当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain.

Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain.

Abstract：

:The inner ear, the sensory organ responsible for hearing and balance, contains specialized sensory and non-sensory epithelia arranged in a highly complex three-dimensional structure. To achieve this complexity, a tight coordination between morphogenesis and cell fate specification is essential during otic development. Tissues surrounding the otic primordium, and more particularly the adjacent segmented hindbrain, have been implicated in specifying structures along the anteroposterior and dorsoventral axes of the inner ear. In this work we have first characterized the generation and axial specification of the otic neurogenic domain, and second, we have investigated the effects of the mutation of kreisler/MafB--a gene transiently expressed in rhombomeres 5 and 6 of the developing hindbrain--in early otic patterning and cell specification. We show that kr/kr embryos display an expansion of the otic neurogenic domain, due to defects in otic patterning. Although many reports have pointed to the role of FGF3 in otic regionalisation, we provide evidence that FGF3 is not sufficient to govern this process. Neither Krox20 nor Fgf3 mutant embryos, characterized by a downregulation or absence of Fgf3 in r5 and r6, display ectopic neuroblasts in the otic primordium. However, Fgf3-/-Fgf10-/- double mutants show a phenotype very similar to kr/kr embryos: they present ectopic neuroblasts along the AP and DV otic axes. Finally, partial rescue of the kr/kr phenotype is obtained when Fgf3 or Fgf10 are ectopically expressed in the hindbrain of kr/kr embryos. These results highlight the importance of hindbrain-derived signals in the regulation of otic neurogenesis.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Vázquez-Echeverría C,Dominguez-Frutos E,Charnay P,Schimmang T,Pujades C

doi

10.1016/j.ydbio.2008.07.025

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

167-78

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(08)01084-1

journal_volume

322

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • XNP-1/ATR-X acts with RB, HP1 and the NuRD complex during larval development in C. elegans.

    abstract：:Mutations in the XNP/ATR-X gene cause several X-linked mental retardation syndromes in humans. The XNP/ATR-X gene encodes a DNA-helicase belonging to the SNF2 family. It has been proposed that XNP/ATR-X might be involved in chromatin remodelling. The lack of a mouse model for the ATR-X syndrome has, however, hampered ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.10.014

    authors： Cardoso C,Couillault C,Mignon-Ravix C,Millet A,Ewbank JJ,Fontés M,Pujol N

    更新日期：2005-02-01 00:00:00

  • Genomics and expression profiles of the Hedgehog and Notch signaling pathways in sea urchin development.

    abstract：:The Hedgehog (Hh) and Notch signal transduction pathways control a variety of developmental processes including cell fate choice, differentiation, proliferation, patterning and boundary formation. Because many components of these pathways are conserved, it was predicted and confirmed that pathway components are largel...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.08.064

    authors： Walton KD,Croce JC,Glenn TD,Wu SY,McClay DR

    更新日期：2006-12-01 00:00:00

  • A screen for downstream effectors of Neurogenin2 in the embryonic neocortex.

    abstract：:Neurogenin (Ngn) 1 and Ngn2 encode basic-helix-loop-helix transcription factors expressed in the developing neocortex. Like other proneural genes, Ngns participate in the specification of neural fates and neuronal identities, but downstream effectors remain poorly defined. We set out to identify Ngn2 effectors in the ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.06.013

    authors： Mattar P,Britz O,Johannes C,Nieto M,Ma L,Rebeyka A,Klenin N,Polleux F,Guillemot F,Schuurmans C

    更新日期：2004-09-15 00:00:00

  • Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish.

    abstract：:Ligands of the transforming growth factor beta (TGFbeta) superfamily, like Nodal and bone morphogenetic protein (BMP), are pivotal to establish left-right (LR) asymmetry in vertebrates. However, the receptors mediating this process are unknown. Here we identified two new type II receptors for BMPs in zebrafish termed ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.11.038

    authors： Monteiro R,van Dinther M,Bakkers J,Wilkinson R,Patient R,ten Dijke P,Mummery C

    更新日期：2008-03-01 00:00:00

  • Vegetal localization of maternal mRNAs is disrupted by VegT depletion.

    abstract：:VegT is an essential maternal regulator of germ layer specification in Xenopus. The localization of VegT mRNA to the vegetal cortex of the oocyte during oogenesis ensures its inheritance by vegetal and not animal cells, and directs the differentiation of vegetal cells into endoderm. Similarly localized mRNAs, Vg1 and ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2001.0495

    authors： Heasman J,Wessely O,Langland R,Craig EJ,Kessler DS

    更新日期：2001-12-15 00:00:00

  • Involvement of the cytoskeleton in the movement of cortical granules during oocyte maturation, and cortical granule anchoring in mouse eggs.

    abstract：:Exocytosis of cortical granules in mouse eggs is required to produce the zona pellucida block to polyspermy. In this study, we examined the role of microfilaments and microtubules in the regulation of cortical granule movement toward the cortex during oocyte maturation and anchoring of cortical granules in the cortex....

