Abstract:
:The earliest muscle in zebrafish arises from iterated sets of two to six cells in each somite, the muscle pioneers (MP). MP develop synchronously in young trunk myotomes adjacent to the notochord, precisely where the horizontal myoseptum will form. They elongate without cell fusion and differentiate hours earlier than surrounding cells, thus providing a simple and accessible system for in vivo study of myogenesis and muscle patterning. Before the MP form definitive myofibrils they assemble long bundles of actin-containing filaments, similar to "stress-fiber-like structures" reported by others. In fub-1 mutants, in which myofibrils are disorganized in all skeletal muscle cells, the MP appear and elongate normally, but ordered actin filament bundles are not seen. This defect could underlie the later myofibrillar ones, consistent with the proposal that actin filament bundles are essential for proper formation of the muscle contractile apparatus.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Felsenfeld AL,Curry M,Kimmel CBdoi
10.1016/0012-1606(91)90314-ssubject
Has Abstractpub_date
1991-11-01 00:00:00pages
23-30issue
1eissn
0012-1606issn
1095-564Xpii
0012-1606(91)90314-Sjournal_volume
148pub_type
杂志文章abstract::Polyspermic Xenopus laevis eggs can be identified easily because of regions of pigment accumulation and white stripes, which arise by a nocodazole-sensitive process. Eggs containing up to four sperm are capable of forming a single embryonic axis. Dispermic eggs display two regions of pigment accumulation, one around e...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90262-9
更新日期:1986-06-01 00:00:00
abstract::During endochondral bone formation, vascular invasion initiates the replacement of avascular cartilage by bone. We demonstrate herein that the cartilage-specific overexpression of VEGF-A(164) in mice results in the hypervascularization of soft connective tissues away from cartilage. Unexpectedly, perichondrial tissue ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.05.552
更新日期:2009-08-15 00:00:00
abstract::Normal growth and morphogenesis of the cranial vault reflect a balance between cell proliferation in the sutures and osteogenesis at the margins of the cranial bones. In the clinical condition craniosynostosis, the sutures fuse prematurely as a result of precocious osteogenic differentiation and craniofacial malformat...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2001.0533
更新日期:2002-03-01 00:00:00
abstract::The Drosophila brain is generated by a complex series of morphogenetic movements. To better understand brain development and to provide a guide for experimental manipulation of brain progenitors, we created a fate map using photoactivated gene expression to mark cells originating within specific mitotic domains and ti...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(03)00220-3
更新日期:2003-08-01 00:00:00
abstract::The Egr family of zinc-finger transcription factors, consisting of Egr1, Egr2, Egr3, and Egr4, are involved in cellular growth and differentiation. Adult Egr3-deficient mice are ataxic and lack muscle spindle proprioceptors that normally develop at the sites of Ia afferent-myotube contacts during embryogenesis. To res...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2001.0202
更新日期:2001-04-15 00:00:00
abstract::The olfactory epithelium (OE) of the mouse provides a unique system for understanding how cell birth and cell death interact to regulate neuron number during development and regeneration. We have examined cell death in the OE in normal adult mice; in adult mice subjected to unilateral olfactory bulbectomy (surgical re...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1995.0025
更新日期:1995-11-01 00:00:00
abstract::The eyes absent (eya) gene plays an essential role in the events that lead to formation of the Drosophila eye; without expression of eya in retinal progenitor cells, they undergo programmed cell death just prior to the morphogenetic furrow, leading to an eyeless or reduced eye phenotype. The eya gene has recently been...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1997.8845
更新日期:1998-04-01 00:00:00
abstract::Mitogen-activated protein kinases (MAPKs) are important regulators of many cellular processes. In mammalian testes, these kinases are involved in controlling cell division, differentiation, survival and death, and are therefore critical to spermatogenesis. Recent studies have also illustrated their involvement in junc...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2005.08.001
更新日期:2005-10-01 00:00:00
abstract::Pole cell formation in embryos of the parthenogenetic midge, Smittia sp., can be delayed or inhibited by irradiation of the posterior egg pole with ultraviolet light (uv). This leaves the schedule of nuclear divisions and chromosome eliminations virtually unaffected. However, uv irradiation delays the precocious migra...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(83)90236-1
更新日期:1983-12-01 00:00:00
abstract::Aurora A is a mitotic kinase essential for cell proliferation. In mice, ablation of Aurora A results in mitotic arrest and pre-implantation lethality, preventing studies at later stages of development. Here we report the effects of Aurora A ablation on embryo patterning at early post-implantation stages. Inactivation ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2012.08.010
更新日期:2012-11-01 00:00:00
abstract::Gene network analysis requires computationally based models which represent the functional architecture of regulatory interactions, and which provide directly testable predictions. The type of model that is useful is constrained by the particular features of developmentally active cis-regulatory systems. These systems...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1006/dbio.2002.0617
更新日期:2002-06-01 00:00:00
abstract::Rex1 (Zfp42), GeneID 132625, is a gene whose expression is closely associated with pluripotency/multipotency in both mouse and human embryonic stem cells. To study the function of the murine Rex1 gene in vivo, we have used cre/lox technology to create Rex1(floxed) mice and mice deficient in Rex1 gene function. Rex1(-/...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2011.05.664
更新日期:2011-08-15 00:00:00
abstract::The vertebral column is derived from somites, which are transient segments of the paraxial mesoderm that are present in developing vertebrates. The strict spatial and temporal regulation of somitogenesis is of crucial developmental importance. Signals such as Wnt and FGF play roles in somitogenesis, but details regard...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.12.034
更新日期:2007-04-15 00:00:00
abstract::Proper development of a multicellular organism relies on well-coordinated regulation of cell fate specification, cell proliferation and cell differentiation. The C. elegans postembryonic mesoderm provides a useful system for uncovering factors involved in these processes and for further dissecting their regulatory rel...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2017.06.011
