Rhodopsin replacement rescues photoreceptor structure during a critical developmental window.

abstract：:Procedures are described for removal of the vitelline membrane from gently fixed Drosophila embryos en masse. The resulting embryos retain excellent structural integrity and are now suitable for a variety of immunocytochemical and biochemical characterizations. ...

journal_title：Developmental biology

authors： Mitchison TJ,Sedat J

更新日期：1983-09-01 00:00:00

abstract：:Multipotent, self-renewing neural stem cells reside in the embryonic mouse telencephalic germinal zone. Using an in vitro neurosphere assay for neural stem cell proliferation, we demonstrate that FGF-responsive neural stem cells are present as early as E8.5 in the anterior neural plate, but EGF-responsive neural stem ...

journal_title：Developmental biology

authors： Tropepe V,Sibilia M,Ciruna BG,Rossant J,Wagner EF,van der Kooy D

更新日期：1999-04-01 00:00:00

abstract：:The embryonic cell lineage of Caenorhabditis elegans has been traced from zygote to newly hatched larva, with the result that the entire cell lineage of this organism is now known. During embryogenesis 671 cells are generated; in the hermaphrodite 113 of these (in the male 111) undergo programmed death and the remaind...

journal_title：Developmental biology

authors： Sulston JE,Schierenberg E,White JG,Thomson JN

更新日期：1983-11-01 00:00:00

abstract：:The cDNA encoding the TATA binding protein was isolated from 8- to 16-cell and morula-stage embryonic libraries of two distantly related species of sea urchin, Strongylocentrotus purpuratus and Lytechinus variegatus, respectively. The two proteins are 96% identical over both the N- and C-terminal domains, suggesting a...

journal_title：Developmental biology

authors： Edelmann L,Zheng L,Wang ZF,Marzluff W,Wessel GM,Childs G

更新日期：1998-12-01 00:00:00

abstract：:Notch pathway is crucial for stem/progenitor cell maintenance, growth and differentiation in a variety of tissues. Using a transgenic cell ablation approach, we found in our previous study that cells expressing Notch1 are crucial for prostate early development and re-growth. Here, we further define the role of Notch s...

journal_title：Developmental biology

authors： Wang XD,Leow CC,Zha J,Tang Z,Modrusan Z,Radtke F,Aguet M,de Sauvage FJ,Gao WQ

更新日期：2006-02-01 00:00:00

abstract：:In the marine bivalve Hiatella flaccida, full-grown oocytes in ovaries are arrested at the first prophase (prophase-I) of meiosis, whereas spawned oocytes have reinitiated meiosis from prophase-I and are again arrested at the first metaphase (metaphase-I). The neurohormone serotonin (5-hydroxytryptamine, 5-HT) was abl...

journal_title：Developmental biology

authors： Deguchi R,Osanai K

更新日期：1995-10-01 00:00:00

abstract：:Gr16 (chromosome 2, 6.9 cM) is a dominant, grey egg mutation of the domestic silkmoth, Bombyx mori, which produces an opaque instead of a translucent chorion. To determine the underlying cause of this defect, we examined the effects of the mutation on chorion ultrastructure, protein accumulation, and biosynthesis patt...

journal_title：Developmental biology

authors： Gautreau D,Zetlan SR,Mazur GD,Goldsmith MR

更新日期：1993-05-01 00:00:00

abstract：:The nervous system development of the sea cucumber Stichopus japonicus was investigated to explore the development of the bilateral larval nervous system into the pentaradial adult form typical of echinoderms. The first nerve cells were detected in the apical region of epidermis in the late gastrula. In the auriculari...

journal_title：Developmental biology

authors： Nakano H,Murabe N,Amemiya S,Nakajima Y

更新日期：2006-04-01 00:00:00

abstract：:A fundamental feature of cartilage differentiation in the developing limb is the formation of a prechondrogenic cell condensation. An apparently similar process of prechondrogenic cell aggregation occurs in micromass cultures of limb bud mesenchyme with the formation of cellular aggregates which often differentiate in...

journal_title：Developmental biology

authors： Cottrill CP,Archer CW,Wolpert L

更新日期：1987-08-01 00:00:00

abstract：:To understand mechanisms of sex determination, it is important to know the lineage relationships of cells comprising the gonads. For example, in mice, the Y-linked gene Sry triggers differentiation of Sertoli cells from a cell population originating in the coelomic epithelium overlying the nascent gonad that also give...