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1998.8945

    authors： Connors SA,Kanatsu-Shinohara M,Schultz RM,Kopf GS

    更新日期：1998-08-01 00:00:00

  • The Galpha4 G protein subunit interacts with the MAP kinase ERK2 using a D-motif that regulates developmental morphogenesis in Dictyostelium.

    abstract：:G protein Galpha subunits contribute to the specificity of different signal transduction pathways in Dictyostelium discoideum but Galpha subunit-effector interactions have not been previously identified. The requirement of the Dictyostelium Galpha4 subunit for MAP kinase (MAPK) activation and the identification of a p...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2009.09.011

    authors： Nguyen HN,Hadwiger JA

    更新日期：2009-11-15 00:00:00

  • WNT5A-Ca2+-CaN-NFAT signalling plays a permissive role during cartilage differentiation in embryonic chick digit development.

    abstract：:During digit development, the correct balance of chondrogenic signals ensures the recruitment of undifferentiated cells into the cartilage lineage or the maintenance of cells at the undifferentiated stage. WNT/β catenin maintains the pool of progenitor cells, whereas TGFβ signalling promotes cartilage differentiation ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2020.10.003

    authors： Farrera-Hernández A,Marín-Llera JC,Chimal-Monroy J

    更新日期：2021-01-01 00:00:00

  • Kif18a is specifically required for mitotic progression during germ line development.

    abstract：:Genome integrity in the developing germ line is strictly required for fecundity. In proliferating somatic cells and in germ cells, there are mitotic checkpoint mechanisms that ensure accurate chromosome segregation and euploidy. There is growing evidence of mitotic cell cycle components that are uniquely required in t...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2015.03.011

    authors： Czechanski A,Kim H,Byers C,Greenstein I,Stumpff J,Reinholdt LG

    更新日期：2015-06-15 00:00:00

  • Plant developmental responses to climate change.

    abstract：:Climate change is multi-faceted, and includes changing concentrations of greenhouse gases in the atmosphere, rising temperatures, changes in precipitation patterns, and increasing frequency of extreme weather events. Here, we focus on the effects of rising atmospheric CO2 concentrations, rising temperature, and drough...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2016.07.023

    authors： Gray SB,Brady SM

    更新日期：2016-11-01 00:00:00

  • Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion.

    abstract：:Cleft palate is one of the most common craniofacial congenital defects in humans. It is associated with multiple genetic and environmental risk factors, including mutations in the genes encoding signaling molecules in the sonic hedgehog (Shh) pathway, which are risk factors for cleft palate in both humans and mice. Ho...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2018.07.003

    authors： Li J,Yuan Y,He J,Feng J,Han X,Jing J,Ho TV,Xu J,Chai Y

    更新日期：2018-09-01 00:00:00

  • Evidence that protein kinase C (PKC) participates in the meiosis I to meiosis II transition in mouse oocytes.

    abstract：:Oocytes from LTXBO mice exhibit a delayed entry into anaphase I and frequently enter interphase after the first meiotic division. This unique oocyte model was used to test the hypothesis that protein kinase C (PKC) may regulate the meiosis I-to-meiosis II transition. PKC activity was detected in LTXBO oocytes at proph...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2001.0311

    authors： Viveiros MM,Hirao Y,Eppig JJ

    更新日期：2001-07-15 00:00:00

  • Regulation of Ci and Su(fu) nuclear import in Drosophila.

    abstract：:The Hedgehog (Hh) signal transduction pathway plays a central role in the development of invertebrates and vertebrates. While much is known about the pathway, the role of Suppressor of fused (Su(fu)), a component of the pathway's signaling complex has remained enigmatic. Previous studies have linked Su(fu) to the cyto...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.02.050

    authors： Sisson BE,Ziegenhorn SL,Holmgren RA

    更新日期：2006-06-01 00:00:00

  • Expression and immunolocalization of p59c-fyn tyrosine kinase in rat eggs.

