当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > CFAP43 modulates ciliary beating in mouse and Xenopus.

CFAP43 modulates ciliary beating in mouse and Xenopus.

Abstract：

:Malfunctions of motile cilia cause a variety of developmental defects and diseases in humans and animal model organisms. Defects include impaired mucociliary clearance of the airways, sperm immotility, hydrocephalus and organ laterality. Here, we characterize the evolutionary conserved Cfap43 gene by loss-of-function experiments in the mouse and the frog Xenopus laevis. Cfap43 is expressed in tissues carrying motile cilia and acts as a target gene of the transcription factor FOXJ1, which is essential for the induction of motile ciliogenesis. We show that CFAP43, a protein of unknown biochemical function, localizes to the ciliary axoneme. CFAP43 is involved in the regulation of the beating frequency of tracheal cilia and loss of CFAP43 causes severe mucus accumulation in the nasal cavity. Likewise, morphant and crispant frog embryos revealed impaired function of motile cilia of the larval epidermis, a model for airway mucociliary epithelia. CFAP43 participates in the formation of flagellar axonemes during spermatogenesis as mice mutant for Cfap43 display male infertility, consistent with observations in male sterile patients. In addition, mice mutant for Cfap43 display early onset hydrocephalus. Together, these results confirm the role of CFAP43 in the male reproductive tract and pinpoint additional functions in airway epithelia mucus clearance and brain development.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Rachev E,Schuster-Gossler K,Fuhl F,Ott T,Tveriakhina L,Beckers A,Hegermann J,Boldt K,Mai M,Kremmer E,Ueffing M,Blum M,Gossler A

doi

10.1016/j.ydbio.2019.12.010

subject

Has Abstract

pub_date

2020-03-15 00:00:00

pages

109-125

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(19)30471-3

journal_volume

459

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis.

    abstract：:Aurora-C was first identified during screening for kinases expressed in mouse sperm and eggs. Herein, we report for the first time the precise subcellular localization of endogenous Aurora-C during male meiotic division. The localization of Aurora-C was analyzed by immunofluorescence staining on chromosome spreads of ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.11.036

    authors： Tang CJ,Lin CY,Tang TK

    更新日期：2006-02-15 00:00:00

  • Inhibition of protein kinase A phenocopies ectopic expression of hedgehog in the CNS of wild-type and cyclops mutant embryos.

    abstract：:The zebrafish hedgehog (hh) family members tiggy-winkle hedgehog (twhh) and sonic hedgehog (shh) are involved in patterning the ventral CNS and proximal eye. Using a dominant negative protein kinase A regulatory subunit mutant, we show that these hh activities are mediated by protein kinase A. The effects of dominant ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1996.0209

    authors： Ungar AR,Moon RT

    更新日期：1996-08-25 00:00:00

  • Suppressor of Hairless and Presenilin phenotypes imply involvement of canonical Notch-signalling in segmentation of the spider Cupiennius salei.

    abstract：:Arthropods, vertebrates, and annelids all have a segmented body. Our recent discovery of involvement of Notch-signalling in spider segmentation revived the discussion on the origin of segmented body plans and suggests the sharing of a common genetic program in a common ancestor. Here, we analysed the spider homologues...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.01.024

    authors： Schoppmeier M,Damen WG

    更新日期：2005-04-01 00:00:00

  • FGF-stimulated outgrowth and proliferation of limb mesoderm is dependent on syndecan-3.

    abstract：:The outgrowth of the mesoderm of the developing limb bud in response to the apical ectodermal ridge (AER) is mediated at least in part by members of the FGF family. Recent studies have indicated that FGFs need to interact with heparan sulfate proteoglycans in order to bind to and activate their specific cell surface r...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8525

    authors： Dealy CN,Seghatoleslami MR,Ferrari D,Kosher RA

    更新日期：1997-04-15 00:00:00

  • Characterization of an islet-activating protein-sensitive site in mouse sperm that is involved in the zona pellucida-induced acrosome reaction.

    abstract：:Recently, it has been suggested that a mouse sperm-associated protein with properties similar to the inhibitory guanine nucleotide-binding regulatory protein Gi plays an intermediary role in the zona pellucida-induced acrosome reaction (Endo, Y., Lee, M. A., and Kopf, G. S. 1987. Dev. Biol. 119, 210-216). In the prese...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(88)90157-1

    authors： Endo Y,Lee MA,Kopf GS

    更新日期：1988-09-01 00:00:00

  • Normal newt limb regeneration requires matrix metalloproteinase function.

