Bef medaka mutant reveals the essential role of c-myb in both primitive and definitive hematopoiesis.

abstract：:The Rho family of small GTPases has been implicated in many neurological disorders including mental retardation, but whether they are involved in primary microcephaly (microcephalia vera) is unknown. Here, we examine the role of Rac1 in mammalian neural progenitors and forebrain development by a conditional gene-targe...

journal_title：Developmental biology

authors： Chen L,Melendez J,Campbell K,Kuan CY,Zheng Y

更新日期：2009-01-01 00:00:00

abstract：:Connective tissue outgrowths of neonatal muscle onto a substratum of bone matrix differentiate into cartilage in response to a bone morphogenetic protein (BMP). The BMP can be separated from bone matrix by extraction with 4 M guanidine hydrochloride (GuHCl) or degraded in situ by endogenous proteolytic enzymes to deac...

journal_title：Developmental biology

authors： Kawamura M,Urist MR

更新日期：1988-12-01 00:00:00

abstract：:To examine the role of postsynaptic activity in regulating the rate of neuromuscular synapse elimination, contractile activity of neonatal rabbit soleus muscles was decreased by chronic superfusion of alpha-bungarotoxin (alpha-BGT) over their surfaces. Superfusion was begun at 6 days postnatal and continued for a vari...

journal_title：Developmental biology

authors： Callaway EM,Van Essen DC

更新日期：1989-02-01 00:00:00

abstract：:Metazoan replication-dependent histone mRNAs accumulate to high levels during S phase as a result of an increase in the rate of histone gene transcription, pre-mRNA processing, and mRNA stability at the G1-S transition. However, relatively little is known about the contribution of these processes to histone expression...

journal_title：Developmental biology

authors： Lanzotti DJ,Kupsco JM,Marzluff WF,Duronio RJ

更新日期：2004-10-01 00:00:00

abstract：:Mammalian sperm must acquire their fertilizing ability after a series of biochemical modifications in the female reproductive tract collectively called capacitation to undergo acrosomal exocytosis, a process that is essential for fertilization. Actin dynamics play a central role in controlling the process of exocytosi...

journal_title：Developmental biology

authors： Romarowski A,Battistone MA,La Spina FA,Puga Molina Ldel C,Luque GM,Vitale AM,Cuasnicu PS,Visconti PE,Krapf D,Buffone MG

更新日期：2015-09-15 00:00:00

abstract：:Fetal human hepatocytes were isolated by collagenase digestion of liver fragments and cultured either alone or mixed with rat liver epithelial cells. Whereas they did not survive more than 2-3 weeks and showed rapid morphologic and functional alterations in conventional culture, fetal hepatocytes survived and retained...

journal_title：Developmental biology

authors： Guguen-Guillouzo C,Clement B,Lescoat G,Glaise D,Guillouzo A

更新日期：1984-09-01 00:00:00

abstract：:Chondrogenesis of mesenchymal cells from the frontonasal mass, mandibles and maxillae of stage-24 chick embryos has been investigated in micromass (high-density) cultures. Distinct differences in the amount and pattern of cartilage differentiation are found. In cultures of frontonasal mass cells, a central sheet of ca...

journal_title：Developmental biology

authors： Wedden SE,Lewin-Smith MR,Tickle C

更新日期：1986-09-01 00:00:00

abstract：:Huntington disease (HD) is an adult-onset neurodegenerative disease characterized by motor, cognitive, and psychiatric symptoms that is caused by a CAG expansion in the HTT gene. Palmitoylation is the addition of saturated fatty acids to proteins by DHHC palmitoylacyl transferases. HTT is palmitoylated by huntingtin i...

journal_title：Developmental biology

authors： Sanders SS,Hou J,Sutton LM,Garside VC,Mui KK,Singaraja RR,Hayden MR,Hoodless PA

更新日期：2015-01-15 00:00:00

abstract：:We have characterized the antigen recognized by mab10, a monoclonal antibody that has been shown to modify outgrowth of thalamic and cortical axons in vitro, and investigated the influence of this antibody on axonal growth in the chicken retina in vivo. Immunopurification, peptide sequencing, and biochemical character...

journal_title：Developmental biology

authors： Monnier PP,Beck SG,Bolz J,Henke-Fahle S

更新日期：2001-01-01 00:00:00

abstract：:Rhodopsin is essential for normal photoreceptor development in Drosophila (O'Tousa et al., 1989; Leonard et al., 1992; Kumar and Ready, 1995) and in mice (Humphries et al., 1997). Here we report studies in which a rhodopsin transgene is expressed at restricted stages during the development of Drosophila photoreceptors...

