Cell death of motoneurons in the chick embryo spinal cord. VIII. Motoneurons prevented from dying in the embryo persist after hatching.

abstract：:Long non-coding RNAs (lncRNAs) have been recently recognized as a major class of regulators in mammalian systems. LncRNAs function by diverse and heterogeneous mechanisms in gene regulation, and are key contributors to development, neurological disorders, and cancer. This emerging importance of lncRNAs, along with rec...

journal_title：Developmental biology

authors： Kraus P,Sivakamasundari V,Lim SL,Xing X,Lipovich L,Lufkin T

更新日期：2013-04-15 00:00:00

abstract：:Two populations of blastomeres become positionally distinct during fourth cleavage in the mouse embryo; the inner cells become enclosed within the embryo and the outer cells form the enclosing layer. The segregation of these two cell populations is important for later development, because it represents the initial ste...

journal_title：Developmental biology

authors： Sutherland AE,Speed TP,Calarco PG

更新日期：1990-01-01 00:00:00

abstract：:Previous experiments have demonstrated that in the septo-hippocampal system choline acetyltransferase (ChAT) is induced by nerve growth factor (NGF) (Gnahn et al. (1983) Dev. Brain Res. 9, 45-52) and that hippocampal NGF and mRNANGF levels are correlated with the density of cholinergic innervation (Korsching et al. (1...

journal_title：Developmental biology

authors： Auburger G,Heumann R,Hellweg R,Korsching S,Thoenen H

更新日期：1987-04-01 00:00:00

abstract：:The salivary system in mammals is comprised of three independently developed pairs of organs, the parotid, submaxillar, and sublingual glands. Each gland is composed of various ductal and acinar cell types that fulfill multiple roles. However, the molecular mechanisms regulating their biogenesis and functions are stil...

journal_title：Developmental biology

authors： Yoshida S,Ohbo K,Takakura A,Takebayashi H,Okada T,Abe K,Nabeshima Y

更新日期：2001-12-15 00:00:00

abstract：:To understand mechanisms of sex determination, it is important to know the lineage relationships of cells comprising the gonads. For example, in mice, the Y-linked gene Sry triggers differentiation of Sertoli cells from a cell population originating in the coelomic epithelium overlying the nascent gonad that also give...

journal_title：Developmental biology

authors： Sekido R,Lovell-Badge R

更新日期：2007-02-01 00:00:00

abstract：:The hallmark of the arthropods is their segmented body, although origin of segmentation, however, is unresolved. In order to shed light on the origin of segmentation we investigated orthologs of pair rule genes (PRGs) and segment polarity genes (SPGs) in a member of the closest related sister-group to the arthropods, ...

journal_title：Developmental biology

authors： Janssen R,Budd GE

更新日期：2013-10-01 00:00:00

abstract：:The insect head is composed of several segments. During embryonic development, the segments fuse to form a rigid head capsule where obvious segmental boundaries are lacking. Hence, the assignment of regions of the insect head to specific segments is hampered, especially with respect to dorsal (vertex) and lateral (gen...

journal_title：Developmental biology

authors： Posnien N,Bucher G

更新日期：2010-02-01 00:00:00

abstract：:The distribution of the catalytic and regulatory subunits of the cAMP-dependent protein kinase between cytoplasm and nucleus was determined during the development of Dictyostelium discoideum. In vegetative amoebae approximately 2% of the subunits were in the nucleus. During development there was an approximately 5-fol...

journal_title：Developmental biology

authors： Woffendin C,Chambers TC,Schaller KL,Leichtling BH,Rickenberg HV

更新日期：1986-05-01 00:00:00

abstract：:Collapsin-1 is a secreted glycoprotein that inhibits the extension of specific growth cones in vitro. It has been hypothesized to serve as a repulsive guidance cue for extending growth cones in vivo. Here we report the distribution of collapsin-1 message as demonstrated by in situ hybridization using digoxigenin-label...

journal_title：Developmental biology

authors： Shepherd I,Luo Y,Raper JA,Chang S

更新日期：1996-01-10 00:00:00

abstract：:The development of the mammalian neocortex requires radial and tangential migration of cells. Radial migration of differentiated neurons from the ventricular zone (VZ) is well established. It is hypothesised that an earlier phase of tangential migration of mitotically active cells lays down a widespread periodically s...

