fucosyltransferase1 and H-type complex carbohydrates modulate epithelial cell proliferation during prostatic branching morphogenesis.

Abstract:

:The prostate undergoes branching morphogenesis dependent on paracrine interactions between the prostatic epithelium and the urogenital mesenchyme. To identify cell-surface molecules that function in this process, monoclonal antibodies raised against epithelial cell-surface antigens were screened for antigen expression in the developing prostate and for their ability to alter development of prostates grown in serum-free organ culture. One antibody defined a unique expression pattern in the developing prostate and inhibited growth and ductal branching of cultured prostates by inhibiting epithelial cell proliferation. Expression cloning showed that this antibody binds fucosyltransferase1, an alpha-(1,2)-fucosyltransferase that synthesizes H-type structures on the complex carbohydrate modifications of some proteins and lipids. The lectin UEA I that binds H-type 2 carbohydrates also inhibited development of cultured prostates. These data demonstrate a previously unrecognized role for fucosyltransferase1 and H-type carbohydrates in controlling the spatial distribution of epithelial cell proliferation during prostatic branching morphogenesis. We also show that fucosyltransferase1 is expressed by epithelial cells derived from benign prostatic hyperplasia or prostate cancer; thus, fucosyltransferase1 may also contribute to pathological prostatic growth. These data further suggest that rare individuals who lack fucosyltransferase1 (Bombay phenotype) should be investigated for altered reproductive function and/or altered susceptibility to benign prostatic hyperplasia and prostate cancer.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Marker PC,Stephan JP,Lee J,Bald L,Mather JP,Cunha GR

doi

10.1006/dbio.2001.0223

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

95-108

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(01)90223-4

journal_volume

233

pub_type

杂志文章
  • Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression.

    abstract::Ovarian germ cell survival is dependent upon the formation of primordial follicles, which occurs during fetal life in the human. Activin contributes to germ cell proliferation and survival at this time. SMADs2 and 3 are central elements in the activin signalling pathway and thus indicate sites of activin action. We ha...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2007.11.026

    authors: Coutts SM,Childs AJ,Fulton N,Collins C,Bayne RA,McNeilly AS,Anderson RA

    更新日期:2008-02-01 00:00:00

  • Tissue-specific functions of the Caenorhabditis elegans p120 Ras GTPase activating protein GAP-3.

    abstract::All metazoan genomes encode multiple RAS GTPase activating proteins (RasGAPs) that negatively regulate the conserved RAS/MAPK signaling pathway. In mammals, several RasGAPs exhibit tumor suppressor activity by preventing excess RAS signal transduction. We have identified gap-3 as the to date missing Caenorhabditiseleg...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2008.08.026

    authors: Stetak A,Gutierrez P,Hajnal A

    更新日期:2008-11-15 00:00:00

  • Changes in endoplasmic reticulum structure during mouse oocyte maturation are controlled by the cytoskeleton and cytoplasmic dynein.

    abstract::Oocyte maturation in mouse is associated with a dramatic reorganisation of the endoplasmic reticulum (ER) from a network of cytoplasmic accumulations in the germinal vesicle-stage oocyte (GV) to a network of distinctive cortical clusters in the metaphase II egg (MII). Multiple lines of evidence suggest that this redis...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2007.02.006

    authors: FitzHarris G,Marangos P,Carroll J

    更新日期:2007-05-01 00:00:00

  • Zebrafish early macrophages colonize cephalic mesenchyme and developing brain, retina, and epidermis through a M-CSF receptor-dependent invasive process.

    abstract::The origin of resident (noninflammatory) macrophages in vertebrate tissues is still poorly understood. In the zebrafish embryo, we recently described a specific lineage of early macrophages that differentiate in the yolk sac before the onset of blood circulation. We now show that these early macrophages spread in the ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.2001.0393

    authors: Herbomel P,Thisse B,Thisse C

    更新日期:2001-10-15 00:00:00

  • Ofd1 is required in limb bud patterning and endochondral bone development.

    abstract::Oral-facial-digital type I (OFDI) syndrome is an X-linked male lethal developmental disorder. It is ascribed to ciliary dysfunction and characterized by malformation of the face, oral cavity, and digits. Conditional inactivation using different Cre lines allowed us to study the role of the Ofd1 transcript in limb deve...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2010.09.020

    authors: Bimonte S,De Angelis A,Quagliata L,Giusti F,Tammaro R,Dallai R,Ascenzi MG,Diez-Roux G,Franco B

    更新日期:2011-01-15 00:00:00

  • Analysis of visual system development in Drosophila melanogaster: mutations at the Glued locus.

