Abstract:
:The location and movement of mammalian gut tissue progenitors, prior to the expression of tissue-specific genes, has been unknown, but this knowledge is essential to identify transitions that lead to cell type specification. To address this, we used vital dyes to label exposed anterior endoderm cells of early somite stage mouse embryos, cultured the embryos into the tissue bud phase of development, and determined the tissue fate of the dye labeled cells. This approach was performed at three embryonic stages that are prior to, or coincident with, foregut tissue patterning (1-3 somites, 4-6 somites, and 7-10 somites). Short-term labeling experiments tracked the movement of tissue progenitor cells during foregut closure. Surprisingly, we found that two distinct types of endoderm-progenitor cells, lateral and medial, arising from three spatially separated embryonic domains, converge to generate the epithelial cells of the liver bud. Whereas the lateral endoderm-progenitors give rise to descendants that are constrained in tissue fate and position along the anterior-posterior axis of the gut, the medial gut endoderm-progenitors give rise to descendants that stream along the anterior-posterior axis at the ventral midline and contribute to multiple gut tissues. The fate map reveals extensive morphogenetic movement of progenitors prior to tissue specification, it permits a detailed analysis of endoderm tissue patterning, and it illustrates that diverse progenitor domains can give rise to individual tissue cell types.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Tremblay KD,Zaret KSdoi
10.1016/j.ydbio.2005.01.003subject
Has Abstractpub_date
2005-04-01 00:00:00pages
87-99issue
1eissn
0012-1606issn
1095-564Xpii
S0012-1606(05)00004-7journal_volume
280pub_type
杂志文章abstract::Metamorphosis in Drosophila results from a hierarchy of ecdysone-induced gene expression initiated at the end of the third larval instar. A now classical model of this hierarchy was proposed based on observations of the activity of polytene chromosome "puffs" which distinguished "early" puffs as those directly induced...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9358
更新日期:1999-09-01 00:00:00
abstract::Multiciliated cells (MCCs) differentiate hundreds of motile cilia that beat to drive fluid movement over various kinds of epithelia. In Xenopus, mice and human, the coiled-coil containing protein Mcidas (Mci) has been shown to be a key transcriptional regulator of MCC differentiation. We have examined Mci function in ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2020.07.005
更新日期:2020-09-15 00:00:00
abstract::Primitive erythropoiesis is regulated in a non cell-autonomous fashion across evolution from frogs to mammals. In Xenopus laevis, signals from the overlying ectoderm are required to induce the mesoderm to adopt an erythroid fate. Previous studies in our lab identified the transcription factor GATA2 as a key regulator ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2015.08.012
更新日期:2015-11-01 00:00:00
abstract::Thyroid hormone (TH) induces dramatic skeletal and tissue remodeling of the anuran head and body at metamorphosis. The expression pattern of TH up-regulated genes has been correlated with tissues that either grow or resorb at metamorphosis. Whereas the expression of the thyroid hormone receptors in Xenopus laevis tadp...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1998.8975
更新日期:1998-11-01 00:00:00
abstract::We have investigated the sequential changes of acetylcholine receptor (AChR) distribution on identified Xenopus laevis muscle cells in culture before and after innervation. AChRs on muscle cells were stained with tetramethylrhodamine-conjugated alpha-bungarotoxin and the distribution of AChR clusters was examined on a...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(84)90006-x
更新日期:1984-05-01 00:00:00
abstract::The rabbit sperm membrane autoantigen RSA-1 is a sialoglycoprotein of 13,000 daltons which first appears on the surface of pachytene spermatocytes. Using specific antiserum to RSA-1 the antigen has been localized by immunofluorescence and immunoperoxidase staining. On testicular cells labeled at 37 degrees C, RSA-1 is...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(81)90400-0
更新日期:1981-06-01 00:00:00
abstract::The Endo16 gene codes for an RGD-containing calcium-binding protein that is found on the basal surfaces and in the extracellular matrix of cells of the invaginating archenteron during sea urchin gastrulation. Previously, we have shown that Endo16 is a single copy gene and we have determined the coding sequence and ana...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0247
更新日期:1996-10-10 00:00:00
