Abstract:
:Pancreatic organogenesis relies on a complex interplay of cell-autonomous and extracellular signals. We demonstrate that the morphogen sonic hedgehog (Shh) is required for pancreatic development in zebrafish. Genetic mutants of Shh and its signaling pathway establish this dependence as specific to endocrine, but not exocrine, pancreas. Using cyclopamine to inhibit hedgehog signaling, we show that transient Shh signaling is necessary during gastrulation for subsequent differentiation of endoderm into islet tissue. A second hedgehog-dependent activity occurring later in development was also identified and may be analogous to the known action of Shh in gut endoderm to direct localization of pancreatic development. The early action of Shh may be part of a more general process allowing neuroendocrine cells to originate in nonneuroectodermally derived tissues.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
diIorio PJ,Moss JB,Sbrogna JL,Karlstrom RO,Moss LGdoi
10.1006/dbio.2002.0573subject
Has Abstractpub_date
2002-04-01 00:00:00pages
75-84issue
1eissn
0012-1606issn
1095-564Xpii
S0012160602905737journal_volume
244pub_type
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