journal_title：Developmental biology

authors： Wilkie AL,Jordan SA,Sharpe JA,Price DJ,Jackson IJ

更新日期：2004-03-01 00:00:00

abstract：:Nerve and muscle development was studied in paralysé mutant mice. The mutant phenotype is first recognizable 6-7 days after birth (PN 6-PN 7) as cessation of muscle growth and weakness and incoordination of movement. Mutant animals die between 2 and 3 weeks of age. Muscle fibers from paralysé mutants had a unimodal di...

journal_title：Developmental biology

authors： Blondet B,Duxson MJ,Harris AJ,Melki J,Guénet JL,Pinçon-Raymond M,Rieger F

更新日期：1989-03-01 00:00:00

abstract：:The vertebrate cranial base is a complex structure composed of bone, cartilage and other connective tissues underlying the brain; it is intimately connected with development of the face and cranial vault. Despite its central importance in craniofacial development, morphogenesis and tissue origins of the cranial base h...

journal_title：Developmental biology

authors： McBratney-Owen B,Iseki S,Bamforth SD,Olsen BR,Morriss-Kay GM

更新日期：2008-10-01 00:00:00

abstract：:Neural crest cells originate in the dorsal neural tube but subsequently undergo an epithelial-to-mesenchymal transition (EMT), delaminate, and migrate to diverse locations in the embryo where they contribute to a variety of derivatives. Cadherins are a family of cell-cell adhesion molecules expressed in a broad range ...

journal_title：Developmental biology

authors： Coles EG,Taneyhill LA,Bronner-Fraser M

更新日期：2007-12-15 00:00:00

abstract：:AKT signaling is an essential intracellular pathway controlling cell homeostasis, cell proliferation and survival, as well as cell migration and differentiation in adults. Alterations impacting the AKT pathway are involved in many pathological conditions in human disease. Similarly, during development, multiple transm...

journal_title：Developmental biology

authors： Sittewelle M,Monsoro-Burq AH

更新日期：2018-12-01 00:00:00

abstract：:The stability of sexual phenotype was examined in a single clone of Hydra oligactis males maintained at two culture temperatures, 18 and 22 degrees C. At these temperatures animals of this species do not reproduce sexually, but reproduce asexually by budding, and males and females are morphologically indistinguishable...

journal_title：Developmental biology

authors： Littlefield CL

更新日期：1986-10-01 00:00:00

abstract：:Lipids are essential for cellular function as sources of fuel, critical signaling molecules and membrane components. Deficiencies in lipid processing and transport underlie many metabolic diseases. To better understand metabolic function as it relates to disease etiology, a whole animal approach is advantageous, one i...

journal_title：Developmental biology

authors： Carten JD,Bradford MK,Farber SA

更新日期：2011-12-15 00:00:00

abstract：:Vertebrate Cdx genes encode homeodomain transcription factors related to caudal in Drosophila. The murine Cdx homologues Cdx1, Cdx2 and Cdx4 play important roles in anterior-posterior patterning of the embryonic axis and the intestine, as well as axial elongation. While our understanding of the ontogenic programs requ...

journal_title：Developmental biology

authors： Grainger S,Lam J,Savory JG,Mears AJ,Rijli FM,Lohnes D

更新日期：2012-01-01 00:00:00

abstract：:To examine the conditions of cell composition necessary for formation of a complete tadpole, defect embryos of 35 series were prepared by removing particular cells from 16- and 32-cell embryos of Xenopus laevis. These defect embryos were cultured and their development was examined. Formation of a complete tadpole did ...

journal_title：Developmental biology

authors： Kageura H

更新日期：1995-08-01 00:00:00

abstract：:Developmental patterning and growth of the vertebrate digestive and respiratory tracts requires interactions between the epithelial endoderm and adjacent mesoderm. The esophagus is a specialized structure that connects the digestive and respiratory systems and its normal development is critical for both. Shh signaling...

journal_title：Developmental biology

authors： Korzh S,Winata CL,Zheng W,Yang S,Yin A,Ingham P,Korzh V,Gong Z

更新日期：2011-11-15 00:00:00

abstract：:cAMP chemoattractant receptors on the surface of Dictyostelium discoideum cells are visualized by means of immunocytochemistry. Receptor antigen is virtually absent from growing cells and begins to accumulate after about 6 hr of starvation, concomitant with the increase in surface cAMP binding activity. In aggregating...

