mutant mouse, which contains only type A spermatogonial germ cells and Sertoli cel...

journal_title：Developmental biology

authors： Tanaka K,Tamura H,Tanaka H,Katoh M,Futamata Y,Seki N,Nishimune Y,Hara T

更新日期：2002-06-15 00:00:00

abstract：:Cyclin J is a cyclin family member that appears to have evolved before the metazoan radiation. Its evolutionary conservation argues for an important role but functional characterizations of Cyclin J have remained very limited. In Drosophila, Cyclin J is expressed only in females. Using transgenic Drosophila lines expr...

journal_title：Developmental biology

authors： Althoff F,Viktorinová I,Kastl J,Lehner CF

更新日期：2009-09-15 00:00:00

abstract：:DNA replication and its connection to M phase restraint are studied extensively at the level of single cells but rarely in the context of a developing animal. C. elegans lin-6 mutants lack DNA synthesis in postembryonic somatic cell lineages, while entry into mitosis continues. These mutants grow slowly and either die...

journal_title：Developmental biology

authors： Korzelius J,The I,Ruijtenberg S,Portegijs V,Xu H,Horvitz HR,van den Heuvel S

更新日期：2011-02-15 00:00:00

abstract：:In amphibians, the composition and pattern of expression of the myosin heavy chain (myHC) gene family are mostly unknown. To understand better the regulation of this complex family, we screened cDNA libraries from swimming tadpole and adult leg muscle RNA and have isolated and partially sequenced clones for several my...

journal_title：Developmental biology

authors： Radice GP,Malacinski GM

更新日期：1989-06-01 00:00:00

abstract：:Among the derivatives of the cephalic neural crest is the ectomesenchyme which subsequently constitutes most of the craniofacial skeleton. There is evidence to suggest that the skeletogenic fate of the hindbrain neural crest is specified before emigration from the neural tube and that Antennapedia class Hox genes are ...

journal_title：Developmental biology

authors： Hunt P,Ferretti P,Krumlauf R,Thorogood P

更新日期：1995-04-01 00:00:00

abstract：:One rapid response of starfish oocytes to the maturation-inducing hormone, 1-methyladenine (1-MA), is the formation of transient actin-filled spikes on the cell surface. The presence and distribution of G- and F-actin and several actin-associated proteins were examined in cortices isolated from oocytes before, during,...

journal_title：Developmental biology

authors： Otto JJ,Schroeder TE

更新日期：1984-02-01 00:00:00

abstract：:We have examined the roles of cell lineage and interactions in the determination of individual identified neurons in the grasshopper embryo by selective ablations of individual cells and/or their neighbors at successive stages following their birth. The neurons in the grasshopper central nervous system (CNS) are produ...

journal_title：Developmental biology

authors： Kuwada JY,Goodman CS

更新日期：1985-07-01 00:00:00

abstract：:During development of the vertebrate visual system, retinal ganglion cell (RGC) axons follow a precise path toward their midbrain targets. Although much is known about the cues that direct RGC axons once they have left the optic disc, less is known about the guidance of axons at earlier stages, when RGCs first send ou...

journal_title：Developmental biology

authors： Ohta K,Tannahill D,Yoshida K,Johnson AR,Cook GM,Keynes RJ

更新日期：1999-07-01 00:00:00

abstract：:Melanoblasts, the precursors of the pigment-producing cells of the skin and hair, are derived from the neural crest and migrate to the skin around 12 days of gestation in the mouse. In adult mice almost all the melanoblasts are confined to the hair follicles except for the epidermal layers of nonhairy skin. The recept...

journal_title：Developmental biology

authors： Jordan SA,Jackson IJ

更新日期：2000-09-15 00:00:00

abstract：:Anuran amphibian embryos (Xenopus laevis and Rana dybowskii) are sensitive to novel gravitational fields. Under simulated weightlessness, (i) the location of the first horizontal cleavage furrow was shifted toward the vegetal pole at the eight-cell stage; (ii) the position of the blastocoel was more centered, and the ...

