Vasa protein expression is restricted to the small micromeres of the sea urchin, but is inducible in other lineages early in development.

abstract：:Heparan sulfate proteoglycans are important modulators of growth factor signaling in a variety of patterning processes. Secreted growth factors that play critical roles in angiogenesis bind to heparan sulfate, and this association is affected by 6-O-sulfation of the heparan sulfate chains. Addition of 6-O-sulfate is c...

journal_title：Developmental biology

authors： Chen E,Stringer SE,Rusch MA,Selleck SB,Ekker SC

更新日期：2005-08-15 00:00:00

abstract：:Unequal first cleavage is characteristic of a diverse group of protostome animals. In the nematode Caenorhabditis elegans, unequal first cleavage is achieved through the interaction of an apparently symmetric mitotic spindle apparatus with a clearly polarized cell cortex. In the clitellate annelid Tubifex tubifex, by ...

journal_title：Developmental biology

authors： Ren X,Weisblat DA

更新日期：2006-04-01 00:00:00

abstract：:Intestinal tract development is a coordinated process involving signaling among the progenitors and developing cells from all three germ layers. Development of endoderm-derived intestinal epithelium has been shown to depend on epigenetic modifications, but whether that is also the case for intestinal tract cell types ...

journal_title：Developmental biology

authors： Ganz J,Melancon E,Wilson C,Amores A,Batzel P,Strader M,Braasch I,Diba P,Kuhlman JA,Postlethwait JH,Eisen JS

更新日期：2019-11-15 00:00:00

abstract：:Trophoblast cells are characterized by an invasive behavior into the surrounding uterine tissue. In rodents, an early peri-/endovascular type of invasion exerted by trophoblast giant cells can be distinguished from a late interstitial type carried out by glycogen trophoblast cells. Analysis of the molecular mechanisms...

journal_title：Developmental biology

authors： Hemberger M,Hughes M,Cross JC

更新日期：2004-07-15 00:00:00

abstract：:This study reports a morphological, skeletal, and molecular characterization of the supernumerary limbs induced by systemic administration of all-trans retinoic acid to egg-cylinder stage mouse embryos. As initially described by Rutledge et al. (Proc. Natl. Acad. Sci. USA 91, 5436, 1994), we have found that oral admin...

journal_title：Developmental biology

authors： Niederreither K,Ward SJ,Dollé P,Chambon P

更新日期：1996-06-15 00:00:00

abstract：:The trkA gene encodes the tyrosine kinase receptor that transduces the NGF signal. We have used a defective herpes simplex virus-1 (HSV-1) vector containing a full-length rat trkA sequence (pHSVtrkA) to express NGF receptors in primary cultures of neonatal nodose neurons and embryonic spinal motor neurons which are no...

journal_title：Developmental biology

authors： Xu H,Federoff H,Maragos J,Parada LF,Kessler JA

更新日期：1994-05-01 00:00:00

abstract：:Actin-related protein 5 (ARP5) is a conserved subunit of the INO80 chromatin-remodeling complex in yeast and mammals. We have characterized the expression and subcellular distribution of Arabidopsis thaliana ARP5 and explored its role in the epigenetic control of multicellular development and DNA repair. ARP5-specific...

journal_title：Developmental biology

authors： Kandasamy MK,McKinney EC,Deal RB,Smith AP,Meagher RB

更新日期：2009-11-01 00:00:00

abstract：:Using sea urchin embryos, we demonstrate that the MEK/MAPK/ERK cascade is essential for the proper progression of the cell cycle. Activation of a limited fraction of MAPK/ERK is required between S-phase and M-phase. Neither DNA replication nor CDK1 activation are impacted by the inhibition of this small active MAPK/ER...

journal_title：Developmental biology

authors： Mulner-Lorillon O,Chassé H,Morales J,Bellé R,Cormier P

更新日期：2017-01-15 00:00:00

abstract：:Major insulin gene transcription factors, such as PDX-1 or NeuroD1, have equally important roles in pancreatic development and the differentiation of pancreatic endocrine cells. Previously, we identified and cloned another critical insulin gene transcription factor MafA (RIPE3b1) and reported that other Maf factors we...

journal_title：Developmental biology

authors： Nishimura W,Kondo T,Salameh T,El Khattabi I,Dodge R,Bonner-Weir S,Sharma A

更新日期：2006-05-15 00:00:00

abstract：:The developing chick limb bud contains several stage-specific populations of muscle colony-forming (MCF) cells. The cell lineage relationships of these populations are not completely understood, but previous studies have suggested that there may be at least two myogenic precursor populations present in the limb bud. T...

