Identification of DNA-binding protein(s) in the developing heart.

abstract：:The germinal vesicle (GV) of starfish oocytes stays just beneath the oocyte cortex at the presumptive animal pole during the long period of oogenesis. We subjected oocytes to a centrifugal force field to detach the GV from the cortex. The association between the cortex and the GV persisted and withstood a small amount...

journal_title：Developmental biology

authors： Miyazaki A,Kamitsubo E,Nemoto SI

更新日期：2000-02-15 00:00:00

abstract：:Drosophila thoracic muscles are comprised of both direct flight muscles (DFMs) and indirect flight muscles (IFMs). The IFMs can be further subdivided into dorsolongitudinal muscles (DLMs) and dorsoventral muscles (DVMs). The correct patterning of each category of muscles requires the coordination of specific executive...

journal_title：Developmental biology

authors： Bernard F,Lalouette A,Gullaud M,Jeantet AY,Cossard R,Zider A,Ferveur JF,Silber J

更新日期：2003-08-15 00:00:00

abstract：:The current academic and business landscape does not provide a clear path for doctoral trainees graduating. Moreover, the fundamental need of the hour is diversification of the workforce where PhD graduates need to be trained to do more beyond basic scientific research. One of the possible paths that is now becoming p...

journal_title：Developmental biology

authors： Sachani SS

更新日期：2020-03-01 00:00:00

abstract：:FbxA is a novel member of a family of proteins that contain an F-box and WD40 repeats and that target specific proteins for degradation via proteasomes. In fruiting bodies formed from cells where the fbxA gene is disrupted (fbxA(-) cells), the spore mass fails to fully ascend the stalk. In addition, fbxA(-) slugs cont...

journal_title：Developmental biology

authors： Nelson MK,Clark A,Abe T,Nomura A,Yadava N,Funair CJ,Jermyn KA,Mohanty S,Firtel RA,Williams JG

更新日期：2000-08-01 00:00:00

abstract：:A complex regulatory cascade is required for normal cardiac development, and many aspects of this network are conserved from Drosophila to mammals. In Drosophila, the seven-up (svp) gene, an ortholog of the vertebrate chick ovalbumin upstream promoter transcription factors (COUP-TFI and II), is initially activated in ...

journal_title：Developmental biology

authors： Ryan KM,Hendren JD,Helander LA,Cripps RM

更新日期：2007-02-15 00:00:00

abstract：:Vertebrate hematopoiesis is characterized by two evolutionally conserved phases of development, i.e., primitive hematopoiesis, which is a transient phenomenon in the early embryo, and definitive hematopoiesis, which takes place in the later stages. Beni fuji (bef) was originally isolated as a medaka mutant that has an...

journal_title：Developmental biology

authors： Moriyama A,Inohaya K,Maruyama K,Kudo A

更新日期：2010-09-15 00:00:00

abstract：:We have tested the role of proteoglycans in the development of feather pattern by culturing 7-day-old embryonic chick skins on medium containing para-nitrophenyl-beta-D-xyloside (2 mM). Xylosides compete with core proteins of proteoglycans by acting as exogenous acceptors for the synthesis of glycosaminoglycans leadin...

journal_title：Developmental biology

authors： Goetinck PF,Carlone DL

更新日期：1988-05-01 00:00:00

abstract：:Analysis of 262 transgenic mouse pedigrees suggests that about 30% of the mice produced by microinjection of plasmids into pronuclei are mosaic in the germline. This implies that in these lines integration of the foreign DNA occurred after the first round of chromosomal DNA replication. In mosaics resulting from delay...

journal_title：Developmental biology

authors： Wilkie TM,Brinster RL,Palmiter RD

更新日期：1986-11-01 00:00:00

abstract：:In previous studies we found that two glycoproteins of 220 and 180 kDa account for 80-90% of the material dissolved from the vitelline coat (VC) of Unio elongatulus egg (Focarelli and Rosati, 1993). The two glycoproteins were purified by electroelution and used to raise the corresponding polyclonal antibodies. Immunof...

journal_title：Developmental biology

authors： Focarelli R,Rosati F

更新日期：1995-10-01 00:00:00

abstract：:Previous experiments in which vitamin A has been administered to developing or regenerating limbs have shown that different limb axes are affected. In regenerating axolotl limbs, serial reduplications in the proximodistal axis are produced. In the developing chick limb bud, mirror-imaged reduplications in the anteropo...

