当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract.

Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract.

Abstract：

:Msx1 and Msx2 are highly conserved, Nk-related homeodomain transcription factors that are essential for a variety of tissue-tissue interactions during vertebrate organogenesis. Here we show that combined deficiencies of Msx1 and Msx2 cause conotruncal anomalies associated with malalignment of the cardiac outflow tract (OFT). Msx1 and Msx2 play dual roles in outflow tract morphogenesis by both protecting secondary heart field (SHF) precursors against apoptosis and inhibiting excessive proliferation of cardiac neural crest, endothelial and myocardial cells in the conotruncal cushions. During incorporation of SHF precursors into the OFT myocardium, ectopic apoptosis in the Msx1-/-; Msx2-/- mutant SHF is associated with reduced expression of Hand1 and Hand2, which from work on Hand1 and Hand2 mutants may be functionally important in the inhibition of apoptosis in Msx1/2 mutants. Later during aorticopulmonary septation, excessive proliferation in the OFT cushion mesenchyme and myocardium of Msx1-/-; Msx2-/- mutants is associated with premature down-regulation of p27(KIP1), an inhibitor of cyclin-dependent kinases. Diminished accretion of SHF precursors to the elongating OFT myocardium and excessive accumulation of mesenchymal cells in the conotruncal cushions may work together to perturb the rotation of the truncus arteriosus, leading to OFT malalignment defects including double-outlet right ventricle, overriding aorta and pulmonary stenosis.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Chen YH,Ishii M,Sun J,Sucov HM,Maxson RE Jr

doi

10.1016/j.ydbio.2007.05.037

subject

Has Abstract

pub_date

2007-08-15 00:00:00

pages

421-37

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(07)01107-4

journal_volume

308

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • Distinct functions of the leucine-rich repeat transmembrane proteins capricious and tartan in the Drosophila tracheal morphogenesis.

    abstract：:A key step in organogenesis of the Drosophila tracheal system is the integration of isolated tracheal metameres into a connected tubular network. The interaction of tracheal cells with surrounding mesodermal cells is crucial in this process. In particular, single mesodermal cells called bridge-cells are essential for ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.04.462

    authors： Krause C,Wolf C,Hemphälä J,Samakovlis C,Schuh R

    更新日期：2006-08-01 00:00:00

  • LKB1 regulates development and the stress response in Dictyostelium.

    abstract：:The serine/threonine kinase LKB1 is a master kinase that regulates a number of critical events such as cell transformation, polarization, development, stress response, and energy metabolism in metazoa. After multiple unsuccessful attempts of generating Dictyostelium lkb1-null cells, an RNAi-based knockdown approach pr...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.10.006

    authors： Veeranki S,Hwang SH,Sun T,Kim B,Kim L

    更新日期：2011-12-15 00:00:00

  • Cardiovascular lesions and skeletal myopathy in mice lacking desmin.

    abstract：:In order to further our understanding of the biological role of desmin, the muscle-specific intermediate filament protein, a null mutation in the desmin gene was introduced into the germ line of mice. Despite the complete lack of desmin, these mice developed and reproduced. Since we show that skeletal, cardiac, and sm...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1996.0122

    authors： Li Z,Colucci-Guyon E,Pinçon-Raymond M,Mericskay M,Pournin S,Paulin D,Babinet C

    更新日期：1996-05-01 00:00:00

  • Topographic targeting and pathfinding errors of retinal axons following overexpression of ephrinA ligands on retinal ganglion cell axons.

    abstract：:In the retinotectal projection, the Eph receptor tyrosine kinase ligands ephrinA2 and ephrinA5 are differentially expressed not only in the tectum, but also in a high-nasal-to-low-temporal pattern in the retina. Recently, we have shown that retrovirally driven overexpression of ephrinA2 on retinal axons leads to topog...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9489

    authors： Dütting D,Handwerker C,Drescher U

    更新日期：1999-12-01 00:00:00

  • PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis.

    abstract：:Caenorhabditis elegans embryonic elongation depends on both epidermal and muscle cells. The hemidesmosome-like junctions, commonly called fibrous organelles (FOs), that attach the epidermis to the extracellular matrix ensure muscle anchoring to the cuticular exoskeleton and play an essential role during elongation. To...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.11.025

    authors： Hetherington S,Gally C,Fritz JA,Polanowska J,Reboul J,Schwab Y,Zahreddine H,Behm C,Labouesse M

    更新日期：2011-02-15 00:00:00

  • The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation.

