Organoid technology for retinal repair.

abstract：:To determine whether spontaneous release of transmitter from the growth cones of neurons exhibits properties similar to the spontaneous release which occurs from the neurons at the neuromuscular junction, release of transmitter from the growth cones of Xenopus neurons in culture was monitored in salines containing var...

journal_title：Developmental biology

authors： Young SH

更新日期：1986-02-01 00:00:00

abstract：:Initial studies suggested that spatial organization of the putative polar body contractile ring was determined by the peripheral aster in Spisula [Biol. Bull. 205 (2003) 192]. Here we report detailed supporting observations, including testing of aster and ring function with inhibitors. The metaphase peripheral aster w...

journal_title：Developmental biology

authors： Pielak RM,Gaysinskaya VA,Cohen WD

更新日期：2004-05-15 00:00:00

abstract：:Septins are guanosine triphosphate-binding proteins that are evolutionally conserved in all eukaryotes other than plants. They function as multimeric complexes that interact with membrane lipids, actomyosin, and microtubules. Based on these interactions, septins play essential roles in the morphogenesis and physiologi...

journal_title：Developmental biology

authors： Torii H,Yoshida A,Katsuno T,Nakagawa T,Ito J,Omori K,Kinoshita M,Yamamoto N

更新日期：2016-11-15 00:00:00

abstract：:Growth factors and the extracellular matrix have been shown to fulfill vital developmental roles in many embryonic systems. Our hypothesis is that a developmental role played by the extracellular matrix in sea urchins may be the binding of a PDGF-like growth factor to promote signaling activity. We report here that an...

journal_title：Developmental biology

authors： Govindarajan V,Ramachandran RK,George JM,Shakes DC,Tomlinson CR

更新日期：1995-12-01 00:00:00

abstract：:Although communications between mammalian oocytes and their surrounding granulosa cells mediated by the Kit-Kit ligand (KL, or stem cell factor, SCF) system have been proven to be crucial for follicular development, Kit downstream signaling pathways in mammalian oocytes are largely unknown. In this study, by using ova...

journal_title：Developmental biology

authors： Reddy P,Shen L,Ren C,Boman K,Lundin E,Ottander U,Lindgren P,Liu YX,Sun QY,Liu K

更新日期：2005-05-15 00:00:00

abstract：:Rhodopsin is essential for normal photoreceptor development in Drosophila (O'Tousa et al., 1989; Leonard et al., 1992; Kumar and Ready, 1995) and in mice (Humphries et al., 1997). Here we report studies in which a rhodopsin transgene is expressed at restricted stages during the development of Drosophila photoreceptors...

journal_title：Developmental biology

authors： Kumar JP,Bowman J,O'Tousa JE,Ready DF

更新日期：1997-08-01 00:00:00

abstract：:Nuclear receptors (NRs) are a large class of ligand-regulated transcriptional modulators that have been shown to play roles in many developmental processes. The Caenorhabditis elegans genome is predicted to encode a large and divergent family of NR proteins. The functions of most of these genes are unknown. As a first...

journal_title：Developmental biology

authors： Miyabayashi T,Palfreyman MT,Sluder AE,Slack F,Sengupta P

更新日期：1999-11-15 00:00:00

abstract：:Morphogenesis of the cartilaginous otic capsule is directed by interactions between the epithelial anlage of the membranous labyrinth (otocyst) and its associated periotic mesenchyme. Utilizing a developmental series of high-density (micromass) cultures of periotic mesenchyme to model capsule chondrogenesis, we have s...

journal_title：Developmental biology

authors： Frenz DA,Van De Water TR

更新日期：1991-03-01 00:00:00

abstract：:This study reports a morphological, skeletal, and molecular characterization of the supernumerary limbs induced by systemic administration of all-trans retinoic acid to egg-cylinder stage mouse embryos. As initially described by Rutledge et al. (Proc. Natl. Acad. Sci. USA 91, 5436, 1994), we have found that oral admin...

journal_title：Developmental biology

authors： Niederreither K,Ward SJ,Dollé P,Chambon P

更新日期：1996-06-15 00:00:00

abstract：:We wish to identify genes involved in mediating early lineage decisions in the mouse embryo. F9 teratocarcinoma cells treated with retinoic acid (RA) in suspension culture develop into embryoid bodies (EBs) with an outer layer of visceral endoderm. In order to identify genes that are involved in establishing this extr...

