Role of CD34 family members in lumen formation in the developing kidney.

abstract：:The proper removal of superfluous neurons through apoptosis and subsequent phagocytosis is essential for normal development of the central nervous system (CNS). During Drosophila embryogenesis, a large number of apoptotic neurons are efficiently engulfed and degraded by phagocytic glia. Here we demonstrate that glial ...

journal_title：Developmental biology

authors： Shklyar B,Sellman Y,Shklover J,Mishnaevski K,Levy-Adam F,Kurant E

更新日期：2014-09-15 00:00:00

abstract：:Hox genes can function as key drivers of segment identity, with Hox mutations in Drosophila often resulting in dramatic homeotic transformations. In addition, however, they can serve other essential functions. In mammals, the study of Hox gene roles in development is complicated by the presence of four Hox clusters wi...

journal_title：Developmental biology

authors： Magella B,Mahoney R,Adam M,Potter SS

更新日期：2018-06-15 00:00:00

abstract：:Cerebellum development involves the coordinated production of multiple neuronal cell types. The cerebellar primordium contains two germinative zones, the rhombic lip (RL) and the ventricular zone (VZ), which generate different types of glutamatergic and GABAergic neurons, respectively. What regulates the specification...

journal_title：Developmental biology

authors： Fernandes M,Antoine M,Hébert JM

更新日期：2012-05-01 00:00:00

abstract：:The mammalian thalamus is an essential diencephalic derivative that plays unique roles in processing and relaying sensory and motor information to and from the cerebral cortex. The profile of transcription factors and lineage tracing experiments revealed a spatiotemporal relationship between diencephalic progenitor do...

journal_title：Developmental biology

authors： Song H,Lee B,Pyun D,Guimera J,Son Y,Yoon J,Baek K,Wurst W,Jeong Y

更新日期：2015-02-15 00:00:00

abstract：:Chordin is the prototype of a group of cysteine-rich domain-containing proteins that bind and modulate signaling of various TGFbeta-like ligands. Chordin-like 1 and 2 (CHL1 and 2) are two members of this group that have been described in human, mouse, and chick. However, in vivo roles for CHL1 and 2 in early developme...

journal_title：Developmental biology

authors： Branam AM,Hoffman GG,Pelegri F,Greenspan DS

更新日期：2010-05-15 00:00:00

abstract：:Newts regenerate lost limbs through a complex process involving dedifferentiation, migration, proliferation, and redifferentiation of cells proximal to the amputation plane. To identify the genes controlling these cellular events, we performed a differential display analysis between regenerating and nonregenerating li...

journal_title：Developmental biology

authors： Vinarsky V,Atkinson DL,Stevenson TJ,Keating MT,Odelberg SJ

更新日期：2005-03-01 00:00:00

abstract：:A monoclonal antibody, Mab 8A2, that recognizes a novel set of gangliosides was produced by immunizing a mouse with Embryonic Day 14 chick optic nerve. Immunohistochemical studies of the developing chick retina revealed a complex pattern of Mab 8A2 immunoreactivity. Initially, staining is concentrated in the optic fib...

journal_title：Developmental biology

authors： Drazba J,Pierce M,Lemmon V

更新日期：1991-05-01 00:00:00

abstract：:Implantation represents a critical step for embryonic development and pregnancy. Its success depends on the complex interplay between a receptive endometrium and a competent embryo. Implantation-related events remain hardly accessible, making implantation a true "black box" in developmental biology. Improved in vitro ...

journal_title：Developmental biology

authors： Ban Z,Knöspel F,Schneider MR

更新日期：2020-07-01 00:00:00

abstract：:Primitive erythropoiesis is regulated in a non cell-autonomous fashion across evolution from frogs to mammals. In Xenopus laevis, signals from the overlying ectoderm are required to induce the mesoderm to adopt an erythroid fate. Previous studies in our lab identified the transcription factor GATA2 as a key regulator ...

journal_title：Developmental biology

authors： Mimoto MS,Kwon S,Green YS,Goldman D,Christian JL

更新日期：2015-11-01 00:00:00

abstract：:Growth factors and the extracellular matrix have been shown to fulfill vital developmental roles in many embryonic systems. Our hypothesis is that a developmental role played by the extracellular matrix in sea urchins may be the binding of a PDGF-like growth factor to promote signaling activity. We report here that an...