journal_title：Developmental biology

authors： Maden M

更新日期：1983-08-01 00:00:00

abstract：:We show that the intermediate filament protein nestin is expressed in myogenic cells and that multiple mechanisms regulate nestin expression at different stages of myogenesis. Cultured embryonic, fetal, and neonatal mouse limb myoblasts initially expressed nestin in the absence of the four muscle regulatory factors (M...

journal_title：Developmental biology

authors： Kachinsky AM,Dominov JA,Miller JB

更新日期：1994-09-01 00:00:00

abstract：:The transcription factors, GATA4, 5 and 6, recognize the same DNA sequence and are all expressed in the developing myocardium. However, knockout studies in the mouse have indicated that none of them are absolutely required for the specification of the myocardium. Here we present evidence for redundancy in this family ...

journal_title：Developmental biology

authors： Peterkin T,Gibson A,Patient R

更新日期：2007-11-15 00:00:00

abstract：:Embryonic morphogenesis relies on the intrinsic ability of cells, often through remodeling the cytoskeleton, to shape epithelial tissues during development. Epithelial invagination is an example of morphogenesis that depends on this remodeling but the cellular mechanisms driving arrangement of cytoskeletal elements ne...

journal_title：Developmental biology

authors： Houssin NS,Martin JB,Coppola V,Yoon SO,Plageman TF Jr

更新日期：2020-06-01 00:00:00

abstract：:Connexin 43 (Cx43) knockout mice and transgenic mice (CMV43) overexpressing the Cx43 gap junction gene exhibit heart defects involving the conotruncus and right ventricle. Based on the heart phenotype and Cx43 gene and transgene expression pattern, we previously proposed that the heart defects may reflect a role for g...

journal_title：Developmental biology

authors： Huang GY,Wessels A,Smith BR,Linask KK,Ewart JL,Lo CW

更新日期：1998-06-01 00:00:00

abstract：:The Drosophila ovarian germline stem cells (GSCs) constantly experience self-renewal and differentiation, ensuring the female fertility throughout life. The balance between GSC self-renewal and differentiation is exquisitely regulated by the stem cell niche, the stem cells themselves and systemic factors. Increasing e...

journal_title：Developmental biology

authors： Xuan T,Xin T,He J,Tan J,Gao Y,Feng S,He L,Zhao G,Li M

更新日期：2013-07-15 00:00:00

abstract：:The mammalian kidney collecting ducts are critical for water, electrolyte and acid-base homeostasis and develop as a branched network of tubular structures composed of principal cells intermingled with intercalated cells. The intermingled nature of the different collecting duct cell types has made it challenging to id...

journal_title：Developmental biology

authors： Grassmeyer J,Mukherjee M,deRiso J,Hettinger C,Bailey M,Sinha S,Visvader JE,Zhao H,Fogarty E,Surendran K

更新日期：2017-04-01 00:00:00

abstract：:To gain an understanding of the genes and mechanisms that govern morphogenesis and its evolution, we have analyzed mutations that disrupt this process in a simple model structure, the male tail tip of the rhabditid nematode C. elegans. During the evolution of rhabditid male tails, there have been several independent c...

journal_title：Developmental biology

authors： Del Rio-Albrechtsen T,Kiontke K,Chiou SY,Fitch DH

更新日期：2006-09-01 00:00:00

abstract：:About 12-17% of the embryos obtained by mating mice carrying the In(X)1H or Paf mutations are of the 39,X (X0) genotype. Depending on the mutant mice used for mating, the monosomic X chromosome can be inherited from the paternal (XP) or the maternal (XM) parent. The XP0 embryos display developmental retardation at gas...

journal_title：Developmental biology

authors： Jamieson RV,Tan SS,Tam PP

更新日期：1998-09-01 00:00:00

abstract：:Neural crest cells migrate along two pathways in the trunk: the ventral path, between the neural tube and somite, and the dorsolateral path, between the somite and overlying ectoderm. In avian embryos, ventral migration precedes dorsolateral migration by nearly 24 h, and the onset of dorsolateral migration coincides w...

journal_title：Developmental biology

authors： Reedy MV,Faraco CD,Erickson CA

更新日期：1998-08-15 00:00:00

abstract：:Notch activation inhibits neuronal differentiation during development of the nervous system; however, the dynamic role of Notch signaling in individual cell lineages remains poorly understood. We have characterized 3.4 kb 5'-regulatory sequence of a Notch target gene, her4, and used it to drive fluorescent gene expres...