更新日期:2017-09-01 00:00:00
abstract::Treatment of metaphase II-arrested hamster eggs with activators of protein kinase C has been reported to promote resumption of the cell cycle, second polar body emission, and pronucleus formation (G.I. Gallicano, S.M. Schwarz, R.W. McGaughey, and D.G. Capco, 1993, Dev. Biol. 156, 94-106). In contrast, we have not obse...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1995.1233
更新日期:1995-08-01 00:00:00
abstract::I report on the synthesis of fibronectin in the developing chick Müllerian duct mesenchymal cells. Before the differentiation of female chick Müllerian duct, the amount of fibronectin in the cells of the right duct is 44% lower than in the left duct. While after differentiation, the amount of fibronectin in the right ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(90)90047-m
更新日期:1990-07-01 00:00:00
abstract::Monoclonal antibodies (mAbs), electrophoresis, immunoblotting, and immunohistochemistry were used to determine the molecular properties of cardiac myosin heavy chain (MHC) isoforms and the regions of the developing chicken heart in which they were expressed. Adult atria expressed three electrophoretically distinct MHC...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(88)90324-7
更新日期:1988-06-01 00:00:00
abstract::The processes of myelination remain incompletely understood but are of profound biomedical importance owing to the several dysmyelinating and demyelinating disorders known in humans. Here, we analyze the zebrafish puma mutant, isolated originally for pigment pattern defects limited to the adult stage. We show that pum...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2010.07.035
更新日期:2010-10-15 00:00:00
abstract::The levels of al-1 and al-2 transcripts change dramatically in response to light and development during the formation of Neurospora crassa asexual spores (conidia). al-1 and al-2 mRNAs accumulate throughout conidiation irrespective of lighting conditions initially at low levels. As conidiation proceeds, two increases ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1995.1129
更新日期:1995-05-01 00:00:00
abstract::Three dominant second-chromosome rearrangement mutations in Drosophila melanogaster, Aristapedioid1 (Arp), vestigial-Depilate (vgD), and vestigial62 (vg62), result in developmental abnormalities of the bristle sense organs on the notum, abdomen, legs, and wing margin. The bristle abnormalities are associated with over...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1994.1039
更新日期:1994-02-01 00:00:00
abstract::In marine teleosts, the aqp1ab water channel plays a vital role in the development of the pelagic egg phenotype. However, the developmental control of aqp1ab activation during oogenesis remains to be established. Here, we report the isolation of the 5'-flanking region of the teleost gilthead seabream aqp1ab gene, in w...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2013.03.001
更新日期:2013-05-15 00:00:00
abstract::Lineage diversification in the vertebrate neural crest may occur via instructive signals acting on pluripotent cells, and/or via early specification of subpopulations towards particular lineages. Mesencephalic neural crest cells normally form cholinergic parasympathetic neurons in the ciliary ganglion, while trunk neu...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.10.024
更新日期:2005-02-01 00:00:00
abstract::The ability of adult vertebrates to repair tissue damage is widespread and impressive; however, the ability to regenerate structurally complex organs such as the limb is limited largely to the salamanders. The fact that most of the tissues of the limb can regenerate has led investigators to question and identify the b...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2012.03.022
更新日期:2012-06-15 00:00:00
abstract::The Hippo tumor suppressor pathway plays many fundamental cell biological roles during animal development. Two central players in controlling Hippo-dependent gene expression are the TEAD transcription factor Scalloped (Sd) and its transcriptional co-activator Yorkie (Yki). Hippo signaling phosphorylates Yki, thereby b...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2019.06.022
更新日期:2019-11-01 00:00:00
abstract::Previous study of the development of the levator ani muscle (LA) revealed that the sex difference in muscle fiber number is under the control of testosterone during the perinatal period. In this study, the development of the LA muscle was examined in both sexes to test the hypothesis that testosterone action determine...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1994.1070
更新日期:1994-03-01 00:00:00
abstract::Using sea urchin embryos, we demonstrate that the MEK/MAPK/ERK cascade is essential for the proper progression of the cell cycle. Activation of a limited fraction of MAPK/ERK is required between S-phase and M-phase. Neither DNA replication nor CDK1 activation are impacted by the inhibition of this small active MAPK/ER...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2016.11.018
更新日期:2017-01-15 00:00:00
abstract::An anterior-posterior concentration difference of fibronectin associated with the endoderm in early chick embryos has been implicated in the directional migration of precardiac mesoderm cells. We have examined the effect of increasing concentrations of an antibody to fibronectin (FN) to test the essentiality of FN to ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(88)90378-8
更新日期:1988-10-01 00:00:00
abstract::After induction and specification in the ectoderm, at the border of the neural plate, the neural crest (NC) population leaves its original territory through a delamination process. Soon afterwards, the NC cells migrate throughout the embryo and colonize a myriad of tissues and organs where they settle and differentiat...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2011.12.041
更新日期:2012-06-01 00:00:00
abstract::During digit development, the correct balance of chondrogenic signals ensures the recruitment of undifferentiated cells into the cartilage lineage or the maintenance of cells at the undifferentiated stage. WNT/β catenin maintains the pool of progenitor cells, whereas TGFβ signalling promotes cartilage differentiation ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2020.10.003
更新日期:2021-01-01 00:00:00
abstract::The distribution of the catalytic and regulatory subunits of the cAMP-dependent protein kinase between cytoplasm and nucleus was determined during the development of Dictyostelium discoideum. In vegetative amoebae approximately 2% of the subunits were in the nucleus. During development there was an approximately 5-fol...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90221-6
更新日期:1986-05-01 00:00:00