Abstract：
:Mesenchymal-epithelial interactions are an important source of information for pattern formation during organogenesis. In the developing excretory system, one of the secreted mesenchymal factors thought to play a critical role in patterning the growth and branching of the epithelial ureteric bud is GDNF. We have tested the requirement for GDNF as a paracrine chemoattractive factor by altering its site of expression during excretory system development. Normally, GDNF is secreted by the metanephric mesenchyme and acts via receptors on the Wolffian duct and ureteric bud epithelium. Misexpression of GDNF in the Wolffian duct and ureteric buds resulted in formation of multiple, ectopic buds, which branched independently of the metanephric mesenchyme. This confirmed the ability of GDNF to induce ureter outgrowth and epithelial branching in vivo. However, in mutant mice lacking endogenous GDNF, kidney development was rescued to a substantial degree by GDNF supplied only by the Wolffian duct and ureteric bud. These results indicate that mesenchymal GDNF is not required as a chemoattractive factor to pattern the growth of the ureteric bud within the developing kidney, and that any positional information provided by the mesenchymal expression of GDNF may provide for renal branching morphogenesis is redundant with other signals.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Shakya R,Jho EH,Kotka P,Wu Z,Kholodilov N,Burke R,D'Agati V,Costantini Fdoi
10.1016/j.ydbio.2005.04.008subject
Has Abstractpub_date
2005-07-01 00:00:00pages
70-84issue
1eissn
0012-1606issn
1095-564Xpii
S0012-1606(05)00218-6journal_volume
283pub_type
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