Abstract:
:A population of hematopoietic progenitors becomes committed within the embryo proper in the floor of the aorta (P-Sp/AGM in the mouse). In birds, this first aspect of intraembryonic hematopoiesis is prominent during embryonic day 3 (E3) as endothelium-associated "intra-aortic clusters." Between E6 and E8, diffuse hematopoiesis then occurs as "para-aortic foci" located in the dorsal mesentery ventral to the aorta. These foci are not associated with endothelium. Whether these two hematopoietic cell populations arise from distinct or common progenitors is not known. We could recently trace back the origin of intra-aortic clusters in the avian embryo by labeling aortic endothelial cells (EC) in vivo with acetylated low-density lipoproteins. This approach established the derivation of early intraembryonic hemopoietic cells from the endothelium, but did not indicate how long during ontogeny such a relationship may exist, since the progeny of EC labeled at E2 could be traced for 1-2 days at most. Here we report that, when E2 aortic ECs were infected prior to the formation of intra-aortic clusters with a nonreplicative LacZ-bearing retroviral vector, numerous cells were labeled in the para-aortic foci at E6. In contrast, when the retroviral vector was inoculated at E4 rather than E2, that is, after the disappearance of intra-aortic clusters, no cells in the para-aortic foci were labeled. Taken together, our results demonstrate that ECs from the aortic floor seed the two aspects of aorta-associated hemopoiesis and that these ECs with hemangioblastic potential are present only transiently in the aorta.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Jaffredo T,Gautier R,Brajeul V,Dieterlen-Lièvre Fdoi
10.1006/dbio.2000.9799subject
Has Abstractpub_date
2000-08-15 00:00:00pages
204-14issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(00)99799-9journal_volume
224pub_type
杂志文章abstract::The development of intrinsic ganglia, comprised of neurons and glia cells that innervate airway smooth muscle, is a recognized component of the growing lung. However, the embryological origin of these neurons and glia is unclear. The lung buds develop as an outgrowth of the foregut, which contains migrating neural cre...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.09.006
更新日期:2005-01-01 00:00:00
abstract::Metamorphosis is a postembryonic developmental process that involves morphophysiological and behavioral changes, allowing organisms to adapt into a novel environment. In some amphibians, aquatic organisms undergo metamorphosis to adapt in a terrestrial environment. In this process, these organisms experience major cha...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2020.08.002
更新日期:2020-10-01 00:00:00
abstract::Acquisition of limb-forming ability by discrete regions of the lateral plate of the chick embryo is thought to depend on a signaling cascade moving sequentially from the area of Hensen's node to the somitic mesoderm, the intermediate mesoderm, and then to the prospective limb-forming regions of the lateral plate (Step...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1997.8646
更新日期:1997-08-15 00:00:00
abstract::The relationship among neuronal type, position, and time course of development of identified neurons was examined in the zebrafish (Brachydanio rerio). The cells studied, the reticulospinal neurons Mauthner, MiM1, and MiV1, are located within the same small region in the hindbrain, differ stereotypically in their posi...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(85)90422-1
更新日期:1985-12-01 00:00:00
abstract::Members of the basic helix-loop-helix family of DNA binding proteins have important roles in the development of subpopulations of neural crest-derived neurons. We have cloned the chicken homologues of dHAND (HAND2) and eHAND (HAND1), basic helix-loop-helix DNA binding proteins whose neuronal expression is restricted t...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9450
更新日期:1999-11-01 00:00:00
abstract::In Drosophila, the RNA helicase VASA (VAS) is required for both germ line formation and oocyte differentiation. While the murine VAS homologue is required for spermatogenesis, it is dispensable for germ line formation. The molecular basis for this apparently dual role of VAS in germ line ontogeny is, however, unclear....
