A genome-wide survey of the evolutionarily conserved Wnt pathways in the sea urchin Strongylocentrotus purpuratus.

abstract：:Polyspermic Xenopus laevis eggs can be identified easily because of regions of pigment accumulation and white stripes, which arise by a nocodazole-sensitive process. Eggs containing up to four sperm are capable of forming a single embryonic axis. Dispermic eggs display two regions of pigment accumulation, one around e...

journal_title：Developmental biology

authors： Render JA,Elinson RP

更新日期：1986-06-01 00:00:00

abstract：:The location and distribution of neural crest-derived Schwann cells during development of the peripheral nerves of chick forelimbs were examined using chick-quail chimeras. Neural crest cells were labeled by transplantation of the dorsal part of the neural tube from a quail donor to a chick host at levels of the neura...

journal_title：Developmental biology

authors： Carpenter EM,Hollyday M

更新日期：1992-03-01 00:00:00

abstract：:Proliferating intestinal stem cells (ISCs) generate all cell types of the Drosophila midgut, including enterocytes, endocrine cells, and gland cells (e.g., copper cells), throughout the lifetime of the animal. Among the signaling mechanisms controlling the balance between ISC self-renewal and the production of differe...

journal_title：Developmental biology

authors： Takashima S,Aghajanian P,Younossi-Hartenstein A,Hartenstein V

更新日期：2016-08-15 00:00:00

abstract：:Developing cardiac myocytes divide a limited number of times before they stop and terminally differentiate, but the mechanism that stops their division is unknown. To help study the stopping mechanism, we defined conditions under which embryonic rat cardiac myocytes cultured in serum-free medium proliferate and exit t...

journal_title：Developmental biology

authors： Burton PB,Raff MC,Kerr P,Yacoub MH,Barton PJ

更新日期：1999-12-15 00:00:00

abstract：:We have identified zebrafish orthologues of glial cell line-derived neurotrophic factor (GDNF) and the ligand-binding component of its receptor GFRalpha1. We examined the mRNA expression pattern of these genes in the developing spinal cord primary motor neurons (PMN), kidney, and enteric nervous systems (ENS) and have...

journal_title：Developmental biology

authors： Shepherd IT,Beattie CE,Raible DW

更新日期：2001-03-15 00:00:00

abstract：:The GRAM domain was found in glucosyltransferases, myotubularins and other membrane-associated proteins. So far, functions for majority of these proteins are yet to be uncovered. In order to address the evolutionary and functional significance of this family members, we have performed a comprehensive investigation on ...

journal_title：Developmental biology

authors： Jiang SY,Ramamoorthy R,Ramachandran S

更新日期：2008-02-15 00:00:00

abstract：:The Egr family of zinc-finger transcription factors, consisting of Egr1, Egr2, Egr3, and Egr4, are involved in cellular growth and differentiation. Adult Egr3-deficient mice are ataxic and lack muscle spindle proprioceptors that normally develop at the sites of Ia afferent-myotube contacts during embryogenesis. To res...

journal_title：Developmental biology

authors： Tourtellotte WG,Keller-Peck C,Milbrandt J,Kucera J

更新日期：2001-04-15 00:00:00

abstract：:The stability of sexual phenotype was examined in a single clone of Hydra oligactis males maintained at two culture temperatures, 18 and 22 degrees C. At these temperatures animals of this species do not reproduce sexually, but reproduce asexually by budding, and males and females are morphologically indistinguishable...

journal_title：Developmental biology

authors： Littlefield CL

更新日期：1986-10-01 00:00:00

abstract：:We defined the cellular mechanisms for genesis, migration, and differentiation of the initial population of olfactory bulb (OB) interneurons. This cohort of early generated cells, many of which become postmitotic on embryonic day (E) 14.5, differentiates into a wide range of mature OB interneurons by postnatal day (P)...

journal_title：Developmental biology

authors： Tucker ES,Polleux F,LaMantia AS

更新日期：2006-09-15 00:00:00

abstract：:The genetic and developmental bases for trait expression and variation in adults are largely unknown. One system in which genes and cell behaviors underlying adult traits can be elucidated is the larval-to-adult transformation of zebrafish, Danio rerio. Metamorphosis in this and many other teleost fishes resembles amp...