journal_title：Developmental biology

authors： Labosky PA,Weir MP,Grabel LB

更新日期：1993-09-01 00:00:00

abstract：:Lumenogenesis of small seamless tubes occurs through intracellular membrane growth and directed vesicle fusion events. Within the Caenorhabditis elegans excretory cell, which forms seamless intracellular tubes (canals) that mediate osmoregulation, lumens grow in length and diameter when vesicles fuse with the expandin...

journal_title：Developmental biology

authors： Armenti ST,Chan E,Nance J

更新日期：2014-10-01 00:00:00

abstract：:pmar1 is a transcription factor in the paired class homeodomain family that was identified and found to be transcribed in micromeres beginning at the fourth cleavage of sea urchin development [Dev. Biol. 246 (2002), 209]. Based on in situ data, molecular perturbation studies, and QPCR data, the recently published gene...

journal_title：Developmental biology

authors： Oliveri P,Davidson EH,McClay DR

更新日期：2003-06-01 00:00:00

abstract：:Axon outgrowth between the spinal cord and the hindlimb of the chick embryo is constrained by three tissues that border axon pathways. Growth cones turn to avoid the posterior sclerotome, perinotochordal mesenchyme, and pelvic girdle precursor during normal development and after experimental manipulation. We wanted to...

journal_title：Developmental biology

authors： Oakley RA,Tosney KW

更新日期：1991-09-01 00:00:00

abstract：:The murine cpk mouse develops a rapid-onset polycystic kidney disease (PKD) with many similarities to human PKD. During kidney development, the transcription factor Pax2 is required for the specification and differentiation of the renal epithelium. In humans, Pax2 is also expressed in juvenile cystic kidneys where it ...

journal_title：Developmental biology

authors： Ostrom L,Tang MJ,Gruss P,Dressler GR

更新日期：2000-03-15 00:00:00

abstract：:In the retinotectal projection, the Eph receptor tyrosine kinase ligands ephrinA2 and ephrinA5 are differentially expressed not only in the tectum, but also in a high-nasal-to-low-temporal pattern in the retina. Recently, we have shown that retrovirally driven overexpression of ephrinA2 on retinal axons leads to topog...

journal_title：Developmental biology

authors： Dütting D,Handwerker C,Drescher U

更新日期：1999-12-01 00:00:00

abstract：:A key step in organogenesis of the Drosophila tracheal system is the integration of isolated tracheal metameres into a connected tubular network. The interaction of tracheal cells with surrounding mesodermal cells is crucial in this process. In particular, single mesodermal cells called bridge-cells are essential for ...

journal_title：Developmental biology

authors： Krause C,Wolf C,Hemphälä J,Samakovlis C,Schuh R

更新日期：2006-08-01 00:00:00

abstract：:FOG-2 is a multi-zinc finger protein that binds the transcriptional activator GATA4 and modulates GATA4-mediated regulation of target genes during heart development. Our previous work has demonstrated that the Nucleosome Remodeling and Deacetylase (NuRD) complex physically interacts with FOG-2 and is necessary for FOG...

journal_title：Developmental biology

authors： Garnatz AS,Gao Z,Broman M,Martens S,Earley JU,Svensson EC

更新日期：2014-11-01 00:00:00

abstract：:Meckel-Gruber syndrome (MKS) is an embryonic lethal ciliopathy resulting from mutations in genes encoding proteins localising to the primary cilium. Mutations in the basal body protein MKS1 account for 7% of cases of MKS. The condition affects the development of multiple organs, including brain, kidney and skeleton. H...

journal_title：Developmental biology

authors： Wheway G,Abdelhamed Z,Natarajan S,Toomes C,Inglehearn C,Johnson CA

更新日期：2013-05-01 00:00:00

abstract：:Two populations of blastomeres become positionally distinct during fourth cleavage in the mouse embryo; the inner cells become enclosed within the embryo and the outer cells form the enclosing layer. The segregation of these two cell populations is important for later development, because it represents the initial ste...

journal_title：Developmental biology

authors： Sutherland AE,Speed TP,Calarco PG

更新日期：1990-01-01 00:00:00

abstract：:The thyroid gland synthesizes thyroxine (T4), which passes through the larval tadpole's circulatory system. The enzyme type II iodothyronine deiodinase (D2) converts thyroxine (T4) to the active hormone 3,5,3'-triiodothyronine (T3) in peripheral tissues. An early response to thyroid hormone (TH) in the Xenopus laevis ...

