Progenitor dispersal and the origin of early neuronal phenotypes in the chick embryo spinal cord.

abstract：:The formation of the spinal cord during early embryonic development in vertebrate embryos is a continuous process that begins at gastrulation and continues through to the completion of somitogenesis. Despite the conserved usage of patterning mechanisms and gene regulatory networks that act to generate specific spinal ...

journal_title：Developmental biology

authors： Steventon B,Martinez Arias A

更新日期：2017-12-01 00:00:00

abstract：:The rabbit sperm membrane autoantigen RSA-1 is a sialoglycoprotein of 13,000 daltons which first appears on the surface of pachytene spermatocytes. Using specific antiserum to RSA-1 the antigen has been localized by immunofluorescence and immunoperoxidase staining. On testicular cells labeled at 37 degrees C, RSA-1 is...

journal_title：Developmental biology

authors： O'Rand MG,Romrell LJ

更新日期：1981-06-01 00:00:00

abstract：:The Hippo tumor suppressor pathway plays many fundamental cell biological roles during animal development. Two central players in controlling Hippo-dependent gene expression are the TEAD transcription factor Scalloped (Sd) and its transcriptional co-activator Yorkie (Yki). Hippo signaling phosphorylates Yki, thereby b...

journal_title：Developmental biology

authors： Xie B,Morton DB,Cook TA

更新日期：2019-11-01 00:00:00

abstract：:In the embryonic mouse retina, retinoic acid (RA) is unevenly distributed along the dorsoventral axis: RA-rich zones in dorsal and ventral retina are separated by a horizontal RA-poor stripe that contains the RA-inactivating enzyme CYP26A1. To explore the developmental role of this arrangement, we studied formation of...

journal_title：Developmental biology

authors： Sakai Y,Luo T,McCaffery P,Hamada H,Dräger UC

更新日期：2004-12-01 00:00:00

abstract：:Transcription factors are key orchestrators of the emergence of neuronal diversity within the developing spinal cord. As such, the two paralogous proteins Pax3 and Pax7 regulate the specification of progenitor cells within the intermediate neural tube, by defining a neat segregation between those fated to form motor c...

journal_title：Developmental biology

authors： Gard C,Gonzalez Curto G,Frarma YE,Chollet E,Duval N,Auzié V,Auradé F,Vigier L,Relaix F,Pierani A,Causeret F,Ribes V

更新日期：2017-12-01 00:00:00

abstract：:Directed cell movement is integral to both embryogenesis and hematopoiesis. In the adult, the chemokine family of secreted proteins signals migration of hematopoietic cells through G-coupled chemokine receptors. We detected embryonic expression of chemokine receptor messages by RT-PCR with degenerate primers at embryo...

journal_title：Developmental biology

authors： McGrath KE,Koniski AD,Maltby KM,McGann JK,Palis J

更新日期：1999-09-15 00:00:00

abstract：:We previously isolated a p53 cDNA from a Xenopus oocyte library. To determine if p53 has a function in the developmental period, we have studied its expression at the RNA and protein levels during the early development of Xenopus laevis. Two p53 transcripts (3 and 2.2 kb) are expressed from the beginning of Xenopus oo...

journal_title：Developmental biology

authors： Tchang F,Gusse M,Soussi T,Méchali M

更新日期：1993-09-01 00:00:00

abstract：:Sensory placodes are unique columnar epithelia with neurogenic potential that develop in the vertebrate head ectoderm next to the neural tube. They contribute to the paired sensory organs and the cranial sensory ganglia generating a wide variety of cell types ranging from lens fibres to sensory receptor cells and neur...

journal_title：Developmental biology

authors： Streit A

更新日期：2004-12-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a complex malignancy with poor prognosis. Several genetic lesions can lead to the disease. One of these corresponds to the NUP98-HOXA9 (NA9) translocation that fuses sequences encoding the N-terminal part of NUP98 to those encoding the DNA-binding domain of HOXA9. Despite several studie...

journal_title：Developmental biology

authors： Baril C,Gavory G,Bidla G,Knævelsrud H,Sauvageau G,Therrien M

更新日期：2017-01-01 00:00:00

abstract：:The cortex and subcortical regions of the developing follicles and eggs of silkmoths are rich in cytoskeletal elements, particularly actin. In situ analysis using [3H]-polyuridylic acid and biotinylated oligo d(T) reveals a pattern of changes in poly(A)+ RNA distribution during oogenesis. The developing pattern of dis...