    abstract：:Initiation of the development of the anterior-posterior axis in the mouse embryo has been thought to take place only when the anterior visceral endoderm (AVE) emerges and starts its asymmetric migration. However, expression of Lefty1, a marker of the AVE, was recently found to initiate before embryo implantation. This...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.06.020

    authors： Torres-Padilla ME,Richardson L,Kolasinska P,Meilhac SM,Luetke-Eversloh MV,Zernicka-Goetz M

    更新日期：2007-09-01 00:00:00

  • Characterization of myogenic cell lines derived by 5-azacytidine treatment.

    abstract：:Three myogenic clonal cell lines were isolated from C3H 10T1/2 C18 cells (10T1/2) treated with 5-azacytidine (5-aza-CR). These lines reproducibly underwent fusion at confluence into functional myotubes capable of contracting in response to acetylcholine. The degree of fusion could be increased two- to threefold if the...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(86)90302-7

    authors： Liu L,Harrington M,Jones PA

    更新日期：1986-10-01 00:00:00

  • Role of basic FGF and oxygen in control of proliferation, survival, and neuronal differentiation in carotid body chromaffin cells.

    abstract：:Crest-derived glomus cells of the carotid body (CB) are O(2)-sensitive chemoreceptors, which resemble sympathoadrenal (SA) chromaffin cells. In this study, we tested whether perinatal rat glomus cells are sensitive to basic fibroblast growth factor (bFGF) in vitro and whether their sensitivity is regulated by oxygen. ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8539

    authors： Nurse CA,Vollmer C

    更新日期：1997-04-15 00:00:00

  • Pax3- and Pax7-mediated Dbx1 regulation orchestrates the patterning of intermediate spinal interneurons.

    abstract：:Transcription factors are key orchestrators of the emergence of neuronal diversity within the developing spinal cord. As such, the two paralogous proteins Pax3 and Pax7 regulate the specification of progenitor cells within the intermediate neural tube, by defining a neat segregation between those fated to form motor c...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2017.06.014

    authors： Gard C,Gonzalez Curto G,Frarma YE,Chollet E,Duval N,Auzié V,Auradé F,Vigier L,Relaix F,Pierani A,Causeret F,Ribes V

    更新日期：2017-12-01 00:00:00

  • Novel gain-of-function alleles demonstrate a role for the heterochronic gene lin-41 in C. elegans male tail tip morphogenesis.

    abstract：:To gain an understanding of the genes and mechanisms that govern morphogenesis and its evolution, we have analyzed mutations that disrupt this process in a simple model structure, the male tail tip of the rhabditid nematode C. elegans. During the evolution of rhabditid male tails, there have been several independent c...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.04.472

    authors： Del Rio-Albrechtsen T,Kiontke K,Chiou SY,Fitch DH

    更新日期：2006-09-01 00:00:00

  • The 5' UTR and 3' UTR of the sperm mitochondria-associated cysteine-rich protein mRNA regulate translation in spermatids by multiple mechanisms in transgenic mice.

    abstract：:The Smcp mRNA encoding the sperm mitochondria-associated cysteine-rich protein is translationally repressed in round spermatids and translationally active in elongated spermatids. The patterns of transcription and translation of fusions of the Smcp promoter, the green fluorescent protein coding region (Gfp) and variou...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.04.468

    authors： Hawthorne SK,Busanelli RR,Kleene KC

    更新日期：2006-09-01 00:00:00

  • Immunohistochemical characterization of delta crystallin-containing retina/optic nerve "boundary" cells in the chick embryo.

    abstract：:The term "transdifferentiation" has been used to describe the apparent phenotypic conversion of chick embryo neural retina Müller glial cells into lens-like cells in vitro. This phenotypic conversion is characterized by expression of such lens-specific proteins as delta crystallin and has been viewed as an example of ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90186-2

    authors： Linser PJ,Irvin CK

    更新日期：1987-06-01 00:00:00

  • The Drosophila larval visual system: high-resolution analysis of a simple visual neuropil.

    abstract：:The task of the visual system is to translate light into neuronal encoded information. This translation of photons into neuronal signals is achieved by photoreceptor neurons (PRs), specialized sensory neurons, located in the eye. Upon perception of light the PRs will send a signal to target neurons, which represent a ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.07.006

    authors： Sprecher SG,Cardona A,Hartenstein V

    更新日期：2011-10-01 00:00:00

  • The "beginnings" of the neural crest.

