Coexpression of embryonic, fetal, and adult globins in erythroid cells of human embryos: relevance to the cell-lineage models of globin switching.

abstract：UNLABELLED:Notch signaling plays an acknowledged role in bile-duct development, but its involvement in cholangiocyte-fate determination remains incompletely understood. We investigated the effects of early Notch2 deletion in Notch2(fl/fl)/Alfp-Cre(tg/-) ("Notch2-cKO") and Notch2(fl/fl)/Alfp-Cre(-/-) ("control") mice. F...

journal_title：Developmental biology

authors： Falix FA,Weeda VB,Labruyere WT,Poncy A,de Waart DR,Hakvoort TB,Lemaigre F,Gaemers IC,Aronson DC,Lamers WH

更新日期：2014-12-15 00:00:00

abstract：:There is a natural curiosity about how organisms give rise to offspring like themselves through a series of reproducible developmental events and how, once mature, these offspring mate and continue the process giving rise the next generation. In the mid-1800s investigators started using gametes and embryos to explore ...

journal_title：Developmental biology

authors： Ernst SG

更新日期：2011-10-15 00:00:00

abstract：:Although skeletal muscles appear superficially alike at different anatomical locations, in reality there is considerably more diversity than previously anticipated. Heterogeneity is not only restricted to completely developed fibers, but is clearly apparent during development at the molecular, cellular and anatomical ...

journal_title：Developmental biology

authors： Biressi S,Molinaro M,Cossu G

更新日期：2007-08-15 00:00:00

abstract：:Sm and Sm-like proteins are core components of the splicesome but have other functions distinct from pre-mRNA processing. Here, we show that Sm proteins also regulate germ cell specification during early C. elegans embryogenesis. SmE and SmG were required to maintain transcriptional quiescence in embryonic germ cell p...

journal_title：Developmental biology

authors： Barbee SA,Evans TC

更新日期：2006-03-01 00:00:00

abstract：:Changes in the intracellular free calcium levels in the cortical region of cleaving Xenopus eggs were examined using semi-synthetic aequorin. We detected periodic oscillations in the free calcium levels accompanying the cleavage cycle as early as the first cleavage onward. The calcium levels began to increase at early...

journal_title：Developmental biology

authors： Kubota HY,Yoshimoto Y,Hiramoto Y

更新日期：1993-12-01 00:00:00

abstract：:A reexamination of the cDNA clones of the Strongylocentrotus purpuratus sea urchin egg receptor for sperm resulted in several important changes to the sequence. By using both rapid amplification of cDNA ends (RACE) and Northern blot analysis for confirmation, the corrected deduced amino acid sequence was shown to lack...

journal_title：Developmental biology

authors： Just ML,Lennarz WJ

更新日期：1997-04-01 00:00:00

abstract：:The PITX1 transcription factor is expressed during hindlimb development, where it plays a critical role in directing hindlimb growth and the specification of hindlimb morphology. While it is known that PITX1 regulates hindlimb formation, in part, through activation of the Tbx4 gene, other transcriptional targets remai...

journal_title：Developmental biology

authors： Wang JS,Infante CR,Park S,Menke DB

更新日期：2018-02-01 00:00:00

abstract：:Ephrins and semaphorins regulate a wide variety of developmental processes, including axon guidance and cell migration. We have studied the roles of the ephrin EFN-4 and the semaphorin MAB-20 in patterning cell-cell contacts among the cells that give rise to the ray sensory organs of Caenorhabditis elegans. In wild-ty...

journal_title：Developmental biology

authors： Hahn AC,Emmons SW

更新日期：2003-04-15 00:00:00

abstract：:To investigate the lineage relationships of neurons and astroglial cells early in central nervous system development, we have analyzed the progeny of neural plate cells in an amphibian embryo (Pleurodeles waltl). A fluorescent tracer, lysinated rhodamine-dextran, was iontophoretically injected into individual precurso...

journal_title：Developmental biology

authors： Soula C,Foulquier F,Duprat AM,Cochard P

更新日期：1993-09-01 00:00:00

abstract：:Sensory perception of light is mediated by specialized Photoreceptor neurons (PRs) in the eye. During development all PRs are genetically determined to express a specific Rhodopsin (Rh) gene and genes mediating a functional phototransduction pathway. While the genetic and molecular mechanisms of PR development is well...

