Neuroglian is expressed on cells destined to form the prothoracic glands of Manduca embryos as they segregate from surrounding cells and rearrange during morphogenesis.

abstract：:Nucleostemin (NS), a member of a family of nucleolar GTP-binding proteins, is highly expressed in proliferating cells such as stem and cancer cells and is involved in the control of cell cycle progression. Both depletion and overexpression of NS result in stabilization of the tumor suppressor p53 protein in vitro. Alt...

journal_title：Developmental biology

authors： Paridaen JT,Janson E,Utami KH,Pereboom TC,Essers PB,van Rooijen C,Zivkovic D,MacInnes AW

更新日期：2011-07-15 00:00:00

abstract：:During heart formation, the heart grows and undergoes dramatic morphogenesis to achieve efficient embryonic function. Both in fish and amniotes, much of the growth occurring after initial heart tube formation arises from second heart field (SHF)-derived progenitor cell addition to the arterial pole, allowing chamber f...

journal_title：Developmental biology

authors： Kula-Alwar D,Marber MS,Hughes SM,Hinits Y

更新日期：2021-02-01 00:00:00

abstract：:Wnt-4, a member of the Wnt family of secreted signaling molecules, is essential for nephrogenesis, but its expression in the presumptive medulla suggests additional developmental roles in kidney organogenesis. We demonstrate here that Wnt-4 signaling plays also a role in the determination of the fate of smooth muscle ...

journal_title：Developmental biology

authors： Itäranta P,Chi L,Seppänen T,Niku M,Tuukkanen J,Peltoketo H,Vainio S

更新日期：2006-05-15 00:00:00

abstract：:Initial studies suggested that spatial organization of the putative polar body contractile ring was determined by the peripheral aster in Spisula [Biol. Bull. 205 (2003) 192]. Here we report detailed supporting observations, including testing of aster and ring function with inhibitors. The metaphase peripheral aster w...

journal_title：Developmental biology

authors： Pielak RM,Gaysinskaya VA,Cohen WD

更新日期：2004-05-15 00:00:00

abstract：:Tyrosinase is the rate-limiting enzyme for the production of melanin pigmentation. In the mouse and other animals, homozygous null mutations in the Tyrosinase gene (Tyr) result in the absence of pigmentation, i.e. albinism. Here we used the CRISPR/Cas9 system to generate mono- and bi-allelic null mutations in the Tyr ...

journal_title：Developmental biology

authors： Yen ST,Zhang M,Deng JM,Usman SJ,Smith CN,Parker-Thornburg J,Swinton PG,Martin JF,Behringer RR

更新日期：2014-09-01 00:00:00

abstract：:Oocyte maturation in mouse is associated with a dramatic reorganisation of the endoplasmic reticulum (ER) from a network of cytoplasmic accumulations in the germinal vesicle-stage oocyte (GV) to a network of distinctive cortical clusters in the metaphase II egg (MII). Multiple lines of evidence suggest that this redis...

journal_title：Developmental biology

authors： FitzHarris G,Marangos P,Carroll J

更新日期：2007-05-01 00:00:00

abstract：:A modification of the scrape-loading/dye transfer technique was used to study gap junctional communication along the anterior-posterior (A-P) axis of embryonic chick wing buds at an early stage of development (stage 20/21) when positional values along the A-P axis are being specified. Extensive intercellular transfer ...

journal_title：Developmental biology

authors： Coelho CN,Kosher RA

更新日期：1991-12-01 00:00:00

abstract：:Cells anchor to substrates by binding to extracellular matrix (ECM). In addition to this anchoring function however, cell-ECM binding is a mechanism for cells to sense their surroundings and to communicate and coordinate behaviour amongst themselves. Several ECM molecules and their receptors play essential roles in mu...

journal_title：Developmental biology

authors： Thorsteinsdóttir S,Deries M,Cachaço AS,Bajanca F

更新日期：2011-06-15 00:00:00

abstract：:The survival effects of brain-derived neurotrophic factor (BDNF) on the ganglion cells of the chick retina were studied in vitro at different embryonic ages. We found these effects to be strongly age-dependent: at E5, when the first ganglion cell axons have crossed the optic chiasm, but not yet reached the tectum, gan...

journal_title：Developmental biology

authors： Rodriguez-Tébar A,Jeffrey PL,Thoenen H,Barde YA

更新日期：1989-12-01 00:00:00

abstract：:C. elegans ahr-1 is orthologous to the mammalian aryl hydrocarbon receptor, and it functions as a transcription factor to regulate the development of certain neurons. Here, we describe the role of ahr-1 in a specific behavior: the aggregation of C. elegans on lawns of bacterial food. This behavior is modulated by nutr...