journal_title：Developmental biology

authors： Neff AW,Yokota H,Chung HM,Wakahara M,Malacinski GM

更新日期：1993-01-01 00:00:00

abstract：:Oocyte maturation (meiosis reinitiation) in starfish is induced by the natural hormone 1-methyladenine (1-MeAde). Oocytes of Evasterias troschelii contain 0.43 pmole cyclic AMP/mg protein and 0.47 pmole cyclic GMP/mg protein. Upon stimulation by 1-MeAde the oocytes undergo a moderate (10-30%) decrease in their cAMP co...

journal_title：Developmental biology

authors： Meijer L,Zarutskie P

更新日期：1987-06-01 00:00:00

abstract：:Exposure of Xenopus animal pole explants to transforming growth factor beta 2 (TGF-beta 2) induced the sequential expression of muscle nicotinic acetylcholine receptor (AChRs) isoforms and their corresponding mRNAs in cells which normally give rise to ectoderm. Single channel recordings revealed two functional classes...

journal_title：Developmental biology

authors： Reuer Q,Kullberg RW,Owens JL

更新日期：1994-11-01 00:00:00

abstract：:Embryonic 4- to 15-day-old quail ciliary ganglia (CG) were grafted into the neural crest migration pathway of 2-day-old chick embryos at the adrenomedullary level of the neural axis. This back-transplantation results in dispersion of cells of the implanted ganglion, their migration in the host embryo, and subsequent p...

journal_title：Developmental biology

authors： Dupin E

更新日期：1984-10-01 00:00:00

abstract：:Spore germination is a defined developmental process that marks a critical point in the life cycle of Dictyostelium discoideum. Upon germination the environmental conditions must be conducive to cell growth to ensure survival of emerged amoebae. However, the signal transduction pathways controlling the various aspects...

journal_title：Developmental biology

authors： Zinda MJ,Singleton CK

更新日期：1998-04-15 00:00:00

abstract：:Vulval epithelial tubes invaginate through concerted cell migration, ring formation, stacking of rings and intra-ring cell fusion in the nematodes Caenorhabditis elegans, Oscheius tipulae and Pristionchus pacificus. The number of rings forming the invaginations is invariantly seven, six, and eight, respectively. We hy...

journal_title：Developmental biology

authors： Kolotuev I,Podbilewicz B

更新日期：2008-01-01 00:00:00

abstract：:Amphibian embryos from the genus Xenopus are among the best species for understanding early vertebrate development and for studying basic cell biological processes. Xenopus, and in particular the diploid Xenopus tropicalis, is also ideal for functional genomics. Understanding the behavior of genes in this accessible m...

journal_title：Developmental biology

authors： Gilchrist MJ,Zorn AM,Voigt J,Smith JC,Papalopulu N,Amaya E

更新日期：2004-07-15 00:00:00

abstract：:Collapsin-1 is a secreted glycoprotein that inhibits the extension of specific growth cones in vitro. It has been hypothesized to serve as a repulsive guidance cue for extending growth cones in vivo. Here we report the distribution of collapsin-1 message as demonstrated by in situ hybridization using digoxigenin-label...

journal_title：Developmental biology

authors： Shepherd I,Luo Y,Raper JA,Chang S

更新日期：1996-01-10 00:00:00

abstract：:The Drosophila brain is tracheated by the cerebral trachea, a branch of the first segmental trachea of the embryo. During larval stages the cerebral trachea splits into several main (primary) branches that grow around the neuropile, forming a perineuropilar tracheal plexus (PNP) at the neuropile surface. Five primary ...

journal_title：Developmental biology

authors： Pereanu W,Spindler S,Cruz L,Hartenstein V

更新日期：2007-02-01 00:00:00

abstract：:Exocytosis of cortical granules in mouse eggs is required to produce the zona pellucida block to polyspermy. In this study, we examined the role of microfilaments and microtubules in the regulation of cortical granule movement toward the cortex during oocyte maturation and anchoring of cortical granules in the cortex....

journal_title：Developmental biology

authors： Connors SA,Kanatsu-Shinohara M,Schultz RM,Kopf GS

更新日期：1998-08-01 00:00:00

abstract：:In tetrapods, the anteroposterior (AP) patterning of the limb is under the control of the antagonistic activities of the secreted factor Sonic hedgehog (Shh) and Gli3R, the truncated repressor form of the transcription factor Gli3. In this report, we show that Msx1 and Msx2 are targets and downstream effectors of Gli3...

