Reporter gene expression in G2 of the 1-cell mouse embryo.

abstract：:Vasa is a DEAD-box RNA helicase that functions in translational regulation of specific mRNAs. In many animals it is essential for germ line development and may have a more general stem cell role. Here we identify vasa in two sea urchin species and analyze the regulation of its expression. We find that vasa protein acc...

journal_title：Developmental biology

authors： Voronina E,Lopez M,Juliano CE,Gustafson E,Song JL,Extavour C,George S,Oliveri P,McClay D,Wessel G

更新日期：2008-02-15 00:00:00

abstract：:The sea urchin sperm receptor isolated from the eggs of Strongylocentrotus purpuratus is a high molecular weight proteoglycan-like molecule. Previous studies in our laboratory suggested that the sperm receptor has two functional components, glycosaminoglycan chains that are responsible for sperm binding and polypeptid...

journal_title：Developmental biology

authors： Ruiz-Bravo N,Lennarz WJ

更新日期：1986-11-01 00:00:00

abstract：:Acquisition of limb-forming ability by discrete regions of the lateral plate of the chick embryo is thought to depend on a signaling cascade moving sequentially from the area of Hensen's node to the somitic mesoderm, the intermediate mesoderm, and then to the prospective limb-forming regions of the lateral plate (Step...

journal_title：Developmental biology

authors： Dealy CN

更新日期：1997-08-15 00:00:00

abstract：:We cloned Xenopus Strabismus (Xstbm), a homologue of the Drosophila planar cell or tissue polarity gene. Xstbm encodes four transmembrane domains in its N-terminal half and a PDZ-binding motif in its C-terminal region, a structure similar to Drosophila and mouse homologues. Xstbm is expressed strongly in the deep cell...

journal_title：Developmental biology

authors： Goto T,Keller R

更新日期：2002-07-01 00:00:00

abstract：:Meckel-Gruber syndrome (MKS) is an embryonic lethal ciliopathy resulting from mutations in genes encoding proteins localising to the primary cilium. Mutations in the basal body protein MKS1 account for 7% of cases of MKS. The condition affects the development of multiple organs, including brain, kidney and skeleton. H...

journal_title：Developmental biology

authors： Wheway G,Abdelhamed Z,Natarajan S,Toomes C,Inglehearn C,Johnson CA

更新日期：2013-05-01 00:00:00

abstract：:In previous studies we found that two glycoproteins of 220 and 180 kDa account for 80-90% of the material dissolved from the vitelline coat (VC) of Unio elongatulus egg (Focarelli and Rosati, 1993). The two glycoproteins were purified by electroelution and used to raise the corresponding polyclonal antibodies. Immunof...

journal_title：Developmental biology

authors： Focarelli R,Rosati F

更新日期：1995-10-01 00:00:00

abstract：:Distal-less 3 (DLX3) gene mutations are etiologic for Tricho-Dento-Osseous syndrome. To investigate the in vivo impact of mutant DLX3 on bone development, we established transgenic (TG) mice expressing the c.571_574delGGGG DLX-3 gene mutation (MT-DLX3) driven by a mouse 2.3 Col1A1 promoter. Microcomputed tomographic a...

journal_title：Developmental biology

authors： Choi SJ,Roodman GD,Feng JQ,Song IS,Amin K,Hart PS,Wright JT,Haruyama N,Hart TC

更新日期：2009-01-01 00:00:00

abstract：:A gene regulatory network subcircuit comprising the otx, wnt8, and blimp1 genes accounts for a moving torus of gene expression that sweeps concentrically across the vegetal domain of the sea urchin embryo. Here we confirm by mutation the inputs into the blimp1cis-regulatory module predicted by network analysis. Its es...

journal_title：Developmental biology

authors： Smith J,Kraemer E,Liu H,Theodoris C,Davidson E

更新日期：2008-01-15 00:00:00

abstract：:Animal development is controlled by gene regulation networks that are composed of sequence-specific transcription factors (TF) and cell signaling molecules (ST). Although housekeeping genes have been reported to show clustering in the animal genomes, whether the genes comprising a given regulatory network are physical...

journal_title：Developmental biology

authors： Shoguchi E,Hamaguchi M,Satoh N

更新日期：2008-04-15 00:00:00

abstract：:In Drosophila, the RNA helicase VASA (VAS) is required for both germ line formation and oocyte differentiation. While the murine VAS homologue is required for spermatogenesis, it is dispensable for germ line formation. The molecular basis for this apparently dual role of VAS in germ line ontogeny is, however, unclear....

