Locale and level of bindin mRNA in maturing testis of the sea urchin, Strongylocentrotus purpuratus.

abstract：:GATA4, a transcription factor expressed in the proximal small intestine but not in the distal ileum, maintains proximal-distal distinctions by multiple processes involving gene repression, gene activation, and cell fate determination. Friend of GATA (FOG) is an evolutionarily conserved family of cofactors whose member...

journal_title：Developmental biology

authors： Beuling E,Bosse T,aan de Kerk DJ,Piaseckyj CM,Fujiwara Y,Katz SG,Orkin SH,Grand RJ,Krasinski SD

更新日期：2008-10-01 00:00:00

abstract：:Hoxa-11 and Hoxd-11 are paralogous genes required for proper development of the vertebral column, the limbs, and the urogenital system. To further explore the functional relationship between these genes, as well as the potential rescue of one function by the other, we have introduced a Hoxd-11-expressing transgene int...

journal_title：Developmental biology

authors： Zákány J,Gérard M,Favier B,Potter SS,Duboule D

更新日期：1996-06-15 00:00:00

abstract：:Defects in heart development are the most common congenital abnormalities in humans, providing a strong incentive to learn more about the underlying causes. Previous studies have implicated the metalloprotease-disintegrins ADAMs (a disintegrin and metalloprotease) 17 and 19 as well as heparin binding EGF-like growth f...

journal_title：Developmental biology

authors： Horiuchi K,Zhou HM,Kelly K,Manova K,Blobel CP

更新日期：2005-07-15 00:00:00

abstract：:Mf1, which encodes a winged-helix/forkhead transcription factor, is the murine homolog of human FKHL7, mutated in individuals with autosomal dominant inherited dysgenesis of the anterior segment of the eye (Axenfeld-Reiger anomaly). Mouse embryos homozygous for null mutations in Mf1 (Mf1(lacZ) and Mf1(ch)) show severe...

journal_title：Developmental biology

authors： Kidson SH,Kume T,Deng K,Winfrey V,Hogan BL

更新日期：1999-07-15 00:00:00

abstract：:The germinal vesicle (GV) of starfish oocytes stays just beneath the oocyte cortex at the presumptive animal pole during the long period of oogenesis. We subjected oocytes to a centrifugal force field to detach the GV from the cortex. The association between the cortex and the GV persisted and withstood a small amount...

journal_title：Developmental biology

authors： Miyazaki A,Kamitsubo E,Nemoto SI

更新日期：2000-02-15 00:00:00

abstract：:Proper development of a multicellular organism relies on well-coordinated regulation of cell fate specification, cell proliferation and cell differentiation. The C. elegans postembryonic mesoderm provides a useful system for uncovering factors involved in these processes and for further dissecting their regulatory rel...

journal_title：Developmental biology

authors： Shen Q,Shi H,Tian C,Ghai V,Liu J

更新日期：2017-09-01 00:00:00

abstract：:Normal growth and morphogenesis of the cranial vault reflect a balance between cell proliferation in the sutures and osteogenesis at the margins of the cranial bones. In the clinical condition craniosynostosis, the sutures fuse prematurely as a result of precocious osteogenic differentiation and craniofacial malformat...

journal_title：Developmental biology

authors： Moore R,Ferretti P,Copp A,Thorogood P

更新日期：2002-03-01 00:00:00

abstract：:Fertilization-related sperm mitochondrial movement occurs at a rate comparable to other actin-myosin-driven movements and is inhibited by cytochalasin B and N-ethyl maleimide in Ascidia ceratodes sperm. F-actin was demonstrated in the tails and mitochondria using NBD-phallacidin fluorescence. Both actin and myosin wer...

journal_title：Developmental biology

authors： Lambert CC,Lambert G

更新日期：1984-12-01 00:00:00

abstract：:Maize leaves are divided into repeated longitudinal units consisting of vascular tissue, bundle sheath (BS), and mesophyll (M) cells. We have carried out a cell lineage analysis of these cell types using six spontaneous striping mutants of maize. We show that certain cell division patterns are preferentially utilized,...

journal_title：Developmental biology

authors： Langdale JA,Lane B,Freeling M,Nelson T

更新日期：1989-05-01 00:00:00

abstract：:The nuclear lamina is an extensive protein network that underlies the inner nuclear envelope. This network includes the LAP2-emerin-MAN1-domain (LEM-D) protein family, proteins that share an association with the chromatin binding protein Barrier-to-autointegration factor (BAF). Loss of individual LEM-D proteins causes...

