Functions of the segment polarity genes midline and H15 in Drosophila melanogaster neurogenesis.

abstract：:The corepressor SMRT acts on a range of transcription factors, including the retinoid and thyroid hormone nuclear receptors. The carboxy-terminal region of SMRT contains CoRNR box motifs that mediate these interactions. We have shown, in Xenopus, that SMRT can exist as isoforms containing either two or three CoRNR box...

journal_title：Developmental biology

authors： Malartre M,Short S,Sharpe C

更新日期：2006-04-15 00:00:00

abstract：:A large subset of mammalian imprinted genes show extra-embryonic lineage (EXEL) specific imprinted expression that is restricted to placental trophectoderm lineages and to visceral yolk sac endoderm (ysE). Isolated ysE provides a homogenous in vivo model of a mid-gestation extra-embryonic tissue to examine the mechani...

journal_title：Developmental biology

authors： Kulinski TM,Casari MR,Guenzl PM,Wenzel D,Andergassen D,Hladik A,Datlinger P,Farlik M,Theussl HC,Penninger JM,Knapp S,Bock C,Barlow DP,Hudson QJ

更新日期：2015-06-15 00:00:00

abstract：:During metamorphosis, the steroid hormone 20-hydroxyecdysone induces morphogenesis of imaginal discs, including the formation of appendages. IMP-E2 is an ecdysone-dependent, single-copy Drosophila gene, whose transcripts accumulate rapidly in imaginal discs in response to the hormone. The IMP-E2 product is secreted at...

journal_title：Developmental biology

authors： Paine-Saunders S,Fristrom D,Fristrom JW

更新日期：1990-08-01 00:00:00

abstract：:In vertebrates, hematopoietic and vascular progenitors develop from ventral mesoderm. The first primitive wave of hematopoiesis yields embryonic red blood cells, whereas progenitor cells of subsequent definitive waves form all hematopoietic cell lineages. In this report we examine the development of hematopoietic and ...

journal_title：Developmental biology

authors： Thompson MA,Ransom DG,Pratt SJ,MacLennan H,Kieran MW,Detrich HW 3rd,Vail B,Huber TL,Paw B,Brownlie AJ,Oates AC,Fritz A,Gates MA,Amores A,Bahary N,Talbot WS,Her H,Beier DR,Postlethwait JH,Zon LI

更新日期：1998-05-15 00:00:00

abstract：:The Jonah gene family consists of approximately 20 genes, distributed in small clusters at eight or more widely dispersed chromosomal sites. Gene clusters differ in the number of genes per cluster, ranging up to four, and in the arrangement of genes within clusters, which include direct repeats, inverted repeats, and ...

journal_title：Developmental biology

authors： Carlson JR,Hogness DS

更新日期：1985-04-01 00:00:00

abstract：:There is a natural curiosity about how organisms give rise to offspring like themselves through a series of reproducible developmental events and how, once mature, these offspring mate and continue the process giving rise the next generation. In the mid-1800s investigators started using gametes and embryos to explore ...

journal_title：Developmental biology

authors： Ernst SG

更新日期：2011-10-15 00:00:00

abstract：:During mouse fertilization the spermatozoon induces a series of low-frequency long-lasting Ca(2+) oscillations. It is generally accepted that these oscillations are due to Ca(2+) release through the inositol 1,4,5-trisphosphate (InsP(3)) receptor. However, InsP(3) microinjection does not mimic sperm-induced Ca(2+) osc...

journal_title：Developmental biology

authors： Jones KT,Nixon VL

更新日期：2000-09-01 00:00:00

abstract：:In order to further our understanding of the biological role of desmin, the muscle-specific intermediate filament protein, a null mutation in the desmin gene was introduced into the germ line of mice. Despite the complete lack of desmin, these mice developed and reproduced. Since we show that skeletal, cardiac, and sm...

journal_title：Developmental biology

authors： Li Z,Colucci-Guyon E,Pinçon-Raymond M,Mericskay M,Pournin S,Paulin D,Babinet C

更新日期：1996-05-01 00:00:00

abstract：:Metazoan development involves a myriad of dynamic cellular processes that require cytoskeletal function. Nonmuscle myosin II plays essential roles in embryonic development; however, knowledge of its role in post-embryonic development, even in model organisms such as Drosophila melanogaster, is only recently being reve...

journal_title：Developmental biology

authors： Franke JD,Montague RA,Kiehart DP

更新日期：2010-09-15 00:00:00

abstract：:Hox genes can function as key drivers of segment identity, with Hox mutations in Drosophila often resulting in dramatic homeotic transformations. In addition, however, they can serve other essential functions. In mammals, the study of Hox gene roles in development is complicated by the presence of four Hox clusters wi...

