Abstract:
:Retinal ganglion cells (RGCs) are the first cell type to differentiate during retinal histogenesis. It has been postulated that specified RGCs subsequently influence the number and fate of the remaining progenitors to produce the rest of the retinal cell types. However, several genetic knockout models have argued against this developmental role for RGCs. Although it is known that RGCs secrete cellular factors implicated in cell proliferation, survival, and differentiation, until now, limited publications have shown that reductions in the RGC number cause significant changes in these processes. In this study, we observed that Math5 and Brn3b double null mice exhibited over a 99% reduction in the number of RGCs during development. This severe reduction of RGCs is accompanied by a drastic loss in the number of all other retinal cell types that was never seen before. Unlike Brn3b null or Math5 null animals, mice null for both alleles lack an optic nerve and have severe retinal dysfunction. Results of this study support the hypothesis that RGCs play a pivotal role in the late phase of mammalian retina development.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Moshiri A,Gonzalez E,Tagawa K,Maeda H,Wang M,Frishman LJ,Wang SWdoi
10.1016/j.ydbio.2008.01.015subject
Has Abstractpub_date
2008-04-15 00:00:00pages
214-27issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(08)00030-4journal_volume
316pub_type
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