Adhesive but not signaling activity of Drosophila N-cadherin is essential for target selection of photoreceptor afferents.

abstract：:Bone morphogenetic protein-4 (BMP-4) induces epidermis and represses neural fate in Xenopus ectoderm. Our previous findings implicate p42 Erk MAP kinase (MAPK) in the response to neural induction. We have examined the effects of BMP-4 on MAPK activity in gastrula ectoderm. Expression of a dominant negative BMP-4 recep...

journal_title：Developmental biology

authors： Goswami M,Uzgare AR,Sater AK

更新日期：2001-08-15 00:00:00

abstract：:Cardiac troponin T (cTnT) is a component of the troponin (Tn) complex in cardiac myocytes, and plays a regulatory role in cardiac muscle contraction by anchoring two other Tn components, troponin I (TnI) and troponin C, to tropomyosin (Tm) on the thin filaments. In order to determine the in vivo function of cTnT, we c...

journal_title：Developmental biology

authors： Nishii K,Morimoto S,Minakami R,Miyano Y,Hashizume K,Ohta M,Zhan DY,Lu QW,Shibata Y

更新日期：2008-10-01 00:00:00

abstract：:The survival effects of brain-derived neurotrophic factor (BDNF) on the ganglion cells of the chick retina were studied in vitro at different embryonic ages. We found these effects to be strongly age-dependent: at E5, when the first ganglion cell axons have crossed the optic chiasm, but not yet reached the tectum, gan...

journal_title：Developmental biology

authors： Rodriguez-Tébar A,Jeffrey PL,Thoenen H,Barde YA

更新日期：1989-12-01 00:00:00

abstract：:Pericytes heterogeneity is based on their morphology, distribution, and markers. It is well known that pericytes from different organs may have distinct embryonic sources. Yamazaki et al. (2017) using several transgenic mouse model reveal by cell-lineage tracing that pericytes are even more heterogeneous than previous...

journal_title：Developmental biology

authors： Dias Moura Prazeres PH,Sena IFG,Borges IDT,de Azevedo PO,Andreotti JP,de Paiva AE,de Almeida VM,de Paula Guerra DA,Pinheiro Dos Santos GS,Mintz A,Delbono O,Birbrair A

更新日期：2017-07-01 00:00:00

abstract：:We have examined the response of bovine oocytes matured in vitro for 24 hr to parthenogenic activation using compounds that increase intracellular calcium (ionomycin) or inhibit protein phosphorylation (6-dimethylaminopurine, DMAP). Treatment with ionomycin alone caused resumption of meiosis (57.8 +/- 7.8%) but not pr...

journal_title：Developmental biology

authors： Susko-Parrish JL,Leibfried-Rutledge ML,Northey DL,Schutzkus V,First NL

更新日期：1994-12-01 00:00:00

abstract：:The prostate undergoes branching morphogenesis dependent on paracrine interactions between the prostatic epithelium and the urogenital mesenchyme. To identify cell-surface molecules that function in this process, monoclonal antibodies raised against epithelial cell-surface antigens were screened for antigen expression...

journal_title：Developmental biology

authors： Marker PC,Stephan JP,Lee J,Bald L,Mather JP,Cunha GR

更新日期：2001-05-01 00:00:00

abstract：:We have compared the ability of uncapacitated, capacitated acrosome intact, and acrosome-reacted hamster sperm to penetrate the cumulus and corona radiata of fresh hamster oocyte-cumulus complexes (OCC) in vitro. This was done using physiological numbers (1-20) of sperm so that cumulus and corona radiata cells did not...

journal_title：Developmental biology

authors： Corselli J,Talbot P

更新日期：1987-07-01 00:00:00

abstract：:An antiserum (anti-H2) directed at the second helix of the helix-loop-helix (HLH) protein MyoD1 reacts with a protein expressed during avian cardiac myocyte differentiation. Indirect immunohistochemical whole mount staining with anti-H2 detected a protein expressed in stage 11 hearts, but not in hearts of older embryo...

journal_title：Developmental biology

authors： Litvin J,Montgomery MO,Goldhamer DJ,Emerson CP Jr,Bader DM

更新日期：1993-04-01 00:00:00

abstract：:Thrombospondin type 1 repeat (TSR) superfamily members regulate diverse biological activities ranging from cell motility to inhibition of angiogenesis. In this study, we verified that mouse protein O-fucosyltransferase-2 (POFUT2) specifically adds O-fucose to TSRs. Using two Pofut2 gene-trap lines, we demonstrated tha...

journal_title：Developmental biology

authors： Du J,Takeuchi H,Leonhard-Melief C,Shroyer KR,Dlugosz M,Haltiwanger RS,Holdener BC

