GATA2 regulates Wnt signaling to promote primitive red blood cell fate.

abstract：:Mechanisms coupling growth and metabolism are conserved in Drosophila and mammals. In metazoans, such coupling is achieved across tissue scales through the regulated secretion of chemical messengers such as insulin that control the metabolism and growth of cells. Although the regulated secretion of Insulin like peptid...

journal_title：Developmental biology

authors： Ashe S,Malhotra V,Raghu P

更新日期：2018-02-01 00:00:00

abstract：:Recently, it has been suggested that a mouse sperm-associated protein with properties similar to the inhibitory guanine nucleotide-binding regulatory protein Gi plays an intermediary role in the zona pellucida-induced acrosome reaction (Endo, Y., Lee, M. A., and Kopf, G. S. 1987. Dev. Biol. 119, 210-216). In the prese...

journal_title：Developmental biology

authors： Endo Y,Lee MA,Kopf GS

更新日期：1988-09-01 00:00:00

abstract：:Progression of germ cells through meiosis is regulated by phosphorylation events. We previously showed the key role of cyclin dependent kinases in meiotic divisions of rat spermatocytes co-cultured with Sertoli cells (SC). In the present study, we used the same culture system to address the role of mitogen-activated p...

journal_title：Developmental biology

authors： Godet M,Sabido O,Gilleron J,Durand P

更新日期：2008-03-01 00:00:00

abstract：:A fundamental feature of cartilage differentiation in the developing limb is the formation of a prechondrogenic cell condensation. An apparently similar process of prechondrogenic cell aggregation occurs in micromass cultures of limb bud mesenchyme with the formation of cellular aggregates which often differentiate in...

journal_title：Developmental biology

authors： Cottrill CP,Archer CW,Wolpert L

更新日期：1987-08-01 00:00:00

abstract：:Cellular interactions with laminin are important for numerous morphogenetic events. In Xenopus, the first of these is neurulation. The integrin alpha6 subunit mediates an attachment of the cells of the neural plate to the underlying basal lamina. A disruption of this interaction results in embryos that fail to neurula...

journal_title：Developmental biology

authors： Lallier TE,DeSimone DW

更新日期：2000-09-01 00:00:00

abstract：:Temporal and spatial aspects of floral determination in seedling terminal buds of the qualitative short-day plant Pharbitis nil were examined using a grafting assay. Floral determination in the terminal buds of 6-day-old P. nil seedlings is rapid; by 9 hr after the end of a 14-hr inductive dark period more than 50% of...

journal_title：Developmental biology

authors： Larkin JC,Felsheim R,Das A

更新日期：1990-02-01 00:00:00

abstract：:The nuclear receptor SpCOUP-TF is the highly conserved sea urchin homologue of the COUP family of transcription factors. Previous results from our laboratory demonstrated that SpCOUP-TF transcripts are localized in the egg and asymmetrically distributed in the early embryonic blastomeres (A. Vlahou et al., 1996, Devel...

journal_title：Developmental biology

authors： Vlahou A,Flytzanis CN

更新日期：2000-02-15 00:00:00

abstract：:Mature hamster eggs exhibit repetitive increases in the intracellular Ca2+ concentration ([Ca2+]i) at fertilization, caused by inositol 1,4,5-trisphosphate (InsP3)-induced Ca2+ release (IICR) from stores. Oscillating Ca2+ rises also occurred in inseminated immature oocytes at the germinal vesicle (GV) stage but the pe...

journal_title：Developmental biology

authors： Fujiwara T,Nakada K,Shirakawa H,Miyazaki S

更新日期：1993-03-01 00:00:00

abstract：:Gap junctions are intercellular channels made of connexins (Cxs) that allow direct communication between adjacent cells. Modulation of Cxs has been associated with abnormal development and function of the mammary gland and breast cancer. However, the mechanisms underlying their expression during normal mammary gland a...

journal_title：Developmental biology

authors： Dianati E,Poiraud J,Weber-Ouellette A,Plante I

更新日期：2016-08-01 00:00:00

abstract：:Symplastic spermatids (sys) male mice are sterile due to a recessive mutation that causes defective adhesion between spermatids and Sertoli cells within the seminiferous epithelium. We show that the mutation in sys mice involves a deletion of 1.24 Mb of chromosome 14. Comparative genomic analysis suggests that this re...