journal_title：Developmental biology

authors： Lallemand Y,Bensoussan V,Cloment CS,Robert B

更新日期：2009-07-15 00:00:00

abstract：:Morphogenesis of the vertebrate head relies on proper dorsal-ventral (D-V) patterning of neural crest cells (NCC) within the pharyngeal arches. Endothelin-1 (Edn1)-induced signaling through the endothelin-A receptor (Ednra) is crucial for cranial NCC patterning within the mandibular portion of the first pharyngeal arc...

journal_title：Developmental biology

authors： Tavares AL,Garcia EL,Kuhn K,Woods CM,Williams T,Clouthier DE

更新日期：2012-11-01 00:00:00

abstract：:Wnt signaling pathways have been demonstrated to play important roles in controlling tissue patterning and cell proliferation. In the gastrointestinal tract, mutations that lead to activation of the canonical Wnt pathway through beta-catenin result in familial and sporadic colon cancers. The downstream transcription f...

journal_title：Developmental biology

authors： Theodosiou NA,Tabin CJ

更新日期：2003-07-15 00:00:00

abstract：:Although mitogen-activated protein kinase (MAPK) is a well-known cell cycle regulator, emerging studies have also implicated its activity in the regulation of intracellular calcium concentration ([Ca2+](i)) and secretion. Those studies raise the hypothesis that MAPK activity during oocyte maturation and early fertiliz...

journal_title：Developmental biology

authors： Matson S,Ducibella T

更新日期：2007-06-15 00:00:00

abstract：:Conserved from Cnidarians to vertebrates, the dorsoventral (DV) axis is patterned by the Chordin-BMP pathway. However, the functions of the pathway's components are very different in different phyla. By modeling it is shown that many observations can be integrated by the assumption that BMP, acting as an inhibitory co...

journal_title：Developmental biology

authors： Meinhardt H

更新日期：2015-09-01 00:00:00

abstract：:Syndecan, a cell surface proteoglycan, binds multiple extracellular ligands, and is developmentally regulated in epithelial and mesenchymal tissues. The branching morphogenesis of embryonic lung is dependent on epithelial-mesenchymal interactions and, based on studies with inhibitors, on proteoglycan synthesis. To ass...

journal_title：Developmental biology

authors： Brauker JH,Trautman MS,Bernfield M

更新日期：1991-10-01 00:00:00

abstract：:Heart valve structures derived from mesenchymal cells of the endocardial cushions (ECs) are composed of highly organized cell lineages and extracellular matrix. Sox9 is a transcription factor required for both early and late stages of cartilage formation that is also expressed in the developing valves of the heart. Th...

journal_title：Developmental biology

authors： Lincoln J,Kist R,Scherer G,Yutzey KE

更新日期：2007-05-01 00:00:00

abstract：:Neural crest cells have broad migratory and differentiative ability that differs according to their axial level of origin. However, their transient nature has limited understanding of their stem cell and self-renewal properties. While an in vitro culture method has made it possible to maintain cranial neural crest cel...

journal_title：Developmental biology

authors： Mohlin S,Kunttas E,Persson CU,Abdel-Haq R,Castillo A,Murko C,Bronner ME,Kerosuo L

更新日期：2019-03-15 00:00:00

abstract：:Maintaining tissue homeostasis is a critical process during infection and inflammation. Tissues with a high intrinsic turnover, such as the intestinal epithelium, must launch a rapid response to infections while simultaneously coordinating cell proliferation and differentiation decisions. In this study, we searched fo...

journal_title：Developmental biology

authors： Zhou J,Florescu S,Boettcher AL,Luo L,Dutta D,Kerr G,Cai Y,Edgar BA,Boutros M

更新日期：2015-03-15 00:00:00

abstract：:The relationship between ascorbic acid concentration and cellular transport mechanisms was studied in chicken embryos (Gallus gallus domesticus). Unincubated (Day 0) fertile eggs did not contain detectable levels of ascorbic acid as assayed by high performance liquid chromatography with electrochemical detection. Howe...

journal_title：Developmental biology

authors： Wilson JX

更新日期：1990-06-01 00:00:00