journal_title：Developmental biology

authors： Cai L,Brown DD

更新日期：2004-02-01 00:00:00

abstract：:These studies were designed to test the hypothesis that sperm nuclear decondensation and male pronuclear formation during hamster fertilization depend upon the ability of the fertilized oocyte to reduce sperm nuclear disulfide bonds. In a first series of experiments, treatment of mature oocytes with the sulfhydryl blo...

journal_title：Developmental biology

authors： Perreault SD,Wolff RA,Zirkin BR

更新日期：1984-01-01 00:00:00

abstract：:The canonical, beta-catenin-dependent Wnt pathway is a crucial player in the early events of Xenopus development. Dorsal axis formation and mesoderm patterning are accepted effects of this pathway, but the regulation of expression of genes involved in mesoderm specification is not. This conclusion is based largely on ...

journal_title：Developmental biology

authors： Vonica A,Gumbiner BM

更新日期：2002-10-01 00:00:00

abstract：:This first study of the onset of spermatogenesis in the sea urchin, Strongylocentrotus purpuratus, was undertaken using individuals reared in the laboratory. Spermatogenesis commences about 11-12 months after metamorphosis in these animals. Bindin message accumulates in late spermatocytes and early spermatids which li...

journal_title：Developmental biology

authors： Cameron RA,Minor JE,Nishioka D,Britten RJ,Davidson EH

更新日期：1990-11-01 00:00:00

abstract：:Early embryonic cells are capable of acquiring numerous developmental fates until they become irreversibly committed to specific lineages depending on intrinsic determinants and/or regional interactions. From fertilization to gastrulation, such pluripotent cells first increase in number and then turn to undergoing dif...

journal_title：Developmental biology

authors： Nakanoh S,Agata K

更新日期：2019-08-15 00:00:00

abstract：:Activin is a potent inducer of axial mesoderm in vitro and may have a similar role in vivo. Xenopus laevis eggs contain significant amounts of activin or activin-like factors, but maternal activin transcripts have not been detected in Xenopus eggs. The maternal activin protein might be translated from activin beta A o...

journal_title：Developmental biology

authors： Rebagliati MR,Dawid IB

更新日期：1993-10-01 00:00:00

abstract：:Developmental boundaries ensure that cells fated to participate in a particular structure are brought together or maintained at the appropriate locale within developing embryos. Parasegment grooves mark the position of boundaries that separate every segment of the Drosophila embryo into anterior and posterior compartm...

journal_title：Developmental biology

authors： Larsen C,Bardet PL,Vincent JP,Alexandre C

更新日期：2008-09-15 00:00:00

abstract：:The role of the wound epithelium in amphibian limb regeneration is not understood. We showed previously that monoclonal antibody (mAb) WE3 stains the wound epithelium but not skin epidermis, suggesting that the WE3 antigen may be a marker for, or be important in, the function of the wound epithelium. In the present st...

journal_title：Developmental biology

authors： Goldhamer DJ,Tomlinson BL,Tassava RA

更新日期：1989-10-01 00:00:00

abstract：:VegT is an essential maternal regulator of germ layer specification in Xenopus. The localization of VegT mRNA to the vegetal cortex of the oocyte during oogenesis ensures its inheritance by vegetal and not animal cells, and directs the differentiation of vegetal cells into endoderm. Similarly localized mRNAs, Vg1 and ...

journal_title：Developmental biology

authors： Heasman J,Wessely O,Langland R,Craig EJ,Kessler DS

更新日期：2001-12-15 00:00:00

abstract：:The origin and development of mouse kidney vasculature were examined in chorioallantoic grafts of early kidney rudiments and of experimentally induced explants of separated metanephric mesenchymes. Whole kidney rudiments developed into advanced stages, expressed the segment-specific antigenic markers of tubules and th...

journal_title：Developmental biology

authors： Sariola H,Ekblom P,Lehtonen E,Saxén L

更新日期：1983-04-01 00:00:00

abstract：:Cloning and sequencing of Tripneustes gratilla genomic DNA and cDNA encoding a developmentally regulated, embryonic messenger RNA, referred to as Tg616, revealed an actin-encoding gene orthologous to the CyI actin gene described from Strongylocentrotus purpuratus. Tg616 and SpCyI share: (1) 150 nucleotides of highly c...

journal_title：Developmental biology

authors： Wang AV,Angerer LM,Dolecki GJ,Lum R,Wang GV,Carlos R,Angerer RC,Humphreys T

更新日期：1994-09-01 00:00:00