    abstract：:Newts regenerate lost limbs through a complex process involving dedifferentiation, migration, proliferation, and redifferentiation of cells proximal to the amputation plane. To identify the genes controlling these cellular events, we performed a differential display analysis between regenerating and nonregenerating li...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.12.003

    authors： Vinarsky V,Atkinson DL,Stevenson TJ,Keating MT,Odelberg SJ

    更新日期：2005-03-01 00:00:00

  • Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish.

    abstract：:Congenital diseases caused by abnormal development of the cranial neural crest usually present craniofacial malformations and heart defects while the precise mechanism is not fully understood. Here, we show that the zebrafish eif3ba mutant caused by pseudo-typed retrovirus insertion exhibited a similar phenotype due t...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2013.06.009

    authors： Xia Z,Tong X,Liang F,Zhang Y,Kuok C,Zhang Y,Liu X,Zhu Z,Lin S,Zhang B

    更新日期：2013-09-01 00:00:00

  • DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop.

    abstract：:Sulfs are secreted sulfatases that catalyse removal of sulfate from Heparan Sulfate Proteoglycans (HSPGs) in the extracellular space. These enzymes are well known to regulate a number of crucial signalling pathways during development. In this study, we report that DSulfatase-1 (DSulf1), the unique Drosophila Sulf prot...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.07.027

    authors： Wojcinski A,Nakato H,Soula C,Glise B

    更新日期：2011-10-01 00:00:00

  • Formation and function of the polar body contractile ring in Spisula.

    abstract：:Initial studies suggested that spatial organization of the putative polar body contractile ring was determined by the peripheral aster in Spisula [Biol. Bull. 205 (2003) 192]. Here we report detailed supporting observations, including testing of aster and ring function with inhibitors. The metaphase peripheral aster w...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.01.033

    authors： Pielak RM,Gaysinskaya VA,Cohen WD

    更新日期：2004-05-15 00:00:00

  • Expression of pluripotency factors in larval epithelia of the frog Xenopus: evidence for the presence of cornea epithelial stem cells.

    abstract：:Understanding the biology of somatic stem cells in self renewing tissues represents an exciting field of study, especially given the potential to harness these cells for tissue regeneration and repair in treating injury and disease. The mammalian cornea contains a population of basal epithelial stem cells involved in ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.12.005

    authors： Perry KJ,Thomas AG,Henry JJ

    更新日期：2013-02-15 00:00:00

  • Preparation of plasma membranes from fertilized sea urchin eggs.

    abstract：:A new method is presented for preparation of highly purified plasma membranes from fertilized sea urchin eggs. The purified plasma membranes are in vesicle form and are highly enriched in ouabain inhibitable, Na+/K+ ATPase activity. Analysis of membrane proteins by sodium dodecyl sulfate-gel electrophoresis indicates ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(83)90106-9

    authors： Ribot H,Decker SJ,Kinsey WH

    更新日期：1983-06-01 00:00:00

  • Octopamine receptor OAMB is required for ovulation in Drosophila melanogaster.

    abstract：:Octopamine is a major monoamine in invertebrates and affects many physiological processes ranging from energy metabolism to complex behaviors. Octopamine binds to receptors located on various cell types and activates distinct signal transduction pathways to produce these diverse effects. We previously identified one o...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2003.07.018

    authors： Lee HG,Seong CS,Kim YC,Davis RL,Han KA

    更新日期：2003-12-01 00:00:00

  • Cdx regulates Dll1 in multiple lineages.

    abstract：:Vertebrate Cdx genes encode homeodomain transcription factors related to caudal in Drosophila. The murine Cdx homologues Cdx1, Cdx2 and Cdx4 play important roles in anterior-posterior patterning of the embryonic axis and the intestine, as well as axial elongation. While our understanding of the ontogenic programs requ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.09.034

    authors： Grainger S,Lam J,Savory JG,Mears AJ,Rijli FM,Lohnes D

    更新日期：2012-01-01 00:00:00

  • A laminin substrate promotes myogenesis in rat skeletal muscle cultures: analysis of replication and development using antidesmin and anti-BrdUrd monoclonal antibodies.