journal_title：Developmental biology

authors： Obholz KL,Akopyan A,Waymire KG,MacGregor GR

更新日期：2006-10-15 00:00:00

abstract：:During vesicular transport between the endoplasmic reticulum and the Golgi, members of the TMED/p24 protein family form hetero-oligomeric complexes that facilitate protein-cargo recognition as well as vesicle budding. In addition, they regulate each other's level of expression. Despite analyses of TMED/p24 protein dis...

journal_title：Developmental biology

authors： Jerome-Majewska LA,Achkar T,Luo L,Lupu F,Lacy E

更新日期：2010-05-01 00:00:00

abstract：:MHM is a chicken Z chromosome-linked locus that is methylated and transcriptionally silent in male cells, but is hypomethylated and transcribed into a long non-coding RNA in female cells. MHM has been implicated in both localised dosage compensation and sex determination in the chicken embryo, but direct evidence is l...

journal_title：Developmental biology

authors： Roeszler KN,Itman C,Sinclair AH,Smith CA

更新日期：2012-06-15 00:00:00

abstract：:Continuous communication between cells is necessary for development of any multicellular organism and depends on the recognition of secreted signals. A wide range of molecules including proteins, peptides, amino acids, nucleic acids, steroids and polylketides are used as intercellular signals in plants and animals. Th...

journal_title：Developmental biology

authors： Loomis WF

更新日期：2014-07-01 00:00:00

abstract：:Proper spatial expression of the wingless (wg) gene in the Drosophila embryonic epidermis is crucial to intrasegmental patterning. Single cell wide wg expression is initiated at the blastoderm stage in response to combinatorial regulation by the pair rule genes. Later, during gastrulation, when the epidermal expressio...

journal_title：Developmental biology

authors： Yoffe KB,Manoukian AS,Wilder EL,Brand AH,Perrimon N

更新日期：1995-08-01 00:00:00

abstract：:Exocytosis of cortical granules in mouse eggs is required to produce the zona pellucida block to polyspermy. In this study, we examined the role of microfilaments and microtubules in the regulation of cortical granule movement toward the cortex during oocyte maturation and anchoring of cortical granules in the cortex....

journal_title：Developmental biology

authors： Connors SA,Kanatsu-Shinohara M,Schultz RM,Kopf GS

更新日期：1998-08-01 00:00:00

abstract：:Retinoic acid (RA) signaling is required for normal development of multiple organs. However, little is known about how RA influences the initial stages of lung development. Here, we used a combination of genetic, pharmacological and explant culture approaches to address this issue, and to investigate how signaling by ...

journal_title：Developmental biology

authors： Desai TJ,Chen F,Lü J,Qian J,Niederreither K,Dollé P,Chambon P,Cardoso WV

更新日期：2006-03-01 00:00:00

abstract：:Developmental boundaries ensure that cells fated to participate in a particular structure are brought together or maintained at the appropriate locale within developing embryos. Parasegment grooves mark the position of boundaries that separate every segment of the Drosophila embryo into anterior and posterior compartm...

journal_title：Developmental biology

authors： Larsen C,Bardet PL,Vincent JP,Alexandre C

更新日期：2008-09-15 00:00:00

abstract：:During the development of locomotion circuits it is essential that motoneurons with distinct subtype identities select the correct trajectories and target muscles. In vertebrates, the generation of motoneurons and myelinating glia depends on Olig2, one of the five Olig family bHLH transcription factors. We investigate...

journal_title：Developmental biology

authors： Oyallon J,Apitz H,Miguel-Aliaga I,Timofeev K,Ferreira L,Salecker I

更新日期：2012-09-15 00:00:00

abstract：:Choroideremia (CHM) is a hereditary eye disease caused by mutations in the X-linked CHM gene. Disruption of the Chm gene in mice resulted in prenatal death of Chm-/Y males and Chm-/Chm+ females that had inherited the mutation from their mothers. Male chimeras and Chm+/Chm- females with paternal transmission of the mut...

journal_title：Developmental biology

authors： Shi W,van den Hurk JA,Alamo-Bethencourt V,Mayer W,Winkens HJ,Ropers HH,Cremers FP,Fundele R

更新日期：2004-08-01 00:00:00

abstract：:The release of intracellular calcium (Ca2+) via either inositol 1,4, 5-trisphosphate receptors (IP3R) or ryanodine receptors (RyR) activates a wide variety of signaling pathways in virtually every type of cell. In the present study we demonstrate that at early stages of development IP3R mRNA and functional IP3-gated C...

