Abstract：
:Continuous communication between cells is necessary for development of any multicellular organism and depends on the recognition of secreted signals. A wide range of molecules including proteins, peptides, amino acids, nucleic acids, steroids and polylketides are used as intercellular signals in plants and animals. They are also used for communication in the social ameba Dictyostelium discoideum when the solitary cells aggregate to form multicellular structures. Many of the signals are recognized by surface receptors that are seven-transmembrane proteins coupled to trimeric G proteins, which pass the signal on to components within the cytoplasm. Dictyostelium cells have to judge when sufficient cell density has been reached to warrant transition from growth to differentiation. They have to recognize when exogenous nutrients become limiting, and then synchronously initiate development. A few hours later they signal each other with pulses of cAMP that regulate gene expression as well as direct chemotactic aggregation. They then have to recognize kinship and only continue developing when they are surrounded by close kin. Thereafter, the cells diverge into two specialized cell types, prespore and prestalk cells, that continue to signal each other in complex ways to form well proportioned fruiting bodies. In this way they can proceed through the stages of a dependent sequence in an orderly manner without cells being left out or directed down the wrong path.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Loomis WFdoi
10.1016/j.ydbio.2014.04.001subject
Has Abstractpub_date
2014-07-01 00:00:00pages
1-16issue
1eissn
0012-1606issn
1095-564Xpii
S0012-1606(14)00192-4journal_volume
391pub_type
杂志文章,评审abstract：:Pax3/7 paired homeodomain transcription factors are important markers of muscle stem cells. Pax3 is required upstream of myod for lateral dermomyotomal cells in the amniote somite to form particular muscle cells. Later Pax3/7-dependent cells generate satellite cells and most body muscle. Here we analyse early myogenes...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2006.10.009
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abstract：:Superior cervical ganglia of postnatal mice with a targeted disruption of the gene for neurotrophin-3 have 50% fewer neurons than those of wild-type mice. In culture, neurotrophin-3 increases the survival of proliferating sympathetic precursors. Both precursor death (W. ElShamy et al., 1996, Development 122, 491-500) ...
journal_title：Developmental biology
pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章,评审
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2014-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-06-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2009.04.038
更新日期：2009-07-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2003.09.015
更新日期：2004-01-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1999.9254
更新日期：1999-05-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(84)90290-2
更新日期：1984-10-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1996.0158
更新日期：1996-07-10 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2006.01.019
更新日期：2006-05-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2019.04.017
更新日期：2019-08-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2004-02-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章,评审
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更新日期：2011-06-15 00:00:00
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pub_type： 杂志文章
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更新日期：1976-09-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2014-11-15 00:00:00
abstract：:Although round spermatid injection can be used to create progeny for males who do not produce mature sperm, the rate of successful embryogenesis after such procedures is significantly lower than that for similar procedures using mature spermatozoa. The mechanisms underlying this difference are unknown. In this study, ...
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pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