journal_title：Developmental biology

authors： Barton LJ,Lovander KE,Pinto BS,Geyer PK

更新日期：2016-07-01 00:00:00

abstract：:In mammals, two spatially and temporally distinct waves of fiber cell differentiation are crucial steps for normal lens development. In between these phases, an anterior growth zone forms in which progenitor cells migrate circumferentially, terminally exit the cell cycle and initiate differentiation at the lens equato...

journal_title：Developmental biology

authors： Le TT,Conley KW,Brown NL

更新日期：2009-04-01 00:00:00

abstract：:Runx2-Cbfa1, a Runt transcription factor, plays important roles during skeletal development. It is required for differentiation and function of osteoblasts. In its absence, chondrocyte hypertrophy is severely impaired and there is no vascularization of cartilage templates during skeletal development. These tissue-spec...

journal_title：Developmental biology

authors： Wang W,Wang YG,Reginato AM,Glotzer DJ,Fukai N,Plotkina S,Karsenty G,Olsen BR

更新日期：2004-06-15 00:00:00

abstract：:This work has identified the enzymes involved in the activation and conjugation of the ubiquitin-like protein NED-8 in Caenorhabditis elegans. A C. elegans conjugating enzyme, UBC-12, is highly specific in its ability to utilize NED-8 as a substrate. Immunostaining shows that NED-8 is conjugated in vivo to a major tar...

journal_title：Developmental biology

authors： Jones D,Candido EP

更新日期：2000-10-01 00:00:00

abstract：:Egg yolk phosvitin is one of the most highly phosphorylated extracellular matrix proteins known in nature with unique physico-chemical properties deemed to be critical during ex-vivo egg embryo development. We have utilized our unique live mouse calvarial bone organ culture models under conditions which dissociates th...

journal_title：Developmental biology

authors： Liu J,Czernick D,Lin SC,Alasmari A,Serge D,Salih E

更新日期：2013-09-01 00:00:00

abstract：:The formation of endocardial endothelium in quail embryos was investigated using in vivo and in vitro systems. Based on the expression of an quail endothelial marker, QH-1, the initial emergence of endothelial precursor cells in the embryo occurs at stage 7+ (two somites) in the posterior parts of the bilateral heart ...

journal_title：Developmental biology

authors： Sugi Y,Markwald RR

更新日期：1996-04-10 00:00:00

abstract：:Neuropilin (previously known as the A5 protein) is a membrane protein identified in Xenopus and is presumed to be involved in the target recognition of the optic nerve fibers. We have isolated cDNAs encoding the chick homologue of neuropilin, using the Xenopus neuropilin cDNA as a hybridization probe. The predicted am...

journal_title：Developmental biology

authors： Takagi S,Kasuya Y,Shimizu M,Matsuura T,Tsuboi M,Kawakami A,Fujisawa H

更新日期：1995-07-01 00:00:00

abstract：:Early embryonic cells are capable of acquiring numerous developmental fates until they become irreversibly committed to specific lineages depending on intrinsic determinants and/or regional interactions. From fertilization to gastrulation, such pluripotent cells first increase in number and then turn to undergoing dif...

journal_title：Developmental biology

authors： Nakanoh S,Agata K

更新日期：2019-08-15 00:00:00

abstract：:The control of cell division is critical to organogenesis, but how this control is achieved is not fully understood. We found that mutations in bed-3, encoding a BED Zn-finger domain transcription factor, confer a phenotype where a specific set of cell divisions during vulval organogenesis is lost. Unlike general cell...

journal_title：Developmental biology

authors： Inoue T,Sternberg PW

更新日期：2010-02-15 00:00:00

abstract：:The s-SHIP protein is a shorter isoform of the longer SHIP1 protein and lacks the N-terminal SH2 domain region contained in SHIP1. s-SHIP is expressed in ES cells and in enriched bone marrow stem cells, and may be controlled by a promoter within intron 5 of the ship1 gene. We therefore examined the potential specifici...

journal_title：Developmental biology

authors： Rohrschneider LR,Custodio JM,Anderson TA,Miller CP,Gu H

更新日期：2005-07-15 00:00:00

abstract：:Treatment of metaphase II-arrested hamster eggs with activators of protein kinase C has been reported to promote resumption of the cell cycle, second polar body emission, and pronucleus formation (G.I. Gallicano, S.M. Schwarz, R.W. McGaughey, and D.G. Capco, 1993, Dev. Biol. 156, 94-106). In contrast, we have not obse...