    abstract：:Fertilization overcomes meiotic arrest by triggering a series of biochemical events, resulting in activation of the egg. A small group of protein tyrosine kinases (PTKs) have been identified in eggs of invertebrates and lower vertebrates and inhibitor studies have suggested that they play a role in late events of egg ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8816

    authors： Talmor A,Kinsey WH,Shalgi R

    更新日期：1998-02-01 00:00:00

  • Two temporal functions of Glass: Ommatidium patterning and photoreceptor differentiation.

    abstract：:Much progress has been made in elucidating the molecular networks required for specifying retinal cells, including photoreceptors, but the downstream mechanisms that maintain identity and regulate differentiation remain poorly understood. Here, we report that the transcription factor Glass has a dual role in establish...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2016.04.012

    authors： Liang X,Mahato S,Hemmerich C,Zelhof AC

    更新日期：2016-06-01 00:00:00

  • Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis.

    abstract：:The Drosophila larval central brain contains about 10,000 differentiated neurons and 200 scattered neural progenitors (neuroblasts), which can be further subdivided into ~95 type I neuroblasts and eight type II neuroblasts per brain lobe. Only type II neuroblasts generate self-renewing intermediate neural progenitors ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.10.020

    authors： Carney TD,Miller MR,Robinson KJ,Bayraktar OA,Osterhout JA,Doe CQ

    更新日期：2012-01-01 00:00:00

  • A role for GATA-6 in vertebrate chondrogenesis.

    abstract：:The GATA family of transcription factors are known to play multiple critical roles in vertebrate developmental processes, including erythropoiesis, endoderm formation and cardiogenesis. There have been no previous demonstrations of a functional role for any GATA family member being associated with musculoskeletal deve...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.12.001

    authors： Alexandrovich A,Qureishi A,Coudert AE,Zhang L,Grigoriadis AE,Shah AM,Brewer AC,Pizzey JA

    更新日期：2008-02-15 00:00:00

  • Severe developmental bone phenotype in ClC-7 deficient mice.

    abstract：:Bone development is dependent on the functionality of three essential cell types: chondrocytes, osteoclasts and osteoblasts. If any of these cell types is dysfunctional, a developmental bone phenotype can result. The bone disease osteopetrosis is caused by osteoclast dysfunction or impaired osteoclastogenesis, leading...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.06.018

    authors： Neutzsky-Wulff AV,Sims NA,Supanchart C,Kornak U,Felsenberg D,Poulton IJ,Martin TJ,Karsdal MA,Henriksen K

    更新日期：2010-08-15 00:00:00

  • A novel cyclic AMP metabolism exhibited by giant cells and its possible role in the sexual development of Dictyostelium discoideum.

    abstract：:In Dictyostelium discoideum cyclic AMP (cAMP) metabolism during macrocyst development, i.e., the sexual cycle of this organism, and in giant cells, i.e., fusion products from opposite mating-type cells, was investigated. The pattern of change in cAMP levels during macrocyst development differed considerably from that ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(84)90104-0

    authors： Abe K,Orii H,Okada Y,Saga Y,Yanagisawa K

    更新日期：1984-08-01 00:00:00

  • Expression of type II iodothyronine deiodinase marks the time that a tissue responds to thyroid hormone-induced metamorphosis in Xenopus laevis.

    abstract：:The thyroid gland synthesizes thyroxine (T4), which passes through the larval tadpole's circulatory system. The enzyme type II iodothyronine deiodinase (D2) converts thyroxine (T4) to the active hormone 3,5,3'-triiodothyronine (T3) in peripheral tissues. An early response to thyroid hormone (TH) in the Xenopus laevis ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2003.10.005

    authors： Cai L,Brown DD

    更新日期：2004-02-01 00:00:00

  • Developmental interactions between the peripheral and central nervous system in Drosophila melanogaster: analysis of the mutant, two-faced.

    abstract：:A genetically complex mutant, two-faced (tfd), which causes the production of extra eye and antennal tissue on the dorsal head cuticle, has been analyzed for connectivity to and projection patterns in the central brain of nerves derived from these extra structures. It has been found that the extra antennal nerves freq...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(85)90370-7

    authors： Lipshitz HD,Kankel DR

    更新日期：1985-01-01 00:00:00

  • Requirement for Mab21l2 during development of murine retina and ventral body wall.

    abstract：:The mab-21 gene was first identified because of its requirement for ray identity specification in Caenorhabditis elegans. It is now known to constitute a family of genes that are highly conserved from vertebrates to invertebrates, and two homologues Mab21l1 and Mab21l2 have been identified in many species. Here we des...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.07.016

    authors： Yamada R,Mizutani-Koseki Y,Koseki H,Takahashi N

    更新日期：2004-10-15 00:00:00

  • Roles of ADAM13-regulated Wnt activity in early Xenopus eye development.

