当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Analysis of corneal development with monoclonal antibodies. I. Differentiation in isolated corneas.

Analysis of corneal development with monoclonal antibodies. I. Differentiation in isolated corneas.

Abstract：

:Monoclonal antibodies highly selective for developmentally regulated antigens present in the cornea (Zak and Linsenmayer, Dev. Biol. 99, 373-381, 1983) have been used to immunohistochemically evaluate differentiation in intact chick corneas cultured on the chorioallantoic membrane (CAM) of host embryos. One antibody is directed against the epithelial cell layer and the other is against the corneal stromal matrix. It has been established that both antigens recognized by the antibodies are expressed de novo in young explanted corneas and that the stromal matrix antigen is a product of the corneal fibroblasts. Thus expression of the antigens can be used as criteria for overt differentiation of the respective cell types. The antibodies have been employed to assess when the corneal epithelial and stromal cells become capable of autonomous differentiation within isolated corneas. To accomplish this, corneas of various ages were explanted with and without adjacent pericorneal tissues. The results indicate that, under the culture conditions employed, corneal stromal differentiation is dependent on the presence of the lens until stage 28 (51/2-6 days of development), which is the time when invasion of the stroma by pericorneal mesenchymal cells is initiated. After stage 28, the stromal matrix antigen was expressed by isolated corneas irrespective of the presence of the lens. Possibly the lens acts by maintaining the integrity of the corneal endothelial monolayer and thus promoting normal migration of pericorneal mesenchymal cells into the primary corneal stroma, where they undergo differentiation. Conversely, differentiation of the corneal epithelium was independent of any pericorneal structure from the earliest stage examined (41/2-5 days of development). It was even independent of overt stromal differentiation, thus suggesting an early and strong determination for this tissue.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Zak NB,Linsenmayer TF

doi

10.1016/0012-1606(85)90047-8

subject

Has Abstract

pub_date

1985-04-01 00:00:00

pages

443-54

issue

2

eissn

0012-1606

issn

1095-564X

pii

0012-1606(85)90047-8

journal_volume

108

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation.

    abstract：:The myogenic basic helix-loop-helix transcription factor myogenin plays an essential role in the differentiation of skeletal muscle and, secondarily, in rib and sternum formation during mouse development. However, virtually nothing is known about the quantitative requirements for myogenin in these processes. Here, we ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1998.9182

    authors： Vivian JL,Gan L,Olson EN,Klein WH

    更新日期：1999-04-01 00:00:00

  • Expression of platelet-derived growth factor (PDGF) and PDGF alpha- and beta-receptors in the peripheral nervous system: an analysis of sciatic nerve and dorsal root ganglia.

    abstract：:Previous studies have shown that cultured Schwann cells secrete platelet-derived growth factor (PDGF) and express PDGF receptors which transmit a mitogenic response particularly when their levels are upregulated by elevation of intracellular cAMP. In this study the expression of PDGF and PDGF alpha- and beta-receptors...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1993.1044

    authors： Eccleston PA,Funa K,Heldin CH

    更新日期：1993-02-01 00:00:00

  • Erratic deposition of agrin during the formation of Xenopus neuromuscular junctions in culture.

    abstract：:In order to disclose the mechanism that regulate synapse development we compared the distributions of agrin, acetylcholine receptors (AChR) and a basal lamina heparan sulfate proteoglycan (HSPG) in sections and cultures prepared from Xenopus laevis and Ambystoma mexicanum embryos. While agrin, AChR and HSPG may accumu...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.1191

    authors： Anderson MJ,Shi ZQ,Grawel R,Zackson SL

    更新日期：1995-07-01 00:00:00

  • Mesendoderm extension and mantle closure in Xenopus laevis gastrulation: combined roles for integrin alpha(5)beta(1), fibronectin, and tissue geometry.

    abstract：:We describe mesendoderm morphogenesis during gastrulation in the frog Xenopus laevis and investigate the mechanics of these movements with tissue explants. When a dorsal marginal zone explant is plated onto fibronectin, the mesendoderm moves away from the dorsal axial tissues as an intact sheet. Mesendodermal cells wi...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2002.0537

    authors： Davidson LA,Hoffstrom BG,Keller R,DeSimone DW

    更新日期：2002-02-15 00:00:00

  • Regulation of broad by the Notch pathway affects timing of follicle cell development.