    abstract::We have analyzed several aspects of the development of flies carrying mutations at the Glued locus. Optic lobe abnormalities in individuals heterozygous for the original Glued allele were previously shown to result from an action of this mutation in the retinula cells. We have estimated when the functioning of this ge...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(83)90256-7

    authors: Harte PJ,Kankel DR

    更新日期:1983-09-01 00:00:00

  • Specification and positioning of parasegment grooves in Drosophila.

    abstract::Developmental boundaries ensure that cells fated to participate in a particular structure are brought together or maintained at the appropriate locale within developing embryos. Parasegment grooves mark the position of boundaries that separate every segment of the Drosophila embryo into anterior and posterior compartm...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2008.04.026

    authors: Larsen C,Bardet PL,Vincent JP,Alexandre C

    更新日期:2008-09-15 00:00:00

  • Complementary striped expression patterns of NK homeobox genes during segment formation in the annelid Platynereis.

    abstract::NK genes are related pan-metazoan homeobox genes. In the fruitfly, NK genes are clustered and involved in patterning various mesodermal derivatives during embryogenesis. It was therefore suggested that the NK cluster emerged in evolution as an ancestral mesodermal patterning cluster. To test this hypothesis, we cloned...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2008.02.013

    authors: Saudemont A,Dray N,Hudry B,Le Gouar M,Vervoort M,Balavoine G

    更新日期:2008-05-15 00:00:00

  • Retinoic acid-metabolizing enzyme Cyp26a1 is essential for determining territories of hindbrain and spinal cord in zebrafish.

    abstract::Retinoic acid (RA) plays a critical role in neural patterning and organogenesis in the vertebrate embryo. Here we characterize a mutant of the zebrafish named giraffe (gir) in which the gene for the RA-degrading enzyme Cyp26a1 is mutated. The gir mutant displayed patterning defects in multiple organs including the com...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2004.11.023

    authors: Emoto Y,Wada H,Okamoto H,Kudo A,Imai Y

    更新日期:2005-02-15 00:00:00

  • An F-Box/WD40 repeat-containing protein important for Dictyostelium cell-type proportioning, slug behaviour, and culmination.

    abstract::FbxA is a novel member of a family of proteins that contain an F-box and WD40 repeats and that target specific proteins for degradation via proteasomes. In fruiting bodies formed from cells where the fbxA gene is disrupted (fbxA(-) cells), the spore mass fails to fully ascend the stalk. In addition, fbxA(-) slugs cont...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.2000.9793

    authors: Nelson MK,Clark A,Abe T,Nomura A,Yadava N,Funair CJ,Jermyn KA,Mohanty S,Firtel RA,Williams JG

    更新日期:2000-08-01 00:00:00

  • MusTRD can regulate postnatal fiber-specific expression.

    abstract::Human MusTRD1alpha1 was isolated as a result of its ability to bind a critical element within the Troponin I slow upstream enhancer (TnIslow USE) and was predicted to be a regulator of slow fiber-specific genes. To test this hypothesis in vivo, we generated transgenic mice expressing hMusTRD1alpha1 in skeletal muscle....

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2006.01.019

    authors: Issa LL,Palmer SJ,Guven KL,Santucci N,Hodgson VR,Popovic K,Joya JE,Hardeman EC

    更新日期:2006-05-01 00:00:00

  • Cell lineage analysis of Schwann cells in the PNS determined by shiverer-normal mouse chimeras.

    abstract::The myelin of the peripheral nervous system from the shiverer mutant mice is characterized by the absence of myelin basic protein, while the other myelin protein components are present at normal levels. Myelin lamella formation is normal in the shiverer mutant. Therefore, by using antiserum against myelin basic protei...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(84)90277-x

    authors: Mikoshiba K,Yokoyama M,Takamatsu K,Tsukada Y,Nomura T

    更新日期:1984-09-01 00:00:00

  • Epicardial GATA factors regulate early coronary vascular plexus formation.

    abstract::During early development, GATA factors have been shown to be important for key events of coronary vasculogenesis, including formation of the epicardium. Myocardial GATA factors are required for coronary vascular (CV) formation; however, the role of epicardial localized GATAs in this process has not been addressed. The...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2013.12.033

    authors: Kolander KD,Holtz ML,Cossette SM,Duncan SA,Misra RP

    更新日期:2014-02-01 00:00:00

  • SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation during Caenorhabditis elegans gastrulation.