    abstract：:Cells from newborn rat hindlimb show greatly enhanced myogenicity when grown on surfaces coated with poly-L-lysine followed by laminin (PLL/Lam) instead of the collagens routinely used. Coating with poly-L-lysine (PLL) alone or with PLL followed by collagen does not enhance myogenicity. Both myogenic and nonmyogenic c...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90327-7

    authors： Foster RF,Thompson JM,Kaufman SJ

    更新日期：1987-07-01 00:00:00

  • The oncofetal gene Pem specifies a divergent paired class homeodomain.

    abstract：:The polypeptide sequence predicted from the Pem oncofetal gene cDNA contains a homeodomain most closely related to the paired class. Pem, paired class member orthodenticle, and the bicoid maternal gene product homeodomains all have lysine residues at a recognition helix position implicated in DNA-binding specificity. ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(91)90467-h

    authors： Rayle RE

    更新日期：1991-07-01 00:00:00

  • Migration pathways of sacral neural crest during development of lower urogenital tract innervation.

    abstract：:The migration and fate of cranial and vagal neural crest-derived progenitor cells (NCPCs) have been extensively studied; however, much less is known about sacral NCPCs particularly in regard to their distribution in the urogenital system. To construct a spatiotemporal map of NCPC migration pathways into the developing...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2017.04.011

    authors： Wiese CB,Deal KK,Ireland SJ,Cantrell VA,Southard-Smith EM

    更新日期：2017-09-01 00:00:00

  • olig2 is required for zebrafish primary motor neuron and oligodendrocyte development.

    abstract：:Oligodendrocytes are produced from the same region of the ventral spinal cord that earlier generated motor neurons in bird and rodent embryos. Motor neuron and oligodendrocyte precursor cells express Olig genes, which encode basic helix-loop-helix transcription factors that play important roles in the development of b...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2002.0738

    authors： Park HC,Mehta A,Richardson JS,Appel B

    更新日期：2002-08-15 00:00:00

  • Dissection of cis-regulatory elements in the C. elegans Hox gene egl-5 promoter.

    abstract：:Hox genes are highly conserved segmental identity genes well known for their complex expression patterns and divergent targets. Here we present an analysis of cis-regulatory elements in the Caenorhabditis elegans Hox gene egl-5, which is expressed in multiple tissues in the posterior region of the nematode. We have ut...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.09.012

    authors： Teng Y,Girard L,Ferreira HB,Sternberg PW,Emmons SW

    更新日期：2004-12-15 00:00:00

  • Cell lineage analysis of Schwann cells in the PNS determined by shiverer-normal mouse chimeras.

    abstract：:The myelin of the peripheral nervous system from the shiverer mutant mice is characterized by the absence of myelin basic protein, while the other myelin protein components are present at normal levels. Myelin lamella formation is normal in the shiverer mutant. Therefore, by using antiserum against myelin basic protei...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(84)90277-x

    authors： Mikoshiba K,Yokoyama M,Takamatsu K,Tsukada Y,Nomura T

    更新日期：1984-09-01 00:00:00

  • Contractile protein isoforms in muscle development.

    abstract：:The contractile proteins of skeletal muscle are often represented by families of very similar isoforms. Protein isoforms can result from the differential expression of multigene families or from multiple transcripts from a single gene via alternative splicing. In many cases the regulatory mechanisms that determine the...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/0012-1606(92)90067-q

    authors： Bandman E

    更新日期：1992-12-01 00:00:00

  • Development of a muscle actin specified by maternal and zygotic mRNA in ascidian embryos.

    abstract：:In this investigation, we characterize the embryonic and adult actins and describe the embryonic expression of a muscle actin in the ascidian Styela. Two-dimensional polyacrylamide gel electrophoresis showed that embryos, tadpole larvae, and adult organs contain three major and two minor isoforms of actin. Two of the ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90404-0

    authors： Tomlinson CR,Bates WR,Jeffery WR

    更新日期：1987-10-01 00:00:00

  • Formation of the first cleavage spindle in nematode embryos.

    abstract：:The distribution of microtubules and microtubule organizing centers in the events leading up to the establishment of the first asymmetric cleavage furrow in nematode embryos was followed using indirect immunofluorescence of antibodies to tubulin. Oocytes arrest in meiotic prophase then undergo two meiotic reduction di...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(84)90117-9

    authors： Albertson DG

    更新日期：1984-01-01 00:00:00

  • Developmental acquisition of genome-wide DNA methylation occurs prior to meiosis in male germ cells.