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.04.004
更新日期:2004-07-01 00:00:00
abstract::Brain 4 (Brn4/Pou3f4) and Pax6 are POU-homeodomain and paired-homeodomain transcription factors, respectively, that are expressed in the brain and the glucagon-expressing cells in the pancreas. Brn4 expression begins at embryonic day 10 in the pancreas, just before pax6 and both appear in the glucagon immunoreactive c...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2003.12.008
更新日期:2004-04-01 00:00:00
abstract::The Drosophila brain is generated by a complex series of morphogenetic movements. To better understand brain development and to provide a guide for experimental manipulation of brain progenitors, we created a fate map using photoactivated gene expression to mark cells originating within specific mitotic domains and ti...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(03)00220-3
更新日期:2003-08-01 00:00:00
abstract::The universal signal for egg activation at fertilization is a rise in cytoplasmic Ca(2+) with defined spatial and temporal kinetics. Mammalian and amphibian eggs acquire the ability to produce such Ca(2+) signals during a maturation period that precedes fertilization and encompasses resumption of meiosis and progressi...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.08.004
更新日期:2004-11-01 00:00:00
abstract::Proper calcium channel and insulin signaling are essential for normal brain development. Leaner mice with a mutation in the P/Q-type voltage-gated calcium channel, Cacna1a, develop cerebellar atrophy and mutations in the homologous human gene are associated with increased migraine and seizure tendency. Similarly, abno...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.06.005
更新日期:2006-10-01 00:00:00
abstract::Many insects undergo katatrepsis, essential reorganization by the extraembryonic membranes that repositions the embryo. Knockdown of the zen gene by RNA interference (RNAi) prevents katatrepsis in the milkweed bug Oncopeltus fasciatus. However, the precise morphogenetic defect has been uncertain, and katatrepsis itsel...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.06.036
更新日期:2009-09-15 00:00:00
abstract::Animal development is controlled by gene regulation networks that are composed of sequence-specific transcription factors (TF) and cell signaling molecules (ST). Although housekeeping genes have been reported to show clustering in the animal genomes, whether the genes comprising a given regulatory network are physical...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.01.009
更新日期:2008-04-15 00:00:00
abstract::The murine cpk mouse develops a rapid-onset polycystic kidney disease (PKD) with many similarities to human PKD. During kidney development, the transcription factor Pax2 is required for the specification and differentiation of the renal epithelium. In humans, Pax2 is also expressed in juvenile cystic kidneys where it ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2000.9618
更新日期:2000-03-15 00:00:00
abstract::Fertilization overcomes meiotic arrest by triggering a series of biochemical events, resulting in activation of the egg. A small group of protein tyrosine kinases (PTKs) have been identified in eggs of invertebrates and lower vertebrates and inhibitor studies have suggested that they play a role in late events of egg ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1997.8816
更新日期:1998-02-01 00:00:00
abstract::Normal growth and morphogenesis of the cranial vault reflect a balance between cell proliferation in the sutures and osteogenesis at the margins of the cranial bones. In the clinical condition craniosynostosis, the sutures fuse prematurely as a result of precocious osteogenic differentiation and craniofacial malformat...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2001.0533
更新日期:2002-03-01 00:00:00
abstract::Polycomb group (PcG) proteins are best known for their role in maintaining stable, mitotically heritable silencing of the homeotic (HOX) genes during development. In addition to loss of homeotic gene silencing, some PcG mutants also have small imaginal discs. These include mutations in E(z), Su(z)12, esc and escl, whi...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2013.03.011
更新日期:2013-08-01 00:00:00
abstract::All metazoan genomes encode multiple RAS GTPase activating proteins (RasGAPs) that negatively regulate the conserved RAS/MAPK signaling pathway. In mammals, several RasGAPs exhibit tumor suppressor activity by preventing excess RAS signal transduction. We have identified gap-3 as the to date missing Caenorhabditiseleg...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.08.026
更新日期:2008-11-15 00:00:00
abstract::Most metazoans are able to grow beyond a few hundred cells and to support differentiated tissues because they elaborate multicellular, epithelial tubes that are indispensable for nutrient and gas exchange. To identify and characterize the cellular behaviors and molecular mechanisms required for the morphogenesis of ep...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2015.10.034
