Vegetal localization of maternal mRNAs is disrupted by VegT depletion.

abstract：:Tyrosinase is the rate-limiting enzyme for the production of melanin pigmentation. In the mouse and other animals, homozygous null mutations in the Tyrosinase gene (Tyr) result in the absence of pigmentation, i.e. albinism. Here we used the CRISPR/Cas9 system to generate mono- and bi-allelic null mutations in the Tyr ...

journal_title：Developmental biology

authors： Yen ST,Zhang M,Deng JM,Usman SJ,Smith CN,Parker-Thornburg J,Swinton PG,Martin JF,Behringer RR

更新日期：2014-09-01 00:00:00

abstract：:Morphogenesis of the Drosophila tracheal system relies on different signalling pathways that have distinct roles in specifying both the migration of the tracheal cells and the particular morphological features of the primary branches. The current view is that the tracheal cells are initially specified as an equivalent...

journal_title：Developmental biology

authors： Franch-Marro X,Casanova J

更新日期：2002-10-15 00:00:00

abstract：:The subdivision of the developing field by region-specific expression of genes encoding transcription factors is an essential step during appendage development in arthropod and vertebrates. In Drosophila leg development, the distal-most region (pretarsus) is specified by the expression of homeobox genes, aristaless an...

journal_title：Developmental biology

authors： Kojima T,Tsuji T,Saigo K

更新日期：2005-03-15 00:00:00

abstract：:The monoclonal antibody HNK-1 was used to identify neural crest cells in serial sections of avian embryos to provide a detailed description of the distribution of trunk neural crest cells. The results indicate the presence of three migratory routes in the trunk: (1) a ventral pathway through the anterior sclerotome; (...

journal_title：Developmental biology

authors： Bronner-Fraser M

更新日期：1986-05-01 00:00:00

abstract：:Ovarian germ cell survival is dependent upon the formation of primordial follicles, which occurs during fetal life in the human. Activin contributes to germ cell proliferation and survival at this time. SMADs2 and 3 are central elements in the activin signalling pathway and thus indicate sites of activin action. We ha...

journal_title：Developmental biology

authors： Coutts SM,Childs AJ,Fulton N,Collins C,Bayne RA,McNeilly AS,Anderson RA

更新日期：2008-02-01 00:00:00

abstract：:We have tested the role of proteoglycans in the development of feather pattern by culturing 7-day-old embryonic chick skins on medium containing para-nitrophenyl-beta-D-xyloside (2 mM). Xylosides compete with core proteins of proteoglycans by acting as exogenous acceptors for the synthesis of glycosaminoglycans leadin...

journal_title：Developmental biology

authors： Goetinck PF,Carlone DL

更新日期：1988-05-01 00:00:00

abstract：:Metazoan replication-dependent histone mRNAs accumulate to high levels during S phase as a result of an increase in the rate of histone gene transcription, pre-mRNA processing, and mRNA stability at the G1-S transition. However, relatively little is known about the contribution of these processes to histone expression...

journal_title：Developmental biology

authors： Lanzotti DJ,Kupsco JM,Marzluff WF,Duronio RJ

更新日期：2004-10-01 00:00:00

abstract：:Insulin-producing beta-cells are present as single cells or in small clusters distributed throughout the pancreas of the Xenopus laevis tadpole. During metamorphic climax when the exocrine pancreas dedifferentiates to progenitor cells, the beta-cells undergo two changes. Insulin mRNA is down regulated at the beginning...

journal_title：Developmental biology

authors： Mukhi S,Horb ME,Brown DD

更新日期：2009-04-15 00:00:00

abstract：:Spermatogonia are adult germline stem cells that can both self-renew and differentiate into spermatocytes. Little is known about factors necessary for spermatogonial differentiation. We identified a novel germ-cell-specific transcription factor that we named Sohlh1 (testis and ovary expressed basic helix-loop-helix (b...

journal_title：Developmental biology

authors： Ballow D,Meistrich ML,Matzuk M,Rajkovic A

更新日期：2006-06-01 00:00:00

abstract：:Distinct groups of dopaminergic neurons develop at defined anatomical sites in the brain to modulate function of a large diversity of local and far-ranging circuits. However, the molecular identity as judged from transcription factor expression has not been determined for all dopaminergic groups. Here, we analyze regi...

journal_title：Developmental biology

authors： Filippi A,Jainok C,Driever W

更新日期：2012-09-01 00:00:00

abstract：:Metamorphosis is a postembryonic developmental process that involves morphophysiological and behavioral changes, allowing organisms to adapt into a novel environment. In some amphibians, aquatic organisms undergo metamorphosis to adapt in a terrestrial environment. In this process, these organisms experience major cha...