journal_title：Developmental biology

authors： Rosemblit N,Moschella MC,Ondriašová E,Gutstein DE,Ondriaš K,Marks AR

更新日期：1999-02-15 00:00:00

abstract：:Dorsoventral specification of the zebrafish gastrula is governed by the functions of the dorsal shield, a region of the embryo functionally analogous to the amphibian Spemann organizer. We report that the bozozok locus encodes the transcription factor nieuwkoid/dharma, a homeobox gene with non-cell-autonomous organize...

journal_title：Developmental biology

authors： Koos DS,Ho RK

更新日期：1999-11-15 00:00:00

abstract：:The clonal multipotential RCJ 3.1 cell line, which gives rise to myotubes, adipocytes, chondrocytes, and osteoblasts, contains different progenitor subpopulations. By limiting dilution analysis, of 296 single colonies identified, approximately 20% contained a single recognizable cell type, approximately 10% contained ...

journal_title：Developmental biology

authors： Grigoriadis AE,Heersche JN,Aubin JE

更新日期：1990-12-01 00:00:00

abstract：:Midline defects account for approximately 5% of congenital abnormalities observed at birth. However, the molecular mechanisms underlying the formation of the ventral body wall are not well understood. Recent studies linked mutations in Porcupine-an O-acetyl transferase mediating Wnt ligand acylation-with defects in th...

journal_title：Developmental biology

authors： Snowball J,Ambalavanan M,Cornett B,Lang R,Whitsett J,Sinner D

更新日期：2015-05-15 00:00:00

abstract：:The msh/Msx family is a subclass of homeobox-containing genes suggested to perform a conserved function in the patterning of the early embryo. We had already isolated a member of this gene family (Ci-msxb) in Ciona intestinalis, which has a very complex expression pattern during embryogenesis. To identify the regulato...

journal_title：Developmental biology

authors： Russo MT,Donizetti A,Locascio A,D'Aniello S,Amoroso A,Aniello F,Fucci L,Branno M

更新日期：2004-03-15 00:00:00

abstract：:COUP-TFII (also known as Nr2f2), a member of the nuclear orphan receptor superfamily, is expressed in several regions of the central nervous system (CNS), including the ventral thalamus, hypothalamus, midbrain, pons, and spinal cord. To address the function of COUP-TFII in the CNS, we generated conditional COUP-TFII k...

journal_title：Developmental biology

authors： Kim BJ,Takamoto N,Yan J,Tsai SY,Tsai MJ

更新日期：2009-02-15 00:00:00

abstract：:Many organisms both undergo dramatic morphological changes during post-embryonic development and also regenerate lost structures, but the roles of epigenetic regulators in such processes are only beginning to be understood. In the present study, the functions of two histone modifiers were examined during metamorphosis...

journal_title：Developmental biology

authors： Chou J,Ferris AC,Chen T,Seok R,Yoon D,Suzuki Y

更新日期：2019-06-01 00:00:00

abstract：:The regulation of cell cycle rate is essential for the correct timing of proliferation and differentiation during development. Changes to cell cycle rate can have profound effects on the size, shape and cell types of a developing organ. We previously identified a zebrafish mutant ceylon (cey) that has a severe reducti...

journal_title：Developmental biology

authors： Hutchinson SA,Tooke-Locke E,Wang J,Tsai S,Katz T,Trede NS

更新日期：2012-08-15 00:00:00

abstract：:Activins are members of the TGF-ss superfamily of secreted growth factors that control a diverse array of processes in vertebrates including endocrine function, cell proliferation, differentiation, immune response and wound repair. In Drosophila, the Activin ligand Dawdle (Daw) has been shown to regulate several aspec...

journal_title：Developmental biology

authors： Ellis JE,Parker L,Cho J,Arora K

更新日期：2010-06-15 00:00:00

abstract：:We have studied the differentiation of the oocyte vitelline coat (VC) and jelly coat (JC) of the starfish, Astropecten aurantiacus. The precursor material of both envelopes is secreted by the oocyte while the follicle cells do not appear to participate in the secretory process. The first indication of differentiation ...

journal_title：Developmental biology

authors： Santella L,Monroy A,Rosati F

更新日期：1983-10-01 00:00:00

abstract：:Bone Morphogenetic Proteins (BMPs) have multiple activities in the developing spinal cord: they specify the identity of the dorsal-most neuronal populations and then direct the trajectories of dorsal interneuron (dI) 1 commissural axons. How are these activities decoded by dorsal neurons to result in different cellula...

journal_title：Developmental biology

authors： Hazen VM,Andrews MG,Umans L,Crenshaw EB 3rd,Zwijsen A,Butler SJ

更新日期：2012-07-15 00:00:00