    abstract：FOREWORD:The neural crest has been the main object of my investigations during my career in science, up to now. It is a fascinating topic for an embryologist because of its two unique characteristics: its large degree of multipotency and the fact that its development involves a phase during which its component cells mi...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2018.07.019

    authors： Le Douarin NM,Dupin E

    更新日期：2018-12-01 00:00:00

  • The Caudal ParaHox gene is required for hindgut development in the mollusc Tritia (a.k.a. Ilyanassa).

    abstract：:Caudal homeobox genes are found across animals, typically linked to two other homeobox genes in what has been called the ParaHox cluster. These genes have been proposed to pattern the anterior-posterior axis of the endoderm ancestrally, but the expression of Caudal in extant groups is varied and often occurs in other ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2020.10.010

    authors： Johnson AB,Lambert JD

    更新日期：2021-02-01 00:00:00

  • CFAP43 modulates ciliary beating in mouse and Xenopus.

    abstract：:Malfunctions of motile cilia cause a variety of developmental defects and diseases in humans and animal model organisms. Defects include impaired mucociliary clearance of the airways, sperm immotility, hydrocephalus and organ laterality. Here, we characterize the evolutionary conserved Cfap43 gene by loss-of-function ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2019.12.010

    authors： Rachev E,Schuster-Gossler K,Fuhl F,Ott T,Tveriakhina L,Beckers A,Hegermann J,Boldt K,Mai M,Kremmer E,Ueffing M,Blum M,Gossler A

    更新日期：2020-03-15 00:00:00

  • Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.

    abstract：:Pancreatic development depends on the transcription factor Pax6, which controls islet cell differentiation and hormone production. To understand the regulation of Pax6 pancreatic expression, we have identified a minimal Pax6 pancreatic enhancer and show that it contains a composite binding site for Meis and Pbx homeop...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.06.030

    authors： Zhang X,Rowan S,Yue Y,Heaney S,Pan Y,Brendolan A,Selleri L,Maas RL

    更新日期：2006-12-15 00:00:00

  • Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling.

    abstract：:In the head of an embryo, a layer of mesenchyme surrounds the brain underneath the surface ectoderm. This cranial mesenchyme gives rise to the meninges, the calvaria (top part of the skull), and the dermis of the scalp. Abnormal development of these structures, especially the meninges and the calvaria, is linked to si...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2019.07.015

    authors： Dasgupta K,Chung JU,Asam K,Jeong J

    更新日期：2019-11-15 00:00:00

  • Evo-engineering and the cellular and molecular origins of the vertebrate spinal cord.

    abstract：:The formation of the spinal cord during early embryonic development in vertebrate embryos is a continuous process that begins at gastrulation and continues through to the completion of somitogenesis. Despite the conserved usage of patterning mechanisms and gene regulatory networks that act to generate specific spinal ...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2017.01.021

    authors： Steventon B,Martinez Arias A

    更新日期：2017-12-01 00:00:00

  • Differential regulation of gamma-crystallin genes during mouse lens development.

    abstract：:Using gene-specific probes derived from four mouse gamma-crystallin cDNAs, we have examined the regulation of different members of the mouse gamma-crystallin gene family during lens development. Our analysis revealed that, while the different gamma-crystallin genes appear to be coordinately activated during embryogene...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90227-2

    authors： Murer-Orlando M,Paterson RC,Lok S,Tsui LC,Breitman ML

    更新日期：1987-01-01 00:00:00

  • Pristionchus pacificus vulva formation: polarized division, cell migration, cell fusion, and evolution of invagination.

    abstract：:Tube formation is a widespread process during organogenesis. Specific cellular behaviors participate in the invagination of epithelial monolayers that form tubes. However, little is known about the evolutionary mechanisms of cell assembly into tubes during development. In Caenorhabditis elegans, the detailed step-to-s...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2003.10.029

    authors： Kolotuev I,Podbilewicz B

    更新日期：2004-02-15 00:00:00

  • Effects of ciliary neurotrophic factor (CNTF) and depolarization on neuropeptide expression in cultured sympathetic neurons.

    abstract：:We examined the effects of ciliary neurotrophic factor (CNTF) and depolarization, two environmental signals that influence noradrenergic and cholinergic function, on neuropeptide expression by cultured sympathetic neurons. Sciatic nerve extract, a rich source of CNTF, increased levels of vasoactive intestinal peptide ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(92)90242-9

    authors： Rao MS,Tyrrell S,Landis SC,Patterson PH

    更新日期：1992-04-01 00:00:00

  • A novel cyclic AMP metabolism exhibited by giant cells and its possible role in the sexual development of Dictyostelium discoideum.