journal_title：Developmental biology

authors： Magella B,Mahoney R,Adam M,Potter SS

更新日期：2018-06-15 00:00:00

abstract：:Previous studies have shown CD34 family member Podocalyxin is required for epithelial lumen formation in vitro. We demonstrate that Endoglycan, a CD34 family member with homology to Podocalyxin, is produced prior to lumen formation in developing nephrons. Endoglycan localizes to Rab11-containing vesicles in nephron pr...

journal_title：Developmental biology

authors： Yang Z,Zimmerman SE,Tsunezumi J,Braitsch C,Trent C,Bryant DM,Cleaver O,González-Manchón C,Marciano DK

更新日期：2016-10-01 00:00:00

abstract：:The rabbit ovum seldom becomes polyspermic despite the presence of supernumerary sperm with easy access to the ovum plasma membrane. The purpose of this study was to characterize the role of ovum investments in blocking polyspermy. Ova were inseminated with capacitated sperm in vitro and were fertilized. Early stages ...

journal_title：Developmental biology

authors： McCulloh DH,Wall RJ,Levitan H

更新日期：1987-04-01 00:00:00

abstract：:We have used a subtractive method to clone novel messages enriched in the heart. Here we show that one such message, bves (blood vessel/epicardial substance) is a novel protein that is highly conserved between chicken and mouse. The bves message is detected at high levels in early chick hearts. Using anti-Bves antibod...

journal_title：Developmental biology

authors： Reese DE,Zavaljevski M,Streiff NL,Bader D

更新日期：1999-05-01 00:00:00

abstract：:Autoradiography has been used to confirm and to extend previous microspectrophotometric studies (Doerder and DeBault, 1975) on the timing of DNA synthesis during conjugation in Tetrahymena thermophila. The majority of DNA synthesis occurs at the expected periods preceding gamete formation and the two postzygotic divis...

journal_title：Developmental biology

authors： Allis CD,Colavito-Shepanski M,Gorovsky MA

更新日期：1987-12-01 00:00:00

abstract：:A subset of macrophages that reside in adult tissues originate from the fetal yolk sac, while others derive from circulating monocytes. These ontologically different macrophage subsets have distinct roles in tissue injury responses, with the embryonic population overall having beneficial activity in cardiac repair. He...

journal_title：Developmental biology

authors： Stevens SM,von Gise A,VanDusen N,Zhou B,Pu WT

更新日期：2016-05-15 00:00:00

abstract：:In Xenopus laevis, the capacity to regenerate a new lens from the outer cornea gradually decreases between stages 50 and 58, is almost negligible during the metamorphic climax, and disappears after metamorphosis. The factors responsible for lens transdifferentiation of the outer cornea are produced by the neural retin...

journal_title：Developmental biology

authors： Filoni S,Bernardini S,Cannata SM,D'Alessio A

更新日期：1997-07-01 00:00:00

abstract：:Previous work has documented the importance of BMPs in eye development. Loss-of-function studies in mice, with targeted deletions in either the Bmp7 or Bmp4 genes, have shown that these molecules are critical for early eye development. On the basis of the asymmetry in the dorsal-ventral expression patterns of several ...

journal_title：Developmental biology

authors： Liu J,Wilson S,Reh T

更新日期：2003-04-01 00:00:00

abstract：:Ca2+-sensitive microelectrodes were used to study changes in cytoplasmic free calcium during progesterone-induced meiotic maturation in Xenopus laevis oocytes. In contrast to previous reports, no changes were detected during the maturation process, although a large activation pulse of Ca2+ was seen when in vitro matur...

journal_title：Developmental biology

authors： Robinson KR

更新日期：1985-06-01 00:00:00

abstract：:Zebrafish heart regeneration relies on the capacity of cardiomyocytes to proliferate upon injury. To understand the principles of this process after cryoinjury-induced myocardial infarction, we established a spatio-temporal map of mitotic cardiomyocytes and their differentiation dynamics. Immunodetection of phosphohis...

journal_title：Developmental biology

authors： Sallin P,de Preux Charles AS,Duruz V,Pfefferli C,Jaźwińska A

更新日期：2015-03-01 00:00:00

abstract：:FbxA is a novel member of a family of proteins that contain an F-box and WD40 repeats and that target specific proteins for degradation via proteasomes. In fruiting bodies formed from cells where the fbxA gene is disrupted (fbxA(-) cells), the spore mass fails to fully ascend the stalk. In addition, fbxA(-) slugs cont...