    abstract::Gastrulation is the first major morphogenetic movement in development and requires dynamic regulation of cell adhesion and the cytoskeleton. Caenorhabditis elegans gastrulation begins with the migration of the two endodermal precursors, Ea and Ep, from the surface of the embryo into the interior. Ea/Ep migration provi...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2010.05.507

    authors: Grana TM,Cox EA,Lynch AM,Hardin J

    更新日期:2010-08-15 00:00:00

  • Natural variation of the expression pattern of the segmentation gene even-skipped in melanogaster.

    abstract::The evolution of canalized traits is a central question in evolutionary biology. Natural variation in highly conserved traits can provide clues about their evolutionary potential. Here we investigate natural variation in a conserved trait-even-skipped (eve) expression at the cellular blastoderm stage of embryonic deve...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2015.06.019

    authors: Jiang P,Ludwig MZ,Kreitman M,Reinitz J

    更新日期:2015-09-01 00:00:00

  • Wnt6 signaling regulates heart muscle development during organogenesis.

    abstract::Mesodermal tissue with heart forming potential (cardiogenic mesoderm) is induced during gastrulation. This cardiogenic mesoderm later differentiates into heart muscle tissue (myocardium) and non-muscular heart tissue. Inhibition of Wnt/beta-catenin signaling is known to be required early for induction of cardiogenic m...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2008.08.032

    authors: Lavery DL,Martin J,Turnbull YD,Hoppler S

    更新日期:2008-11-15 00:00:00

  • Gradients of differentiation in wild-type and bithorax mutants of Drosophila.

    abstract::We present evidence to show that differentiation in wing cells to produce hairs is synchronous over the distal 90% of the wing surface (approximately 28,000 cells). In spite of this synchrony within such a large area a temporal gradient exists between zones (in general anterior to posterior) on the animal surface with...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(83)90047-7

    authors: Mitchell HK,Petersen NS

    更新日期:1983-02-01 00:00:00

  • Developmentally acquired PKA localisation in mouse oocytes and embryos.

    abstract::Localisation of Protein Kinase A (PKA) by A-Kinase Anchoring Proteins (AKAPs) is known to coordinate localised signalling complexes that target cAMP-mediated signalling to specific cellular sub-domains. The cAMP PKA signalling pathway is implicated in both meiotic arrest and meiotic resumption, thus spatio-temporal ch...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2008.01.045

    authors: Webb RJ,Tinworth L,Thomas GM,Zaccolo M,Carroll J

    更新日期:2008-05-01 00:00:00

  • Mesodermal expression of integrin α5β1 regulates neural crest development and cardiovascular morphogenesis.

    abstract::Integrin α5-null embryos die in mid-gestation from severe defects in cardiovascular morphogenesis, which stem from defective development of the neural crest, heart and vasculature. To investigate the role of integrin α5β1 in cardiovascular development, we used the Mesp1(Cre) knock-in strain of mice to ablate integrin ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2014.09.014

    authors: Liang D,Wang X,Mittal A,Dhiman S,Hou SY,Degenhardt K,Astrof S

    更新日期:2014-11-15 00:00:00

  • BMP receptor-activated Smads confer diverse functions during the development of the dorsal spinal cord.

    abstract::Bone Morphogenetic Proteins (BMPs) have multiple activities in the developing spinal cord: they specify the identity of the dorsal-most neuronal populations and then direct the trajectories of dorsal interneuron (dI) 1 commissural axons. How are these activities decoded by dorsal neurons to result in different cellula...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2012.05.014

    authors: Hazen VM,Andrews MG,Umans L,Crenshaw EB 3rd,Zwijsen A,Butler SJ

    更新日期:2012-07-15 00:00:00

  • Drosophila Cyclin J is a mitotically stable Cdk1 partner without essential functions.

    abstract::Cyclin J is a cyclin family member that appears to have evolved before the metazoan radiation. Its evolutionary conservation argues for an important role but functional characterizations of Cyclin J have remained very limited. In Drosophila, Cyclin J is expressed only in females. Using transgenic Drosophila lines expr...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2009.06.042

    authors: Althoff F,Viktorinová I,Kastl J,Lehner CF

    更新日期:2009-09-15 00:00:00

  • Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells.

    abstract::Islet1 (Isl1) is a LIM homedomain protein that plays a pivotal role in cardiac progenitors of the second heart field. Here, lineage studies with an inducible isl1-cre demonstrated that most Isl1 progenitors have migrated into the heart by E9. Although Isl1 expression is downregulated in most cardiac progenitors as the...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2006.12.048

    authors: Sun Y,Liang X,Najafi N,Cass M,Lin L,Cai CL,Chen J,Evans SM

    更新日期:2007-04-01 00:00:00

  • A genetic map of Xenopus tropicalis.