journal_title：Developmental biology

authors： Sekido R,Lovell-Badge R

更新日期：2007-02-01 00:00:00

abstract：:Cell division is arguably the most fundamental developmental process for single-celled and multicellular organisms alike. The pathway from one cell division to the next is known as the cell cycle. A conserved biochemical regulatory network controls progress along this pathway in plants, animals, and yeasts. This revie...

journal_title：Developmental biology

authors： Jacobs T

更新日期：1992-09-01 00:00:00

abstract：:Dictyostelium discoideum is a simple eukaryote that lives as an amoeba until starvation triggers aggregation. The aggregate forms a slug which then develops into a fruiting body with two main cell types, stalk and spore cells. Two mechanisms have been proposed to explain cell-type differentiation. Studies using expres...

journal_title：Developmental biology

authors： Clay JL,Ammann RR,Gomer RH

更新日期：1995-12-01 00:00:00

abstract：:Synapse elimination was examined in the developing frog cutaneous pectoris muscle using histological and electrophysiological techniques. Morphological synapse elimination occurred in two phases. The first phase, which began at the time of metamorphosis and continued until the second to third postmetamorphic week, was...

journal_title：Developmental biology

authors： Morrison-Graham K

更新日期：1983-10-01 00:00:00

abstract：:One function of the Wingless signaling pathway is to determine the naked, cuticle cell fate choice in the trunk epidermis of Drosophila larvae. The zinc finger protein Teashirt binds to the transactivator domain of Armadillo to modulate Wingless signaling output in the embryonic trunk and contributes to the naked cell...

journal_title：Developmental biology

authors： Angelats C,Gallet A,Thérond P,Fasano L,Kerridge S

更新日期：2002-01-01 00:00:00

abstract：:Tube formation is a widespread process during organogenesis. Specific cellular behaviors participate in the invagination of epithelial monolayers that form tubes. However, little is known about the evolutionary mechanisms of cell assembly into tubes during development. In Caenorhabditis elegans, the detailed step-to-s...

journal_title：Developmental biology

authors： Kolotuev I,Podbilewicz B

更新日期：2004-02-15 00:00:00

abstract：:The development of the Drosophila leg is a good model to study processes of pattern formation, cell death and segmentation. Such processes require the coordinate activity of different genes and signaling pathways that progressively subdivide the leg territory into smaller domains. One of the main pathways needed for l...

journal_title：Developmental biology

authors： Guarner A,Manjón C,Edwards K,Steller H,Suzanne M,Sánchez-Herrero E

更新日期：2014-01-15 00:00:00

abstract：:The Xenopus helix-loop-helix transcription factor Hairy2 is essential for neural crest progenitor survival and maintains cells in a mitotic undifferentiated pre-neural crest state. However, its mode of action remains largely unknown. Here we show that a Hairy2 DNA-binding mutant is unable to promote cell survival and ...

journal_title：Developmental biology

authors： Nichane M,Ren X,Souopgui J,Bellefroid EJ

更新日期：2008-10-15 00:00:00

abstract：:A small number of signaling pathways are used repeatedly during organogenesis, and they can have drastically different effects on the same population of cells depending on the embryonic stage. How cellular competence changes over developmental time is not well understood. Here we used Xenopus, mouse, and human pluripo...

journal_title：Developmental biology

authors： Rankin SA,McCracken KW,Luedeke DM,Han L,Wells JM,Shannon JM,Zorn AM

更新日期：2018-02-01 00:00:00

abstract：:Cellular dedifferentiation underlies topical issues in biology such as regeneration and nuclear cloning and has common features in plants and animals. In plants, this process characterizes the transition of differentiated leaf cells to protoplasts (plant cells devoid of cell walls) and is accompanied by global chromat...

journal_title：Developmental biology

authors： Grafi G,Ben-Meir H,Avivi Y,Moshe M,Dahan Y,Zemach A

更新日期：2007-06-15 00:00:00

abstract：:Suppression of wing fate and specification of haltere fate in Drosophila by the homeotic gene Ultrabithorax is a classical example of Hox regulation of serial homology (Lewis, E.B. 1978. Nature 276, 565-570) and has served as a paradigm for understanding homeotic gene function. We have used DNA microarray analyses to ...

journal_title：Developmental biology

authors： Mohit P,Makhijani K,Madhavi MB,Bharathi V,Lal A,Sirdesai G,Reddy VR,Ramesh P,Kannan R,Dhawan J,Shashidhara LS