journal_title：Developmental biology

authors： Kumar JP,Bowman J,O'Tousa JE,Ready DF

更新日期：1997-08-01 00:00:00

abstract：:We show that the intermediate filament protein nestin is expressed in myogenic cells and that multiple mechanisms regulate nestin expression at different stages of myogenesis. Cultured embryonic, fetal, and neonatal mouse limb myoblasts initially expressed nestin in the absence of the four muscle regulatory factors (M...

journal_title：Developmental biology

authors： Kachinsky AM,Dominov JA,Miller JB

更新日期：1994-09-01 00:00:00

abstract：:We present a genetic, developmental and molecular analysis of lethal(1)discs large-1[l(1)d.lg-1; Stewart et al., 1972], an oncogene of Drosophila. Mutations in this gene cause the imaginal discs to grow by cell proliferation beyond their normal final size, transform into solid tumors, fuse with one another and the bra...

journal_title：Developmental biology

authors： Woods DF,Bryant PJ

更新日期：1989-07-01 00:00:00

abstract：:We determined expression and function of a cell membrane protein in the developing chick retinotectal system identified by a monoclonal antibody (mAb 4H5) and the corresponding antiserum. Our data revealed that the protein shares a series of properties, including the N-terminal amino acid sequence, with a cell adhesio...

journal_title：Developmental biology

authors： Pollerberg GE,Mack TG

更新日期：1994-10-01 00:00:00

abstract：:In the vertebrate head, crucial parts of the sense organs and sensory ganglia develop from special regions, the cranial placodes. Despite their cellular and functional diversity, they arise from a common field of multipotent progenitors and acquire distinct identity later under the influence of local signalling. Here ...

journal_title：Developmental biology

authors： Grocott T,Tambalo M,Streit A

更新日期：2012-10-01 00:00:00

abstract：:This first study of the onset of spermatogenesis in the sea urchin, Strongylocentrotus purpuratus, was undertaken using individuals reared in the laboratory. Spermatogenesis commences about 11-12 months after metamorphosis in these animals. Bindin message accumulates in late spermatocytes and early spermatids which li...

journal_title：Developmental biology

authors： Cameron RA,Minor JE,Nishioka D,Britten RJ,Davidson EH

更新日期：1990-11-01 00:00:00

abstract：:The purpose of this study was to examine part of the trophoblast cell multilineage pathway and its modulation by retinoic acid. A method for studying trophoblast cell differentiation along the spongiotrophoblast cell pathway in vitro was established and characterized. Cells were isolated from junctional zones of Day 1...

journal_title：Developmental biology

authors： Lu XJ,Deb S,Soares MJ

更新日期：1994-05-01 00:00:00

abstract：:Choroideremia (CHM) is a hereditary eye disease caused by mutations in the X-linked CHM gene. Disruption of the Chm gene in mice resulted in prenatal death of Chm-/Y males and Chm-/Chm+ females that had inherited the mutation from their mothers. Male chimeras and Chm+/Chm- females with paternal transmission of the mut...

journal_title：Developmental biology

authors： Shi W,van den Hurk JA,Alamo-Bethencourt V,Mayer W,Winkens HJ,Ropers HH,Cremers FP,Fundele R

更新日期：2004-08-01 00:00:00

abstract：:The lethal(3)discs overgrown (dco) locus of Drosophila melanogaster, located on the third chromosome at cytogenetic position 100A5,6-100B1,2, is necessary for normal development and growth control in the imaginal discs of the larva. Three recessive lethal alleles (dco2, dco3, and dco18) in heteroallelic combinations a...

journal_title：Developmental biology

authors： Jursnich VA,Fraser SE,Held LI Jr,Ryerse J,Bryant PJ

更新日期：1990-08-01 00:00:00

abstract：:A mutant gene dose-dependent inhibition of cerebellar granule cell neuron survival and neurite growth in dissociated cultures of cerebellum from 7-day-old heterozygous (+/wv) and homozygous (wv/wv) weaver mutant mice (M. Willinger, D. M. Margolis, and R. L. Sidman. (1981), J. Supramol. Struc. 17, 79-86) has previously...

journal_title：Developmental biology

authors： Willinger M,Margolis DM

更新日期：1985-01-01 00:00:00

abstract：:Specific binding of spermatozoa to the zona pellucida that surrounds mammalian eggs is a key step in the fertilization process. However, the sperm proteins that recognise zona pellucida receptors remain contentious despite longstanding research efforts to identify them. Here we present evidence that proacrosin, a tiss...