journal_title：Developmental biology

authors： Krøvel AV,Olsen LC

更新日期：2004-07-01 00:00:00

abstract：:During its development the epidermis of the pf/pf mutant mouse is invaded by cells from the underlying dermis. These invading cells establish a network of cells including fibroblasts, endothelial cells, and nerve fibers, throughout the epidermis. Subsequent to these events the keratohyalin protein, filaggrin, is drast...

journal_title：Developmental biology

authors： Fisher C,Dale BA,Kollar EJ

更新日期：1984-04-01 00:00:00

abstract：:The commitment and differentiation of the alveolar type I (AT1) cell lineage is a critical step for the formation of distal lung saccules, which are the primitive alveolar units required for postnatal respiration. How AT1 cells arise from the distal lung epithelial progenitor cells prior to birth and whether this proc...

journal_title：Developmental biology

authors： Wang X,Wang Y,Snitow ME,Stewart KM,Li S,Lu M,Morrisey EE

更新日期：2016-06-15 00:00:00

abstract：:Regulation of gene expression during early embryonic development in the rabbit was investigated by quantitative assay of firefly luciferase activity obtained by microinjection of three plasmid constructs using the regulatory region of polyomavirus promoter (PrPyV) with two different enhancer sequences (wild type or mu...

journal_title：Developmental biology

authors： Christians E,Rao VH,Renard JP

更新日期：1994-07-01 00:00:00

abstract：:It has been difficult to examine the role of TGF-ß in post-natal tooth development due to perinatal lethality in many of the signaling deficient mouse models. To address the role of Tgfbr2 in postnatal tooth development, we generated a mouse in which Tgfbr2 was deleted in odontoblast- and bone-producing mesenchyme. Os...

journal_title：Developmental biology

authors： Wang Y,Cox MK,Coricor G,MacDougall M,Serra R

更新日期：2013-10-01 00:00:00

abstract：:The t haplotypes are variant forms of the proximal portion of chromosome 17 in the mouse. The t haplotypes alter spermatogenesis and many also contain lethal factors. Although the lethal factors vary between t haplotypes, all t haplotypes have the same effect on sperm, that of altering sperm function in fertilization....

journal_title：Developmental biology

authors： Olds-Clarke P,Johnson LR

更新日期：1993-01-01 00:00:00

abstract：:Cerebral and spinal vascular systems are organized individually, and they then conjugate at their border, through the integration of basilar artery and vertebral arteries. Zebrafish (Danio rerio) is an ideal organism for studying early vascular development, and the precise procedure of cranial and truncal vascular for...

journal_title：Developmental biology

authors： Kimura E,Isogai S,Hitomi J

更新日期：2015-10-01 00:00:00

abstract：:Because the formation of a mature nerve terminal requires the accumulation of large quantities of synaptic vesicles, the expression of synaptic vesicle proteins would be expected to correlate with synaptogenesis. However, previous studies have provided conflicting evidence on this point. We have examined the developme...

journal_title：Developmental biology

authors： Lou X,Bixby JL

更新日期：1993-09-01 00:00:00

abstract：:An important developmental question concerns whether neurotransmitter phenotype is an inherent property of neurons or is influenced by target tissues. This issue can be addressed in the avian ciliary ganglion (CG) which contains two cholinergic populations, ciliary and choroid neurons, that differentially express the ...

journal_title：Developmental biology

authors： Darland DC,Nishi R

更新日期：1998-10-15 00:00:00

abstract：:Although the formation and maintenance of epithelial tubes are essential for the viability of multicellular organisms, our understanding of the molecular and cellular events coordinating tubulogenesis is relatively limited. Here, we focus on the activities of Ribbon, a novel BTB-domain containing nuclear protein, in t...

journal_title：Developmental biology

authors： Kerman BE,Cheshire AM,Myat MM,Andrew DJ

更新日期：2008-08-01 00:00:00

abstract：:Insulin-producing beta-cells are present as single cells or in small clusters distributed throughout the pancreas of the Xenopus laevis tadpole. During metamorphic climax when the exocrine pancreas dedifferentiates to progenitor cells, the beta-cells undergo two changes. Insulin mRNA is down regulated at the beginning...

journal_title：Developmental biology

authors： Mukhi S,Horb ME,Brown DD

更新日期：2009-04-15 00:00:00

abstract：:Retinal ganglion cells (RGCs) are the first cell type to differentiate during retinal histogenesis. It has been postulated that specified RGCs subsequently influence the number and fate of the remaining progenitors to produce the rest of the retinal cell types. However, several genetic knockout models have argued agai...