    abstract：:During Drosophila oogenesis, activation of Notch signaling in the follicular epithelium (FE) around stage 6 of oogenesis is essential for entry into the endocycle and a series of other changes such as cell differentiation and migration of subsets of the follicle cells. Notch induces the expression of zinc finger prote...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2014.04.024

    authors： Jia D,Tamori Y,Pyrowolakis G,Deng WM

    更新日期：2014-08-01 00:00:00

  • Heterochrony and the phylotypic period.

    abstract：:There has been a resurgence of interest in comparative embryology. It is now important to be able to compare gene expression in different species at similar developmental stages. One phenomenon which may make it difficult to compare embryos in this way is heterochrony--a change in developmental timing during evolution...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1006/dbio.1995.8041

    authors： Richardson MK

    更新日期：1995-12-01 00:00:00

  • The effect of epidermal growth factor on neonatal incisor differentiation in the mouse.

    abstract：:The effect of epidermal growth factor (EGF) on cellular differentiation of the neonatal mouse mandibular incisor was examined autoradiographically using tritiated thymidine ([3H]TDR) and tritiated proline ([3H]PRO). On days 0 (day of birth), 1, and 2, EGF was administered (3 micrograms/g body wt) sc to neonates. Mice ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90506-9

    authors： Topham RT,Chiego DJ Jr,Gattone VH 2nd,Hinton DA,Klein RM

    更新日期：1987-12-01 00:00:00

  • A Smad3 transgenic reporter reveals TGF-beta control of zebrafish spinal cord development.

    abstract：:TGF-beta (TGFβ) family mediated Smad signaling is involved in mesoderm and endoderm specifications, left-right asymmetry formation and neural tube development. The TGFβ1/2/3 and Activin/Nodal signal transduction cascades culminate with activation of SMAD2 and/or SMAD3 transcription factors and their overactivation are...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2014.09.025

    authors： Casari A,Schiavone M,Facchinello N,Vettori A,Meyer D,Tiso N,Moro E,Argenton F

    更新日期：2014-12-01 00:00:00

  • The location and distribution of neural crest-derived Schwann cells in developing peripheral nerves in the chick forelimb.

    abstract：:The location and distribution of neural crest-derived Schwann cells during development of the peripheral nerves of chick forelimbs were examined using chick-quail chimeras. Neural crest cells were labeled by transplantation of the dorsal part of the neural tube from a quail donor to a chick host at levels of the neura...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(92)90014-8

    authors： Carpenter EM,Hollyday M

    更新日期：1992-03-01 00:00:00

  • NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursors.

    abstract：:Superior cervical ganglia of postnatal mice with a targeted disruption of the gene for neurotrophin-3 have 50% fewer neurons than those of wild-type mice. In culture, neurotrophin-3 increases the survival of proliferating sympathetic precursors. Both precursor death (W. ElShamy et al., 1996, Development 122, 491-500) ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9269

    authors： Francis N,Farinas I,Brennan C,Rivas-Plata K,Backus C,Reichardt L,Landis S

    更新日期：1999-06-15 00:00:00

  • Incorporation and dispersal of sperm surface antigens in plasma membranes of inseminated sea urchin (Arbacia punctulata) eggs and oocytes.

    abstract：:Monoclonal antibodies have been generated to determine the fate of sperm-specific surface components of the sea urchin, Arbacia punctulata, subsequent to gamete fusion. Monoclonal antibody-7 (MAB-7) reacted with two polypeptide bands having apparent molecular masses of 33 and 35 kDa derived from the sperm plasma membr...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(89)80036-3

    authors： Longo FJ

    更新日期：1989-01-01 00:00:00

  • Post-implantation mouse conceptuses produce paracrine signals that regulate the uterine endometrium undergoing decidualization.

    abstract：:The uterus undergoes a series of dramatic changes in response to an implanting conceptus that, in some mammalian species, includes differentiation of the endometrial stroma into decidual tissue. This process, called decidualization, can be induced artificially in rodents indicating that the conceptus may not be essent...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.03.006

    authors： Bany BM,Cross JC

    更新日期：2006-06-15 00:00:00

  • Activation of pmar1 controls specification of micromeres in the sea urchin embryo.

    abstract：:pmar1 is a transcription factor in the paired class homeodomain family that was identified and found to be transcribed in micromeres beginning at the fourth cleavage of sea urchin development [Dev. Biol. 246 (2002), 209]. Based on in situ data, molecular perturbation studies, and QPCR data, the recently published gene...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(03)00108-8

    authors： Oliveri P,Davidson EH,McClay DR

    更新日期：2003-06-01 00:00:00

  • The chick's marginal zone and primitive streak formation. II. Quantification of the marginal zone's potencies--temporal and spatial aspects.

