当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Ca2+ release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos.

Ca2+ release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos.

Abstract：

:We recently demonstrated a critical role for two-pore channel type 2 (TPC2)-mediated Ca2+ release during the differentiation of slow (skeletal) muscle cells (SMC) in intact zebrafish embryos, via the introduction of a translational-blocking morpholino antisense oligonucleotide (MO). Here, we extend our study and demonstrate that knockdown of TPC2 with a non-overlapping splice-blocking MO, knockout of TPC2 (via the generation of a tpcn2dhkz1a mutant line of zebrafish using CRISPR/Cas9 gene-editing), or the pharmacological inhibition of TPC2 action with bafilomycin A1 or trans-ned-19, also lead to a significant attenuation of SMC differentiation, characterized by a disruption of SMC myofibrillogenesis and gross morphological changes in the trunk musculature. When the morphants were injected with tpcn2-mRNA or were treated with IP3/BM or caffeine (agonists of the inositol 1,4,5-trisphosphate receptor (IP3R) and ryanodine receptor (RyR), respectively), many aspects of myofibrillogenesis and myotomal patterning (and in the case of the pharmacological treatments, the Ca2+ signals generated in the SMCs), were rescued. STED super-resolution microscopy revealed a close physical relationship between clusters of RyR in the terminal cisternae of the sarcoplasmic reticulum (SR), and TPC2 in lysosomes, with a mean estimated separation of ~52-87nm. Our data therefore add to the increasing body of evidence, which indicate that localized Ca2+ release via TPC2 might trigger the generation of more global Ca2+ release from the SR via Ca2+-induced Ca2+ release.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Kelu JJ,Webb SE,Parrington J,Galione A,Miller AL

doi

10.1016/j.ydbio.2017.03.031

subject

Has Abstract

pub_date

2017-05-15 00:00:00

pages

109-129

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(16)30821-1

journal_volume

425

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development.

    abstract：:Heart valve structures derived from mesenchymal cells of the endocardial cushions (ECs) are composed of highly organized cell lineages and extracellular matrix. Sox9 is a transcription factor required for both early and late stages of cartilage formation that is also expressed in the developing valves of the heart. Th...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.02.002

    authors： Lincoln J,Kist R,Scherer G,Yutzey KE

    更新日期：2007-05-01 00:00:00

  • Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophila development.

    abstract：:Cdc42, a member of the Rho family of GTP binding proteins, functions in the formation of polarized actin structures, in elongation of cell shape, and in cell signaling. Although genetic mutations previously have not been available in multicellular organisms, studies have attempted to discern Cdc42 functions in organis...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9671

    authors： Genova JL,Jong S,Camp JT,Fehon RG

    更新日期：2000-05-01 00:00:00

  • Hedgehog signaling patterns mesoderm in the sea urchin.

    abstract：:The Hedgehog (Hh) signaling pathway is essential for patterning many structures in vertebrates including the nervous system, chordamesoderm, limb and endodermal organs. In the sea urchin, a basal deuterostome, Hh signaling is shown to participate in organizing the mesoderm. At gastrulation the Hh ligand is expressed b...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2009.04.018

    authors： Walton KD,Warner J,Hertzler PH,McClay DR

    更新日期：2009-07-01 00:00:00

  • Role of HB-GAM (heparin-binding growth-associated molecule) in proliferation arrest in cells of the developing rat limb and its expression in the differentiating neuromuscular system.

    abstract：:HB-GAM (heparin-binding growth-associated molecule) is a secretory, extracellular matrix-associated protein that was isolated by screening for proteins that enhance neurite outgrowth in perinatal rat brain neurons. In the present study we have investigated the possible role of HB-GAM in cell proliferation in the devel...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1996.0199

    authors： Szabat E,Rauvala H

    更新日期：1996-08-25 00:00:00

  • The 82F late puff contains the L82 gene, an essential member of a novel gene family.

    abstract：:Metamorphosis in Drosophila results from a hierarchy of ecdysone-induced gene expression initiated at the end of the third larval instar. A now classical model of this hierarchy was proposed based on observations of the activity of polytene chromosome "puffs" which distinguished "early" puffs as those directly induced...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9358

    authors： Stowers RS,Russell S,Garza D

    更新日期：1999-09-01 00:00:00

  • Xenopus laevis zygote arrest 2 (zar2) encodes a zinc finger RNA-binding protein that binds to the translational control sequence in the maternal Wee1 mRNA and regulates translation.