journal_title：Developmental biology

authors： Yeo SY,Kim M,Kim HS,Huh TL,Chitnis AB

更新日期：2007-01-15 00:00:00

abstract：:A mouse mammary epithelial cell line with morphogenetic properties in vivo, Comma-Dbeta, was used to isolate and to characterize mammary progenitor cells. We found that a homogeneous cell population expressing high surface levels of stem cell antigen 1 (Sca-1) was able to give rise in vivo to ductal and alveolar struc...

journal_title：Developmental biology

authors： Deugnier MA,Faraldo MM,Teulière J,Thiery JP,Medina D,Glukhova MA

更新日期：2006-05-15 00:00:00

abstract：:Tissue specificity of cell adhesion was directly characterized in a unit cell interaction using a novel laser trapping cell manipulator in combination with a fixed micropipet. We quantified the adhesive specificity of endodermal and ectodermal epithelial cells from Hydra, which are known to sort out within hours after...

journal_title：Developmental biology

authors： Sato-Maeda M,Uchida M,Graner F,Tashiro H

更新日期：1994-03-01 00:00:00

abstract：:Development of the mammalian external genitalia is controlled by a network of signaling molecules and transcription factors. Because FGF signaling plays a central role in this complicated morphogenetic process, we investigated the role of Sprouty genes, which are important intracellular modulators of FGF signaling, du...

journal_title：Developmental biology

authors： Ching ST,Cunha GR,Baskin LS,Basson MA,Klein OD

更新日期：2014-02-01 00:00:00

abstract：:Huntington disease (HD) is an adult-onset neurodegenerative disease characterized by motor, cognitive, and psychiatric symptoms that is caused by a CAG expansion in the HTT gene. Palmitoylation is the addition of saturated fatty acids to proteins by DHHC palmitoylacyl transferases. HTT is palmitoylated by huntingtin i...

journal_title：Developmental biology

authors： Sanders SS,Hou J,Sutton LM,Garside VC,Mui KK,Singaraja RR,Hayden MR,Hoodless PA

更新日期：2015-01-15 00:00:00

abstract：:Implantation represents a critical step for embryonic development and pregnancy. Its success depends on the complex interplay between a receptive endometrium and a competent embryo. Implantation-related events remain hardly accessible, making implantation a true "black box" in developmental biology. Improved in vitro ...

journal_title：Developmental biology

authors： Ban Z,Knöspel F,Schneider MR

更新日期：2020-07-01 00:00:00

abstract：:The corepressor SMRT acts on a range of transcription factors, including the retinoid and thyroid hormone nuclear receptors. The carboxy-terminal region of SMRT contains CoRNR box motifs that mediate these interactions. We have shown, in Xenopus, that SMRT can exist as isoforms containing either two or three CoRNR box...

journal_title：Developmental biology

authors： Malartre M,Short S,Sharpe C

更新日期：2006-04-15 00:00:00

abstract：:Antibodies to nonerythroid alpha spectrin (p 230) were used to study the distribution of this polypeptide in mouse germ cells, zygote, and early embryonic cells. In the primordial germ cells, fetal oocytes, and spermatogonia, spectrin was found predominantly in the form of a narrow condensed subplasmalemmal band, as i...

journal_title：Developmental biology

authors： Damjanov I,Damjanov A,Lehto VP,Virtanen I

更新日期：1986-03-01 00:00:00

abstract：:We have previously shown that the Caenorhabditis elegans gut-specific esterase gene (Ce-ges-1) has the unusual ability to be expressed in different modules of the embryonic digestive tract (anterior pharynx, posterior pharynx, and rectum) depending on sequence elements within the Ce-ges-1 promoter. In the present pape...

journal_title：Developmental biology

authors： Marshall SD,McGhee JD

更新日期：2001-11-15 00:00:00

abstract：:Development of the Drosophila embryonic midgut is dependent on a number of genes, including tinman and bagpipe, which are required for formation of the visceral mesoderm, and the homeotic genes and their targets, which act locally in the visceral mesoderm to direct formation of specific midgut constrictions. Here we r...

journal_title：Developmental biology

authors： Cimbora DM,Sakonju S

更新日期：1995-06-01 00:00:00

abstract：:Congenital diseases caused by abnormal development of the cranial neural crest usually present craniofacial malformations and heart defects while the precise mechanism is not fully understood. Here, we show that the zebrafish eif3ba mutant caused by pseudo-typed retrovirus insertion exhibited a similar phenotype due t...

journal_title：Developmental biology

authors： Xia Z,Tong X,Liang F,Zhang Y,Kuok C,Zhang Y,Liu X,Zhu Z,Lin S,Zhang B

更新日期：2013-09-01 00:00:00