    abstract：:In Dictyostelium discoideum cyclic AMP (cAMP) metabolism during macrocyst development, i.e., the sexual cycle of this organism, and in giant cells, i.e., fusion products from opposite mating-type cells, was investigated. The pattern of change in cAMP levels during macrocyst development differed considerably from that ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(84)90104-0

    authors： Abe K,Orii H,Okada Y,Saga Y,Yanagisawa K

    更新日期：1984-08-01 00:00:00

  • Inhibition of protein kinases after an induced calcium transient causes transition of bovine oocytes to embryonic cycles without meiotic completion.

    abstract：:We have examined the response of bovine oocytes matured in vitro for 24 hr to parthenogenic activation using compounds that increase intracellular calcium (ionomycin) or inhibit protein phosphorylation (6-dimethylaminopurine, DMAP). Treatment with ionomycin alone caused resumption of meiosis (57.8 +/- 7.8%) but not pr...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1994.1351

    authors： Susko-Parrish JL,Leibfried-Rutledge ML,Northey DL,Schutzkus V,First NL

    更新日期：1994-12-01 00:00:00

  • Expression pattern of GDNF, c-ret, and GFRalphas suggests novel roles for GDNF ligands during early organogenesis in the chick embryo.

    abstract：:We have cloned a partial cDNA of chicken glial cell line-derived neurotrophic factor (GDNF) and systematically examined its expression pattern as well as that of GDNF-binding components (GDNF family receptor alpha-1 and 2: GFRalpha-1 and 2) and a common signal transduction receptor (c-ret protooncogene: RET) during ve...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9543

    authors： Homma S,Oppenheim RW,Yaginuma H,Kimura S

    更新日期：2000-01-01 00:00:00

  • Gdf11 is a negative regulator of chondrogenesis and myogenesis in the developing chick limb.

    abstract：:GDF11, a new member of the TGF-beta gene superfamily, regulates anterior/posterior patterning in the axial skeleton during mouse embryogenesis. Gdf11 null mice display skeletal abnormalities that appear to represent anterior homeotic transformations of vertebrae consistent with high levels of Gdf11 expression in...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9981

    authors： Gamer LW,Cox KA,Small C,Rosen V

    更新日期：2001-01-15 00:00:00

  • Explant cultures of teleost spinal cord: source of neurite outgrowth.

    abstract：:The source of neurite outgrowth in explant cultures of normal adult Apteronotus spinal cord was examined. Explants which contained the central region of spinal cord, including ependyma, showed neurite outgrowth in culture. Explants which did not contain ependyma showed no neurite outgrowth. It is concluded that the ep...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90062-5

    authors： Anderson MJ,Waxman SG,Fong HL

    更新日期：1987-02-01 00:00:00

  • An age of enlightenment for cilia: The FASEB summer research conference on the "Biology of Cilia and Flagella".

    abstract：:From July 19-24, 2015, 169 clinicians and basic scientists gathered in the vertiginous heights of Snowmass, Colorado (2502 m) for the fourth FASEB summer research conference on the 'Biology of Cilia and Flagella'. Organizers Maureen Barr (Rutgers University), Iain Drummond (Massachusetts General Hospital/Harvard Medic...

    journal_title：Developmental biology

    pub_type：

    doi：10.1016/j.ydbio.2015.10.030

    authors： Tran PV,Lechtreck KF

    更新日期：2016-01-15 00:00:00

  • Cell lineage analysis of neural induction: origins of cells forming the induced nervous system.

    abstract：:Horseradish peroxidase (HRP) was used as an intracellular lineage tracer in two experiments designed to reveal the sites of origin of cells that formed the duplicate embryo which developed in relation to an organizer grafted in the ventral marginal zone (VMZ) of Xenopus laevis embryos. In the first experiment a dorsal...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(84)90180-5

    authors： Jacobson M

    更新日期：1984-03-01 00:00:00

  • Correct cell-type-specific expression of a fusion gene injected into sea urchin eggs.

    abstract：:A fusion gene construct containing the bacterial chloramphenicol acetyltransferase (CAT) gene under the control of CyIIIa actin gene regulatory sequences was injected into unfertilized eggs of the urchin Strongylocentrotus purpuratus, and early pluteus stage embryos that developed from these eggs were fixed and sectio...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90193-x

    authors： Hough-Evans BR,Franks RR,Cameron RA,Britten RJ,Davidson EH

    更新日期：1987-06-01 00:00:00