journal_title：Developmental biology

authors： Govindarajan V,Ramachandran RK,George JM,Shakes DC,Tomlinson CR

更新日期：1995-12-01 00:00:00

abstract：:Fertilization-related sperm mitochondrial movement occurs at a rate comparable to other actin-myosin-driven movements and is inhibited by cytochalasin B and N-ethyl maleimide in Ascidia ceratodes sperm. F-actin was demonstrated in the tails and mitochondria using NBD-phallacidin fluorescence. Both actin and myosin wer...

journal_title：Developmental biology

authors： Lambert CC,Lambert G

更新日期：1984-12-01 00:00:00

abstract：:Although local epithelial-mesenchymal tissue interactions which are presumably mediated by extracellular matrix molecules are important regulators of tooth morphogenesis and differentiation, our studies have indicated that these developmental processes also depend on circulating molecules. The iron-carrying serum prot...

journal_title：Developmental biology

authors： Partanen AM,Ekblom P,Thesleff I

更新日期：1985-09-01 00:00:00

abstract：:Thyroid hormone (TH) induces dramatic skeletal and tissue remodeling of the anuran head and body at metamorphosis. The expression pattern of TH up-regulated genes has been correlated with tissues that either grow or resorb at metamorphosis. Whereas the expression of the thyroid hormone receptors in Xenopus laevis tadp...

journal_title：Developmental biology

authors： Berry DL,Rose CS,Remo BF,Brown DD

更新日期：1998-11-01 00:00:00

abstract：:A functional ribosomal protein mRNA, encoding the 60 S subunit protein L1, has been synthesized in vitro using bacteriophage SP6 RNA polymerase. This mRNA directs the synthesis of a product indistinguishable from L1 protein purified from Xenopus ovarian ribosomes. Our results show that L1 synthesis in stage VI oocytes...

journal_title：Developmental biology

authors： Baum EZ,Hyman LE,Wormington WM

更新日期：1988-03-01 00:00:00

abstract：:Similar amounts of expression of a luciferase reporter gene that is driven by the SV40 early promoter are detected in G2 of 1-cell mouse embryo following injection of the male pronucleus in either early or mid/late S. No luciferase activity is observed when the male pronucleus is injected in early S and the embryos an...

journal_title：Developmental biology

authors： Ram PT,Schultz RM

更新日期：1993-04-01 00:00:00

abstract：:We have identified zebrafish orthologues of glial cell line-derived neurotrophic factor (GDNF) and the ligand-binding component of its receptor GFRalpha1. We examined the mRNA expression pattern of these genes in the developing spinal cord primary motor neurons (PMN), kidney, and enteric nervous systems (ENS) and have...

journal_title：Developmental biology

authors： Shepherd IT,Beattie CE,Raible DW

更新日期：2001-03-15 00:00:00

abstract：:Mouse sperm surface galactosyltransferase (GalTase) mediates fertilization by binding to its appropriate glycoconjugate substrate in the egg zona pellucida. GalTase is present throughout all stages of spermatogenesis, during which time it redistributes within the plasma membrane from a uniform, diffuse distribution on...

journal_title：Developmental biology

authors： Scully NF,Shur BD

更新日期：1988-01-01 00:00:00

abstract：:Named for its assembly near exon-exon junctions during pre-mRNA splicing, the exon junction complex (EJC) regulates multiple aspects of RNA biochemistry, including export of spliced mRNAs from the nucleus and translation. Transcriptome analyses have revealed broad EJC occupancy of spliced metazoan transcripts, yet inh...

journal_title：Developmental biology

authors： Kimball C,Powers K,Dustin J,Poirier V,Pellettieri J

更新日期：2020-01-01 00:00:00

abstract：:The effect of epidermal growth factor (EGF) on cellular differentiation of the neonatal mouse mandibular incisor was examined autoradiographically using tritiated thymidine ([3H]TDR) and tritiated proline ([3H]PRO). On days 0 (day of birth), 1, and 2, EGF was administered (3 micrograms/g body wt) sc to neonates. Mice ...

journal_title：Developmental biology

authors： Topham RT,Chiego DJ Jr,Gattone VH 2nd,Hinton DA,Klein RM

更新日期：1987-12-01 00:00:00

abstract：:We have studied the differentiation of the oocyte vitelline coat (VC) and jelly coat (JC) of the starfish, Astropecten aurantiacus. The precursor material of both envelopes is secreted by the oocyte while the follicle cells do not appear to participate in the secretory process. The first indication of differentiation ...