更新日期:2016-01-01 00:00:00
abstract::We have studied the effect of saline and acid extracts of chick brain on the total number of acetylcholine (ACh) receptors and the number of receptor clusters in cultured chick muscle cells. Myotubes in 7-day cultures responded more rapidly to brain extract than did myotubes in 4-day cultures, so the older cells were ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(83)90039-8
更新日期:1983-02-01 00:00:00
abstract::Amphibian embryos from the genus Xenopus are among the best species for understanding early vertebrate development and for studying basic cell biological processes. Xenopus, and in particular the diploid Xenopus tropicalis, is also ideal for functional genomics. Understanding the behavior of genes in this accessible m...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.04.023
更新日期:2004-07-15 00:00:00
abstract::We have identified zebrafish orthologues of glial cell line-derived neurotrophic factor (GDNF) and the ligand-binding component of its receptor GFRalpha1. We examined the mRNA expression pattern of these genes in the developing spinal cord primary motor neurons (PMN), kidney, and enteric nervous systems (ENS) and have...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2000.0145
更新日期:2001-03-15 00:00:00
abstract::To form a gonad, germ cells (GCs) and somatic gonadal precursor cells (SGPs) must migrate to the correct location in the developing embryo and establish the cell-cell interactions necessary to create proper gonad architecture. During gonad morphogenesis, SGPs send out cellular extensions to ensheath the individual GCs...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2012.04.027
更新日期:2012-07-15 00:00:00
abstract::The remarkable regenerative capacity displayed by plants and various vertebrates, such as amphibians, is largely based on the capability of somatic cells to undergo dedifferentiation. In this process, mature cells reverse their state of differentiation and acquire pluripotentiality--a process preceding not only reentr...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2003.12.027
更新日期:2004-04-01 00:00:00
abstract::Immunocytochemical studies were performed to determine if denervated rodent iris produces nerve growth factor (NGF) in a form chemically similar to that of the 7S NGF complex in mouse submandibular glands. Antisera to the alpha, beta, and gamma subunits of 7S NGF were raised in rabbits and characterized on immunoblots...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90201-0
更新日期:1986-04-01 00:00:00
abstract::Chromatin insulators orchestrate gene transcription during embryo development and cell differentiation by stabilizing interactions between distant genomic sites. Mutations in genes encoding insulator proteins are generally lethal, making in vivo functional analyses of insulator proteins difficult. In Drosophila, howev...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2015.03.024
更新日期:2015-07-01 00:00:00
abstract::In the small-optic-lobes (sol) and sine oculis (so) mutants of Drosophila melanogaster extensive cell death occurs in the optic lobes during the first half of pupal development. Gynandromorph flies show that the sol mutation acts primarily on cells of the medulla cortex. Degeneration of medullar ganglion cells occurs ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(84)90050-2
更新日期:1984-07-01 00:00:00
abstract::The protein content of various size follicles was measured in Fundulus heteroclitus and indicated four phases of increase relative to follicle volume: Phases I (previtellogenic; estimated to be less than 0.01 mg/mm3), II (vitellogenic; 0.20 mg/mm3), III (early maturation; 0.03 mg/mm3), and IV (late maturation; 0 mg/mm...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(85)90106-x
更新日期:1985-08-01 00:00:00
abstract::Octopamine is a major monoamine in invertebrates and affects many physiological processes ranging from energy metabolism to complex behaviors. Octopamine binds to receptors located on various cell types and activates distinct signal transduction pathways to produce these diverse effects. We previously identified one o...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2003.07.018
更新日期:2003-12-01 00:00:00
abstract::Monoclonal antibodies highly selective for developmentally regulated antigens present in the cornea (Zak and Linsenmayer, Dev. Biol. 99, 373-381, 1983) have been used to immunohistochemically evaluate differentiation in intact chick corneas cultured on the chorioallantoic membrane (CAM) of host embryos. One antibody i...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(85)90047-8
更新日期:1985-04-01 00:00:00
abstract::In studies initially focused on roles of nonmuscle myosin IIA (NMIIA) in the developing mouse epidermis, we have discovered that a previously described cytokeratin 5 (K5)-Cre gene construct is expressed in early embryo development. Mice carrying floxed alleles of the nonmuscle myosin II heavy chain gene (NMHC IIA(flox...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2013.07.017
更新日期:2013-10-01 00:00:00