    abstract：:Zygote arrest (Zar) proteins are crucial for early embryonic development, but their molecular mechanism of action is unknown. The Translational Control Sequence (TCS) in the 3' untranslated region (UTR) of the maternal mRNA, Wee1, mediates translational repression in immature Xenopus oocytes and translational activati...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.06.012

    authors： Charlesworth A,Yamamoto TM,Cook JM,Silva KD,Kotter CV,Carter GS,Holt JW,Lavender HF,MacNicol AM,Ying Wang Y,Wilczynska A

    更新日期：2012-09-15 00:00:00

  • Analysis of early human neural crest development.

    abstract：:The outstanding migration and differentiation capacities of neural crest cells (NCCs) have fascinated scientists since Wilhelm His described this cell population in 1868. Today, after intense research using vertebrate model organisms, we have gained considerable knowledge regarding the origin, migration and differenti...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.05.012

    authors： Betters E,Liu Y,Kjaeldgaard A,Sundström E,García-Castro MI

    更新日期：2010-08-15 00:00:00

  • Integrin alpha v subunit is expressed on mesodermal cell surfaces during amphibian gastrulation.

    abstract：:Mesodermal cell migration during amphibian gastrulation is dependent on cellular interactions with fibronectin. One mechanism whereby cells bind fibronectin is through alpha v-containing integrin heterodimers. In order to investigate the role of alpha v in amphibian gastrulation, we have cloned the Pleurodeles homolog...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.1212

    authors： Alfandari D,Whittaker CA,DeSimone DW,Darribère T

    更新日期：1995-08-01 00:00:00

  • Cavitation in the mouse preimplantation embryo: Na/K-ATPase and the origin of nascent blastocoele fluid.

    abstract：:This study tested the proposition that Na/K-ATPase activity could be involved in the morphogenetic aspects of mouse blastocyst formation by facilitating the localization of certain organelles to apposed borders, the production of nascent blastocoele fluid, and cavitation. It was assumed that such Na/K-ATPase activity ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(84)90290-2

    authors： Wiley LM

    更新日期：1984-10-01 00:00:00

  • The sea urchin kinome: a first look.

    abstract：:This paper reports a preliminary in silico analysis of the sea urchin kinome. The predicted protein kinases in the sea urchin genome were identified, annotated and classified, according to both function and kinase domain taxonomy. The results show that the sea urchin kinome, consisting of 353 protein kinases, is close...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.08.074

    authors： Bradham CA,Foltz KR,Beane WS,Arnone MI,Rizzo F,Coffman JA,Mushegian A,Goel M,Morales J,Geneviere AM,Lapraz F,Robertson AJ,Kelkar H,Loza-Coll M,Townley IK,Raisch M,Roux MM,Lepage T,Gache C,McClay DR,Manning G

    更新日期：2006-12-01 00:00:00

  • Roles of ADAM13-regulated Wnt activity in early Xenopus eye development.

    abstract：:Pericellular proteolysis by ADAM family metalloproteinases has been widely implicated in cell signaling and development. We recently found that Xenopus ADAM13, an ADAM metalloproteinase, is required for activation of canonical Wnt signaling during cranial neural crest (CNC) induction by regulating a novel crosstalk be...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.12.031

    authors： Wei S,Xu G,Bridges LC,Williams P,Nakayama T,Shah A,Grainger RM,White JM,DeSimone DW

    更新日期：2012-03-01 00:00:00

  • Drosophila male and female germline stem cell niches require the nuclear lamina protein Otefin.

    abstract：:The nuclear lamina is an extensive protein network that underlies the inner nuclear envelope. This network includes the LAP2-emerin-MAN1-domain (LEM-D) protein family, proteins that share an association with the chromatin binding protein Barrier-to-autointegration factor (BAF). Loss of individual LEM-D proteins causes...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2016.05.001

    authors： Barton LJ,Lovander KE,Pinto BS,Geyer PK

    更新日期：2016-07-01 00:00:00

  • Gonadogenesis in Pristionchus pacificus and organ evolution: development, adult morphology and cell-cell interactions in the hermaphrodite gonad.

    abstract：:The nematode gonad is an exemplary system for the study of organogenesis and fundamental problems in developmental and cellular biology. Nematode gonads vary dramatically across species (Chitwood, B.G., Chitwood, M.B., 1950. Introduction to Nematology." University Park Press, Baltimore; Felix, M.A., Sternberg, P.W., 1...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.09.021

    authors： Rudel D,Riebesell M,Sommer RJ

    更新日期：2005-01-01 00:00:00

  • A nuclear extract, prepared from mass-isolated germinal vesicles, retains a factor able to sustain a cytoplasmic cycle of starfish oocytes.