journal_title：Developmental biology

authors： Mishra AK,Bargmann BOR,Tsachaki M,Fritsch C,Sprecher SG

更新日期：2016-02-15 00:00:00

abstract：:The origin of resident (noninflammatory) macrophages in vertebrate tissues is still poorly understood. In the zebrafish embryo, we recently described a specific lineage of early macrophages that differentiate in the yolk sac before the onset of blood circulation. We now show that these early macrophages spread in the ...

journal_title：Developmental biology

authors： Herbomel P,Thisse B,Thisse C

更新日期：2001-10-15 00:00:00

abstract：:The dysgenetic lens (dyl) mouse mutant has mutations in Foxe3, which inactivate DNA binding by the encoded forkhead transcription factor. Here we confirm, by targeted inactivation, that Foxe3 mutations are responsible for the dyl phenotype, which include loss of lens epithelium; a small, cataractic lens; and failure o...

journal_title：Developmental biology

authors： Blixt A,Landgren H,Johansson BR,Carlsson P

更新日期：2007-02-01 00:00:00

abstract：:The current gene regulatory network (GRN) for the sea urchin embryo pertains to pregastrular specification functions in the endomesodermal territories. Here we extend gene regulatory network analysis to the adjacent oral and aboral ectoderm territories over the same period. A large fraction of the regulatory genes pre...

journal_title：Developmental biology

authors： Su YH,Li E,Geiss GK,Longabaugh WJ,Krämer A,Davidson EH

更新日期：2009-05-15 00:00:00

abstract：:HB-GAM (heparin-binding growth-associated molecule) is a secretory, extracellular matrix-associated protein that was isolated by screening for proteins that enhance neurite outgrowth in perinatal rat brain neurons. In the present study we have investigated the possible role of HB-GAM in cell proliferation in the devel...

journal_title：Developmental biology

authors： Szabat E,Rauvala H

更新日期：1996-08-25 00:00:00

abstract：:Zygotes and embryos of the fucoid brown alga Pelvetia compressa undergo a series of asymmetric cleavages. We are interested in the developmental role of these cleavages and the mechanism controlling their alignment. To assess the importance of division plane alignment, the orientation of the first asymmetric division ...

journal_title：Developmental biology

authors： Bisgrove SR,Kropf DL

更新日期：1998-02-15 00:00:00

abstract：:The relationship between ascorbic acid concentration and cellular transport mechanisms was studied in chicken embryos (Gallus gallus domesticus). Unincubated (Day 0) fertile eggs did not contain detectable levels of ascorbic acid as assayed by high performance liquid chromatography with electrochemical detection. Howe...

journal_title：Developmental biology

authors： Wilson JX

更新日期：1990-06-01 00:00:00

abstract：:Angiogenesis relies on specialized endothelial tip cells to extend toward guidance cues in order to direct growing blood vessels. Although many of the signaling pathways that control this directional endothelial sprouting are well known, the specific cellular mechanisms that mediate this process remain to be fully elu...

journal_title：Developmental biology

authors： Yang H,Fang L,Zhan R,Hegarty JM,Ren J,Hsiai TK,Gleeson JG,Miller YI,Trejo J,Chi NC

更新日期：2015-08-15 00:00:00

abstract：:Metathoracic limb buds were removed unilaterally from Locusta migratoria embryos at 30% of embryonic development, thereby depriving limb-innervating neurons of the opportunity of innervating their normal target muscles. The operated embryos were allowed to hatch and develop to adulthood, and then the connections betwe...

journal_title：Developmental biology

authors： Whitington PM

更新日期：1985-02-01 00:00:00

abstract：:Only a subset of cleavage stage blastomeres in the Xenopus embryo is competent to contribute cells to the retina; ventral vegetal blastomeres do not form retina even when provided with neuralizing factors or transplanted to the most retinogenic position of the embryo. These results suggest that endogenous maternal fac...

journal_title：Developmental biology

authors： Yan B,Moody SA

更新日期：2007-05-01 00:00:00

abstract：:The release of intracellular calcium (Ca2+) via either inositol 1,4, 5-trisphosphate receptors (IP3R) or ryanodine receptors (RyR) activates a wide variety of signaling pathways in virtually every type of cell. In the present study we demonstrate that at early stages of development IP3R mRNA and functional IP3-gated C...