    abstract：:When a posterior fragment of the chick's marginal zone (PM) was exchanged with equal sized lateral marginal zone fragment (LM), of the same blastoderm, its capacity to initiate an ectopic primitive streak (PS) was found to be both size and stage dependent. Good correlation was demonstrated between the areas of PM frag...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(89)90091-2

    authors： Eyal-Giladi H,Khaner O

    更新日期：1989-07-01 00:00:00

  • Microinjection of lectins, hyaluronidase, and hyaluronate fragments interferes with cleavage delay and mesoderm induction in embryos of Patella vulgata.

    abstract：:In embryos of Patella vulgata at the 32-cell stage, one of the four vegetally located macromeres makes contacts with overlying animal micromeres. As a result, this macromere (designated 3D) divides significantly later than the other macromeres and forms the mesodermal stem cell 4d. Shortly before and during this inter...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(89)90239-x

    authors： Kühtreiber WM,van Dongen CA

    更新日期：1989-04-01 00:00:00

  • FGF-10 plays an essential role in the growth of the fetal prostate.

    abstract：:Induction and branching morphogenesis of the prostate are dependent on androgens, which act via the mesenchyme to induce prostatic epithelial development. One mechanism by which the mesenchyme may regulate the epithelium is through secreted growth factors such as FGF-10. We have examined the male reproductive tract of...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(03)00250-1

    authors： Donjacour AA,Thomson AA,Cunha GR

    更新日期：2003-09-01 00:00:00

  • Maturation of Xenopus oocytes is not accompanied by electrode-detectable calcium changes.

    abstract：:Ca2+-sensitive microelectrodes were used to study changes in cytoplasmic free calcium during progesterone-induced meiotic maturation in Xenopus laevis oocytes. In contrast to previous reports, no changes were detected during the maturation process, although a large activation pulse of Ca2+ was seen when in vitro matur...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(85)90475-0

    authors： Robinson KR

    更新日期：1985-06-01 00:00:00

  • The 3'UTR of nanos2 directs enrichment in the germ cell lineage of the sea urchin.

    abstract：:Nanos is a translational regulator required for the survival and maintenance of primordial germ cells during embryogenesis. Three nanos homologs are present in the genome of the sea urchin Strongylocentrotus purpuratus (Sp), and each nanos mRNA accumulates specifically in the small micromere (sMic) lineage. We found t...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2013.01.019

    authors： Oulhen N,Yoshida T,Yajima M,Song JL,Sakuma T,Sakamoto N,Yamamoto T,Wessel GM

    更新日期：2013-05-01 00:00:00

  • Identification of c-Kit receptor as a regulator of adult neural stem cells in the mammalian eye: interactions with Notch signaling.

    abstract：:Neural stem cells are present in specific regions of the adult central nervous system (CNS). Recent evidence suggests that the ciliary epithelium (CE), a CNS derivative, in the adult mammalian eye, harbors a quiescent population of neural stem cells. Here, we report the identification of c-Kit signaling as one of the ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.05.023

    authors： Das AV,James J,Zhao X,Rahnenführer J,Ahmad I

    更新日期：2004-09-01 00:00:00

  • Cell signaling during development of Dictyostelium.

    abstract：:Continuous communication between cells is necessary for development of any multicellular organism and depends on the recognition of secreted signals. A wide range of molecules including proteins, peptides, amino acids, nucleic acids, steroids and polylketides are used as intercellular signals in plants and animals. Th...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2014.04.001

    authors： Loomis WF

    更新日期：2014-07-01 00:00:00

  • Identification of a novel polypeptide involved in the formation of DNA-containing vesicles during macronuclear development in Tetrahymena.

    abstract：:An abundant phosphoprotein with an apparent molecular mass of 65 kDa (p65) has been identified that is enriched in developing new macronuclei (or anlagen) isolated from the holotrichous ciliate, Tetrahymena thermophila. During early stages of macronuclear development, p65 is actively synthesized and deposited into you...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1994.1264

    authors： Madireddi MT,Davis MC,Allis CD

    更新日期：1994-10-01 00:00:00

  • Developmentally acquired PKA localisation in mouse oocytes and embryos.

