Abstract:
:Ca2+-sensitive microelectrodes were used to study changes in cytoplasmic free calcium during progesterone-induced meiotic maturation in Xenopus laevis oocytes. In contrast to previous reports, no changes were detected during the maturation process, although a large activation pulse of Ca2+ was seen when in vitro matured eggs were parthenogenetically activated. The resting level of Ca2+ in the oocytes was 0.14 microM +/- 0.05.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Robinson KRdoi
10.1016/0012-1606(85)90475-0subject
Has Abstractpub_date
1985-06-01 00:00:00pages
504-8issue
2eissn
0012-1606issn
1095-564Xpii
0012-1606(85)90475-0journal_volume
109pub_type
杂志文章abstract::To investigate the lineage relationships of neurons and astroglial cells early in central nervous system development, we have analyzed the progeny of neural plate cells in an amphibian embryo (Pleurodeles waltl). A fluorescent tracer, lysinated rhodamine-dextran, was iontophoretically injected into individual precurso...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1233
更新日期:1993-09-01 00:00:00
abstract::We show that the intermediate filament protein nestin is expressed in myogenic cells and that multiple mechanisms regulate nestin expression at different stages of myogenesis. Cultured embryonic, fetal, and neonatal mouse limb myoblasts initially expressed nestin in the absence of the four muscle regulatory factors (M...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1994.1248
更新日期:1994-09-01 00:00:00
abstract::The organization of the embryonic neural plate requires coordination of multiple signal transduction pathways, including fibroblast growth factors (FGFs), bone morphogenetic proteins (BMPs), and WNTs. Many studies have suggested that a critical component of this process is the patterning of posterior neural tissues by...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.06.019
更新日期:2009-09-01 00:00:00
abstract::The role of the wound epithelium in amphibian limb regeneration is not understood. We showed previously that monoclonal antibody (mAb) WE3 stains the wound epithelium but not skin epidermis, suggesting that the WE3 antigen may be a marker for, or be important in, the function of the wound epithelium. In the present st...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(89)90188-7
更新日期:1989-10-01 00:00:00
abstract::Germ line transformation has been used to map the cis regulatory DNA elements responsible for the precise and evolutionarily stable developmental expression of the s18 chorion gene. Constructs containing chimeric combinations of Drosophila melanogaster and D. grimshawi DNA regions, as well as D. grimshawi sequences al...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90160-i
更新日期:1992-07-01 00:00:00
abstract::Eph receptors play important roles in axon guidance at the midline. In the auditory system, growth of axons across the midline is an important determinant of auditory function. The avian cochlear nucleus, n. magnocellularis (NM), makes bilateral projections to its target, n. laminaris (NL). We examined the time course...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.03.010
更新日期:2006-07-01 00:00:00
abstract::Despite differences in the formation of neural precursors, all arthropod species analyzed so far generate about 30 single precursors (insects/crustaceans) or precursor groups (chelicerates/myriapods) per hemi-segment. In Drosophila, each precursor has a distinct identity conferred by segment polarity and dorso-ventral...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2005.11.029
更新日期:2006-02-15 00:00:00
abstract::Stable subdivision of Drosophila limbs into Anterior (A) and Posterior (P) compartments is a consequence of asymmetric signaling by Hedgehog (Hh) from P to A cells. The activity of the homeodomain protein Engrailed (En) in P cells has been reported to help to generate this asymmetry by inducing the expression of hedge...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.01.006
更新日期:2009-03-15 00:00:00
abstract::Embryonic morphogenesis relies on the intrinsic ability of cells, often through remodeling the cytoskeleton, to shape epithelial tissues during development. Epithelial invagination is an example of morphogenesis that depends on this remodeling but the cellular mechanisms driving arrangement of cytoskeletal elements ne...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2020.02.014
更新日期:2020-06-01 00:00:00
abstract::Msx1 and Msx2 are highly conserved, Nk-related homeodomain transcription factors that are essential for a variety of tissue-tissue interactions during vertebrate organogenesis. Here we show that combined deficiencies of Msx1 and Msx2 cause conotruncal anomalies associated with malalignment of the cardiac outflow tract...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2007.05.037
更新日期:2007-08-15 00:00:00
abstract::The lizards are evolutionarily the closest vertebrates to humans that demonstrate the ability to regenerate entire appendages containing cartilage, muscle, skin, and nervous tissue. We previously isolated PAX7-positive cells from muscle of the green anole lizard, Anolis carolinensis, that can differentiate into multin...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2017.08.037
更新日期:2018-01-15 00:00:00
abstract::Accumulating evidence indicates that the endometrial extracellular matrix (ECM) modulates trophoblast adhesion during mouse blastocyst implantation. In previous studies of adhesion-competent mouse blastocysts, we have demonstrated that integrin-mediated fibronectin (FN)-binding activity on the apical surface of tropho...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2002.0644
更新日期:2002-05-15 00:00:00
abstract::Embryonic organizers are signaling centers that coordinate developmental events within an embryo. Localized to either an individual cell or group of cells, embryonic organizing activity induces the specification of other cells in the embryo and can influence formation of body axes. In the spiralian Capitella teleta, p...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2018.01.004
更新日期:2018-03-01 00:00:00
abstract::The insect head is composed of several segments. During embryonic development, the segments fuse to form a rigid head capsule where obvious segmental boundaries are lacking. Hence, the assignment of regions of the insect head to specific segments is hampered, especially with respect to dorsal (vertex) and lateral (gen...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.11.010
更新日期:2010-02-01 00:00:00