更新日期：2010-10-01 00:00:00

abstract：:An understanding of heart development is critical in any systems biology approach to cardiovascular disease. The interpretation of data generated from high-throughput technologies (such as microarray and proteomics) is also essential to this approach. However, characterizing the role of genes in the processes underlyi...

journal_title：Developmental biology

authors： Khodiyar VK,Hill DP,Howe D,Berardini TZ,Tweedie S,Talmud PJ,Breckenridge R,Bhattarcharya S,Riley P,Scambler P,Lovering RC

更新日期：2011-06-01 00:00:00

abstract：:The chicken retina is capable of limited regeneration. In response to injury, some Müller glia proliferate and de-differentiate into progenitor cells. However, most of these progenitors fail to differentiate into neurons. The Notch pathway is upregulated during retinal regeneration in both fish and amphibians. Since t...

journal_title：Developmental biology

authors： Hayes S,Nelson BR,Buckingham B,Reh TA

更新日期：2007-12-01 00:00:00

abstract：:The cDNA encoding the TATA binding protein was isolated from 8- to 16-cell and morula-stage embryonic libraries of two distantly related species of sea urchin, Strongylocentrotus purpuratus and Lytechinus variegatus, respectively. The two proteins are 96% identical over both the N- and C-terminal domains, suggesting a...

journal_title：Developmental biology

authors： Edelmann L,Zheng L,Wang ZF,Marzluff W,Wessel GM,Childs G

更新日期：1998-12-01 00:00:00

abstract：:Modulation of reactive oxygen species (ROS) plays a key role in signal transduction pathways. Selenoproteins act controlling the redox balance of the cell. We have studied how the alteration of the redox balance caused by patufet (selD(ptuf)), a null mutation in the Drosophila melanogaster selenophosphate synthetase 1...

journal_title：Developmental biology

authors： Morey M,Serras F,Baguñà J,Hafen E,Corominas M

更新日期：2001-10-01 00:00:00

abstract：:Synapse elimination was examined in the developing frog cutaneous pectoris muscle using histological and electrophysiological techniques. Morphological synapse elimination occurred in two phases. The first phase, which began at the time of metamorphosis and continued until the second to third postmetamorphic week, was...

journal_title：Developmental biology

authors： Morrison-Graham K

更新日期：1983-10-01 00:00:00

abstract：:The evolutionary divergence of cnidarian and bilaterian lineages from their remote metazoan ancestor occurred at an unknown depth in time before the Cambrian, since crown group representatives of each are found in Lower Cambrian fossil assemblages. We report here a variety of putative embryonic, larval, and adult micr...

journal_title：Developmental biology

authors： Chen JY,Oliveri P,Gao F,Dornbos SQ,Li CW,Bottjer DJ,Davidson EH

更新日期：2002-08-01 00:00:00

abstract：:The unfertilized oocyte contains various granules which serve as storage sites for proteins, the majority which are yolk granules or platelets. Yolk granules are thought to provide the developing embryo with nutrients essential for its survival, while other granules contain proteins such as enzymes and extracellular m...

journal_title：Developmental biology

authors： Reimer CL,Crawford BJ

更新日期：1995-02-01 00:00:00

abstract：:Procedures are described for removal of the vitelline membrane from gently fixed Drosophila embryos en masse. The resulting embryos retain excellent structural integrity and are now suitable for a variety of immunocytochemical and biochemical characterizations. ...

journal_title：Developmental biology

authors： Mitchison TJ,Sedat J

更新日期：1983-09-01 00:00:00

abstract：:Growth factors and the extracellular matrix have been shown to fulfill vital developmental roles in many embryonic systems. Our hypothesis is that a developmental role played by the extracellular matrix in sea urchins may be the binding of a PDGF-like growth factor to promote signaling activity. We report here that an...

journal_title：Developmental biology

authors： Govindarajan V,Ramachandran RK,George JM,Shakes DC,Tomlinson CR

更新日期：1995-12-01 00:00:00

abstract：:We examined the effects of ciliary neurotrophic factor (CNTF) and depolarization, two environmental signals that influence noradrenergic and cholinergic function, on neuropeptide expression by cultured sympathetic neurons. Sciatic nerve extract, a rich source of CNTF, increased levels of vasoactive intestinal peptide ...

journal_title：Developmental biology

authors： Rao MS,Tyrrell S,Landis SC,Patterson PH

更新日期：1992-04-01 00:00:00

abstract：:We have previously shown that the adenosine analog 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR), an activator of AMP-activated protein kinase (AMPK), stimulates an increase in AMPK activity and induces meiotic resumption in mouse oocytes [Downs, S.M., Hudson, E.R., Hardie, D.G., 2002. A potential rol...