journal_title：Developmental biology

authors： Gaboriau D,Howes EA,Clark J,Jones R

更新日期：2007-06-15 00:00:00

abstract：:Previous studies suggest that sensory innervation of muscles is patterned by motor innervation. Muscle afferent projections mirror motor projections after various experimental manipulations and muscle afferents fail to project to muscle in the absence of motoneurons. It is not known, however, whether muscle afferents ...

journal_title：Developmental biology

authors： Wang G,Scott SA

更新日期：1997-06-01 00:00:00

abstract：:XX gonads differentiate into ovaries, a morphologic event evident by embryonic day 13.5 (E13.5) in mice. To identify early markers of oogenesis, sex-specific urogenital ridge cDNA libraries were constructed from E12-13 embryos. After mass excision and isolation of plasmid DNA, approximately 4800 expressed sequence tag...

journal_title：Developmental biology

authors： Takasaki N,McIsaac R,Dean J

更新日期：2000-07-01 00:00:00

abstract：:The hallmark of the arthropods is their segmented body, although origin of segmentation, however, is unresolved. In order to shed light on the origin of segmentation we investigated orthologs of pair rule genes (PRGs) and segment polarity genes (SPGs) in a member of the closest related sister-group to the arthropods, ...

journal_title：Developmental biology

authors： Janssen R,Budd GE

更新日期：2013-10-01 00:00:00

abstract：:In the head of an embryo, a layer of mesenchyme surrounds the brain underneath the surface ectoderm. This cranial mesenchyme gives rise to the meninges, the calvaria (top part of the skull), and the dermis of the scalp. Abnormal development of these structures, especially the meninges and the calvaria, is linked to si...

journal_title：Developmental biology

authors： Dasgupta K,Chung JU,Asam K,Jeong J

更新日期：2019-11-15 00:00:00

abstract：:Previous attempts to study sorting out of Drosophila imaginal disc cells have been hampered by an inability to thoroughly dissociate these cells and the need to use cuticular markers which require several days of in vivo culture. This study overcomes these limitations by using a new dissociation procedure and a geneti...

journal_title：Developmental biology

authors： Fehon RG,Schubiger G

更新日期：1985-04-01 00:00:00

abstract：:The canonical, beta-catenin-dependent Wnt pathway is a crucial player in the early events of Xenopus development. Dorsal axis formation and mesoderm patterning are accepted effects of this pathway, but the regulation of expression of genes involved in mesoderm specification is not. This conclusion is based largely on ...

journal_title：Developmental biology

authors： Vonica A,Gumbiner BM

更新日期：2002-10-01 00:00:00

abstract：:Syndecan-3 is one of four identified members of a family of transmembrane proteoglycans (the syndecans) that possess highly similar cytoplasmic and transmembrane domains and may function as extracellular matrix receptors and/or low affinity receptors for signaling molecules such as FGF. We previously reported the clon...

journal_title：Developmental biology

authors： Gould SE,Upholt WB,Kosher RA

更新日期：1995-04-01 00:00:00

abstract：:The zebrafish hedgehog (hh) family members tiggy-winkle hedgehog (twhh) and sonic hedgehog (shh) are involved in patterning the ventral CNS and proximal eye. Using a dominant negative protein kinase A regulatory subunit mutant, we show that these hh activities are mediated by protein kinase A. The effects of dominant ...

journal_title：Developmental biology

authors： Ungar AR,Moon RT

更新日期：1996-08-25 00:00:00

abstract：:Dictyostelium discoideum amoebas display colonial multicellularity where starving amoebas aggregate to form migrating slugs and fruiting bodies consisting of spores and three supporting cell types. To resolve the cell signalling mechanism that control sporulation, we use insertional mutagenesis of amoebas transformed ...

journal_title：Developmental biology

authors： Yamada Y,Schaap P

更新日期：2019-08-15 00:00:00

abstract：:The cDNA encoding the TATA binding protein was isolated from 8- to 16-cell and morula-stage embryonic libraries of two distantly related species of sea urchin, Strongylocentrotus purpuratus and Lytechinus variegatus, respectively. The two proteins are 96% identical over both the N- and C-terminal domains, suggesting a...

journal_title：Developmental biology

authors： Edelmann L,Zheng L,Wang ZF,Marzluff W,Wessel GM,Childs G

更新日期：1998-12-01 00:00:00