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The Caenorhabditis elegans NR4A nuclear receptor is required for spermatheca morphogenesis.

Abstract：

:The gene nhr-6 encodes the Caenorhabditis elegans ortholog of the NR4A nuclear receptor. We determined the biological functions of NHR-6 through the isolation and characterization of a deletion allele of nhr-6, lg6001. We demonstrate that nhr-6 has an essential role in the development of the C. elegans somatic gonad. Specifically, nhr-6 is required for the development of the hermaphrodite spermatheca, a somatic gonad organ that serves as the site of sperm storage and oocyte fertilization. Using a variety of spermatheca cell markers, we have determined that loss of nhr-6 function causes severe morphological defects in the spermatheca and associated spermathecal valves. This appears to be due to specific requirements for nhr-6 in regulating cell proliferation and cell differentiation during development of these structures. The improper development of these structures in nhr-6(lg6001) mutants leads to defects in ovulation and significantly reduced fecundity of C. elegans hermaphrodites. The phenotypes of nhr-6(lg6001) mutants are consistent with a role for nhr-6 in organogenesis, similar to the functions of its mammalian homologs.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Gissendanner CR,Kelley K,Nguyen TQ,Hoener MC,Sluder AE,Maina CV

doi

10.1016/j.ydbio.2007.11.014

subject

Has Abstract

pub_date

2008-01-15 00:00:00

pages

767-86

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(07)01544-8

journal_volume

313

pub_type

杂志文章

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