abstract::In most ascidians, metamorphosis of tadpole-like swimming larvae is accompanied by dynamic changes in their shape to form sessile adults. The mechanisms underlying ascidian metamorphosis have been debated for a long time. Although recent molecular studies have revealed the presence of various molecules involving in th...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.11.026
更新日期:2009-02-15 00:00:00
abstract::We examined the effects of ciliary neurotrophic factor (CNTF) and depolarization, two environmental signals that influence noradrenergic and cholinergic function, on neuropeptide expression by cultured sympathetic neurons. Sciatic nerve extract, a rich source of CNTF, increased levels of vasoactive intestinal peptide ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90242-9
更新日期:1992-04-01 00:00:00
abstract::Although communications between mammalian oocytes and their surrounding granulosa cells mediated by the Kit-Kit ligand (KL, or stem cell factor, SCF) system have been proven to be crucial for follicular development, Kit downstream signaling pathways in mammalian oocytes are largely unknown. In this study, by using ova...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2005.02.013
更新日期:2005-05-15 00:00:00
abstract::During mouse fertilization the spermatozoon induces a series of low-frequency long-lasting Ca(2+) oscillations. It is generally accepted that these oscillations are due to Ca(2+) release through the inositol 1,4,5-trisphosphate (InsP(3)) receptor. However, InsP(3) microinjection does not mimic sperm-induced Ca(2+) osc...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2000.9826
更新日期:2000-09-01 00:00:00
abstract::The location and movement of mammalian gut tissue progenitors, prior to the expression of tissue-specific genes, has been unknown, but this knowledge is essential to identify transitions that lead to cell type specification. To address this, we used vital dyes to label exposed anterior endoderm cells of early somite s...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2005.01.003
更新日期:2005-04-01 00:00:00
abstract::Connective tissue outgrowths of neonatal muscle onto a substratum of bone matrix differentiate into cartilage in response to a bone morphogenetic protein (BMP). The BMP can be separated from bone matrix by extraction with 4 M guanidine hydrochloride (GuHCl) or degraded in situ by endogenous proteolytic enzymes to deac...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(88)90339-9
更新日期:1988-12-01 00:00:00
abstract::The mouse Otlx2 gene is a new member of the paired-like family of homeobox genes whose human homologue, RIEG, is involved in Rieger syndrome, an autosomal-dominant disorder. One of the cardinal features of Rieger syndrome is dental hypoplasia, indicating that Otlx2/RIEG activity is essential for normal tooth developme...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1997.8672
更新日期:1997-09-15 00:00:00
abstract::The universal signal for egg activation at fertilization is a rise in cytoplasmic Ca(2+) with defined spatial and temporal kinetics. Mammalian and amphibian eggs acquire the ability to produce such Ca(2+) signals during a maturation period that precedes fertilization and encompasses resumption of meiosis and progressi...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.08.004
更新日期:2004-11-01 00:00:00
abstract::Bone morphogenetic protein-4 (BMP-4) induces epidermis and represses neural fate in Xenopus ectoderm. Our previous findings implicate p42 Erk MAP kinase (MAPK) in the response to neural induction. We have examined the effects of BMP-4 on MAPK activity in gastrula ectoderm. Expression of a dominant negative BMP-4 recep...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2001.0338
更新日期:2001-08-15 00:00:00
abstract::The cardiac neural crest contains ectomesenchymal and neural anlagen that are necessary for normal heart development. It is not known whether other regions of the neural crest are capable of supporting normal heart development. In the experiments reported herein, quail donor embryos provided cardiac, trunk, or mesence...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(89)90112-7
更新日期:1989-08-01 00:00:00
abstract::We have isolated a cDNA of the DEAD protein family from a Xenopus ovary cDNA library. Northern hybridization revealed that the mRNA corresponding to the cDNA [XVLG1 (Xenopus vasa-like gene)] was specifically expressed in adult testis and ovary. The deduced amino acid sequence of XVLG1 was relatively homologous to that...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1994.1093
更新日期:1994-04-01 00:00:00
abstract::The Toll signaling pathway functions in several Drosophila processes, including dorsal-ventral pattern formation and the immune response. Here, we demonstrate that this pathway is required in the epidermis for proper muscle development. Previously, we showed that the zygotic Toll protein is necessary for normal muscle...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1998.8915
更新日期:1998-07-01 00:00:00
abstract::Spermatogenesis is initiated by the interaction of germ cells and somatic cells in seminiferous tubules. We used cDNA microarrays and representational difference analysis to identify genes that are expressed in the testis of the jsd/jsd mutant mouse, which contains only type A spermatogonial germ cells and Sertoli cel...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2002.0671
更新日期:2002-06-15 00:00:00
abstract::The earliest muscle in zebrafish arises from iterated sets of two to six cells in each somite, the muscle pioneers (MP). MP develop synchronously in young trunk myotomes adjacent to the notochord, precisely where the horizontal myoseptum will form. They elongate without cell fusion and differentiate hours earlier than...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(91)90314-s
更新日期:1991-11-01 00:00:00
abstract::Neurons and glia are produced in stereotyped patterns after neuroblast cell division during development of the Drosophila central nervous system. The first cell division of thoracic neuroblast 6-4 (NB6-4T) is asymmetric, giving rise to a glial precursor cell and a neuronal precursor cell. In contrast, abdominal NB6-4 ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2000.9727
更新日期:2000-06-15 00:00:00
abstract::An antiserum (anti-H2) directed at the second helix of the helix-loop-helix (HLH) protein MyoD1 reacts with a protein expressed during avian cardiac myocyte differentiation. Indirect immunohistochemical whole mount staining with anti-H2 detected a protein expressed in stage 11 hearts, but not in hearts of older embryo...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1088
更新日期:1993-04-01 00:00:00