journal_title：Developmental biology

authors： Watson CA,Sauman I,Berry SJ

更新日期：1993-02-01 00:00:00

abstract：:Early (alpha) histone genes are one of several histone gene families in the sea urchin genome. They are expressed at high levels in blastula-stage embryos and are inactivated by the early gastrula stage. By microinjecting mutant early H2B genes into sea urchin zygotes and monitoring their transcriptional activity in b...

journal_title：Developmental biology

authors： Bell J,Char BR,Maxson R

更新日期：1992-04-01 00:00:00

abstract：:The role of retinoic acid (RA) in limb development is unclear, although it has been suggested to be a proximalizing factor which plays a morphogenetic role in pattern formation. Exogenous RA produces a teratogenic effect on limb morphology; similarly, changes in the endogenous distribution of RA following genetic abla...

journal_title：Developmental biology

authors： Pennimpede T,Cameron DA,MacLean GA,Petkovich M

更新日期：2010-03-01 00:00:00

abstract：:We studied the pathway of 5S ribosomal RNA (rRNA) during oogenesis in Xenopus from its storage in the cytoplasm to incorporation into ribosomes in the nucleus. Ribonucleoprotein particle (RNP) assembly assays reveal striking differences in the behavior of oocyte-type and somatic-type 5S rRNA after microinjection into ...

journal_title：Developmental biology

authors： Allison LA,North MT,Neville LA

更新日期：1995-04-01 00:00:00

abstract：:To examine the relationship between growth hormone (GH) and insulin-like growth factor 1 (IGF1) in controlling postnatal growth, we performed a comparative analysis of dwarfing phenotypes manifested in mouse mutants lacking GH receptor, IGF1, or both. This genetic study has provided conclusive evidence demonstrating t...

journal_title：Developmental biology

authors： Lupu F,Terwilliger JD,Lee K,Segre GV,Efstratiadis A

更新日期：2001-01-01 00:00:00

abstract：:Clotting is critical in limiting hemolymph loss and initiating wound healing in insects as in vertebrates. It is also an important immune defense, quickly forming a secondary barrier to infection, immobilizing bacteria and thereby promoting their killing. However, hemolymph clotting is one of the least understood immu...

journal_title：Developmental biology

authors： Scherfer C,Qazi MR,Takahashi K,Ueda R,Dushay MS,Theopold U,Lemaitre B

更新日期：2006-07-01 00:00:00

abstract：:The prostate gland develops from the urogenital sinus by a testosterone-dependent process of ductal morphogenesis. Sonic hedgehog (Shh) is expressed in the urogenital sinus epithelium and the time course of expression coincides with the formation of the main prostatic ducts. Expression is most abundant in the lumen of...

journal_title：Developmental biology

authors： Podlasek CA,Barnett DH,Clemens JQ,Bak PM,Bushman W

更新日期：1999-05-01 00:00:00

abstract：:Zygotic Wnt signaling has been shown to be involved in dorsoventral mesodermal patterning in Xenopus embryos, but how it regulates different myogenic gene expression in the lateral mesodermal domains is not clear. Here, we use transient exposure of embryos or explants to lithium, which mimics Wnt/beta-catenin signalin...

journal_title：Developmental biology

authors： Shi DL,Bourdelas A,Umbhauer M,Boucaut JC

更新日期：2002-05-01 00:00:00

abstract：:The shoot meristem generates all of the aerial structures of an adult plant. It is organized in three layers which produce the epidermis (L1 layer) and the subepidermal layers (L2 and L3). The origin of adult structures has previously been fate mapped to the primary meristem for L2 and L3 tissues. In this work we cons...

journal_title：Developmental biology

authors： Schnittger A,Grini PE,Folkers U,Hülskamp M

更新日期：1996-05-01 00:00:00

abstract：:Heart valve structures derived from mesenchymal cells of the endocardial cushions (ECs) are composed of highly organized cell lineages and extracellular matrix. Sox9 is a transcription factor required for both early and late stages of cartilage formation that is also expressed in the developing valves of the heart. Th...

journal_title：Developmental biology

authors： Lincoln J,Kist R,Scherer G,Yutzey KE

更新日期：2007-05-01 00:00:00

abstract：:The t haplotypes are variant forms of the proximal portion of chromosome 17 in the mouse. The t haplotypes alter spermatogenesis and many also contain lethal factors. Although the lethal factors vary between t haplotypes, all t haplotypes have the same effect on sperm, that of altering sperm function in fertilization....