journal_title：Developmental biology

authors： Qin H,Zhai Z,Powell-Coffman JA

更新日期：2006-10-15 00:00:00

abstract：:Lineage specification of multipotent progenitor cells is governed by a balance of lineage-affiliated transcription factors, such as GATA1 and PU.1, which regulate the choice between erythroid and myelomonocytic fates. But how ratios of lineage-determining transcription factors stabilize progenitor cells and resolve th...

journal_title：Developmental biology

authors： Huang S,Guo YP,May G,Enver T

更新日期：2007-05-15 00:00:00

abstract：:Brain 4 (Brn4/Pou3f4) and Pax6 are POU-homeodomain and paired-homeodomain transcription factors, respectively, that are expressed in the brain and the glucagon-expressing cells in the pancreas. Brn4 expression begins at embryonic day 10 in the pancreas, just before pax6 and both appear in the glucagon immunoreactive c...

journal_title：Developmental biology

authors： Heller RS,Stoffers DA,Liu A,Schedl A,Crenshaw EB 3rd,Madsen OD,Serup P

更新日期：2004-04-01 00:00:00

abstract：:In many organisms early embryogenesis is characterised by a period refractory to transcription. In Caenorhabditis elegans, the one-cell embryo is transcriptionally inactive, but at around eight-cell stage transcription is activated in the somatic lineage. This model suggests that histone tail modifications associated ...

journal_title：Developmental biology

authors： Wang S,Fisher K,Poulin GB

更新日期：2011-07-15 00:00:00

abstract：:Cellular interactions with laminin are important for numerous morphogenetic events. In Xenopus, the first of these is neurulation. The integrin alpha6 subunit mediates an attachment of the cells of the neural plate to the underlying basal lamina. A disruption of this interaction results in embryos that fail to neurula...

journal_title：Developmental biology

authors： Lallier TE,DeSimone DW

更新日期：2000-09-01 00:00:00

abstract：:The transcription factors, GATA4, 5 and 6, recognize the same DNA sequence and are all expressed in the developing myocardium. However, knockout studies in the mouse have indicated that none of them are absolutely required for the specification of the myocardium. Here we present evidence for redundancy in this family ...

journal_title：Developmental biology

authors： Peterkin T,Gibson A,Patient R

更新日期：2007-11-15 00:00:00

abstract：:The embryonic vertebrate heart consists of two epithelia: the myocardium and endothelium, separated by the myocardial basement membrane (MBM). The myocardium has been shown to induce endothelial transformation into prevalvular mesenchyme in a temporally and site restricted manner. Previously, we hypothesized that the ...

journal_title：Developmental biology

authors： Mjaatvedt CH,Markwald RR

更新日期：1989-11-01 00:00:00

abstract：:The role of fibronectin in mesoderm cell migration and and the importance of mesoderm migration for gastrulation in Xenopus are examined. To allow for migration, a stable interface must exist between migrating mesoderm cells and the cells of the substrate layer, the blastocoel roof. We show that maintenance of this in...

journal_title：Developmental biology

authors： Winklbauer R,Keller RE

更新日期：1996-08-01 00:00:00

abstract：:The Drosophila Suppressor of Hairy wing [Su(Hw)] insulator protein has an essential role in the development of the female germline. Here we investigate the function of Su(Hw) in the ovary. We show that Su(Hw) is universally expressed in somatic cells, while germ cell expression is dynamic. Robust levels accumulate in ...

journal_title：Developmental biology

authors： Baxley RM,Soshnev AA,Koryakov DE,Zhimulev IF,Geyer PK

更新日期：2011-08-15 00:00:00

abstract：:Despite differences in the formation of neural precursors, all arthropod species analyzed so far generate about 30 single precursors (insects/crustaceans) or precursor groups (chelicerates/myriapods) per hemi-segment. In Drosophila, each precursor has a distinct identity conferred by segment polarity and dorso-ventral...

journal_title：Developmental biology

authors： Chipman AD,Stollewerk A

更新日期：2006-02-15 00:00:00

abstract：:This study tested the proposition that Na/K-ATPase activity could be involved in the morphogenetic aspects of mouse blastocyst formation by facilitating the localization of certain organelles to apposed borders, the production of nascent blastocoele fluid, and cavitation. It was assumed that such Na/K-ATPase activity ...