journal_title：Developmental biology

authors： Parichy DM,Turner JM

更新日期：2003-04-15 00:00:00

abstract：:Notch activation inhibits neuronal differentiation during development of the nervous system; however, the dynamic role of Notch signaling in individual cell lineages remains poorly understood. We have characterized 3.4 kb 5'-regulatory sequence of a Notch target gene, her4, and used it to drive fluorescent gene expres...

journal_title：Developmental biology

authors： Yeo SY,Kim M,Kim HS,Huh TL,Chitnis AB

更新日期：2007-01-15 00:00:00

abstract：:The hallmark of the arthropods is their segmented body, although origin of segmentation, however, is unresolved. In order to shed light on the origin of segmentation we investigated orthologs of pair rule genes (PRGs) and segment polarity genes (SPGs) in a member of the closest related sister-group to the arthropods, ...

journal_title：Developmental biology

authors： Janssen R,Budd GE

更新日期：2013-10-01 00:00:00

abstract：:This investigation provides the first systematic determination of the cellular and molecular progression of vocal fold (VF) epithelium development in a murine model. We define five principal developmental events that constitute the progression from VF initiation in the embryonic anterior foregut tube to fully differen...

journal_title：Developmental biology

authors： Lungova V,Verheyden JM,Herriges J,Sun X,Thibeault SL

更新日期：2015-03-15 00:00:00

abstract：:Oligodendrocytes are produced from the same region of the ventral spinal cord that earlier generated motor neurons in bird and rodent embryos. Motor neuron and oligodendrocyte precursor cells express Olig genes, which encode basic helix-loop-helix transcription factors that play important roles in the development of b...

journal_title：Developmental biology

authors： Park HC,Mehta A,Richardson JS,Appel B

更新日期：2002-08-15 00:00:00

abstract：:Nicastrin is a recently identified member of high-molecular weight complexes containing presenilin. The Caenorhabditis elegans homolog of nicastrin, aph-2, was shown to be required for GLP-1/Notch signaling in the early embryo. In addition to the maternal-effect embryonic lethal phenotype, aph-2 mutant animals also di...

journal_title：Developmental biology

authors： Levitan D,Yu G,St George Hyslop P,Goutte C

更新日期：2001-12-15 00:00:00

abstract：:The Drosophila salivary gland is a simple tubular organ derived from a contiguous epithelial primordium, which is established by the activities of the homeodomain-containing proteins Sex combs reduced (SCR), Extradenticle (EXD), and Homothorax (HTH). EGF signaling along the ventral midline specifies the salivary duct ...

journal_title：Developmental biology

authors： Haberman AS,Isaac DD,Andrew DJ

更新日期：2003-06-15 00:00:00

abstract：:Using DiI fluorescent dextrans, we have created fate maps of the neural plate and early neural tube describing the extent of progenitor cell dispersal and the spatial origin of morphologically distinct neuronal cell types along the dorsoventral axis of the developing chick spinal cord. Nonuniform dispersal and mixing ...

journal_title：Developmental biology

authors： Erskine L,Patel K,Clarke JD

更新日期：1998-07-01 00:00:00

abstract：:Serendipity delta (sry delta) is a member of a set of Drosophila zinc finger protein genes showing maximal transcription during oogenesis. By using transformant lines, we monitored the zygotic expression of the sry delta gene and characterized some biochemical properties of a sry delta/beta-galactosidase fusion protei...

journal_title：Developmental biology

authors： Payre F,Yanicostas C,Vincent A

更新日期：1989-12-01 00:00:00

abstract：:Cultured cells obtained from developing chick heart valvular and septal primordial tissues (cardiac cushions) and myocardium were tested for their capacity to bind, internalize, and degrade hyaluronate. A presumptive lysosomal hyaluronidase capable of hyaluronate degradation has been previously isolated and partially ...

journal_title：Developmental biology

authors： Bernanke DH,Orkin RW

更新日期：1984-12-01 00:00:00

abstract：:The protein tyrosine phosphatase PTP1, which mediates reversible phosphorylation on tyrosine, has been shown to play an important regulatory role during Dictyostelium development. Mutants lacking PTP1 develop more rapidly than normal, while strains that overexpress PTP1 display aberrant morphology. However, the signal...

journal_title：Developmental biology

authors： Early A,Gamper M,Moniakis J,Kim E,Hunter T,Williams JG,Firtel RA

更新日期：2001-04-01 00:00:00

abstract：:The embryonic dorsal vessel in Drosophila possesses anteroposterior polarity and is subdivided into two chamber-like portions, the aorta in the anterior and the heart in the posterior. The heart portion features a wider bore as compared with the aorta and develops inflow valves (ostia) that allow the pumping of hemoly...