journal_title：Developmental biology

authors： Wang M,Van Haastert PJ,Devreotes PN,Schaap P

更新日期：1988-07-01 00:00:00

abstract：:For both the intricate morphogenetic layout of the sensory cells in the ear and the elegantly radial arrangement of the sensory neurons in the nose, numerous signaling molecules and genetic determinants are required in concert to generate these specialized neuronal populations that help connect us to our environment. ...

journal_title：Developmental biology

authors： Maier EC,Saxena A,Alsina B,Bronner ME,Whitfield TT

更新日期：2014-05-01 00:00:00

abstract：:In many animals, the first cue for development is transcripts and/or proteins that are provided maternally and are localized at specific regions of fertilized eggs and early embryos. The ascidian is known to exhibit a mosaic mode of development, which is largely dependent on localized maternal factors. In early Ciona ...

journal_title：Developmental biology

authors： Yamada L

更新日期：2006-08-15 00:00:00

abstract：:Krox-20, originally identified as a member of "immediate-early" genes, plays a crucial role in the formation of two specific segments in the hindbrain during early development of the vertebrate nervous system. Here we cloned a genomic sequence of Xenopus Krox-20 (XKrox-20) and studied functions of a promoter element i...

journal_title：Developmental biology

authors： Watanabe T,Hongo I,Kidokoro Y,Okamoto H

更新日期：2005-01-15 00:00:00

abstract：:The vertebrate liver and heart arise from adjacent cell layers in the anterior lateral (AL) endoderm and mesoderm of late gastrula embryos, and the earliest stages of liver and heart development are interrelated through reciprocal tissue interactions. Although classical embryological studies performed several decades ...

journal_title：Developmental biology

authors： Zhang W,Yatskievych TA,Baker RK,Antin PB

更新日期：2004-04-15 00:00:00

abstract：:Horseradish peroxidase (HRP) was used as an intracellular lineage tracer in two experiments designed to reveal the sites of origin of cells that formed the duplicate embryo which developed in relation to an organizer grafted in the ventral marginal zone (VMZ) of Xenopus laevis embryos. In the first experiment a dorsal...

journal_title：Developmental biology

authors： Jacobson M

更新日期：1984-03-01 00:00:00

abstract：:Optimal maturation of oocytes and successful development of preimplantation embryos is essential for reproduction. We performed DNA microarray analyses of ovarian transcripts and identified glial cell line-derived neurotrophic factor (GDNF) secreted by cumulus, granulosa, and theca cells as an ovarian factor stimulate...

journal_title：Developmental biology

authors： Kawamura K,Ye Y,Kawamura N,Jing L,Groenen P,Gelpke MS,Rauch R,Hsueh AJ,Tanaka T

更新日期：2008-03-01 00:00:00

abstract：:The segmental origin and migratory pattern of neural crest cells at the trunk level of avian embryos was studied, with special emphasis on the formation of the dorsal root ganglia (DRG) which organize in the anterior half of each somite. Neural crest cells were visualized using the quail-chick marker and HNK-1 immunof...

journal_title：Developmental biology

authors： Teillet MA,Kalcheim C,Le Douarin NM

更新日期：1987-04-01 00:00:00

abstract：:Antenna structure varies widely among insects, in contrast to the well-conserved structure of legs. The adult capitate antenna of the red flour beetle, Tribolium castaneum, is composed of eleven articles, organized into four distinct morphological regions (scape, pedicel, funicle and club). Here, we report the use of ...

journal_title：Developmental biology

authors： Angelini DR,Kikuchi M,Jockusch EL

更新日期：2009-03-01 00:00:00

abstract：:Metamorphosis in Drosophila results from a hierarchy of ecdysone-induced gene expression initiated at the end of the third larval instar. A now classical model of this hierarchy was proposed based on observations of the activity of polytene chromosome "puffs" which distinguished "early" puffs as those directly induced...

journal_title：Developmental biology

authors： Stowers RS,Russell S,Garza D

更新日期：1999-09-01 00:00:00

abstract：:The serine/threonine kinase LKB1 is a master kinase that regulates a number of critical events such as cell transformation, polarization, development, stress response, and energy metabolism in metazoa. After multiple unsuccessful attempts of generating Dictyostelium lkb1-null cells, an RNAi-based knockdown approach pr...

journal_title：Developmental biology

authors： Veeranki S,Hwang SH,Sun T,Kim B,Kim L

更新日期：2011-12-15 00:00:00