    abstract：:The germinal vesicle (GV) of starfish oocytes contains a factor which is required to drive the cytoplasmic cycle of the meiotic division. Biochemical investigation of this factor has been difficult due to the small quantities of obtainable GV materials. To overcome this, we have developed a mass-isolation procedure fo...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(92)90187-l

    authors： Nemoto S,Yamamoto K,Hashimoto N

    更新日期：1992-06-01 00:00:00

  • Cholecalcin (28-kDa calcium-binding protein) in the rat hippocampus: development in normal animals and in altered thyroid states. An immunocytochemical study.

    abstract：:An immunocytochemical study of cholecalcin (28-kDa calcium-binding protein, CaBP, calbindin) was carried out during the development of the rat hippocampus. In normal animals, the protein appeared from Postnatal Day 3 in the granule cells of the dentate gyrus and from Day 5 in the CA1-CA2 pyramidal cells of Ammon's hor...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90474-x

    authors： Rami A,Bréhier A,Thomasset M,Rabié A

    更新日期：1987-11-01 00:00:00

  • Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis.

    abstract：:During development, cells craft an impressive array of actin-based structures, mediating events as diverse as cytokinesis, apical constriction, and cell migration. One challenge is to determine how cells regulate actin assembly and disassembly to carry out these cell behaviors. During Drosophila oogenesis diverse cell...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2009.06.030

    authors： Gates J,Nowotarski SH,Yin H,Mahaffey JP,Bridges T,Herrera C,Homem CC,Janody F,Montell DJ,Peifer M

    更新日期：2009-09-01 00:00:00

  • Identifying genes differentially expressed between PGCs and ES cells reveals a role for CREB-binding protein in germ cell survival.

    abstract：:Primordial germ cells (PGCs) are the embryonic precursors of the adult gametes. Although restricted in developmental potency, PGCs express many of the same molecular markers as pluripotent embryonic stem (ES) cells and can give rise to embryonal carcinoma (EC) cells, the stem cells of testicular tumors, in vivo. Likew...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.08.029

    authors： Elliott AM,de Miguel MP,Rebel VI,Donovan PJ

    更新日期：2007-11-15 00:00:00

  • The effect of agrin and laminin on acetylcholine receptor dynamics in vitro.

    abstract：:Using optical imaging assays, we investigated the dynamics of acetylcholine receptors (AChRs) at laminin-associated clusters on cultured myotubes in the absence or presence of the nerve-derived clustering factor, agrin. Using fluorescence recovery after photobleaching (FRAP) on fluorescent bungarotoxin-labeled recepto...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.09.041

    authors： Bruneau EG,Macpherson PC,Goldman D,Hume RI,Akaaboune M

    更新日期：2005-12-01 00:00:00

  • Evolutionary developmental biology its roots and characteristics.

    abstract：:The rise of evolutionary developmental biology was not the progressive isolation and characterization of developmental genes and gene networks. Many obstacles had to be overcome: the idea that all genes were more or less involved in development; the evidence that developmental processes in insects had nothing in commo...

    journal_title：Developmental biology

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.ydbio.2011.03.013

    authors： Morange M

    更新日期：2011-09-01 00:00:00

  • Levels of the ubiquitin ligase substrate adaptor MEL-26 are inversely correlated with MEI-1/katanin microtubule-severing activity during both meiosis and mitosis.

    abstract：:The MEI-1/MEI-2 microtubule-severing complex, katanin, is required for oocyte meiotic spindle formation and function in C. elegans, but the microtubule-severing activity must be quickly downregulated so that it does not interfere with formation of the first mitotic spindle. Post-meiotic MEI-1 inactivation is accomplis...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2009.04.004

    authors： Johnson JL,Lu C,Raharjo E,McNally K,McNally FJ,Mains PE

    更新日期：2009-06-15 00:00:00

  • Downregulation of Notch mediates the seamless transition of individual Drosophila neuroepithelial progenitors into optic medullar neuroblasts during prolonged G1.

    abstract：:The first step in the development of the Drosophila optic medullar primordia is the expansion of symmetrically dividing neuroepithelial cells (NEs); this step is then followed by the appearance of asymmetrically dividing neuroblasts (NBs). However, the mechanisms responsible for the change from NEs to NBs remain uncle...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.12.044

    authors： Orihara-Ono M,Toriya M,Nakao K,Okano H

    更新日期：2011-03-01 00:00:00

  • FGF8/17/18 functions together with FGF9/16/20 during formation of the notochord in Ciona embryos.

    abstract：:Fibroblast growth factor (FGF) signalling has been implicated in the generation of mesoderm and neural fates in chordate embryos including ascidians and vertebrates. In Ciona, FGF9/16/20 has been implicated in both of these processes. However, in FGF9/16/20 knockdown embryos, notochord fate recovers during later devel...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.08.075

    authors： Yasuo H,Hudson C

    更新日期：2007-02-01 00:00:00

  • The switch from cAMP-independent to cAMP-dependent arrest of meiotic prophase is associated with coordinated GPR3 and CDK1 expression in mouse oocytes.

