Abstract：
:Aurora-C was first identified during screening for kinases expressed in mouse sperm and eggs. Herein, we report for the first time the precise subcellular localization of endogenous Aurora-C during male meiotic division. The localization of Aurora-C was analyzed by immunofluorescence staining on chromosome spreads of mouse spermatocytes or in squashed seminiferous tubules. Aurora-C was first detected at clusters of chromocenters in diplotene spermatocytes and was concentrated at centromeres in metaphase I and II. Interestingly, Aurora-C was also found along the chromosome axes, including both the regions of centromeres and the chromosome arms in diakinesis. During the anaphase I/telophase I and anaphase II/telophase II transitions, Aurora-C was relocalized to the spindle midzone and midbody. A similar distribution pattern was also observed for Aurora-B during male meiotic divisions. Surprisingly, we detected no Aurora-C in mitotic spermatogonia. Furthermore, immunoprecipitation analyses revealed that INCENP associated with Aurora-C in the male testis. We propose that INCENP recruits Aurora-C (or some other factor(s) recruit INCENP and Aurora-C) to meiotic chromosomes, while Aurora-C may either work alone or cooperate with Aurora-B to regulate chromosome segregation during male meiosis.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Tang CJ,Lin CY,Tang TKdoi
10.1016/j.ydbio.2005.11.036subject
Has Abstractpub_date
2006-02-15 00:00:00pages
398-410issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(05)00866-3journal_volume
290pub_type
杂志文章abstract：:The Ca2+ oscillations initiated by the fertilizing sperm (but terminating concomitant with pronucleus formation) apparently ensure that the events constituting egg activation occur in the correct temporal order; early events (e.g., cortical granule exocytosis) require fewer oscillations than later events (e.g., recrui...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2006.08.041
更新日期：2006-12-15 00:00:00
abstract：:The eyes absent (eya) gene plays an essential role in the events that lead to formation of the Drosophila eye; without expression of eya in retinal progenitor cells, they undergo programmed cell death just prior to the morphogenetic furrow, leading to an eyeless or reduced eye phenotype. The eya gene has recently been...
journal_title：Developmental biology
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journal_title：Developmental biology
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journal_title：Developmental biology
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journal_title：Developmental biology
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journal_title：Developmental biology
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journal_title：Developmental biology
pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2007-05-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1985-03-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2004.12.003
更新日期：2005-03-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2018.04.023
更新日期：2018-10-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.2001.0530
更新日期：2002-02-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1999.9246
更新日期：1999-05-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2006.09.003
更新日期：2006-11-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2000-09-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2008-01-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1996-10-10 00:00:00
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更新日期：1983-09-01 00:00:00
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journal_title：Developmental biology
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更新日期：1996-08-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2019-04-15 00:00:00
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更新日期：2007-11-15 00:00:00
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更新日期：2011-02-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1997-04-15 00:00:00