journal_title：Developmental biology

authors： Moore GD,Kopf GS,Schultz RM

更新日期：1995-08-01 00:00:00

abstract：:The vertebrate pituitary gland is a key endocrine control organ that contains six distinct hormone secreting cell types. In this study, we analyzed the role of direct cell-to-cell Delta-Notch signaling in zebrafish anterior pituitary cell type specification. We demonstrate that initial formation of the anterior pituit...

journal_title：Developmental biology

authors： Dutta S,Dietrich JE,Westerfield M,Varga ZM

更新日期：2008-07-15 00:00:00

abstract：:Neuronal differentiation requires a coordinated intracellular response to diverse extracellular stimuli, but the role of specific signaling mechanisms in regulating this process is still poorly understood. Soluble guanylate cyclases (sGCs), which can be stimulated by diffusible free radical gasses such as nitric oxide...

journal_title：Developmental biology

authors： Wright JW,Schwinof KM,Snyder MA,Copenhaver PF

更新日期：1998-12-01 00:00:00

abstract：:The murine homeobox genes Msx-1 and Msx-2 are related to the Drosophila msh gene and are expressed in a variety of tissues during mouse embryogenesis. We now report the developmentally regulated expression of Msx-1 and Msx-2 in the mouse mammary gland and show that their expression patterns point toward significant fu...

journal_title：Developmental biology

authors： Friedmann Y,Daniel CW

更新日期：1996-07-10 00:00:00

abstract：:Lens growth involves the proliferation of epithelial cells, followed by their migration to the equator region and differentiation into secondary fiber cells. It is widely accepted that fibroblast growth factor (FGF) signaling is required for the differentiation of lens epithelial cells into crystallin-rich fibers, but...

journal_title：Developmental biology

authors： Song X,Sato Y,Felemban A,Ito A,Hossain M,Ochiai H,Yamamoto T,Sekiguchi K,Tanaka H,Ohta K

更新日期：2012-08-01 00:00:00

abstract：:The inactivation of the prolactin receptor gene by homologous recombination has made it possible to investigate the role of prolactin signaling in mammary gland development without resort to ablative surgery of the endocrine glands. In knockout mice lacking the prolactin receptor, mammary development is normal up to p...

journal_title：Developmental biology

authors： Brisken C,Kaur S,Chavarria TE,Binart N,Sutherland RL,Weinberg RA,Kelly PA,Ormandy CJ

更新日期：1999-06-01 00:00:00

abstract：:Myoblasts of the L6 rat cell line were grown in Ham's F12 nutrient medium containing 10% fetal calf serum (F12 + FCS). Although the cells were confluent by 6 days in culture, fusion was not observed even if cultures were maintained for 10-14 days. At least 80% of the cells in such confluent unfused cultures were in th...

journal_title：Developmental biology

authors： Pinset C,Whalen RG

更新日期：1984-04-01 00:00:00

abstract：:Connective tissue outgrowths of neonatal muscle onto a substratum of bone matrix differentiate into cartilage in response to a bone morphogenetic protein (BMP). The BMP can be separated from bone matrix by extraction with 4 M guanidine hydrochloride (GuHCl) or degraded in situ by endogenous proteolytic enzymes to deac...

journal_title：Developmental biology

authors： Kawamura M,Urist MR

更新日期：1988-12-01 00:00:00

abstract：:Three unrelated chromosome 2q14.1-14.2 region translocations caused the split hand/foot limb malformation development in humans by an unknown mechanism. Their etiology was described by the autosomal dominant inheritance with incomplete penetrance genetic model although authors stated, "the understanding of the genotyp...

journal_title：Developmental biology

authors： Klar AJ

更新日期：2015-12-01 00:00:00

abstract：:Vertebrate pigment cells are derived from neural crest, a tissue that also forms most of the peripheral nervous system and a variety of ectomesenchymal cell types. Formation of pigment cells from multipotential neural crest cells involves a number of common developmental processes. Pigment cells must be specified; the...

journal_title：Developmental biology

authors： Kelsh RN,Schmid B,Eisen JS

更新日期：2000-09-15 00:00:00

abstract：:During primary neurogenesis in Xenopus, a cascade of helix--loop--helix (HLH) transcription factors regulates neuronal determination and differentiation. While XNeuroD functions at a late step in this cascade to regulate neuronal differentiation, the factors that carry out terminal differentiation are still unknown. W...

journal_title：Developmental biology

authors： Pozzoli O,Bosetti A,Croci L,Consalez GG,Vetter ML

更新日期：2001-05-15 00:00:00