    abstract：:Mammalian oocytes are arrested in meiotic prophase from around the time of birth until just before ovulation. Following an extended period of growth, they are stimulated to mature to the metaphase II stage by a preovulatory luteinizing hormone (LH) surge that occurs with each reproductive cycle. Small, growing oocytes...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2017.12.014

    authors： Firmani LD,Uliasz TF,Mehlmann LM

    更新日期：2018-02-01 00:00:00

  • Spectrin in mouse gametogenesis and embryogenesis.

    abstract：:Antibodies to nonerythroid alpha spectrin (p 230) were used to study the distribution of this polypeptide in mouse germ cells, zygote, and early embryonic cells. In the primordial germ cells, fetal oocytes, and spermatogonia, spectrin was found predominantly in the form of a narrow condensed subplasmalemmal band, as i...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(86)90389-1

    authors： Damjanov I,Damjanov A,Lehto VP,Virtanen I

    更新日期：1986-03-01 00:00:00

  • The enzymatic activity of Drosophila AWD/NDP kinase is necessary but not sufficient for its biological function.

    abstract：:The Drosophila abnormal wing discs (awd) gene encodes the subunit of a protein that has nucleoside diphosphate kinase (NDP kinase) activity. Null mutations of the awd gene cause lethality after puparium formation. Larvae homozygous for such mutations have small imaginal discs, lymph glands, and brain lobes. Neither th...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1996.0184

    authors： Xu J,Liu LZ,Deng XF,Timmons L,Hersperger E,Steeg PS,Veron M,Shearn A

    更新日期：1996-08-01 00:00:00

  • Expression pattern of GDNF, c-ret, and GFRalphas suggests novel roles for GDNF ligands during early organogenesis in the chick embryo.

    abstract：:We have cloned a partial cDNA of chicken glial cell line-derived neurotrophic factor (GDNF) and systematically examined its expression pattern as well as that of GDNF-binding components (GDNF family receptor alpha-1 and 2: GFRalpha-1 and 2) and a common signal transduction receptor (c-ret protooncogene: RET) during ve...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9543

    authors： Homma S,Oppenheim RW,Yaginuma H,Kimura S

    更新日期：2000-01-01 00:00:00

  • Exogenous tenascin inhibits mesodermal cell migration during amphibian gastrulation.

    abstract：:We have used amphibian gastrulation as a model system to study the action of the extracellular matrix (ECM) glycoprotein tenascin on mesodermal cell migration. Tenascin function was assayed in vitro during spreading of isolated cells from the dorsal marginal zone (DMZ) and during cell migration from DMZ explants. Plas...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(90)90256-i

    authors： Riou JF,Shi DL,Chiquet M,Boucaut JC

    更新日期：1990-02-01 00:00:00

  • Intracellular calcium release channel expression during embryogenesis.

    abstract：:The release of intracellular calcium (Ca2+) via either inositol 1,4, 5-trisphosphate receptors (IP3R) or ryanodine receptors (RyR) activates a wide variety of signaling pathways in virtually every type of cell. In the present study we demonstrate that at early stages of development IP3R mRNA and functional IP3-gated C...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1998.9120

    authors： Rosemblit N,Moschella MC,Ondriašová E,Gutstein DE,Ondriaš K,Marks AR

    更新日期：1999-02-15 00:00:00

  • Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities.

    abstract：:Inverse gradients of transcriptional repressors antagonize the transcriptional effector response to morphogens. However, the role of such inverse regulation might not manifest solely from lack of repressors. Sonic hedgehog (Shh) patterns the forebrain by being expressed ventrally; however, absence of antagonizing Gli3...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2019.03.011

    authors： Shimada IS,Somatilaka BN,Hwang SH,Anderson AG,Shelton JM,Rajaram V,Konopka G,Mukhopadhyay S

    更新日期：2019-06-01 00:00:00

  • Interactions between metaphase and interphase factors in heterokaryons produced by fusion of mouse oocytes and zygotes.

    abstract：:The cytoplasmic factor responsible for chromosome condensation was introduced into mouse zygotes at different times after fertilization by fusion of the zygotes with metaphase I oocytes. In 72% of heterokaryons obtained after fusion of early zygotes (14-18 hr post-human chorionic gonadotrophin (HCG) with oocytes, the ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(86)90352-0

    authors： Bałakier H,Masui Y

    更新日期：1986-09-01 00:00:00