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Contacts between the commissural axons and the floor plate cells are mediated by nectins.

Abstract：

:During development of the central nervous system (CNS), commissural axons grow toward the ventral midline. After crossing the floor plate, they abruptly change their trajectory from the circumferential to the longitudinal axis. The contacts between the commissural axons and the floor plate cells are involved in this axonal guidance, but their mechanisms or structures have not fully been understood. In this study, we found that nectin-1 and -3, immunoglobulin-like cell-cell adhesion molecules, asymmetrically localized at the contact sites between the commissural axons and the floor plate cells, respectively. In vitro perturbation of the endogenous trans-interaction between nectin-1 and -3 caused abnormal fasciculation of the commissural axons and impairment of the contacts, and resulted in failure in longitudinal turns of the commissural axons at the contralateral sites of the rat hindbrain. These results indicate that the contacts between the commissural axons and the floor plate cells are mediated by the hetero-trans-interaction between nectin-1 and -3 and involved in regulation of the trajectory of the commissural axons.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Okabe N,Shimizu K,Ozaki-Kuroda K,Nakanishi H,Morimoto K,Takeuchi M,Katsumaru H,Murakami F,Takai Y

doi

10.1016/j.ydbio.2004.05.034

subject

Has Abstract

pub_date

2004-09-15 00:00:00

pages

244-56

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012160604004130

journal_volume

273

pub_type

杂志文章

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