journal_title：Developmental biology

authors： Santella L,Monroy A,Rosati F

更新日期：1983-10-01 00:00:00

abstract：:Cytotrophoblasts are specialized epithelial cells of the human placenta that differentiate to acquire tumor-like properties that allow them to invade the uterus. Concurrently, they develop endothelial-like characteristics. This transformation allows cytotrophoblasts to replace the maternal cells that line uterine vess...

journal_title：Developmental biology

authors： Zhou Y,Bellingard V,Feng KT,McMaster M,Fisher SJ

更新日期：2003-11-01 00:00:00

abstract：:Despite differences in the formation of neural precursors, all arthropod species analyzed so far generate about 30 single precursors (insects/crustaceans) or precursor groups (chelicerates/myriapods) per hemi-segment. In Drosophila, each precursor has a distinct identity conferred by segment polarity and dorso-ventral...

journal_title：Developmental biology

authors： Chipman AD,Stollewerk A

更新日期：2006-02-15 00:00:00

abstract：:The notochord is the defining characteristic of the chordate embryo and plays critical roles as a signaling center and as the primitive skeleton. In this study we show that early notochord development in Xenopus embryos is regulated by apoptosis. We find apoptotic cells in the notochord beginning at the neural groove ...

journal_title：Developmental biology

authors： Malikova MA,Van Stry M,Symes K

更新日期：2007-11-15 00:00:00

abstract：:Developmental effects of six mutations in the gene encoding the majority of alpha-tubulin in all tissues at all stages of Drosophila melanogaster development have been examined. All six alleles produce at least partially stable alpha 84B protein. In genetic assays, two of these alleles approximate the null condition. ...

journal_title：Developmental biology

authors： Matthews KA,Kaufman TC

更新日期：1987-01-01 00:00:00

abstract：:Recently, it has been suggested that a mouse sperm-associated protein with properties similar to the inhibitory guanine nucleotide-binding regulatory protein Gi plays an intermediary role in the zona pellucida-induced acrosome reaction (Endo, Y., Lee, M. A., and Kopf, G. S. 1987. Dev. Biol. 119, 210-216). In the prese...

journal_title：Developmental biology

authors： Endo Y,Lee MA,Kopf GS

更新日期：1988-09-01 00:00:00

abstract：:During development of the vertebrate visual system, retinal ganglion cell (RGC) axons follow a precise path toward their midbrain targets. Although much is known about the cues that direct RGC axons once they have left the optic disc, less is known about the guidance of axons at earlier stages, when RGCs first send ou...

journal_title：Developmental biology

authors： Ohta K,Tannahill D,Yoshida K,Johnson AR,Cook GM,Keynes RJ

更新日期：1999-07-01 00:00:00

abstract：:In studies initially focused on roles of nonmuscle myosin IIA (NMIIA) in the developing mouse epidermis, we have discovered that a previously described cytokeratin 5 (K5)-Cre gene construct is expressed in early embryo development. Mice carrying floxed alleles of the nonmuscle myosin II heavy chain gene (NMHC IIA(flox...

journal_title：Developmental biology

authors： Crish J,Conti MA,Sakai T,Adelstein RS,Egelhoff TT

更新日期：2013-10-01 00:00:00

abstract：:The ancestral state of animal gastrulation and its bearing for our understanding of bilaterian evolution still is one of the most controversially discussed topics in the field of evolutionary and developmental biology. One hypothesis, the so-called amphistomy scenario, suggests the presence of a slit-like blastopore i...

journal_title：Developmental biology

authors： Janssen R,Budd GE

更新日期：2017-07-01 00:00:00

abstract：:The role of retrograde signaling between target cells and their presynaptic partners during early cell-cell interactions was examined in cell culture. Using time-lapse video microscopy and fura-2 calcium analysis, we followed contacts between presynaptic neurites of Helisoma motoneurons and muscle fibers dissociated f...

journal_title：Developmental biology

authors： Zoran MJ,Funte LR,Kater SB,Haydon PG

更新日期：1993-07-01 00:00:00

abstract：:The dopaminergic neurons of the basal ganglia play critical roles in CNS function and human disease, but specification of dopamine neuron phenotype is poorly understood in vertebrates. We performed an in vivo screen in zebrafish to identify dopaminergic neuron enhancers, in order to facilitate studies on the specifica...

journal_title：Developmental biology

authors： Fujimoto E,Stevenson TJ,Chien CB,Bonkowsky JL

更新日期：2011-04-15 00:00:00