journal_title：Developmental biology

authors： Lo PC,Skeath JB,Gajewski K,Schulz RA,Frasch M

更新日期：2002-11-15 00:00:00

abstract：:Mouse oocytes at metaphase I of meiotic maturation were treated with puromycin, which caused the condensed chromosomes to become decondensed to form an interphase nucleus. The chromosomes returned to a metaphase state 6.3 hr after the oocytes were transferred to puromycin-free medium [H. J. Clarke and Y. Masui (1983) ...

journal_title：Developmental biology

authors： Clarke HJ,Masui Y

更新日期：1985-03-01 00:00:00

abstract：:The myelin of the peripheral nervous system from the shiverer mutant mice is characterized by the absence of myelin basic protein, while the other myelin protein components are present at normal levels. Myelin lamella formation is normal in the shiverer mutant. Therefore, by using antiserum against myelin basic protei...

journal_title：Developmental biology

authors： Mikoshiba K,Yokoyama M,Takamatsu K,Tsukada Y,Nomura T

更新日期：1984-09-01 00:00:00

abstract：:Although the formation and maintenance of epithelial tubes are essential for the viability of multicellular organisms, our understanding of the molecular and cellular events coordinating tubulogenesis is relatively limited. Here, we focus on the activities of Ribbon, a novel BTB-domain containing nuclear protein, in t...

journal_title：Developmental biology

authors： Kerman BE,Cheshire AM,Myat MM,Andrew DJ

更新日期：2008-08-01 00:00:00

abstract：:How natural variation in embryo size affects patterning of the Drosophila embryo dorsal-ventral (DV) axis is not known. Here we examined quantitatively the relationship between nuclear distribution of the Dorsal transcription factor, boundary positions for several target genes, and DV axis length. Data were obtained f...

journal_title：Developmental biology

authors： Garcia M,Nahmad M,Reeves GT,Stathopoulos A

更新日期：2013-09-01 00:00:00

abstract：:Xenopus laevis is among the few species that are capable of fully regenerating a lost lens de novo. This occurs upon removal of the lens, when secreted factors from the retina are permitted to reach the cornea epithelium and trigger it to form a new lens. Although many studies have investigated the retinal factors tha...

journal_title：Developmental biology

authors： Thomas AG,Henry JJ

更新日期：2014-02-15 00:00:00

abstract：:Tie1 is a receptor tyrosine kinase expressed in endothelial cells, where it modulates Angiopoietin/Tie2 signaling. Previous studies have shown that mouse Tie1 mutants exhibit severe cardiovascular defects; however, much remains to be learned about the role of Tie1, especially during cardiac development. To further und...

journal_title：Developmental biology

authors： Carlantoni C,Allanki S,Kontarakis Z,Rossi A,Piesker J,Günther S,Stainier DYR

更新日期：2021-01-01 00:00:00

abstract：:The mouse protamine mRNAs, Prm-1 and Prm-2, are translationally repressed for several days during male germ cell differentiation. The translational delay of mouse Prm-1 mRNA has previously been shown to be dependent upon cis-acting elements that reside in the last 62 nucleotides of the Prm-1 3' untranslated region (3'...

journal_title：Developmental biology

authors： Fajardo MA,Haugen HS,Clegg CH,Braun RE

更新日期：1997-11-01 00:00:00

abstract：:Germ line transformation has been used to map the cis regulatory DNA elements responsible for the precise and evolutionarily stable developmental expression of the s18 chorion gene. Constructs containing chimeric combinations of Drosophila melanogaster and D. grimshawi DNA regions, as well as D. grimshawi sequences al...

journal_title：Developmental biology

authors： Swimmer C,Kashevsky H,Mao G,Kafatos FC

更新日期：1992-07-01 00:00:00

abstract：:Hedgehog (Hh) proteins are secreted molecules that play an essential role in development and tumorigenesis. In Drosophila cultured cells, phosphorylation of the kinesin-like Costal2 (Cos2) protein at Ser572 is triggered by the kinase fused (Fu) upon Hh pathway activation. Here, we validate the first phospho-antibody f...

journal_title：Developmental biology

authors： Raisin S,Ruel L,Ranieri N,Staccini-Lavenant L,Thérond PP

更新日期：2010-08-01 00:00:00