journal_title：Developmental biology

authors： Moshiri A,Gonzalez E,Tagawa K,Maeda H,Wang M,Frishman LJ,Wang SW

更新日期：2008-04-15 00:00:00

abstract：:In higher organisms, mononucleated myoblasts fuse to form multinucleated myotubes. During this process, myoblasts undergo specific changes in cell morphology and cytoarchitecture. Previously, we have shown that the actin regulator Kette (Hem-2/Nap-1) is essential for myoblast fusion. In this study, we describe the rol...

journal_title：Developmental biology

authors： Schäfer G,Weber S,Holz A,Bogdan S,Schumacher S,Müller A,Renkawitz-Pohl R,Onel SF

更新日期：2007-04-15 00:00:00

abstract：:Molecular mechanisms regulating the remodeling of the lymphatic vasculature from an immature plexus of vessels to a hierarchal network of initial and collecting lymphatics are not well understood. One gene thought to be important for this process is Angiopoietin-2 (Ang-2). Ang2(-/-) mice have previously been reported ...

journal_title：Developmental biology

authors： Dellinger M,Hunter R,Bernas M,Gale N,Yancopoulos G,Erickson R,Witte M

更新日期：2008-07-15 00:00:00

abstract：:We recently demonstrated a critical role for two-pore channel type 2 (TPC2)-mediated Ca2+ release during the differentiation of slow (skeletal) muscle cells (SMC) in intact zebrafish embryos, via the introduction of a translational-blocking morpholino antisense oligonucleotide (MO). Here, we extend our study and demon...

journal_title：Developmental biology

authors： Kelu JJ,Webb SE,Parrington J,Galione A,Miller AL

更新日期：2017-05-15 00:00:00

abstract：:In vertebrates, nodal-related genes are crucial for specifying mesendodermal cell fates. Six nodal-related genes have been identified in Xenopus, but only one, nodal, has been identified in the mouse. The Xenopus nodal-related gene 3 (Xnr3), however, lacks the mesoderm-inducing activity of the other five nodal-related...

journal_title：Developmental biology

authors： Haramoto Y,Tanegashima K,Onuma Y,Takahashi S,Sekizaki H,Asashima M

更新日期：2004-01-01 00:00:00

abstract：:The task of the visual system is to translate light into neuronal encoded information. This translation of photons into neuronal signals is achieved by photoreceptor neurons (PRs), specialized sensory neurons, located in the eye. Upon perception of light the PRs will send a signal to target neurons, which represent a ...

journal_title：Developmental biology

authors： Sprecher SG,Cardona A,Hartenstein V

更新日期：2011-10-01 00:00:00

abstract：:Hedgehog proteins have been implicated in the control of myogenesis in the medial vertebrate somite. In the mouse, normal epaxial expression of the myogenic transcription factor gene myf5 is dependent on Sonic hedgehog. Here we examine in zebrafish the interaction between Hedgehog signals, the expression of myoD famil...

journal_title：Developmental biology

authors： Coutelle O,Blagden CS,Hampson R,Halai C,Rigby PW,Hughes SM

更新日期：2001-08-01 00:00:00

abstract：:Drosophila nemo (nmo) and other Nemo-like kinase family members (Nlks) are well-established key regulators of numerous conserved signaling pathways, such as Wg and BMP. nmo mutants display pleiotropic defects at different developmental stages, including the embryo. In this study we describe a detailed characterization...

journal_title：Developmental biology

authors： Braid LR,Lee W,Uetrecht AC,Swarup S,Papaianni G,Heiler A,Verheyen EM

更新日期：2010-07-01 00:00:00

abstract：:The fertilized ascidian egg is thought to be comprised of distinct regions of tissue-specific cytoplasmic determinants. This idea was tested by bisecting fertilized eggs into egg fragments and culturing them until the unoperated controls developed into larvae. Fertilized eggs were bisected using a microsurgical method...

journal_title：Developmental biology

authors： Bates WR

更新日期：1988-09-01 00:00:00

abstract：:Rex1 (Zfp42), GeneID 132625, is a gene whose expression is closely associated with pluripotency/multipotency in both mouse and human embryonic stem cells. To study the function of the murine Rex1 gene in vivo, we have used cre/lox technology to create Rex1(floxed) mice and mice deficient in Rex1 gene function. Rex1(-/...

journal_title：Developmental biology

authors： Rezende NC,Lee MY,Monette S,Mark W,Lu A,Gudas LJ

更新日期：2011-08-15 00:00:00