    abstract::We present a genetic map for Xenopus tropicalis, consisting of 2886 Simple Sequence Length Polymorphism (SSLP) markers. Using a bioinformatics-based strategy, we identified unique SSLPs within the X. tropicalis genome. Scaffolds from X. tropicalis genome assembly 2.0 (JGI) were scanned for Simple Sequence Repeats (SSR...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2011.03.022

    authors: Wells DE,Gutierrez L,Xu Z,Krylov V,Macha J,Blankenburg KP,Hitchens M,Bellot LJ,Spivey M,Stemple DL,Kowis A,Ye Y,Pasternak S,Owen J,Tran T,Slavikova R,Tumova L,Tlapakova T,Seifertova E,Scherer SE,Sater AK

    更新日期:2011-06-01 00:00:00

  • Vegetal localization of maternal mRNAs is disrupted by VegT depletion.

    abstract::VegT is an essential maternal regulator of germ layer specification in Xenopus. The localization of VegT mRNA to the vegetal cortex of the oocyte during oogenesis ensures its inheritance by vegetal and not animal cells, and directs the differentiation of vegetal cells into endoderm. Similarly localized mRNAs, Vg1 and ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.2001.0495

    authors: Heasman J,Wessely O,Langland R,Craig EJ,Kessler DS

    更新日期:2001-12-15 00:00:00

  • UNC-85, a C. elegans homolog of the histone chaperone Asf1, functions in post-embryonic neuroblast replication.

    abstract::Normal animal development requires accurate cell divisions, not only in the early stages of rapid embryonic cleavages, but also in later developmental stages. The Caenorhabditis elegans unc-85 gene is implicated only in cell divisions that occur post-embryonically, primarily in terminal neuronal lineages. Variable pos...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2008.04.013

    authors: Grigsby IF,Finger FP

    更新日期:2008-07-01 00:00:00

  • Expression of a novel histone 2B during mouse spermiogenesis.

    abstract::During mammalian spermiogenesis transitional proteins and protamines replace histones on the DNA as the chromatin condenses. While previous studies suggested that histone genes are inactive postmeiotically, we have shown both by steady-state RNA analysis and nuclear run-off transcription assays that histone 2b (H2b) t...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(89)90299-6

    authors: Moss SB,Challoner PB,Groudine M

    更新日期:1989-05-01 00:00:00

  • A MAPK pathway is involved in the control of mitosis after fertilization of the sea urchin egg.

    abstract::Activation and role of mitogen-activated protein (MAP) kinase (MAPK) during mitosis are still matters of controversy in early embryos. We report here that an ERK-like protein is present and highly phosphorylated in unfertilized sea urchin eggs. This MAPK becomes dephosphorylated after fertilization and a small pool of...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2005.03.008

    authors: Zhang WL,Huitorel P,Glass R,Fernandez-Serra M,Arnone MI,Chiri S,Picard A,Ciapa B

    更新日期:2005-06-01 00:00:00

  • Effects of calcium-BAPTA buffers and the calmodulin antagonist W-7 on mouse egg activation.

    abstract::Results of numerous experiments indicate that the transient rise in intracellular Ca2+ following sperm-egg fusion is essential for the subsequent events that constitute egg activation. Some events of egg activation, e.g., cortical granule exocytosis, however, appear more sensitive to intracellular Ca2+ than other even...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1996.0331

    authors: Xu Z,Lefevre L,Ducibella T,Schultz RM,Kopf GS

    更新日期:1996-12-15 00:00:00

  • Zebrafish chordin-like and chordin are functionally redundant in regulating patterning of the dorsoventral axis.

    abstract::Chordin is the prototype of a group of cysteine-rich domain-containing proteins that bind and modulate signaling of various TGFbeta-like ligands. Chordin-like 1 and 2 (CHL1 and 2) are two members of this group that have been described in human, mouse, and chick. However, in vivo roles for CHL1 and 2 in early developme...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2010.03.001

    authors: Branam AM,Hoffman GG,Pelegri F,Greenspan DS

    更新日期:2010-05-15 00:00:00

  • The direction of neurite growth in a weak DC electric field depends on the substratum: contributions of adhesivity and net surface charge.

    abstract::We investigated the influence of the growth surface on the direction of Xenopus spinal neurite growth in the presence of a dc electric field of physiological magnitude. The direction of galvanotropism was determined by the substratum; neurites grew toward the negative electrode (cathode) on untreated Falcon tissue cul...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1998.9039

    authors: Rajnicek AM,Robinson KR,McCaig CD

    更新日期:1998-11-15 00:00:00