journal_title：Developmental biology

authors： Seed J,Hauschka SD

更新日期：1984-12-01 00:00:00

abstract：:Artificial extracellular matrices composed of collagen, glycosaminoglycans (GAG), proteoglycans (PG), plasma fibronectin (FN), and a hyaluronate-binding protein (HABP) have been prepared that morphologically resemble embryonic extracellular matrices in vivo at the light and electron microscope level. The effect of eac...

journal_title：Developmental biology

authors： Turley EA,Erickson CA,Tucker RP

更新日期：1985-06-01 00:00:00

abstract：:Embryonic morphogenesis relies on the intrinsic ability of cells, often through remodeling the cytoskeleton, to shape epithelial tissues during development. Epithelial invagination is an example of morphogenesis that depends on this remodeling but the cellular mechanisms driving arrangement of cytoskeletal elements ne...

journal_title：Developmental biology

authors： Houssin NS,Martin JB,Coppola V,Yoon SO,Plageman TF Jr

更新日期：2020-06-01 00:00:00

abstract：:A gene regulatory network subcircuit comprising the otx, wnt8, and blimp1 genes accounts for a moving torus of gene expression that sweeps concentrically across the vegetal domain of the sea urchin embryo. Here we confirm by mutation the inputs into the blimp1cis-regulatory module predicted by network analysis. Its es...

journal_title：Developmental biology

authors： Smith J,Kraemer E,Liu H,Theodoris C,Davidson E

更新日期：2008-01-15 00:00:00

abstract：:The distribution and ontogeny of four neuropeptides in developing chick lumbosacral sensory and sympathetic ganglia were studied using immunohistochemical techniques. Antibodies to two of these peptides, substance P (SP) and calcitonin gene-related peptide (CGRP), stained small neurons in the medial part of the dorsal...

journal_title：Developmental biology

authors： New HV,Mudge AW

更新日期：1986-08-01 00:00:00

abstract：:In most ascidians, metamorphosis of tadpole-like swimming larvae is accompanied by dynamic changes in their shape to form sessile adults. The mechanisms underlying ascidian metamorphosis have been debated for a long time. Although recent molecular studies have revealed the presence of various molecules involving in th...

journal_title：Developmental biology

authors： Nakayama-Ishimura A,Chambon JP,Horie T,Satoh N,Sasakura Y

更新日期：2009-02-15 00:00:00

abstract：:We have identified a cellular efflux pump, RhT, with the properties of an MDR transporter-a type of ATP-binding cassette transporter whose substrates include small hydrophobic molecules. RhT transports rhodamine 123 (Rh123) and is inhibited by low temperature, energy poisons, and several MDR transport inhibitors, such...

journal_title：Developmental biology

authors： Good JR,Kuspa A

更新日期：2000-04-01 00:00:00

abstract：:In this study, we demonstrate the developmental activation, in the zebrafish embryo, of a surveillance mechanism which triggers apoptosis to remove damaged cells. We determine the time course of activation of this mechanism by exposing embryos to camptothecin, an agent which specifically inhibits topoisomerase I withi...

journal_title：Developmental biology

authors： Ikegami R,Hunter P,Yager TD

更新日期：1999-05-15 00:00:00

abstract：:The embryonic dorsal vessel in Drosophila possesses anteroposterior polarity and is subdivided into two chamber-like portions, the aorta in the anterior and the heart in the posterior. The heart portion features a wider bore as compared with the aorta and develops inflow valves (ostia) that allow the pumping of hemoly...

journal_title：Developmental biology

authors： Lo PC,Skeath JB,Gajewski K,Schulz RA,Frasch M

更新日期：2002-11-15 00:00:00

abstract：:Missense mutations in the MYH3 gene encoding myosin heavy chain-embryonic (MyHC-embryonic) have been reported to cause two skeletal muscle contracture syndromes, Freeman Sheldon Syndrome (FSS) and Sheldon Hall Syndrome (SHS). Two residues in MyHC-embryonic that are most frequently mutated, leading to FSS, R672 and T17...

journal_title：Developmental biology

authors： Das S,Kumar P,Verma A,Maiti TK,Mathew SJ

更新日期：2019-05-15 00:00:00

abstract：:PDGFB is a growth factor which is vital for the completion of normal prenatal development. In this study, we report the phenotypic analysis of placentas from mouse conceptuses that lack a functional PDGFB or PDGFRbeta gene. Placentas of both types of mutant exhibit changes in the labyrinthine layer, including dilated ...

journal_title：Developmental biology

authors： Ohlsson R,Falck P,Hellström M,Lindahl P,Boström H,Franklin G,Ahrlund-Richter L,Pollard J,Soriano P,Betsholtz C