abstract::A series of chimeras was generated by injecting single normal, parthenogenetic, or androgenetic blastomeres carrying transgenic markers under the zona pellucida of nontransgenic eight-cell embryos. These chimeras were cultured to the blastocyst stage and sectioned, and the transgenic component was detected by in situ ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(89)80028-4
更新日期:1989-02-01 00:00:00
abstract::Tbx18 has been shown to be essential for ureteral development. However, it remains unclear whether it plays a direct role in kidney development. Here we addressed this by focusing on examining the pattern and contribution of Tbx18+ cells in the kidney and its role in kidney vascular development. Expression studies and...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2014.04.006
更新日期:2014-07-01 00:00:00
abstract::Mutations at the murine steel (Sl) locus encoding the ligand for the c-kit receptor result in defects in gametogenesis, hematopoiesis, and melanogenesis. Steel Panda (Slpan) is an allele at the Sl locus obtained by an X-ray mutagenesis protocol. Slpan/Slpan homozygotes are mildly anemic black-eyed whites with pigmente...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1115
更新日期:1993-05-01 00:00:00
abstract::In this paper we present a structural and functional characterization of a new sea urchin embryo transcription factor, SpRunt-1. This factor was isolated by means of its specific interaction with a cis-regulatory target site of the CyIIIa gene. Here we show that this target site, the P7I site, is required for normal e...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0050
更新日期:1996-02-25 00:00:00
abstract::Growth factor signaling regulates tissue-tissue interactions to control organogenesis and tissue homeostasis. Specifically, transforming growth factor beta (TGFβ) signaling plays a crucial role in the development of cranial neural crest (CNC) cell-derived bone, and loss of Tgfbr2 in CNC cells results in craniofacial s...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2015.02.010
更新日期:2015-04-15 00:00:00
abstract::The cellular control of the switch from embryonic to fetal globin formation in man was investigated with studies of globin expression in erythroid cells of 35- to 56-day-old embryos. Analyses of globins synthesized in vivo and in cultures of erythroid progenitors (burst-forming units, BFUe) showed that cells of the yo...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(87)90441-6
更新日期:1987-09-01 00:00:00
abstract::Isotopes of a number of crustacean myofibrillar proteins have been identified with sodium dodecyl sulfate-polyacrylamide electrophoresis, and their distribution in muscles of the snapping shrimp has been examined. Fast-slow differences in distribution have been observed for myosin light chains and tropomyosin. In cont...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(84)90081-2
更新日期:1984-11-01 00:00:00
abstract::Canonical Wnt signalling is known to be involved in the regulation of differentiation and proliferation in the context of endodermal organogenesis. Wnt mediated beta-catenin activation is understood to be modulated by secreted Frizzled-related proteins, such as XsFRP5, which is dynamically expressed in the prospective...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.03.004
更新日期:2009-05-15 00:00:00
abstract::Retinal ganglion cells (RGCs) are the first cell type to differentiate during retinal histogenesis. It has been postulated that specified RGCs subsequently influence the number and fate of the remaining progenitors to produce the rest of the retinal cell types. However, several genetic knockout models have argued agai...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.01.015
更新日期:2008-04-15 00:00:00
abstract::The development of the Drosophila leg is a good model to study processes of pattern formation, cell death and segmentation. Such processes require the coordinate activity of different genes and signaling pathways that progressively subdivide the leg territory into smaller domains. One of the main pathways needed for l...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2013.10.011
更新日期:2014-01-15 00:00:00
abstract::In many animals, the first cue for development is transcripts and/or proteins that are provided maternally and are localized at specific regions of fertilized eggs and early embryos. The ascidian is known to exhibit a mosaic mode of development, which is largely dependent on localized maternal factors. In early Ciona ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.05.018
更新日期:2006-08-15 00:00:00
abstract::We previously isolated a p53 cDNA from a Xenopus oocyte library. To determine if p53 has a function in the developmental period, we have studied its expression at the RNA and protein levels during the early development of Xenopus laevis. Two p53 transcripts (3 and 2.2 kb) are expressed from the beginning of Xenopus oo...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1230
