Abstract:
:Changes in gene regulatory networks are a major engine for creating developmental novelty during evolution. Conversely, regulatory linkages that survive for very long evolutionary periods might be characteristic of ancient and abstract functions of fundamental utility to all metazoans. The proneural genes, which encode a distinctive family of basic helix-loop-helix (bHLH) transcriptional activators, act to promote neural cell fates in the ectoderm of diverse species. Here we report that these genes have been associated for at least 600-700 million years--since before the cnidarian/bilaterian divergence--with a high-affinity binding site for Hairy/Enhancer of split (Hes) repressor proteins. We suggest that the systematic identification of such ancient and conserved connections will be a powerful means of uncovering the primordial functions of transcription factors and signaling systems.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Rebeiz M,Stone T,Posakony JWdoi
10.1016/j.ydbio.2005.03.004subject
Has Abstractpub_date
2005-05-15 00:00:00pages
299-308issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(05)00145-4journal_volume
281pub_type
杂志文章abstract::During early heart development the expression pattern of N-cadherin, a calcium-dependent cell adhesion molecule, suggests its involvement in morphoregulation and the stabilization of cardiomyocyte differentiation. N-cadherin's adhesive activity is dependent upon its interaction with the intracellular catenins. An asso...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1997.8570
更新日期:1997-05-15 00:00:00
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journal_title:Developmental biology
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0168
更新日期:1996-07-10 00:00:00
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journal_title:Developmental biology
pub_type: 历史文章,杂志文章
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更新日期:2011-09-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2015.04.023
更新日期:2015-08-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90323-4
更新日期:1986-10-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2000.0113
更新日期:2001-02-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0237
更新日期:1996-10-10 00:00:00
abstract::Plakoglobin and beta-catenin are cytoplasmic proteins associated with the intracellular plaques of cell adhesive junctions. While plakoglobin is present in both adherens junctions and desmosomes, beta-catenin is associated with the cadherins that accumulate only in adherens junctions. Both beta-catenin and plakoglobin...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90118-z
更新日期:1992-10-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2001.0498
更新日期:2002-01-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2017.11.017
更新日期:2018-02-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2011.01.016
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abstract::To analyse cell migration and the differentiation potential of migratory stem cells in Hydractinia, we generated animals with an eGFP reporter gene stably expressed and transmitted via the germline. The transgene was placed under the control of two different actin promoters and the promoter of elongation factor-1α. On...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2010.08.017
更新日期:2010-12-01 00:00:00
abstract::The structure of the three polypeptide chains of the laminin subunits and the number of glycosylation sites in each polypeptide chain were determined using peptide mapping by high-performance liquid chromatography. Analysis of the [35S]methionine-labeled underglycosylated laminin isolated from tunicamycin (TM)-treated...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(83)90367-6
更新日期:1983-08-01 00:00:00
abstract::Mutations in the XNP/ATR-X gene cause several X-linked mental retardation syndromes in humans. The XNP/ATR-X gene encodes a DNA-helicase belonging to the SNF2 family. It has been proposed that XNP/ATR-X might be involved in chromatin remodelling. The lack of a mouse model for the ATR-X syndrome has, however, hampered ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.10.014
更新日期:2005-02-01 00:00:00
abstract::The dorsal-ventral axis of the Xenopus embryo is approximately determined by the point of sperm entry, which occurs randomly about the animal-vegetal axis of the egg. Two cytoplasmic components were studied whose spatial arrangements and local concentration patterns appear to reflect the forming dorsal-ventral axis. F...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(85)90457-9
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
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doi:10.1016/j.ydbio.2018.04.010
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1995.1223
更新日期:1995-08-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.03.023
更新日期:2004-07-01 00:00:00
abstract::Germ cells provide maternal mRNAs that are stored in the oocyte, and later translated at a specific time of development. In this context, gene regulation depends mainly on post-transcriptional mechanisms that contribute to keep maternal transcripts in a stable and translationally silent state. In recent years, small n...
journal_title:Developmental biology
pub_type: 杂志文章,评审
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更新日期:2016-08-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1998.8975
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abstract::We previously isolated a p53 cDNA from a Xenopus oocyte library. To determine if p53 has a function in the developmental period, we have studied its expression at the RNA and protein levels during the early development of Xenopus laevis. Two p53 transcripts (3 and 2.2 kb) are expressed from the beginning of Xenopus oo...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1230
更新日期:1993-09-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(85)90009-0
更新日期:1985-03-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2011.02.009
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2005.12.022
更新日期:2006-03-15 00:00:00