journal_title：Developmental biology

authors： Nelson MK,Clark A,Abe T,Nomura A,Yadava N,Funair CJ,Jermyn KA,Mohanty S,Firtel RA,Williams JG

更新日期：2000-08-01 00:00:00

abstract：:Botryllus schlosseri is a colonial marine urochordate in which all adult organisms (called zooids) in a colony die synchronously by apoptosis (programmed cell death) in cyclical fashion. During this death phase called takeover, cell corpses within the dying organism are engulfed by circulating phagocytic cells. The "o...

journal_title：Developmental biology

authors： Lauzon RJ,Ishizuka KJ,Weissman IL

更新日期：2002-09-15 00:00:00

abstract：:Pole cell formation in embryos of the parthenogenetic midge, Smittia sp., can be delayed or inhibited by irradiation of the posterior egg pole with ultraviolet light (uv). This leaves the schedule of nuclear divisions and chromosome eliminations virtually unaffected. However, uv irradiation delays the precocious migra...

journal_title：Developmental biology

authors： von Brunn A,Kalthoff K

更新日期：1983-12-01 00:00:00

abstract：:Recently, it has been suggested that a mouse sperm-associated protein with properties similar to the inhibitory guanine nucleotide-binding regulatory protein Gi plays an intermediary role in the zona pellucida-induced acrosome reaction (Endo, Y., Lee, M. A., and Kopf, G. S. 1987. Dev. Biol. 119, 210-216). In the prese...

journal_title：Developmental biology

authors： Endo Y,Lee MA,Kopf GS

更新日期：1988-09-01 00:00:00

abstract：:Results of numerous experiments indicate that the transient rise in intracellular Ca2+ following sperm-egg fusion is essential for the subsequent events that constitute egg activation. Some events of egg activation, e.g., cortical granule exocytosis, however, appear more sensitive to intracellular Ca2+ than other even...

journal_title：Developmental biology

authors： Xu Z,Lefevre L,Ducibella T,Schultz RM,Kopf GS

更新日期：1996-12-15 00:00:00

abstract：:Fertilized eggs of the leech Helobdella triserialis undergo a cytoplasmic reorganization which generates domains of nonyolky cytoplasm, called teloplasm, at the animal and vegetal poles. The segregation of teloplasm to one cell of the eight-cell embryo is responsible for a unique developmental fate of that cell, i.e.,...

journal_title：Developmental biology

authors： Astrow SH,Holton B,Weisblat DA

更新日期：1989-10-01 00:00:00

abstract：:A pair of the Drosophila eye-antennal disc gives rise to four distinct organs (eyes, antennae, maxillary palps, and ocelli) and surrounding head cuticle. Developmental processes of this imaginal disc provide an excellent model system to study the mechanism of regional specification and subsequent organogenesis. The do...

journal_title：Developmental biology

authors： Yorimitsu T,Kiritooshi N,Nakagoshi H

更新日期：2011-08-15 00:00:00

abstract：:Myogenic precursors in adult skeletal muscle (satellite cells) are mitotically quiescent but can proliferate in response to a variety of stresses including muscle injury. To gain further understanding of adult myoblasts, we analyzed myogenesis of satellite cells on intact fibers isolated from adult rat muscle. In this...

journal_title：Developmental biology

authors： Yablonka-Reuveni Z,Rivera AJ

更新日期：1994-08-01 00:00:00

abstract：:Named for its assembly near exon-exon junctions during pre-mRNA splicing, the exon junction complex (EJC) regulates multiple aspects of RNA biochemistry, including export of spliced mRNAs from the nucleus and translation. Transcriptome analyses have revealed broad EJC occupancy of spliced metazoan transcripts, yet inh...

journal_title：Developmental biology

authors： Kimball C,Powers K,Dustin J,Poirier V,Pellettieri J

更新日期：2020-01-01 00:00:00

abstract：:Because the formation of a mature nerve terminal requires the accumulation of large quantities of synaptic vesicles, the expression of synaptic vesicle proteins would be expected to correlate with synaptogenesis. However, previous studies have provided conflicting evidence on this point. We have examined the developme...

journal_title：Developmental biology

authors： Lou X,Bixby JL

更新日期：1993-09-01 00:00:00

abstract：:Hoxa-11 and Hoxd-11 are paralogous genes required for proper development of the vertebral column, the limbs, and the urogenital system. To further explore the functional relationship between these genes, as well as the potential rescue of one function by the other, we have introduced a Hoxd-11-expressing transgene int...

journal_title：Developmental biology

authors： Zákány J,Gérard M,Favier B,Potter SS,Duboule D

更新日期：1996-06-15 00:00:00