journal_title：Developmental biology

authors： Wiley LM

更新日期：1984-10-01 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) regulate a number of major developmental processes, but their roles in synovial joint formation remain unknown. Here we created conditional mouse embryo mutants lacking Ext1 in developing joints by mating Ext1(f/f) and Gdf5-Cre mice. Ext1 encodes a subunit of the Ext1/Ext2 Golgi-a...

journal_title：Developmental biology

authors： Mundy C,Yasuda T,Kinumatsu T,Yamaguchi Y,Iwamoto M,Enomoto-Iwamoto M,Koyama E,Pacifici M

更新日期：2011-03-01 00:00:00

abstract：:The tadpole-type larva of Ciona has emerged as an intriguing model system for the study of neurodevelopment. The Ciona intestinalis connectome has been recently mapped, revealing the smallest central nervous system (CNS) known in any chordate, with only 177 neurons. This minimal CNS is highly reminiscent of larger CNS...

journal_title：Developmental biology

authors： Sharma S,Wang W,Stolfi A

更新日期：2019-04-15 00:00:00

abstract：:Octopamine is a major monoamine in invertebrates and affects many physiological processes ranging from energy metabolism to complex behaviors. Octopamine binds to receptors located on various cell types and activates distinct signal transduction pathways to produce these diverse effects. We previously identified one o...

journal_title：Developmental biology

authors： Lee HG,Seong CS,Kim YC,Davis RL,Han KA

更新日期：2003-12-01 00:00:00

abstract：:Pioneer axons in insect legs are experimentally accessible model systems for the molecular identification and cellular localization of guidance cues regulating the path of axon growth. A detailed study of the Fe2 pioneer axons in the legs of the cockroach was performed to examine the diversity of guidance mechanisms. ...

journal_title：Developmental biology

authors： Rajan I,Denburg JL

更新日期：1997-10-15 00:00:00

abstract：:Pluripotent stem cells, termed embryonic germ (EG) cells, have been generated from both human and mouse primordial germ cells (PGCs). Like embryonic stem (ES) cells, EG cells have the potential to differentiate into all germ layer derivatives and may also be important for any future clinical applications. The developm...

journal_title：Developmental biology

authors： Shovlin TC,Durcova-Hills G,Surani A,McLaren A

更新日期：2008-01-15 00:00:00

abstract：:Hippo (Hpo) signaling plays a critical role in restricting tissue growth and organ size in both invertebrate and vertebrate animals. However, how the Hpo kinase is regulated during development has not been clearly understood. Using a Bimolecular Fluorescence Complementation assay, we have investigated the functional s...

journal_title：Developmental biology

authors： Deng Y,Matsui Y,Zhang Y,Lai ZC

更新日期：2013-03-15 00:00:00

abstract：:The dopaminergic neurons of the basal ganglia play critical roles in CNS function and human disease, but specification of dopamine neuron phenotype is poorly understood in vertebrates. We performed an in vivo screen in zebrafish to identify dopaminergic neuron enhancers, in order to facilitate studies on the specifica...

journal_title：Developmental biology

authors： Fujimoto E,Stevenson TJ,Chien CB,Bonkowsky JL

更新日期：2011-04-15 00:00:00

abstract：:DNA replication and its connection to M phase restraint are studied extensively at the level of single cells but rarely in the context of a developing animal. C. elegans lin-6 mutants lack DNA synthesis in postembryonic somatic cell lineages, while entry into mitosis continues. These mutants grow slowly and either die...

journal_title：Developmental biology

authors： Korzelius J,The I,Ruijtenberg S,Portegijs V,Xu H,Horvitz HR,van den Heuvel S

更新日期：2011-02-15 00:00:00

abstract：:We investigated whether the inhibition of proteoglycan synthesis and salivary branching morphogenesis by beta-D-xyloside was related to the deposition and processing of newly synthesized glycosaminoglycans at the basal epithelial surface that correlates with normal branching activity. Forty eight-hour cultures of cont...

journal_title：Developmental biology

authors： Spooner BS,Bassett K,Stokes B

更新日期：1985-05-01 00:00:00

abstract：:BMP-2 and BMP-4 are known to be involved in the early events which specify the cardiac lineage. Their later patterns of expression in the developing mouse and chick heart, in the myocardium overlying the atrioventricular canal (AV) and outflow tract (OFT) cushions, also suggest that they may play a role in valvoseptal...

journal_title：Developmental biology

authors： Allen SP,Bogardi JP,Barlow AJ,Mir SA,Qayyum SR,Verbeek FJ,Anderson RH,Francis-West PH,Brown NA,Richardson MK

更新日期：2001-07-01 00:00:00