    abstract：:Pericellular proteolysis by ADAM family metalloproteinases has been widely implicated in cell signaling and development. We recently found that Xenopus ADAM13, an ADAM metalloproteinase, is required for activation of canonical Wnt signaling during cranial neural crest (CNC) induction by regulating a novel crosstalk be...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.12.031

    authors： Wei S,Xu G,Bridges LC,Williams P,Nakayama T,Shah A,Grainger RM,White JM,DeSimone DW

    更新日期：2012-03-01 00:00:00

  • Tissue- and developmental stage-specific imprinting of the mouse proinsulin gene, Ins2.

    abstract：:We have investigated the imprinting status of two insulin genes using an interspecific recombinant congenic mouse strain carrying Ins1 and Ins2 alleles from Mus spretus on a C57BL/6 genetic background. At Days 12.5, 13.5, and 14.5 of gestation, expression of both parental alleles of both Ins1 and Ins2 was detected in ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.1114

    authors： Deltour L,Montagutelli X,Guenet JL,Jami J,Páldi A

    更新日期：1995-04-01 00:00:00

  • Developmentally regulated expression of temporally distinct beta-glucosidase isozymes in Dictyostelium discoideum.

    abstract：:During development of Dictyostelium discoideum, the cellular specific activity of beta-glucosidase increases before aggregation, declines to low levels during pseudoplasmodium formation, and increases rapidly during culmination. In addition, two electrophoretically distinct isozymes of beta-glucosidase are present at ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90407-6

    authors： Golumbeski GS Jr,Dimond RL

    更新日期：1987-10-01 00:00:00

  • Gpbox (Psx2), a homeobox gene preferentially expressed in female germ cells at the onset of sexual dimorphism in mice.

    abstract：:XX gonads differentiate into ovaries, a morphologic event evident by embryonic day 13.5 (E13.5) in mice. To identify early markers of oogenesis, sex-specific urogenital ridge cDNA libraries were constructed from E12-13 embryos. After mass excision and isolation of plasmid DNA, approximately 4800 expressed sequence tag...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9741

    authors： Takasaki N,McIsaac R,Dean J

    更新日期：2000-07-01 00:00:00

  • Early differentiation of vertebrate spinal neurons in the absence of voltage-dependent Ca2+ and Na+ influx.

    abstract：:The development of the action potential and responses to neurotransmitters have been described for a population of embryonic spinal neurons developing in vivo. A comparable pattern is seen for spinal neurons developing in dissociated cell culture. The impulse appears very early in this developmental sequence, and the ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(84)90065-4

    authors： Bixby JL,Spitzer NC

    更新日期：1984-11-01 00:00:00

  • An intrinsic timer that controls cell-cycle withdrawal in cultured cardiac myocytes.

    abstract：:Developing cardiac myocytes divide a limited number of times before they stop and terminally differentiate, but the mechanism that stops their division is unknown. To help study the stopping mechanism, we defined conditions under which embryonic rat cardiac myocytes cultured in serum-free medium proliferate and exit t...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9524

    authors： Burton PB,Raff MC,Kerr P,Yacoub MH,Barton PJ

    更新日期：1999-12-15 00:00:00

  • Dynamic expression of broad-complex isoforms mediates temporal control of an ecdysteroid target gene at the onset of Drosophila metamorphosis.

    abstract：:Metamorphosis in Drosophila melanogaster is orchestrated by the steroid hormone ecdysone, which triggers a cascade of primary-response transcriptional regulators and secondary effector genes during the third larval instar and prepupal periods of development. The early ecdysone-response Broad-Complex (BR-C) gene, a key...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9879

    authors： Mugat B,Brodu V,Kejzlarova-Lepesant J,Antoniewski C,Bayer CA,Fristrom JW,Lepesant JA

    更新日期：2000-11-01 00:00:00

  • Transient apical polarization of Gliotactin and Coracle is required for parallel alignment of wing hairs in Drosophila.

    abstract：:In Drosophila, wing hairs are aligned in a distally oriented, parallel array. The frizzled pathway determines proximal-distal cell polarity in the wing; however, in frizzled pathway mutants, wing hairs remain parallel. How wing hairs align has not been determined. We have demonstrated a novel role for the septate junc...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.07.040

    authors： Venema DR,Zeev-Ben-Mordehai T,Auld VJ

    更新日期：2004-11-15 00:00:00