Abstract:
:XX gonads differentiate into ovaries, a morphologic event evident by embryonic day 13.5 (E13.5) in mice. To identify early markers of oogenesis, sex-specific urogenital ridge cDNA libraries were constructed from E12-13 embryos. After mass excision and isolation of plasmid DNA, approximately 4800 expressed sequence tags were determined and compared to existing databases. Few cDNAs were specifically expressed in the urogenital ridge, but one, designated GPBOX, encodes a 227-amino-acid homeobox protein that is first expressed at E10.5 in the embryo as well as in the extraembryonic tissues. The Gpbox gene is single copy in the mouse genome and is located on the X chromosome in close proximity to two other homeobox genes, Pem and Psx1. Within the embryo, its expression is limited to the gonad, and transcripts are not detected in adult tissues. Although comparable levels are initially present in both sexes, GPBOX transcripts accumulate faster in female germ cells and peak at E12.5 when they are present in fivefold greater abundance than in males. The persistence of GPBOX transcripts in female germ cells until E15.5 and their virtual disappearance in males by E13.5 suggest that Gpbox may play a role in mammalian oogenesis.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Takasaki N,McIsaac R,Dean Jdoi
10.1006/dbio.2000.9741subject
Has Abstractpub_date
2000-07-01 00:00:00pages
181-93issue
1eissn
0012-1606issn
1095-564Xpii
S0012-1606(00)99741-0journal_volume
223pub_type
杂志文章abstract::Organismal growth and body size are influenced by both genetic and environmental factors. We have utilized the strong molecular genetic techniques available in the nematode Caenorhabditis elegans to identify genetic determinants of body size. In C. elegans, DBL-1, a member of the conserved family of secreted growth fa...
journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:2011-04-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章,评审
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journal_title:Developmental biology
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journal_title:Developmental biology
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journal_title:Developmental biology
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journal_title:Developmental biology
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pub_type: 杂志文章
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journal_title:Developmental biology
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journal_title:Developmental biology
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pub_type: 杂志文章
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journal_title:Developmental biology
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pub_type: 杂志文章,评审
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更新日期:1985-06-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章,评审
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