    abstract：:The development of germ cells is a highly ordered process that begins during fetal growth and is completed in the adult. Epigenetic modifications that occur in germ cells are important for germ cell function and for post-fertilization embryonic development. We have previously shown that male germ cells in the adult mo...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.05.002

    authors： Oakes CC,La Salle S,Smiraglia DJ,Robaire B,Trasler JM

    更新日期：2007-07-15 00:00:00

  • Regulation of specific developmental fates of larval- and adult-type muscles during metamorphosis of the frog Xenopus.

    abstract：:During anuran metamorphosis, larval-type myotubes in both trunk and tail are removed by apoptosis, and only trunk muscles are replaced by newly formed adult-type myotubes. In the present study, we clarified the regulatory mechanisms for specific developmental fates of adult and larval muscles. Two distinct (adult and ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2002.0800

    authors： Shimizu-Nishikawa K,Shibota Y,Takei A,Kuroda M,Nishikawa A

    更新日期：2002-11-01 00:00:00

  • Differential expression and tissue distribution of type I and type II neurofibromins during mouse fetal development.

    abstract：:Mutations in the NF1 gene may cause developmental abnormalities and the formation of a variety of tumors of neural crest origin in humans. The NF1 gene codes for a large protein, neurofibromin (nf), which is structurally and functionally related to yeast and human ras-GTPase-activating proteins (ras-GAPs). Recently, t...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1994.1052

    authors： Huynh DP,Nechiporuk T,Pulst SM

    更新日期：1994-02-01 00:00:00

  • The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure.

    abstract：:Closure of the cranial neural tube depends on normal development of the head mesenchyme. Homozygous-mutant embryos for the ENU-induced open mind (opm) mutation exhibit exencephaly associated with defects in head mesenchyme development and dorsal-lateral hinge point formation. The head mesenchyme in opm mutant embryos ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.03.018

    authors： Zohn IE,Anderson KV,Niswander L

    更新日期：2007-06-01 00:00:00

  • Distinct transcriptional regulation of Nanos2 in the germ line and soma by the Wnt and delta/notch pathways.

    abstract：:Specification of the primordial germ cells (PGCs) is essential for sexually reproducing animals. Although the mechanisms of PGC specification are diverse between organisms, the RNA binding protein Nanos is consistently required in the germ line in all species tested. How Nanos is selectively expressed in the germ line...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2019.04.010

    authors： Oulhen N,Swartz SZ,Wang L,Wikramanayake A,Wessel GM

    更新日期：2019-08-01 00:00:00

  • Glycoprotein constituents of the vitelline coat of Phallusia mammillata (Ascidiacea) with fertilization inhibiting activity.

    abstract：:Vitelline coats (VCs) of Phallusia mammillata were isolated and purified following homogenization of live eggs in order to investigate the molecular basis of sperm-egg recognition. Clean VCs were partly solubilized by sonication in H2O and the soluble fraction (SFVC), derived from the outer surface of VCs, was used fo...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(91)90272-5

    authors： Litscher E,Honegger TG

    更新日期：1991-12-01 00:00:00

  • Fractal geometry in rat chimeras demonstrates that a repetitive cell division program may generate liver parenchyma.

    abstract：:In the development of mammalian organs, a rapid and robust expansion of the parenchymal compartment must occur following allocation of organ primordia. This expansion must be regulated so that sufficient tissue mass is generated for further organization into functional tissues. The discovery that mosaic patches in the...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1994.1274

    authors： Khokha MK,Landini G,Iannaccone PM

    更新日期：1994-10-01 00:00:00

  • GATA2 regulates Wnt signaling to promote primitive red blood cell fate.

    abstract：:Primitive erythropoiesis is regulated in a non cell-autonomous fashion across evolution from frogs to mammals. In Xenopus laevis, signals from the overlying ectoderm are required to induce the mesoderm to adopt an erythroid fate. Previous studies in our lab identified the transcription factor GATA2 as a key regulator ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2015.08.012

    authors： Mimoto MS,Kwon S,Green YS,Goldman D,Christian JL

    更新日期：2015-11-01 00:00:00