更新日期：1999-08-01 00:00:00

abstract：:Suppression of wing fate and specification of haltere fate in Drosophila by the homeotic gene Ultrabithorax is a classical example of Hox regulation of serial homology (Lewis, E.B. 1978. Nature 276, 565-570) and has served as a paradigm for understanding homeotic gene function. We have used DNA microarray analyses to ...

journal_title：Developmental biology

authors： Mohit P,Makhijani K,Madhavi MB,Bharathi V,Lal A,Sirdesai G,Reddy VR,Ramesh P,Kannan R,Dhawan J,Shashidhara LS

更新日期：2006-03-15 00:00:00

abstract：:One of the earliest steps in embryonic development is the establishment of the future body axes. Morphological and molecular data place the Ambulacraria (echinoderms and hemichordates) within the Deuterostomia and as the sister taxon to chordates. Extensive work over the last decades in echinoid (sea urchins) echinode...

journal_title：Developmental biology

authors： Röttinger E,Martindale MQ

更新日期：2011-06-01 00:00:00

abstract：:The dopaminergic neurons of the basal ganglia play critical roles in CNS function and human disease, but specification of dopamine neuron phenotype is poorly understood in vertebrates. We performed an in vivo screen in zebrafish to identify dopaminergic neuron enhancers, in order to facilitate studies on the specifica...

journal_title：Developmental biology

authors： Fujimoto E,Stevenson TJ,Chien CB,Bonkowsky JL

更新日期：2011-04-15 00:00:00

abstract：:Extraocular muscles (EOM) represent a unique muscle group that controls eye movements and originates from head mesoderm, while the more typically studied body and limb muscles are somite-derived. Aiming to investigate myogenic progenitors (satellite cells) in EOM versus limb and diaphragm of adult mice, we have been u...

journal_title：Developmental biology

authors： Stuelsatz P,Shearer A,Yablonka-Reuveni Z

更新日期：2014-01-15 00:00:00

abstract：:Developmental pattern formation allows cells within a tissue or organ to coordinate their development and establish cell types in relationship to one another. To better characterize the developmental patterning events within one organ, the C. elegans hindgut, we have analyzed the expression pattern of several genes us...

journal_title：Developmental biology

authors： Sewell ST,Zhang G,Uttam A,Chamberlin HM

更新日期：2003-10-01 00:00:00

abstract：:Metamorphosis is a postembryonic developmental process that involves morphophysiological and behavioral changes, allowing organisms to adapt into a novel environment. In some amphibians, aquatic organisms undergo metamorphosis to adapt in a terrestrial environment. In this process, these organisms experience major cha...

journal_title：Developmental biology

authors： Palacios-Martinez J,Caballero-Perez J,Espinal-Centeno A,Marquez-Chavoya G,Lomeli H,Salas-Vidal E,Schnabel D,Chimal-Monroy J,Cruz-Ramirez A

更新日期：2020-10-01 00:00:00

abstract：:Chordin is the prototype of a group of cysteine-rich domain-containing proteins that bind and modulate signaling of various TGFbeta-like ligands. Chordin-like 1 and 2 (CHL1 and 2) are two members of this group that have been described in human, mouse, and chick. However, in vivo roles for CHL1 and 2 in early developme...

journal_title：Developmental biology

authors： Branam AM,Hoffman GG,Pelegri F,Greenspan DS

更新日期：2010-05-15 00:00:00

abstract：:Planarians are well-known for their exceptional regenerative abilities. This investigation focuses on the involvement of a Y-box protein, defined by the presence of a cold-shock domain, in regeneration-specific processes. Previous studies have shown that developmentally expressed Y-box proteins bind to mRNA molecules ...

journal_title：Developmental biology

authors： Salvetti A,Batistoni R,Deri P,Rossi L,Sommerville J

更新日期：1998-09-15 00:00:00

abstract：:Cranial placodes are specialized ectodermal regions in the developing vertebrate head that give rise to both neural and non-neural cell types of the neuroendocrine system and the sense organs of the visual, olfactory and acoustic systems. The cranial placodes develop from a panplacodal region which is specifically mar...

journal_title：Developmental biology

authors： Posnien N,Koniszewski N,Bucher G

更新日期：2011-02-01 00:00:00

abstract：:Ephrin-B2, a member of the Eph/ephrin family of cell signaling molecules, has been implicated in the guidance of cranial and trunk neural crest cells (NCC) and development of the branchial arches(BA), but detailed examination in mice has been hindered by embryonic lethality of Efnb2 null loss of function due to a requ...

journal_title：Developmental biology

authors： Lewis AE,Hwa J,Wang R,Soriano P,Bush JO

更新日期：2015-10-15 00:00:00