更新日期:1993-09-01 00:00:00
abstract::Morphogenesis of the anterior metatarsal skin (scutate scale region), from 9.5 to 12 days of development, results in the formation of orderly patterned scale ridges. It is after the initial formation of the Definitive Scale Ridge that the characteristic outer and inner epidermal surfaces differentiate. The hard, plate...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(05)80016-8
更新日期:1991-09-01 00:00:00
abstract::Sprouty proteins function as negative regulators of the receptor tyrosine kinase (RTK)-mediated Ras/Raf/MAPK pathway in many varied physiological and developmental processes, inhibiting growth factor-induced cellular proliferation, migration and differentiation. Like other negative regulators, Sprouty proteins are exp...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2015.09.005
更新日期:2015-10-15 00:00:00
abstract::We present a genetic, developmental and molecular analysis of lethal(1)discs large-1[l(1)d.lg-1; Stewart et al., 1972], an oncogene of Drosophila. Mutations in this gene cause the imaginal discs to grow by cell proliferation beyond their normal final size, transform into solid tumors, fuse with one another and the bra...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(89)90092-4
更新日期:1989-07-01 00:00:00
abstract::We have studied the effect of saline and acid extracts of chick brain on the total number of acetylcholine (ACh) receptors and the number of receptor clusters in cultured chick muscle cells. Myotubes in 7-day cultures responded more rapidly to brain extract than did myotubes in 4-day cultures, so the older cells were ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(83)90039-8
更新日期:1983-02-01 00:00:00
abstract::Vertebrate morphology has been evolutionarily modified by natural and/or artificial selection. The morphological variation of goldfish is a representative example. In particular, the twin-tail strain of ornamental goldfish shows highly diverged anal and caudal fin morphology: bifurcated anal and caudal fins. Recent mo...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2016.11.022
更新日期:2017-07-15 00:00:00
abstract::Despite differences in the formation of neural precursors, all arthropod species analyzed so far generate about 30 single precursors (insects/crustaceans) or precursor groups (chelicerates/myriapods) per hemi-segment. In Drosophila, each precursor has a distinct identity conferred by segment polarity and dorso-ventral...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2005.11.029
更新日期:2006-02-15 00:00:00
abstract::The prostate undergoes branching morphogenesis dependent on paracrine interactions between the prostatic epithelium and the urogenital mesenchyme. To identify cell-surface molecules that function in this process, monoclonal antibodies raised against epithelial cell-surface antigens were screened for antigen expression...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2001.0223
更新日期:2001-05-01 00:00:00
abstract::We have previously reported the detection of cAMP waves within monolayers of aggregating Dictyostelium discoideum cells (K. J. Tomchik and P.N. Devreotes, 1981, Science 212, 443-446). The computer-assisted analysis presented here of the fluorographic images of the cAMP waves reveals (1) all the waves have a consistent...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(83)90178-1
更新日期:1983-04-01 00:00:00
abstract::Endogenous patterns of retinoic acid (RA) signaling in avian cardiac morphogenesis were characterized by localized expression of a key RA-synthetic enzyme, RALDH2, which displayed a biphasic pattern during heart development. RALDH2 immunoreactivity was initially apparent posterior to Hensen's node of stage 5-6 embryos...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9588
更新日期:2000-03-01 00:00:00
abstract::Here we describe a novel set of peptidergic neurons conserved throughout all developmental stages in the Drosophila central nervous system (CNS). We show that a small complement of 28 apterous-expressing cells (Ap-let neurons) in the ventral nerve cord (VNC) of Drosophila larvae co-express numerous gene products. The ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.01.015
更新日期:2004-05-01 00:00:00
abstract::The zebrafish hedgehog (hh) family members tiggy-winkle hedgehog (twhh) and sonic hedgehog (shh) are involved in patterning the ventral CNS and proximal eye. Using a dominant negative protein kinase A regulatory subunit mutant, we show that these hh activities are mediated by protein kinase A. The effects of dominant ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0209
更新日期:1996-08-25 00:00:00