Abstract：
:BMP-2 and BMP-4 are known to be involved in the early events which specify the cardiac lineage. Their later patterns of expression in the developing mouse and chick heart, in the myocardium overlying the atrioventricular canal (AV) and outflow tract (OFT) cushions, also suggest that they may play a role in valvoseptal development. In this study, we have used a recombinant retrovirus expressing noggin to inhibit the function of BMP-2/4 in the developing chick heart. This procedure resulted in abnormal development of the OFT and the ventricular septum. A spectrum of abnormalities was seen ranging from common arterial trunk to double outlet right ventricle. In hearts infected with noggin virus, where the neural crest cells have been labelled, the results show that BMP-2/4 function is required for the migration of neural crest cells into the developing OFT to form the aortopulmonary septum. Prior to septation, misexpression of noggin also leads to a decrease in the number of proliferating mesenchymal cells within the proximal cushions of the outflow tract. These results suggest that BMP-2/4 function may mediate several key events during cardiac development.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Allen SP,Bogardi JP,Barlow AJ,Mir SA,Qayyum SR,Verbeek FJ,Anderson RH,Francis-West PH,Brown NA,Richardson MKdoi
10.1006/dbio.2001.0291subject
Has Abstractpub_date
2001-07-01 00:00:00pages
98-109issue
1eissn
0012-1606issn
1095-564Xpii
S0012-1606(01)90291-Xjournal_volume
235pub_type
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