    abstract：:Localisation of Protein Kinase A (PKA) by A-Kinase Anchoring Proteins (AKAPs) is known to coordinate localised signalling complexes that target cAMP-mediated signalling to specific cellular sub-domains. The cAMP PKA signalling pathway is implicated in both meiotic arrest and meiotic resumption, thus spatio-temporal ch...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.01.045

    authors： Webb RJ,Tinworth L,Thomas GM,Zaccolo M,Carroll J

    更新日期：2008-05-01 00:00:00

  • Cell movements during the initial phase of gastrulation in the sea urchin embryo.

    abstract：:The morphogenetic processes responsible for the initial phase of gastrulation in sea urchin embryos are not known. Here we report observations of the size and position of clones of cells derived from horseradish peroxidase (HRP)-injected mesomeres and macromeres. The displacement of these clones during the initial pha...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(91)90255-2

    authors： Burke RD,Myers RL,Sexton TL,Jackson C

    更新日期：1991-08-01 00:00:00

  • Developmental testis-specific regulation of mRNA levels and mRNA translational efficiencies for TATA-binding protein mRNA isoforms.

    abstract：:Early spermatids contain roughly 1000-fold more TATA-binding protein (TBP) mRNA than do somatic cells. The appearance of TBP-overexpressing spermatids in the developing testis is accompanied by a large increase in whole-organ levels of total RNA and of poly(A)+ RNA per cell. Whereas somatic cells initiate transcriptio...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8514

    authors： Schmidt EE,Schibler U

    更新日期：1997-04-01 00:00:00

  • Organoid technology for retinal repair.

    abstract：:A major cause for vision impairment and blindness in industrialized countries is the loss of the light-sensing retinal tissue in the eye. Photoreceptor damage is one of the main characteristics found in retinal degeneration diseases, such as Retinitis Pigmentosa or age-related macular degeneration. The lack of effecti...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2017.09.028

    authors： Llonch S,Carido M,Ader M

    更新日期：2018-01-15 00:00:00

  • Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice.

    abstract：:Molecular mechanisms regulating the remodeling of the lymphatic vasculature from an immature plexus of vessels to a hierarchal network of initial and collecting lymphatics are not well understood. One gene thought to be important for this process is Angiopoietin-2 (Ang-2). Ang2(-/-) mice have previously been reported ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.04.024

    authors： Dellinger M,Hunter R,Bernas M,Gale N,Yancopoulos G,Erickson R,Witte M

    更新日期：2008-07-15 00:00:00

  • Ubx dynamically regulates Dpp signaling by repressing Dad expression during copper cell regeneration in the adult Drosophila midgut.

    abstract：:The gastrointestinal (GI) tract of metazoans is lined by a series of regionally distinct epithelia. To maintain structure and function of the GI tract, regionally diversified differentiation of somatic stem cell (SC) lineages is critical. The adult Drosophila midgut provides an accessible model to study SC regulation ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2016.08.027

    authors： Li H,Qi Y,Jasper H

    更新日期：2016-11-15 00:00:00

  • Glial progenitors of the neonatal subventricular zone differentiate asynchronously, leading to spatial dispersion of glial clones and to the persistence of immature glia in the adult mammalian CNS.

    abstract：:The subventricular zone (SVZ) of the developing mammalian forebrain gives rise to astrocytes and oligodendrocytes in the neocortex and white matter, and neurons in the olfactory bulb in perinatal life. We have examined the developmental fates and spatial distributions of the descendants of single SVZ cells by infectin...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.02.024

    authors： Zerlin M,Milosevic A,Goldman JE

    更新日期：2004-06-01 00:00:00

  • Reception and transduction of the serotonin signal responsible for meiosis reinitiation in oocytes of the Japanese clam Ruditapes philippinarum.

    abstract：:Prophase-arrested oocytes of Ruditapes philippinarum are triggered to undergo germinal vesicle breakdown under the influence of the neurohormone serotonin (5HT) and then arrest in metaphase 1. Our data show that these oocytes possess a single class of original 5HT receptors. Their binding parameters have been determin...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1994.1222

    authors： Gobet I,Durocher Y,Leclerc C,Moreau M,Guerrier P

    更新日期：1994-08-01 00:00:00

  • The Jonah genes: a new multigene family in Drosophila melanogaster.

    abstract：:The Jonah gene family consists of approximately 20 genes, distributed in small clusters at eight or more widely dispersed chromosomal sites. Gene clusters differ in the number of genes per cluster, ranging up to four, and in the arrangement of genes within clusters, which include direct repeats, inverted repeats, and ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(85)90038-7

    authors： Carlson JR,Hogness DS

    更新日期：1985-04-01 00:00:00