journal_title：Developmental biology

authors： Olds-Clarke P,Johnson LR

更新日期：1993-01-01 00:00:00

abstract：:Using two different models of pregnancy failure in mice, we show in this communication that preimplantation embryonic development can be controlled, in vivo, with cytokines. In one model, described by us previously, CSF-1 is shown to block gestations in plugged females due to its induction of defective early developme...

journal_title：Developmental biology

authors： Tartakovsky B,Ben-Yair E

更新日期：1991-08-01 00:00:00

abstract：:Notch signaling has a fundamental role in stem cell maintenance and in cell fate choice in the intestine of different species. Canonically, Notch signaling represses the expression of transcription factors of the achaete-scute like (ASCL) or atonal related protein (ARP) families. Identifying the ARP/ASCL genes express...

journal_title：Developmental biology

authors： Flasse LC,Stern DG,Pirson JL,Manfroid I,Peers B,Voz ML

更新日期：2013-04-15 00:00:00

abstract：:Retinoic acid (RA) plays a critical role in neural patterning and organogenesis in the vertebrate embryo. Here we characterize a mutant of the zebrafish named giraffe (gir) in which the gene for the RA-degrading enzyme Cyp26a1 is mutated. The gir mutant displayed patterning defects in multiple organs including the com...

journal_title：Developmental biology

authors： Emoto Y,Wada H,Okamoto H,Kudo A,Imai Y

更新日期：2005-02-15 00:00:00

abstract：:The germinal vesicle (GV) of starfish oocytes contains a factor which is required to drive the cytoplasmic cycle of the meiotic division. Biochemical investigation of this factor has been difficult due to the small quantities of obtainable GV materials. To overcome this, we have developed a mass-isolation procedure fo...

journal_title：Developmental biology

authors： Nemoto S,Yamamoto K,Hashimoto N

更新日期：1992-06-01 00:00:00

abstract：:Somatic gonadal niche cells control the survival, differentiation, and proliferation of germline stem cells. The establishment of this niche-stem cell relationship is critical, and yet the precursors to these two cell types are often born at a distance from one another. The simple Caenorhabditis elegans gonadal primor...

journal_title：Developmental biology

authors： Rohrschneider MR,Nance J

更新日期：2013-07-15 00:00:00

abstract：:Runx2-Cbfa1, a Runt transcription factor, plays important roles during skeletal development. It is required for differentiation and function of osteoblasts. In its absence, chondrocyte hypertrophy is severely impaired and there is no vascularization of cartilage templates during skeletal development. These tissue-spec...

journal_title：Developmental biology

authors： Wang W,Wang YG,Reginato AM,Glotzer DJ,Fukai N,Plotkina S,Karsenty G,Olsen BR

更新日期：2004-06-15 00:00:00

abstract：:Stimulation of epithelial cell cycling by the neuropeptide head activator was analyzed in Hydra magnipapillata and compared with the action of head activator on bud formation and tentacle formation during head regeneration. The results obtained indicate that head activator treatment stimulates epithelial cell division...

journal_title：Developmental biology

authors： Hobmayer B,Holstein TW,David CN

更新日期：1997-03-01 00:00:00

abstract：:The changes in the intracellular pH (pHi) of sea urchin sperm associated with motility initiation and acrosome reaction were investigated using uptake of two different probes; 9-aminoacridine and methylamine, as a qualitative index. Sperm suspended in Na+-free sea water were immotile and able to concentrate these amin...

journal_title：Developmental biology

authors： Lee HC,Johnson C,Epel D

更新日期：1983-01-01 00:00:00

abstract：:Paracrine signaling mediated by FGF-10 and the FGF-R2IIIb receptor is required for formation of the lung. To determine the temporal requirements for FGF signaling during pulmonary morphogenesis, Sprouty-4 (Spry-4), an intracellular FGF receptor antagonist, was expressed in epithelial cells of the fetal lung under cont...

journal_title：Developmental biology

authors： Perl AK,Hokuto I,Impagnatiello MA,Christofori G,Whitsett JA

更新日期：2003-06-01 00:00:00

abstract：:Mutations at the Drosophila melanogaster locus female sterile (1) homeotic (fs(1)h) result in segmental abnormalities including missing organs and homeotic transformations in the progeny of mutant mothers. Homeotic transformations are enhanced when the zygotes carry one of several third chromosome mutations, specifica...

journal_title：Developmental biology

authors： Digan ME,Haynes SR,Mozer BA,Dawid IB,Forquignon F,Gans M

更新日期：1986-03-01 00:00:00