journal_title：Developmental biology

authors： Chen J,Hudson E,Chi MM,Chang AS,Moley KH,Hardie DG,Downs SM

更新日期：2006-03-15 00:00:00

abstract：:Monoclonal antibodies (mAbs), electrophoresis, immunoblotting, and immunohistochemistry were used to determine the molecular properties of cardiac myosin heavy chain (MHC) isoforms and the regions of the developing chicken heart in which they were expressed. Adult atria expressed three electrophoretically distinct MHC...

journal_title：Developmental biology

authors： Evans D,Miller JB,Stockdale FE

更新日期：1988-06-01 00:00:00

abstract：:Ammonium transporter C (AmtC) is one of three transporters in Dictyostelium that have been proposed to regulate entry and exit of ammonia in a cell type dependent manner and to mediate ammonia signaling. Previous work demonstrated that disruption of the amtC gene results in a slugger phenotype in which the cells remai...

journal_title：Developmental biology

authors： Kirsten JH,Xiong Y,Dunbar AJ,Rai M,Singleton CK

更新日期：2005-11-01 00:00:00

abstract：:The origin of the avian cardiovascular system from the primitive streak has been mapped by the construction of quail/chick transplantation chimeras, the use of QH-1 (an antiquail endothelial/endocardial cell marker), and injections of a vital fluorescent dye (DiI) into the primitive streak. Our studies reveal that the...

journal_title：Developmental biology

authors： Garcia-Martinez V,Schoenwolf GC

更新日期：1993-10-01 00:00:00

abstract：:The embryonic dorsal vessel in Drosophila possesses anteroposterior polarity and is subdivided into two chamber-like portions, the aorta in the anterior and the heart in the posterior. The heart portion features a wider bore as compared with the aorta and develops inflow valves (ostia) that allow the pumping of hemoly...

journal_title：Developmental biology

authors： Lo PC,Skeath JB,Gajewski K,Schulz RA,Frasch M

更新日期：2002-11-15 00:00:00

abstract：:The distribution of the catalytic and regulatory subunits of the cAMP-dependent protein kinase between cytoplasm and nucleus was determined during the development of Dictyostelium discoideum. In vegetative amoebae approximately 2% of the subunits were in the nucleus. During development there was an approximately 5-fol...

journal_title：Developmental biology

authors： Woffendin C,Chambers TC,Schaller KL,Leichtling BH,Rickenberg HV

更新日期：1986-05-01 00:00:00

abstract：:This study reports a morphological, skeletal, and molecular characterization of the supernumerary limbs induced by systemic administration of all-trans retinoic acid to egg-cylinder stage mouse embryos. As initially described by Rutledge et al. (Proc. Natl. Acad. Sci. USA 91, 5436, 1994), we have found that oral admin...

journal_title：Developmental biology

authors： Niederreither K,Ward SJ,Dollé P,Chambon P

更新日期：1996-06-15 00:00:00

abstract：:Morphogenesis of the anterior metatarsal skin (scutate scale region), from 9.5 to 12 days of development, results in the formation of orderly patterned scale ridges. It is after the initial formation of the Definitive Scale Ridge that the characteristic outer and inner epidermal surfaces differentiate. The hard, plate...

journal_title：Developmental biology

authors： Shames RB,Jennings AG,Sawyer RH

更新日期：1991-09-01 00:00:00

abstract：:A group of proteins judged on several criteria to be yolk proteins have been isolated from a homogenate of the nematode Caenorhabditis elegans. Comparison of partial proteolysis fragments indicates that the two bands of a 170,000-dalton doublet (yp170) are closely related; bands observed at 115,000 daltons (yp115) and...

journal_title：Developmental biology

authors： Sharrock WJ

更新日期：1983-03-01 00:00:00

abstract：:Inhibitor of differentiation and DNA-binding (Id) proteins, Id1 to Id4, function in the regulation of cellular proliferation and differentiation. Id proteins have been shown to interact with bHLH proteins and other proteins involved in regulating cellular proliferation and differentiation, suggesting a widespread regu...

journal_title：Developmental biology

authors： Sakamoto S,Tateya T,Omori K,Kageyama R

更新日期：2020-04-15 00:00:00

abstract：:During digit development, the correct balance of chondrogenic signals ensures the recruitment of undifferentiated cells into the cartilage lineage or the maintenance of cells at the undifferentiated stage. WNT/β catenin maintains the pool of progenitor cells, whereas TGFβ signalling promotes cartilage differentiation ...

journal_title：Developmental biology

authors： Farrera-Hernández A,Marín-Llera JC,Chimal-Monroy J

更新日期：2021-01-01 00:00:00