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Hedgehog signaling patterns mesoderm in the sea urchin.

Abstract：

:The Hedgehog (Hh) signaling pathway is essential for patterning many structures in vertebrates including the nervous system, chordamesoderm, limb and endodermal organs. In the sea urchin, a basal deuterostome, Hh signaling is shown to participate in organizing the mesoderm. At gastrulation the Hh ligand is expressed by the endoderm downstream of the Brachyury and FoxA transcription factors in the endomesoderm gene regulatory network. The co-receptors Patched (Ptc) and Smoothened (Smo) are expressed by the neighboring skeletogenic and non-skeletogenic mesoderm. Perturbations of Hh, Ptc and Smo cause embryos to develop with skeletal defects and inappropriate non-skeletogenic mesoderm patterning, although initial specification of mesoderm occurs without detectable abnormalities. Perturbations of the pathway caused late defects in skeletogenesis and in the non-skeletogenic mesoderm, including altered numbers of pigment and blastocoelar cells, randomized left-right asymmetry of coelomic pouches, and disorganized circumesophageal muscle causing an inability to swallow. Together the data support the requirement of Hh signaling in patterning each of the mesoderm subtypes in the sea urchin embryo.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Walton KD,Warner J,Hertzler PH,McClay DR

doi

10.1016/j.ydbio.2009.04.018

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

26-37

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(09)00265-6

journal_volume

331

pub_type

杂志文章

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