journal_title：Developmental biology

authors： Palacios-Martinez J,Caballero-Perez J,Espinal-Centeno A,Marquez-Chavoya G,Lomeli H,Salas-Vidal E,Schnabel D,Chimal-Monroy J,Cruz-Ramirez A

更新日期：2020-10-01 00:00:00

abstract：:NK genes are related pan-metazoan homeobox genes. In the fruitfly, NK genes are clustered and involved in patterning various mesodermal derivatives during embryogenesis. It was therefore suggested that the NK cluster emerged in evolution as an ancestral mesodermal patterning cluster. To test this hypothesis, we cloned...

journal_title：Developmental biology

authors： Saudemont A,Dray N,Hudry B,Le Gouar M,Vervoort M,Balavoine G

更新日期：2008-05-15 00:00:00

abstract：:Three different null alleles of the myogenic bHLH gene MRF4/herculin/Myf-6 were created recently. The three alleles were similar in design but were surprisingly different in the intensity of their phenotypes, which ranged from complete viability of homozygotes to complete lethality. One possible explanation for these ...

journal_title：Developmental biology

authors： Yoon JK,Olson EN,Arnold HH,Wold BJ

更新日期：1997-08-15 00:00:00

abstract：:Mutations in the NF1 gene may cause developmental abnormalities and the formation of a variety of tumors of neural crest origin in humans. The NF1 gene codes for a large protein, neurofibromin (nf), which is structurally and functionally related to yeast and human ras-GTPase-activating proteins (ras-GAPs). Recently, t...

journal_title：Developmental biology

authors： Huynh DP,Nechiporuk T,Pulst SM

更新日期：1994-02-01 00:00:00

abstract：:In adult vertebrates, fibroblast growth factor (FGF) synergizes with many hematopoietic cytokines to stimulate the proliferation of hematopoietic progenitors. In vertebrate development, the FGF signaling pathway is important in the formation of some derivatives of ventroposterior mesoderm. However, the function of FGF...

journal_title：Developmental biology

authors： Xu RH,Ault KT,Kim J,Park MJ,Hwang YS,Peng Y,Sredni D,Kung Hf

更新日期：1999-04-15 00:00:00

abstract：:In the spawned Xenopus egg, germ plasm is found as cytoplasmic islands spread over a wide cortical region of the vegetal pole. However, by the blastula stage, the same material is found concentrated into a few large blastomeres at the floor of the blastocoel. Components of the germ plasm can be specifically labeled wi...

journal_title：Developmental biology

authors： Savage RM,Danilchik MV

更新日期：1993-06-01 00:00:00

abstract：:In the deuterostomes and ecdysozoans that have been studied (e.g. chordates and insects), neural fate specification relies on signaling from surrounding cells. However, very little is known about mechanisms of neural specification in the third major bilaterian clade, spiralians. Using blastomere isolation in the annel...

journal_title：Developmental biology

authors： Carrillo-Baltodano AM,Meyer NP

更新日期：2017-11-15 00:00:00

abstract：:This study reports a morphological, skeletal, and molecular characterization of the supernumerary limbs induced by systemic administration of all-trans retinoic acid to egg-cylinder stage mouse embryos. As initially described by Rutledge et al. (Proc. Natl. Acad. Sci. USA 91, 5436, 1994), we have found that oral admin...

journal_title：Developmental biology

authors： Niederreither K,Ward SJ,Dollé P,Chambon P

更新日期：1996-06-15 00:00:00

abstract：:The role of retinoic acid (RA) in limb development is unclear, although it has been suggested to be a proximalizing factor which plays a morphogenetic role in pattern formation. Exogenous RA produces a teratogenic effect on limb morphology; similarly, changes in the endogenous distribution of RA following genetic abla...

journal_title：Developmental biology

authors： Pennimpede T,Cameron DA,MacLean GA,Petkovich M

更新日期：2010-03-01 00:00:00

abstract：:Limb buds in the limbless chick begin to form normally but fail to form an AER and ultimately degenerate. Wnt7a and LMX-1, which are restricted to the dorsal half of a normal limb bud, are expressed throughout the ectoderm and mesenchyme of the mutant buds, respectively. Engrailed-1, normally expressed in ventral limb...

