Abstract：
:The serine/threonine kinase LKB1 is a master kinase that regulates a number of critical events such as cell transformation, polarization, development, stress response, and energy metabolism in metazoa. After multiple unsuccessful attempts of generating Dictyostelium lkb1-null cells, an RNAi-based knockdown approach proved effective. Depletion of lkb1 with a knockdown construct displayed severe reduction in prespore cell differentiation and precocious induction of prestalk cells, which were reminiscent of cells lacking GSK3. Similar to gsk3(-) cells, lkb1 depleted cells displayed lower GSK3 activity than wild type cells during development and compromised cAMP-mediated inhibition of the DIF-1 mediated ecmB induction. In response to stress insult, the kinase activity of LKB1, but not that of GSK3, increased. Therefore, LKB1 positively functions at the upstream of GSK3 during development and responds to stress insults independently from GSK3.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Veeranki S,Hwang SH,Sun T,Kim B,Kim Ldoi
10.1016/j.ydbio.2011.10.006subject
Has Abstractpub_date
2011-12-15 00:00:00pages
351-7issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(11)01301-7journal_volume
360pub_type
杂志文章abstract：:The location and distribution of neural crest-derived Schwann cells during development of the peripheral nerves of chick forelimbs were examined using chick-quail chimeras. Neural crest cells were labeled by transplantation of the dorsal part of the neural tube from a quail donor to a chick host at levels of the neura...
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pub_type： 杂志文章
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journal_title：Developmental biology
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