Abstract：
:The scalloped and vestigial genes are both required for the formation of the Drosophila wing, and recent studies have indicated that they can function as a heterodimeric complex to regulate the expression of downstream target genes. We have analyzed the consequences of complete loss of scalloped function, ectopic expression of scalloped, and ectopic expression of vestigial on the development of the Drosophila wing imaginal disc. Clones of cells mutant for a strong allele of scalloped fail to proliferate within the wing pouch, but grow normally in the wing hinge and notum. Cells overexpressing scalloped fail to proliferate in both notal and wing-blade regions of the disc, and this overexpression induces apoptotic cell death. Clones of cells overexpressing vestigial grow smaller or larger than control clones, depending upon their distance from the dorsal-ventral compartment boundary. These studies highlight the importance of correct scalloped and vestigial expression levels to normal wing development. Our studies of vestigial-overexpressing clones also reveal two further aspects of wing development. First, in the hinge region vestigial exerts both a local inhibition and a long-range induction of wingless expression. These and other observations imply that vestigial-expressing cells in the wing blade organize the development of surrounding wing-hinge cells. Second, clones of cells overexpressing vestigial exhibit altered cell affinities. Our analysis of these clones, together with studies of scalloped mutant clones, implies that scalloped- and vestigial-dependent cell adhesion contributes to separation of the wing blade from the wing hinge and to a gradient of cell affinities along the dorsal-ventral axis of the wing.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Liu X,Grammont M,Irvine KDdoi
10.1006/dbio.2000.9939subject
Has Abstractpub_date
2000-12-15 00:00:00pages
287-303issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(00)99939-1journal_volume
228pub_type
杂志文章abstract：:Previous experiments have demonstrated that in the septo-hippocampal system choline acetyltransferase (ChAT) is induced by nerve growth factor (NGF) (Gnahn et al. (1983) Dev. Brain Res. 9, 45-52) and that hippocampal NGF and mRNANGF levels are correlated with the density of cholinergic innervation (Korsching et al. (1...
journal_title：Developmental biology
pub_type： 杂志文章
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abstract：:Mesenchymal-epithelial interactions are an important source of information for pattern formation during organogenesis. In the developing excretory system, one of the secreted mesenchymal factors thought to play a critical role in patterning the growth and branching of the epithelial ureteric bud is GDNF. We have teste...
journal_title：Developmental biology
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journal_title：Developmental biology
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journal_title：Developmental biology
pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
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journal_title：Developmental biology
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2005-07-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2005.10.045
更新日期：2006-03-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1998.8912
更新日期：1998-07-01 00:00:00
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journal_title：Developmental biology
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更新日期：2017-08-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2009.06.042
更新日期：2009-09-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章,评审
doi：10.1006/dbio.1996.0035
更新日期：1996-02-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章,评审
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journal_title：Developmental biology
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journal_title：Developmental biology
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doi：10.1006/dbio.1996.0083
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journal_title：Developmental biology
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journal_title：Developmental biology
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journal_title：Developmental biology
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更新日期：1998-12-01 00:00:00
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journal_title：Developmental biology
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更新日期：2010-04-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2000-08-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章,评审
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2016-08-15 00:00:00
abstract：:Successful fertilization requires that sperm are activated prior to contacting an oocyte. In C. elegans, this activation process, called spermiogenesis, transforms round immobile spermatids into motile, fertilization-competent spermatozoa. We describe the phenotypic and genetic characterization of spe-43, a new compon...
journal_title：Developmental biology
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更新日期：2018-04-15 00:00:00