更新日期：2006-03-15 00:00:00

abstract：:The developing chick limb bud contains several stage-specific populations of muscle colony-forming (MCF) cells. The cell lineage relationships of these populations are not completely understood, but previous studies have suggested that there may be at least two myogenic precursor populations present in the limb bud. T...

journal_title：Developmental biology

authors： Seed J,Hauschka SD

更新日期：1984-12-01 00:00:00

abstract：:Directed cell movement is integral to both embryogenesis and hematopoiesis. In the adult, the chemokine family of secreted proteins signals migration of hematopoietic cells through G-coupled chemokine receptors. We detected embryonic expression of chemokine receptor messages by RT-PCR with degenerate primers at embryo...

journal_title：Developmental biology

authors： McGrath KE,Koniski AD,Maltby KM,McGann JK,Palis J

更新日期：1999-09-15 00:00:00

abstract：:Autoradiography has been used to confirm and to extend previous microspectrophotometric studies (Doerder and DeBault, 1975) on the timing of DNA synthesis during conjugation in Tetrahymena thermophila. The majority of DNA synthesis occurs at the expected periods preceding gamete formation and the two postzygotic divis...

journal_title：Developmental biology

authors： Allis CD,Colavito-Shepanski M,Gorovsky MA

更新日期：1987-12-01 00:00:00

abstract：:The colonial tunicate Botrylloides leachi can regenerate functional adults from minute vasculature fragments, in a poorly understood phenomenon termed Whole Body Regeneration (WBR). Using Piwi expression (Bl-Piwi), blood cell labeling and electron microscopy, we show that WBR develops through activation, mobilization ...

journal_title：Developmental biology

authors： Rinkevich Y,Rosner A,Rabinowitz C,Lapidot Z,Moiseeva E,Rinkevich B

更新日期：2010-09-01 00:00:00

abstract：:In embryos of Patella vulgata at the 32-cell stage, one of the four vegetally located macromeres makes contacts with overlying animal micromeres. As a result, this macromere (designated 3D) divides significantly later than the other macromeres and forms the mesodermal stem cell 4d. Shortly before and during this inter...

journal_title：Developmental biology

authors： Kühtreiber WM,van Dongen CA

更新日期：1989-04-01 00:00:00

abstract：:TGF-beta (TGFβ) family mediated Smad signaling is involved in mesoderm and endoderm specifications, left-right asymmetry formation and neural tube development. The TGFβ1/2/3 and Activin/Nodal signal transduction cascades culminate with activation of SMAD2 and/or SMAD3 transcription factors and their overactivation are...

journal_title：Developmental biology

authors： Casari A,Schiavone M,Facchinello N,Vettori A,Meyer D,Tiso N,Moro E,Argenton F

更新日期：2014-12-01 00:00:00

abstract：:Vertebrate pigment cells are derived from neural crest, a tissue that also forms most of the peripheral nervous system and a variety of ectomesenchymal cell types. Formation of pigment cells from multipotential neural crest cells involves a number of common developmental processes. Pigment cells must be specified; the...

journal_title：Developmental biology

authors： Kelsh RN,Schmid B,Eisen JS

更新日期：2000-09-15 00:00:00

abstract：:The heart is the first organ to form and function in the vertebrate embryo. Furthermore, differences between the left and right sides of the embryo become first detectable during cardiac development. We observed strong cardiac laterality phenotypes in medaka embryos by manipulating Groucho protein activity. The phenot...

journal_title：Developmental biology

authors： Bajoghli B,Aghaallaei N,Soroldoni D,Czerny T

更新日期：2007-03-01 00:00:00

abstract：:Cell-cell fusion is a fundamental cellular process that is essential for development as well as fertilization. Myoblast fusion to form multinucleated skeletal muscle myotubes is a well studied, yet incompletely understood example of cell-cell fusion that is essential for formation of contractile skeletal muscle tissue...

journal_title：Developmental biology

authors： Duan R,Gallagher PJ

更新日期：2009-01-15 00:00:00

abstract：:The dysgenetic lens (dyl) mouse mutant has mutations in Foxe3, which inactivate DNA binding by the encoded forkhead transcription factor. Here we confirm, by targeted inactivation, that Foxe3 mutations are responsible for the dyl phenotype, which include loss of lens epithelium; a small, cataractic lens; and failure o...

journal_title：Developmental biology

authors： Blixt A,Landgren H,Johansson BR,Carlsson P

更新日期：2007-02-01 00:00:00