journal_title：Developmental biology

authors： Rosemblit N,Moschella MC,Ondriašová E,Gutstein DE,Ondriaš K,Marks AR

更新日期：1999-02-15 00:00:00

abstract：:Several genomic clones were isolated from a Drosophila library screened with cDNA prepared from abundant adult female mRNA. Cytoplasmic dot hybridizations have shown that the genes in all of these clones are expressed only in posteclosion (stages 8-14) follicles. One set of overlapping clones (lambda 20, lambda 28, an...

journal_title：Developmental biology

authors： Higgins MJ,Walker VK,Holden JA,White BN

更新日期：1984-09-01 00:00:00

abstract：:We have used a subtractive method to clone novel messages enriched in the heart. Here we show that one such message, bves (blood vessel/epicardial substance) is a novel protein that is highly conserved between chicken and mouse. The bves message is detected at high levels in early chick hearts. Using anti-Bves antibod...

journal_title：Developmental biology

authors： Reese DE,Zavaljevski M,Streiff NL,Bader D

更新日期：1999-05-01 00:00:00

abstract：:This investigation provides the first systematic determination of the cellular and molecular progression of vocal fold (VF) epithelium development in a murine model. We define five principal developmental events that constitute the progression from VF initiation in the embryonic anterior foregut tube to fully differen...

journal_title：Developmental biology

authors： Lungova V,Verheyden JM,Herriges J,Sun X,Thibeault SL

更新日期：2015-03-15 00:00:00

abstract：:Several Strongylocentrotus purpuratus gene cis-regulatory regions contain asymmetric C4 sequences which are core elements of target sites for a specific DNA-protein interaction. Blastula stage nuclear extract contains five proteins which specifically bind to these target sites, resulting in a characteristic pattern of...

journal_title：Developmental biology

authors： Zeller RW,Coffman JA,Harrington MG,Britten RJ,Davidson EH

更新日期：1995-06-01 00:00:00

abstract：:For both the intricate morphogenetic layout of the sensory cells in the ear and the elegantly radial arrangement of the sensory neurons in the nose, numerous signaling molecules and genetic determinants are required in concert to generate these specialized neuronal populations that help connect us to our environment. ...

journal_title：Developmental biology

authors： Maier EC,Saxena A,Alsina B,Bronner ME,Whitfield TT

更新日期：2014-05-01 00:00:00

abstract：:Previous studies have shown that cultured Schwann cells secrete platelet-derived growth factor (PDGF) and express PDGF receptors which transmit a mitogenic response particularly when their levels are upregulated by elevation of intracellular cAMP. In this study the expression of PDGF and PDGF alpha- and beta-receptors...

journal_title：Developmental biology

authors： Eccleston PA,Funa K,Heldin CH

更新日期：1993-02-01 00:00:00

abstract：:Serotonin is a classical small-molecule neurotransmitter with known effects on developmental processes. Previous studies have shown a developmental role for serotonin in the fly peripheral nervous system. In this study, we show that serotonin can modulate the development of serotonergic varicosities within the fly cen...

journal_title：Developmental biology

authors： Sykes PA,Condron BG

更新日期：2005-10-01 00:00:00

abstract：:Early (alpha) histone genes are one of several histone gene families in the sea urchin genome. They are expressed at high levels in blastula-stage embryos and are inactivated by the early gastrula stage. By microinjecting mutant early H2B genes into sea urchin zygotes and monitoring their transcriptional activity in b...

journal_title：Developmental biology

authors： Bell J,Char BR,Maxson R

更新日期：1992-04-01 00:00:00

abstract：:The msh/Msx family is a subclass of homeobox-containing genes suggested to perform a conserved function in the patterning of the early embryo. We had already isolated a member of this gene family (Ci-msxb) in Ciona intestinalis, which has a very complex expression pattern during embryogenesis. To identify the regulato...

journal_title：Developmental biology

authors： Russo MT,Donizetti A,Locascio A,D'Aniello S,Amoroso A,Aniello F,Fucci L,Branno M

更新日期：2004-03-15 00:00:00

abstract：:Morphogenesis of the Drosophila tracheal system relies on different signalling pathways that have distinct roles in specifying both the migration of the tracheal cells and the particular morphological features of the primary branches. The current view is that the tracheal cells are initially specified as an equivalent...

journal_title：Developmental biology

authors： Franch-Marro X,Casanova J

更新日期：2002-10-15 00:00:00