journal_title：Developmental biology

authors： Noramly S,Pisenti J,Abbott U,Morgan B

更新日期：1996-11-01 00:00:00

abstract：:Nanos is a translational regulator required for the survival and maintenance of primordial germ cells during embryogenesis. Three nanos homologs are present in the genome of the sea urchin Strongylocentrotus purpuratus (Sp), and each nanos mRNA accumulates specifically in the small micromere (sMic) lineage. We found t...

journal_title：Developmental biology

authors： Oulhen N,Yoshida T,Yajima M,Song JL,Sakuma T,Sakamoto N,Yamamoto T,Wessel GM

更新日期：2013-05-01 00:00:00

abstract：:Extraocular muscles (EOM) represent a unique muscle group that controls eye movements and originates from head mesoderm, while the more typically studied body and limb muscles are somite-derived. Aiming to investigate myogenic progenitors (satellite cells) in EOM versus limb and diaphragm of adult mice, we have been u...

journal_title：Developmental biology

authors： Stuelsatz P,Shearer A,Yablonka-Reuveni Z

更新日期：2014-01-15 00:00:00

abstract：:Insulin-like growth factor-1 (IGF-1) is believed to play a role in the regulation of brain growth. The identity of cells responsible for its synthesis in the immature brain, however, has not been established. To identify potential sites of IGF-1 synthesis, in situ hybridization has been utilized to localize IGF-1 mRNA...

journal_title：Developmental biology

authors： Bartlett WP,Li XS,Williams M,Benkovic S

更新日期：1991-09-01 00:00:00

abstract：:Polychaete annelids and arthropods are both segmented protostome invertebrates. To investigate whether the segmented body plan of these two phyla share a common molecular ground pattern, we report the developmental expression of orthologues of the arthropod segment polarity genes engrailed (en), hedgehog (hh), and win...

journal_title：Developmental biology

authors： Seaver EC,Kaneshige LM

更新日期：2006-01-01 00:00:00

abstract：:Primitive blood constitutes the ventralmost mesoderm in amphibians, and its cleavage-stage origin reveals important clues about the orientation of the dorsal/ventral axis in the embryo. In recent years, investigators employing various lineage-labeling strategies have reported disparate results for the origin of primit...

journal_title：Developmental biology

authors： Lane MC,Sheets MD

更新日期：2002-08-01 00:00:00

abstract：:It is known that secreted proteins from the anterior lateral endoderm, FGF8 and BMP2, are involved in mesodermal cardiac differentiation, which determines the first cardiac field, defined by the expression of the earliest specific cardiac markers Nkx-2.5 and Gata4. However, the molecular mechanisms responsible for ear...

journal_title：Developmental biology

authors： Lopez-Sanchez C,Franco D,Bonet F,Garcia-Lopez V,Aranega A,Garcia-Martinez V

更新日期：2015-10-01 00:00:00

abstract：:This study evaluated Na/K-ATPase alpha 1- and alpha 3-subunit isoform polypeptide expression and localization during bovine preattachment development. Na/K-ATPase cation transport activity from the one-cell to blastocyst stage was also determined by measuring ouabain-sensitive 86Rb+ uptake. Both alpha1- and alpha 3-su...

journal_title：Developmental biology

authors： Betts DH,Barcroft LC,Watson AJ

更新日期：1998-05-01 00:00:00

abstract：:Cell-cell fusion is a fundamental cellular process that is essential for development as well as fertilization. Myoblast fusion to form multinucleated skeletal muscle myotubes is a well studied, yet incompletely understood example of cell-cell fusion that is essential for formation of contractile skeletal muscle tissue...

journal_title：Developmental biology

authors： Duan R,Gallagher PJ

更新日期：2009-01-15 00:00:00

abstract：:Proper patterning and growth of oral structures including teeth, tongue, and palate rely on epithelial-mesenchymal interactions involving coordinated regulation of signal transduction. Understanding molecular mechanisms underpinning oral-facial development will provide novel insights into the etiology of common congen...

journal_title：Developmental biology

authors： Lin C,Fisher AV,Yin Y,Maruyama T,Veith GM,Dhandha M,Huang GJ,Hsu W,Ma L

更新日期：2011-08-01 00:00:00

abstract：:The ciliated band of the Strongylocentrotus purpuratus embryo consists of a columnar epithelium, 3-5 cells wide, which gives rise to a small number of neuroblasts. It arises late in development, as a border separating the squamous epithelial cells of the oral and aboral ectoderm. To determine the lineage origins of th...

journal_title：Developmental biology

authors： Cameron RA,Britten RJ,Davidson EH

更新日期：1993-12-01 00:00:00